133 resultados para Amalgamation


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We report detailed evidence for a new paleo-suture zone (the Kumta suture) on the western margin of southern India. The c. 15-km-wide, westward dipping suture zone contains garnet-biotite, fuchsite-haematite, chlorite-quartz, quartz-phengite schists, biotite augen gneiss, marble and amphibolite. The isochemical phase diagram estimations and the high-Si phengite composition of quartz-phengite schist suggest a near-peak condition of c. 18 kbar at c. 550 degrees C, followed by near-isothermal decompression. The detrital SHRIMP U-Pb zircon ages from quartz-phengite schist give four age populations ranging from 3280 to 2993 Ma. Phengite from quartz-phengite schist and biotite from garnet-biotite schist have K-Ar metamorphic ages of ca. 1326 and ca. 1385 Ma respectively. Electron microprobe-CHIME ages of in situ zircons in quartz-phengite schist (ca. 3750 Ma and ca. 1697 Ma) are consistent with the above results. The Bondla ultramafic-gabbro complex in the west of the Kumta suture compositionally represents an arc with K-Ar biotite ages from gabbro in the range 1644-1536 Ma. On the eastern side of the suture are weakly deformed and unmetamorphosed shallow westward-dipping sedimentary rocks of the Sirsi shelf, which has the following upward stratigraphy: pebbly quartzite/sandstone, turbidite, magnetite iron formation, and limestone; farther east the lower lying quartzite has an unconformable contact with ca. 2571 Ma quartzo-feldspathic gneisses of the Dharwar block with a ca. 1733 Ma biotite cooling age. To the west of the suture is a c. 60-km-wide Karwar block mainly consisting of tonalite-trondhjemite-granodiorite (TTG) and amphibolite. The TTGs have U-Pb zircon magmatic ages of ca. 3200 Ma with a rare inherited core age of ca. 3601 Ma. The K-Ar biotite cooling age from the TTGs (1746 Ma and 1796 Ma) and amphibolite (ca. 1697 Ma) represents late-stage uplift. Integration of geological, structural and geochronological data from western India and eastern Madagascar suggest diachronous ocean closure during the amalgamation of Rodinia; in the north at around ca. 1380 Ma, and a progression toward the south until ca. 750 Ma. Satellite imagery based regional structural lineaments suggests that the Betsimisaraka suture continues into western India as the Kumta suture and possibly farther south toward a suture in the Coorg area, representing in total a c. 1000 km long Rodinian suture. (C) 2013 Elsevier B.V. All rights reserved.

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Madurai Block, the largest crustal block in the Southern Granulite Terrane (SGT) of Peninsular India, preserves the imprints of multistage tectonic evolution. Here, we present U-Pb and Hf isotope data on zircons from a charnockite-granite suite in the north-western part of this block. The oscillatory zoning, and the LREE to HREE enriched patterns of the zircons with positive Ce and negative Eu anomalies suggest that the zircon cores are of magmatic origin, with ages in the range of 2634-2435 Ma implying Neoarchean-Paleoproterozoic magmatism followed by subsequent metamorphism and protocontinent formation in the north-western part of the Madurai Block. A regional 550-500 Ma metamorphic overprint is also preserved in the zircons coinciding with the final amalgamation of the Gondwana supercontinent. The Hf isotopic data suggest that the granite and charnockite were derived from isotopically heterogeneous juvenile crustal domains and the charnockites show a significant contribution of mantle-derived components. Therefore, the Hf isotopic data reflect mixing of crustal and mantle-derived sources for the generation of Neoarchean crust in the north-western Madurai Block, possibly in a suprasubduction zone setting during continent building processes. (c) 2014 Elsevier Ltd. All rights reserved.

