995 resultados para Apuldrefield Manor, Eng.
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Pós-graduação em Educação - FFC
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Die vorliegende Dissertation analysiert die Middleware- Technologien CORBA (Common Object Request Broker Architecture), COM/DCOM (Component Object Model/Distributed Component Object Model), J2EE (Java-2-Enterprise Edition) und Web Services (inklusive .NET) auf ihre Eignung bzgl. eng und lose gekoppelten verteilten Anwendungen. Zusätzlich werden primär für CORBA die dynamischen CORBA-Komponenten DII (Dynamic Invocation Interface), IFR (Interface Repository) und die generischen Datentypen Any und DynAny (dynamisches Any) im Detail untersucht. Ziel ist es, a. konkrete Aussagen über diese Komponenten zu erzielen, und festzustellen, in welchem Umfeld diese generischen Ansätze ihre Berechtigung finden. b. das zeitliche Verhalten der dynamischen Komponenten bzgl. der Informationsgewinnung über die unbekannten Objekte zu analysieren. c. das zeitliche Verhalten der dynamischen Komponenten bzgl. ihrer Kommunikation zu messen. d. das zeitliche Verhalten bzgl. der Erzeugung von generischen Datentypen und das Einstellen von Daten zu messen und zu analysieren. e. das zeitliche Verhalten bzgl. des Erstellens von unbekannten, d. h. nicht in IDL beschriebenen Datentypen zur Laufzeit zu messen und zu analysieren. f. die Vorzüge/Nachteile der dynamischen Komponenten aufzuzeigen, ihre Einsatzgebiete zu definieren und mit anderen Technologien wie COM/DCOM, J2EE und den Web Services bzgl. ihrer Möglichkeiten zu vergleichen. g. Aussagen bzgl. enger und loser Koppelung zu tätigen. CORBA wird als standardisierte und vollständige Verteilungsplattform ausgewählt, um die o. a. Problemstellungen zu untersuchen. Bzgl. seines dynamischen Verhaltens, das zum Zeitpunkt dieser Ausarbeitung noch nicht oder nur unzureichend untersucht wurde, sind CORBA und die Web Services richtungsweisend bzgl. a. Arbeiten mit unbekannten Objekten. Dies kann durchaus Implikationen bzgl. der Entwicklung intelligenter Softwareagenten haben. b. der Integration von Legacy-Applikationen. c. der Möglichkeiten im Zusammenhang mit B2B (Business-to-Business). Diese Problemstellungen beinhalten auch allgemeine Fragen zum Marshalling/Unmarshalling von Daten und welche Aufwände hierfür notwendig sind, ebenso wie allgemeine Aussagen bzgl. der Echtzeitfähigkeit von CORBA-basierten, verteilten Anwendungen. Die Ergebnisse werden anschließend auf andere Technologien wie COM/DCOM, J2EE und den Web Services, soweit es zulässig ist, übertragen. Die Vergleiche CORBA mit DCOM, CORBA mit J2EE und CORBA mit Web Services zeigen im Detail die Eignung dieser Technologien bzgl. loser und enger Koppelung. Desweiteren werden aus den erzielten Resultaten allgemeine Konzepte bzgl. der Architektur und der Optimierung der Kommunikation abgeleitet. Diese Empfehlungen gelten uneingeschränkt für alle untersuchten Technologien im Zusammenhang mit verteilter Verarbeitung.
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The thesis moves from the need of understanding how a historical building would behave in case of earthquake and this purpose is strongly linked to the fact that the majority of Italian structures are old ones placed in seismic sites. Primarily an architectural and chronological research is provided in order to figure out how the building has developed in time; then, after the reconstruction of the skeleton of the analyzed element (“Villa i Bossi” in Gragnone, AR), a virtual model is created such that the main walls and sections are tested according to the magnitude of expected seismic events within the reference area. This approach is basically aimed at verifying the structure’s reliability as composed by single units; the latter are treated individually in order to find out all the main critical points where rehabilitation might be needed. Finally the most harmful sections are studied in detail and proper strengthening is advised according to the current know-how.
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Previous work has shown that the -tocopherol transfer protein ( -TTP) can bind to vesicular or immobilized phospholipid membranes. Revealing the molecular mechanisms by which -TTP associates with membranes is thought to be critical to understanding its function and role in the secretion of tocopherol from hepatocytes into the circulation. Calculations presented in the Orientations of Proteins in Membranes database have provided a testable model for the spatial arrangement of -TTP and other CRAL-TRIO family proteins with respect to the lipid bilayer. These calculations predicted that a hydrophobic surface mediates the interaction of -TTP with lipid membranes. To test the validity of these predictions, we used site-directed mutagenesis and examined the substituted mutants with regard to intermembrane ligand transfer, association with lipid layers and biological activity in cultured hepatocytes. Substitution of residues in helices A8 (F165A and F169A) and A10 (I202A, V206A and M209A) decreased the rate of intermembrane ligand transfer as well as protein adsorption to phospholipid bilayers. The largest impairment was observed upon mutation of residues that are predicted to be fully immersed in the lipid bilayer in both apo (open) and holo (closed) conformations such as Phe165 and Phe169. Mutation F169A, and especially F169D, significantly impaired -TTP-assisted secretion of -tocopherol outside cultured hepatocytes. Mutation of selected basic residues (R192H, K211A, and K217A) had little effect on transfer rates, indicating no significant involvement of nonspecific electrostatic interactions with membranes.
