Cognitive-Behavioural Analysis System of Psychotherapy (CBASP), a drug, or their combination: differential therapeutics for persistent depressive disorder: a study protocol of an individual participant data network meta-analysis.

INTRODUCTION Despite important advances in psychological and pharmacological treatments of persistent depressive disorders in the past decades, their responses remain typically slow and poor, and differential responses among different modalities of treatments or their combinations are not well understood. Cognitive-Behavioural Analysis System of Psychotherapy (CBASP) is the only psychotherapy that has been specifically designed for chronic depression and has been examined in an increasing number of trials against medications, alone or in combination. When several treatment alternatives are available for a certain condition, network meta-analysis (NMA) provides a powerful tool to examine their relative efficacy by combining all direct and indirect comparisons. Individual participant data (IPD) meta-analysis enables exploration of impacts of individual characteristics that lead to a differentiated approach matching treatments to specific subgroups of patients. METHODS AND ANALYSIS We will search for all randomised controlled trials that compared CBASP, pharmacotherapy or their combination, in the treatment of patients with persistent depressive disorder, in Cochrane CENTRAL, PUBMED, SCOPUS and PsycINFO, supplemented by personal contacts. Individual participant data will be sought from the principal investigators of all the identified trials. Our primary outcomes are depression severity as measured on a continuous observer-rated scale for depression, and dropouts for any reason as a proxy measure of overall treatment acceptability. We will conduct a one-step IPD-NMA to compare CBASP, medications and their combinations, and also carry out a meta-regression to identify their prognostic factors and effect moderators. The model will be fitted in OpenBUGS, using vague priors for all location parameters. For the heterogeneity we will use a half-normal prior on the SD. ETHICS AND DISSEMINATION This study requires no ethical approval. We will publish the findings in a peer-reviewed journal. The study results will contribute to more finely differentiated therapeutics for patients suffering from this chronically disabling disorder. TRIAL REGISTRATION NUMBER CRD42016035886.

Elimination of prions by branched polyamines and implications for therapeutics

We report that branched polyamines, including polyamidoamide dendimers, polypropyleneimine, and polyethyleneimine, are able to purge PrPSc, the protease-resistant isoform of the prion protein, from scrapie-infected neuroblastoma (ScN2a) cells in culture. The removal of PrPSc by these compounds depends on both the concentration of branched polymer and the duration of exposure. Chronic exposure of ScN2a cells to low noncytotoxic concentrations of branched polyamines for 1 wk reduced PrPSc to an undetectable level, a condition that persisted at least 3 wk after removal of the compound. Structure–activity analysis revealed that a high surface density of primary amino groups is required for polyamines to eliminate PrPSc effectively from cells. The removal of PrPSc by branched polyamines is attenuated by chloroquine in living cells, and exposure of scrapie-infected brain extracts with branched polyamines at acidic pH rendered the PrPSc susceptible to protease in vitro, suggesting that endosomes or lysozomes may be the site of action. Our studies suggest that branched polyamines might be useful therapeutic agents for treatment of prion diseases and perhaps a variety of other degenerative disorders.

Modern therapeutics, medical and surgical; including the diseases of women and children. A compendium of recent formulae and therapeutical directions from the practice of eminent contemporary physicians, American and foreign.

Combined ed. of his Modern medical therapeutics, Modern surgical therapeutics, Therapeutics of gynecology and Obstetrics, and Therapeutics of diseases of children.

Elements of materia medica and therapeutics : including the recent discoveries and analysis of medicines /

Fecha sacada del prólogo de la 3a. edición.

Elements of electro-biology, or the voltaic mechanism of man of electro-pathology, especially of the nervous system and of electro-therapeutics /

Mode of access: Internet.

Lectures on materia medica and therapeutics, delivered in the College of Physicians and Surgeons of the University of the State of New York /

Mode of access: Internet.

Elements of materia medica and therapeutics : including the recent discoveries and analyses of medicines /

Mode of access: Internet.

A manual of materia medica and therapeutics : including the preparations of the pharmacopoeias of London, Edinburgh and Dublin... /

Índice.

Special pathology and therapeutics of the diseases of domestic animals,

Translation of Spezielle Pathologie und Therapie der Haustiere.

A text-book of practical therapeutics, with especial reference to the application of remedial measures to disease and their employment upon a rational basis.

Mode of access: Internet.

Therapeutics of the circulation.

Mode of access: Internet.

Therapeutics, materia medica, and pharmacy, including the special therapeutics of diseases and symptoms, the physiological and therapeutical actions of drugs, the modern materia medica, official and practical pharmacy, minute directions for prescription writing, also the antidotal and antagonistic treatment of poisoning,

Tables on lining-papers.

The theory of ions : a consideration of its place in biology and therapeutics /

Mode of access: Internet.

Veterinary pharmacology and therapeutics.

Mode of access: Internet.