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Despite decades of research, it remains to be established whether the transformation of a liquid into a glass is fundamentally thermodynamic or dynamic in origin. Although observations of growing length scales are consistent with thermodynamic perspectives, the purely dynamic approach of the Dynamical Facilitation (DF) theory lacks experimental support. Further, for vitrification induced by randomly freezing a subset of particles in the liquid phase, simulations support the existence of an underlying thermodynamic phase transition, whereas the DF theory remains unexplored. Here, using video microscopy and holographic optical tweezers, we show that DF in a colloidal glass-forming liquid grows with density as well as the fraction of pinned particles. In addition, we observe that heterogeneous dynamics in the form of string-like cooperative motion emerges naturally within the framework of facilitation. Our findings suggest that a deeper understanding of the glass transition necessitates an amalgamation of existing theoretical approaches.

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This thesis covers four different problems in the understanding of vortex sheets, and these are presented in four chapters.

In Chapter 1, free streamline theory is used to determine the steady solutions of an array of identical, hollow or stagnant core vortices in an inviscid, incompressible fluid. Assuming the array is symmetric to rotation through π radians about an axis through any vortex centre, there are two solutions or no solutions depending on whether A^(1/2)/L is less than or greater than 0.38 where A is the area of the vortex and L is the separation distance. Stability analysis shows that the more deformed shape is unstable to infinitesimal symmetric disturbances which leave the centres of the vortices undisplaced.

Chapter 2 is concerned with the roll-up of vortex sheets in homogeneous fluid. The flow over conventional and ring wings is used to test the method of Fink and Soh (1974). Despite modifications which improve the accuracy of the method, unphysical results occur. A possible explanation for this is that small scales are important and an alternate method based on "Cloud-in-Cell" techniques is introduced. The results show small scale growth and amalgamation into larger structures.

The motion of a buoyant pair of line vortices of opposite circulation is considered in Chapter 3. The density difference between the fluid carried by the vortices and the fluid outside is considered small, so that the Boussinesq approximation may be used. A macroscopic model is developed which shows the formation of a detrainment filament and this is included as a modification to the model. The results agree well with the numerical solution as developed by Hill (1975b) and show that after an initial slowdown, the vortices begin to accelerate downwards.

Chapter 4 reproduces completely a paper that has already been published (Baker, Barker, Bofah and Saffman (1974)) on the effect of "vortex wandering" on the measurement of velocity profiles of the trailing vortices behind a wing.

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A bacia de Bengala, localizada a Nordeste da Índia tem uma história evolutiva extraordinária, diretamente controlada bela fragmentação do Gondwana. O início da formação desta bacia é considerada como sendo relacionada ao final do evento da quebra, datado em 126 Ma quando a Índia separou do continente Antártico e da Austrália. Desde então, a placa continental Indiana viajou do pólo sul a uma velocidade muito rápida (16 cm/a) chocando-se com o hemisfério norte e fundindo-se com a Placa Eurasiana. Durante a viagem passou por cima de um hot spot, onde hoje estão localizadas as ilhas Seicheles, resultando em um dos maiores derrames de lava basáltica do mundo, conhecido como Deccan Trap. Na região onde a bacia de Bengala foi formada, não houve aporte significativo de sedimentos siliciclásticos, resultando na deposição de uma espessa plataforma carbonática do Cretáceo tardio ao Eoceno. Após este período, devido a colisão com algumas microplacas e a amalgamação com a Placa Eurasiana, um grande volume sedimentar siliciclástico foi introduzido para a bacia, associado também ao soerguimento da cadeia de montanhas dos Himalaias. Atualmente, a Bacia de Bengala possui mais de 25 km de sedimentos, coletados neste depocentro principal. Nesta dissertação foram aplicados conceitos básicos de sismoestratigrafia na interpretação de algumas linhas regionais. As linhas sísmicas utilizadas foram adquiridas recentemente por programa sísmico especial, o qual permitiu o imageamento sísmico a mais de 35km dentro da litosfera (crosta continental e transicional). O dado permitiu interpretar eventos tectônicos, como a presença dos Seawards Dipping Reflectors (SDR) na crosta transicional, coberto por sedimentos da Bacia de Bengala. Além da interpretação sísmica amarrada a alguns poços de controle, o programa de modelagem sedimentar Beicip Franlab Dionisos, foi utilizado para modelar a história de preenchimento da bacia para um período de 5,2 Ma. O nível relativo do nível do mar e a taxa de aporte sedimentar foram os pontos chaves considerados no modelo. Através da utilização dos dados sísmicos, foi possível reconhecer dez quebras de plataformas principais, as quais foram utilizadas no modelo, amarrados aos seus respectivos tempos geológico, provenientes dos dados dos poços do Plioceno ao Holoceno. O resultado do modelo mostrou que a primeira metade modelada pode ser considerada como um sistema deposicional retrogradacional, com algum picos transgressivos. Este sistema muda drasticamente para um sistema progradacional, o qual atuou até o Holoceno. A seção modelada também mostra que no período considerado o total de volume depositado foi em torno de 2,1 x 106 km3, equivalente a 9,41 x 1014 km3/Ma.