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Introduction:Today, many countries, regardless of developed or developing, are trying to promote decentralization. According to Manor, as his quoting of Nickson’s argument, decentralization stems from the necessity to strengthen local governments as proxy of civil society to fill the yawning gap between the state and civil society (Manor [1999]: 30). With the end to the Cold War following the collapse of the Soviet Union rendering the cause of the “leadership of the central government to counter communism” meaningless, Manor points out, it has become increasingly difficult to respond flexibly to changes in society under the centralized system. Then, what benefits can be expected from the effectuation of decentralization? Litvack-Ahmad-Bird cited the four points: attainment of allocative efficiency in the face of different local preferences for local public goods; improvement to government competitiveness; realization of good governance; and enhancement of the legitimacy and sustainability of heterogeneous national states (Litvack, Ahmad & Bird [1998]: 5). They all contribute to reducing the economic and social costs of a central government unable to respond to changes in society and enhancing the efficiency of state administration through the delegation of authority to local governments. Why did Indonesia have a go at decentralization? As Maryanov recognizes, reasons for the implementation of decentralization in Indonesia have never been explicitly presented (Maryanov [1958]: 17). But there was strong momentum toward building a democratic state in Indonesia at the time of independence, and as indicated by provisions of Article 18 of the 1945 Constitution, there was the tendency in Indonesia from the beginning to debate decentralization in association with democratization. That said debate about democratization was fairly abstract and the main points are to ease the tensions, quiet the complaints, satisfy the political forces and thus stabilize the process of government (Maryanov [1958]: 26-27). What triggered decentralization in Indonesia in earnest, of course, was the collapse of the Soeharto regime in May 1998. The Soeharto regime, regarded as the epitome of the centralization of power, became incapable of effectively dealing with problems in administration of the state and development administration. Besides, the post-Soeharto era of “reform (reformasi)” demanded the complete wipeout of the Soeharto image. In contraposition to the centralization of power was decentralization. The Soeharto regime that ruled Indonesia for 32 years was established in 1966 under the banner of “anti-communism.” The end of the Cold War structure in the late 1980s undermined the legitimate reason the centralization of power to counter communism claimed by the Soeharto regime. The factor for decentralization cited by Manor is applicable here. Decentralization can be interpreted to mean not only the reversal of the centralized system of government due to its inability to respond to changes in society, as Manor points out, but also the participation of local governments in the process of the nation state building through the more positive transfer of power (democratic decentralization) and in the coordinated pursuit with the central government for a new shape of the state. However, it is also true that a variety of problems are gushing out in the process of implementing decentralization in Indonesia. This paper discusses the relationship between decentralization and the formation of the nation state with the awareness of the problems and issues described above. Section 1 retraces the history of decentralization by examining laws and regulations for local administration and how they were actually implemented or not. Section 2 focuses on the relationships among the central government, local governments, foreign companies and other actors in the play over the distribution of profits from exploitation of natural resources, and examines the process of the ulterior motives of these actors and the amplification of mistrust spawning intense conflicts that, in extreme cases, grew into separation and independence movements. Section 3 considers the merits and demerits at this stage of decentralization implemented since 2001 and shed light on the significance of decentralization in terms of the nation state building. Finally, Section 4 attempts to review decentralization as the “opportunity to learn by doing” for the central and local governments in the process of the nation state building. In the context of decentralization in Indonesia, deconcentration (dekonsentrasi), decentralization (desentralisasi) and support assignments (tugas pembantuan; medebewind, a Dutch word, was used previously) are defined as follows. Dekonsentrasi means that when the central government puts a local office of its own, or an outpost agency, in charge of implementing its service without delegating the administrative authority over this particular service. The outpost agency carries out the services as instructed by the central government. A head of a local government, when acting for the central government, gets involved in the process of dekonsentrasi. Desentralisasi, meanwhile, occurs when the central government cedes the administrative authority over a particular service to local governments. Under desentralisasi, local governments can undertake the particular service at their own discretion, and the central government, after the delegation of authority, cannot interfere with how local governments handle that service. Tugas pembantuan occur when the central government makes local governments or villages, or local governments make villages, undertake a particular service. In this case, the central government, or local governments, provides funding, equipment and materials necessary, and officials of local governments and villages undertake the service under the supervision and guidance of the central or local governments. Tugas pembantuan are maintained until local governments and villages become capable of undertaking that particular service on their own.