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A chegada dos primeiros habitantes há cerca de 15.000 anos e de colonos portugueses e escravos africanos, desde o século 15, em sucessivas migrações na América do Sul, levaram à formação de populações miscigenadas com raízes consideravelmente diversificadas. É notável a heterogeneidade populacional decorrente dessas migrações e do processo de amalgamento de indígenas a partir dos contatos entre os diferentes grupos étnicos, iniciados com a colonização da América pelos europeus. A despeito da elevada miscigenação, ainda se pode encontrar no Brasil populações que, majoritariamente, mantém a identidade genética dos seus ancestrais mais remotos. O objetivo desse estudo foi caracterizar a ancestralidade da população de Santa Isabel do Rio Negro, Amazonas, com fortes traços fenotípicos ameríndios, e da tribo indígena Terena de Mato Grosso do Sul. Para isto, foram estudados marcadores uniparentais paternos ligados à região não recombinante do cromossomo Y e maternos presentes na região controle do DNA mitocondrial (mtDNA). Em relação à herança paterna, foram genotipados 31 indivíduos de Santa Isabel do Rio Negro, sendo que os Terena já haviam sido estudados sob este aspecto. Quanto ao mtDNA, foram estudados 76 indivíduos de ambos os sexos e 51 Indivíduos do sexo masculino de Santa Isabel do Rio Negro e dos Terena, respectivamente. A análise de marcadores Y-SNPs possibilitou a caracterização de 55% dos cromossomos Y dos indivíduos de Santa Isabel do Rio Negro como pertencentes ao haplogrupo Q1a3a*, característico de ameríndio. Através do mtDNA, foi verificado que o haplogrupo A é o mais frequente nas duas populações, com percentuais de 34% e 42% em Santa Isabel do Rio Negro e na tribo Terena, respectivamente, observando-se no tocante à ancestralidade materna a não ocorrência de diferenciação genética significativa entre as duas populações. Por outro lado, a análise do cromossomo Y revelou a ocorrência de distância genética significativa entre elas, o que pode ser resultante da diferença entre os tamanhos das amostras populacionais ou refletir diferenças entre rotas migratórias dos ameríndios anteriormente à colonização. Os resultados mostram ainda que os genomas mitocondriais autóctones foram melhor preservados, e que novos haplogrupos do cromossomo Y foram introduzidos recentemente na população ameríndia. É, portanto, possível concluir que a população de Santa Isabel do Rio Negro e a tribo indígena Terena apresentam um significativo grau de conservação da ancestralidade ameríndia, apesar do longo histórico de contato com europeus e africanos, os outros povos formadores da população brasileira.

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Nesta dissertação foram estudas rochas máficas dos complexos alcalinos de Morro de São João, Rio Bonito, Tanguá, Gericinó-Mendanha, Morro Redondo, Itatiaia e Passa Quatro. Essas rochas ocorrem na forma de diques e/ou sills. As amostras coletadas foram classificadas como lamprófiros, fonolitos, gabros e diabásios alcalinos. A análise geoquímica permitiu identificar um trend fortemente insaturado e um trend moderadamente alcalino para os complexos estudados. O primeiro é caracterizado por foiditos e fonolitos como membros parentais e mais evoluídos, respectivamente, enquanto o segundo tem basaltos alcalinos como membros parentais e traquitos como os mais evoluídos. Todas as amostras plotam no campo da série alcalina, sendo majoritariamente miaskíticas, sódicas ou potássicas. Adicionalmente, o estudo geoquímico indicou que os complexos alcalinos representam câmaras magmáticas distintas, onde diferentes processos evolutivos tiveram lugar. As modelagens apontaram dois processos de diferenciação distintos nos complexos estudados. Os complexos alcalinos de Morro de São João, Morro Redondo, Gericinó-Mendanha e Itatiaia estariam relacionados a processos de cristalização fracionada. Por outro lado, o Complexo Alcalino de Passa Quatro teria sido diferenciado por processos de cristalização fracionada com esvaziamento e posterior reabastecimento da câmara magmática (RTF). De um modo geral, esses modelos indicaram a presença de mais do que uma série magmática nos complexos estudados e a não cogeneticidade entre as séries agpaíticas e miaskíticas. A discriminação de fontes foi feita com base na análise dos elementos terras raras das amostras parentais de cada um dos complexos (gabro em Morro de São João e lamprófiro nos demais). No entanto, este procedimento não foi aplicado para o Complexo Alcalino de Morro Redondo, uma vez que todas as suas amostras apresentaram valores de MgO muito abaixo do típico para líquidos parentais. O líquido parental do Complexo Alcalino do Gericinó-Mendanha apresentou razões de La/Yb e La/Nb, maior e menor que a unidade, respectivamente, típicas de derivação a partir fontes férteis. Os líquidos parentais dos outros complexos alcalinos tiveram suas razões La/Yb e La/Nb maiores que a unidade, típicas de derivação a partir de fontes enriquecidas. Os modelos desenvolvidos revelaram que os líquidos parentais de cada um dos complexos estudados estariam relacionados a fontes lherzolíticas com granada residual. Além disso, a fusão parcial destas fontes teria ocorrido num intervalo de 1 a 7% dentro da zona da granada. Finalmente, as modelagens petrogenéticas elaboradas permitiram a proposição de um cenário geodinâmico, envolvendo a descompressão adiabática do manto litosférico e sublitosférico anomalamente aquecidos. As características geoquímicas dos líquidos parentais parecem ter sido controladas essencialmente pela mistura desses dois tipos de fontes.

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280 p.

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Fisheries employ a number of people and fisheries industry is truly an amalgamation of various disparate sectors. Fisheries play an important role in Indian economy and it provides employment to a number of people. For planning of integrated development of fisheries industry and resource management, a considerable amount of information is required. In this paper a study of the disparate sectors with regards to the nature of work, number of workers, sex-wise participation, earning type and earning in Indian Rupees in the year 1991-92, 1992-93, 1993-94 and 1999-2000 has been done in a selected fishing village. The geographical locale where the study has been done is Versova fishing village which is a major fish landing centre in Mumbai. The study has revealed that there are a number of disparate sectors in fisheries and in this fishing village on an average, a boat owner provided employment to 30-60 people in the year 1994 and to 19-25 people in 1999. Though this number has shown a decreasing trend with the advancement of years, it is however, seen that a number of people are employed in various disparate sectors in fisheries. It is necessary to highlight this and in any developmental planning, all these sectors should be given equal importance.

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This is a review of electrodes based on nontoxic solid amalgams (MeSAE) (prepared by amalgamation of soft metal powders) in connection with some other kinds of voltammetric electrodes is given. Information is summarized on various types of MeSAEs (esp. AgSAE, CuSAE, AuSAE), pretreatment of their surfaces, their hydrogen overvoltage in aqueous solutions, conditions for their testing, electroanalytical parameters and use, in compared with the hanging mercury drop electrode (HMDE). Although the solid amalgam electrodes do not reach the quality of the HMDE, in many cases they represent its possible alternative. The broad range of voltammetric applications of the MeSAEs, especially of the AgSAEs, their good mechanical stability, simple handling, and new aspects of their use in electrochemical techniques are documented by numerous examples.

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Heavy mineral assemblages, chemical compositions of diagnostic heavy minerals such as garnet and tourmaline, and U-Pb ages and Hf isotopic compositions of zircons are very effective means to determine sediment provenance. An integrated application of the above provides insight on the lithologies, crystallization ages and crustal formation ages of the parent magma of sediment source areas. As a result, the locations and characteristics of potential source areas can be constrained and contributions of different source regions may be evaluated. In addition, the study provides evidence for the magmatic and tectonic history of source areas using a novel approach. The heavy mineral assemblages, and chemical compositions of detrital garnets and tourmalines, U-Pb ages and Hf isotopic compositions of zircons for sand and loess samples deposited since the Last Glacial Maximum (LGM) from the Hulunbeier, Keerqin and Hunshandake sandlands were analyzed and compared to those of central-southern Mongolia, the central Tarim and surrounding potential source areas, the Central Asian Orogenic Belt (CAOB) and North China Craton (NCC). The following remarks on provenance and tectonic history can be made: 1. The source compositional characteristics of the Hulunbeier, Keerqin and Hunshandake sandlands are similar. They are derived from the CAOB and NCC whose contributions for the Keerqin and Hunshandake sandland are about 50%. For the Hulunbeier sandland it is somewhat less, about 40%. 2. Loesses around of the sandlands have the identical source signiture as the sands, implying that they are sorted by the same wind regime. 3. The source characteristics of the present and LGM sands are the same, providing direct evidence that the present sands originated from the reworking of LGM sands. 4. The provenance characteristics of the three sandlands differ from those of the Tarim. As a result, the possibility that the three eastern sandlands were sourced from the Taklimakan desert can be ruled out. 5. The source compositions of sand samples derived from the CAOB indicate that the occurrence of Archean and Paleoproterozoic metamorphic basement rocks is limited and continuous subduction-accretion events from the Neoproterozoic to the Mesozoic occurred. This implies that the CAOB is a orogenic collage belt similar to the present day southwest-Pacific, and formed by the amalgamation of small forearc and backarc ocean basins occurring between island arcs and microcontinents during continuous collision and accretion. The Hf isotopic signitures of detrital zircons indicate that large amounts of juvenile mantle materials were added to the CAOB crust during the Phanerozoic.

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Based on a viewpoint of an intricate system demanding high, this thesis advances a new concept that urban sustainable development stratagem is a high harmony and amalgamation among urban economy, geo-environment and tech-capital, and the optimum field of which lies in their mutual matching part, which quantitatively demarcates the optimum value field of urban sustainable development and establishes the academic foundation to describe and analyze sustainable development stratagem. And establishes a series of cause-effect model, a analysissitus model, flux model as well as its recognizing mode for urban system are established by the approach of System Dynamics, which can distinguish urban states by its polarity of entropy flows. At the same time, the matter flow, energy flow and information flow which exist in the course of urban development are analyzed based on the input/output (I/O) relationships of urban economy. And a new type of I/O relationships, namely new resources-environment account, are established, in which both resource and environment factors are considered. All above that settles a theoretic foundation for resource economy and environment economy as well as quantitative relationships of inter-function between urban development and geoenvironment, and gives a new approach to analyze natinal economy and urban sustainable development. Based on an analysis of the connection between resource-environmental construct of geoenvironment and urban economy development, the Geoenvironmental Carrying Capability (GeCC) is analyzed. Further more, a series of definitions and formula about the Gross Carrying Capability (GCC), Structure Carrying Capability (SCC) and Impulse Carrying Capability (ICC) is achieved, which can be applied to evaluate both the quality and capacity of geoenvironment and thereunder to determine the scale and velocity for urban development. A demonstrative study of the above is applied to Beihai city (Guangxi province, PRC), and the numerical value laws between the urban development and its geoenvironment is studied by the I/O relationship in the urban economy as following: · the relationships between the urban economic development and land use as well as consumption of underground water, metal mineral, mineral energy source, metalloid mineral and other geologic resources. · the relationships between urban economy and waste output such as industrial "3 waste", dust, rubbish and living polluted water as well as the restricting impact of both resource-environmental factors and tech-capital on the urban grow. · Optimization and control analysis on the reciprocity between urban economy and its geoenvironment are discussed, and sensitive factors and its order of the urban geoenvironmental resources, wastes and economic sections are fixed, which can be applied to determine the urban industrial structure, scale, grow rate matching with its geoenvironment and tech-capital. · a sustainable development stratagem for the city is suggested.

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本研究选择有代表性的陕西省潼关县(小秦岭地区)采金地区作为研究对象,从环境地球化学的角度出发,研究了该地区由于受采金活动的影响后,大气、水体、土壤以及农作物中总汞和甲基汞的分布,探讨汞在采金地区环境中迁移、转化和富集的环境地球化学行为和规律,并估算了渲关县及全国在过去二十多年里,由混汞法炼金活动向环境释放汞的总量,最后对混汞法采金地区的环境管理提出可行性建一议。通过本论文的详细研究,主要得出以下结论:1.潼关县辖区大气汞的分布呈明显的空间梯度关系,炼金厂密集区大气汞含量明显高于其它地区,距离炼金厂越远,大气汞含量越低。大型炼金厂混汞提金车间内的平均大气汞浓度为18,047ng/m~3,最高达33,080ng/m~3;距离炼金厂密集区较近和较远的居民区的平均大气汞浓度分别为385ng/m~3和77ng/m~3;而一些偏远地区大气汞的平均浓度降至29ng/m~3,受炼金活动影响较 小的黄河沿岸背景区的平均大气汞浓度只有2ng/m~3。通过估算,潼关县炼金矿工汞蒸气的平均摄入量高达72,804~75,268ng/d,而当地非矿工居民(成人)每天的摄入量也有924~4,620ng。2.潼关县内泉水和井水中总汞的平均浓度有329.2ng/L,其中各形态汞的浓度都相对较高,说明金矿地区的汞背景值可能较高,且地下水也可能受到一定程度的汞污染;冷暖两季水样中溶解态汞浓度和暖季的甲基汞浓度要比泉水和井水中的溶解态汞和甲基汞浓度分别高出几倍,其它形态汞则要高出几百倍;水样中的活性汞和溶解态汞浓度表现出极显著的相关关系;冷季水样的活性汞和溶解态汞平均浓度要略高于暖季的水样,而颗粒态汞恰恰相反;两季采集的一些水样中活性汞在溶解态汞中占有较高的比例,但总汞均以颗粒态为主,大多超过50%。3.冷暖两季沉积物中平均总汞浓度分别高达151.1和44.6μg/g,甲基汞平均浓度分别为7.1和3.6ng/g,而暖季沉积物中总汞与甲基汞含量表现出极显著的相关关系;水体颗粒物和沉积物主要来源于炼金厂排出的废渣和尾矿,拥有较高的重金属(Hg、Fe、Mn和Cu)含量,且两者之间体现出一定的继承关系,但颗粒物由于粒径小,表面积大,含有机颗粒多,吸附能力强,所以其中的重金属含量要明显高于沉积物中的重金属含量;颗粒物中汞含量与Fe、Mn、Cu的含量之间均表现出极显著的相关性,而沉积物中汞含量仅与Cu含量之间有一定的相关性,与其它重金属含量的相关性不明显。4.潼关县辖区金矿石中汞的平均含量是69.2ng/g,而炼金尾矿中汞的平均含量竟高达628,4林吮,高出原矿石样中汞平均含量10,000倍,其它重金属(Fe、Mn、Cu)由于受炼金活动影响较小,其含量变化并不十分明显;黄土由于自身的特殊质地和性质,受炼金活动的干扰较小,其中的各重金属含量能够较好的反映其背景含量水平;撞关地区采集的土壤样品中总汞和甲基汞含量均要比黄土中的含量高约50倍,而其它重金属含量与黄土背景值无明显差异;土壤中甲基汞在总汞含量中所占比例较小(分布在0.001%~0.57%之间),说明潼关地区土壤中汞的甲基化水平较低。5.苔鲜样品中的高汞含量反映了采金地区较高的大气汞沉降水平;河流水藻中高含量的总汞和甲基汞体现出汞在生物体内超强的富集作用;潼关县大多数农作物样品中的汞主要来源于大气,且几乎所有样品的汞含量都严重超出国家食用标准,最高超标倍数达到60;农作物中甲基汞含量占总汞的比例在0.12%~12.34%之间波动,其中蔬菜类作物的甲基汞比例要高于粮食作物,而总体来说,作物体内的总汞和甲基汞含量之间表现出一定的负相关关系;通过估算,潼关县居民由于粮食作物(小麦)的食用每天摄入的总汞量高达54,72Ong,要高于当地居民(非矿工)通过呼吸吸入的汞蒸气量,且已超出国际上对人体汞摄入量标准的有关规定。6.潼关县水体、沉积物、土壤以及农作物中的甲基汞含量相对总汞而言,都表现了相对较低的水平,原因可能是受石英脉型金矿地区地质背景的影响,大量存在的Fe、Mn类化合物对离子态汞有着较强的束缚能力,减缓或抑制了甲基化的发生。7.通过混汞法生产黄金的产量和汞释放因子的调研和确定,估算在1980~2003年期间,全国混汞炼金行业向环境释放汞累计达1476.6t,其中约有78%进入大气;而仅潼关县就有116.5t,约占全国的7.9%:目前(1996年以后),由于混汞法工艺的改进,汞的释放量大大降低,全国混汞炼金行业平均每年释放汞约30t,憧关县平均每年有3.9t,约占全国年平均释放量的13%。

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Jackson, Peter, 'France and the Problems of Security and Disarmament after the First World War', Journal of Strategic Studies (2006) 29(2) pp.247-280 Special Issue: Enforcing arms limits: Germany post 1919; Iraq post 1991 RAE2008

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Introduction: Older individuals are particularly vulnerable to potentially inappropriate prescribing (PIP), drug related problems (DRPs) and adverse drug reactions (ADRs). A number of different interventions have been proposed to address these issues. However to-date there is a paucity of well-designed trials examining the impact of such interventions. Therefore the aims of this work were to: (i) establish a baseline PIP prevalence both nationally and internationally using the STOPP, Beers and PRISCUS criteria, (ii) identify the most comprehensive method of assessing PIP in older individuals, (iii) develop a structured pharmacist intervention supported by a computer decisions support system (CDSS) and (iv) examine the impact of this intervention on prescribing and incidence of ADRs. Results: This work identified high rates of PIP across all three healthcare settings in Ireland, 84.7% in the long term care, 70.7% in secondary care and 43.3% in primary care being reported. This work identified that for a comprehensive assessment of prescribing to be undertaken, an amalgamation of all three criteria should be deployed simultaneously. High prevalences of DRPs and PIP in older hospitalised individuals were identified. With 82.0% and 76.3% of patients reported to have at least one DRP or PIP instance respectively. The structured pharmacist intervention demonstrated a positive impact on prescribing, with a significant reduction MAI scores being reported. It also resulted in the intervention patients’ having a reduced risk of experiencing an ADR when compared to the control patients (absolute risk reduction of 6.8 (95% CI 1.5% - 12.3%)) and the number needed to treat = 15 (95% CI 8 - 68). However the intervention was found to have no significant effect on length of stay or mortality rate. Conclusion: This work shows that PIP is highly prevalent in older individuals across three healthcare settings in Ireland. This work also demonstrates that a structured pharmacist intervention support by a dedicated CDSS can significantly improve the appropriateness of prescribing and reduce the incidence of ADRs in older acutely ill hospitalised individuals.