Una identificación poética : Jaime Gil de Biedma lee Juan de Mairena, de Antonio Machado

"Puestos a escoger entre nuestras concepciones poéticas y la fidelidad a la propia experiencia, finalmente optamos por esta última". Esa frase de Jaime Gil de Biedma bien podría formar parte de uno de los aforismos del libro Juan de Mairena, de Antonio Machado. La problemática de la conformidad de lo ético junto a lo estético nos lleva a la propuesta de ese artículo, es decir, el análisis del importante papel de la obra Juan de Mairena para la afirmación de una posición ético-poética en la obra de Jaime Gil

Una identificación poética : Jaime Gil de Biedma lee Juan de Mairena, de Antonio Machado

"Puestos a escoger entre nuestras concepciones poéticas y la fidelidad a la propia experiencia, finalmente optamos por esta última". Esa frase de Jaime Gil de Biedma bien podría formar parte de uno de los aforismos del libro Juan de Mairena, de Antonio Machado. La problemática de la conformidad de lo ético junto a lo estético nos lleva a la propuesta de ese artículo, es decir, el análisis del importante papel de la obra Juan de Mairena para la afirmación de una posición ético-poética en la obra de Jaime Gil

Clássicos do terror como proposta de letramento literário: Machado e Stevenson em sala de aula

Acompanha: Da crueldade à duplicidade da alma humana: sequência expandida a partir de clássicos do terror

Melhoria da Atenção aos Usuários com Hipertensão Arterial Sistêmica e/ou Diabetes Mellitus na UBS Dr. José Matheus Arnaldo dos Santos, Cruzeiro do Sul/Acre

MACHADO, Jendry Morales. Melhoria da atenção à saúde dos Hipertensos e/ou Diabéticos da Unidade de Saúde da Família José Matheus Arnaldo dos Santos, Cruzeiro do Sul/ Acre. 2015. 97 folhas. Trabalho de Conclusão de Curso – Curso de Especialização em Saúde de Família – Modalidade a Distância, Universidade Federal de Pelotas, Pelotas, 2015. A Hipertensão Arterial Sistêmica e a Diabetes Mellitus representam um grande desafio à Saúde Pública. Estima-se que um em cada três adultos (maior ou igual há 25 anos) tem hipertensão arterial e um em cada dez adultos tem Diabetes Mellitus. O objetivo geral deste trabalho foi melhorar a qualidade da atenção ao hipertenso e diabético na Unidade Dr. José Matheus Arnaldo dos Santos. Com base nas recomendações do Ministério da Saúde, toda a equipe da unidade foi envolvida em um projeto de intervenção na área específica, com duração de 12 semanas. Neste tempo a equipe focou em objetivos específicos (ampliar cobertura, melhorar a adesão, a qualidade do atendimento, a qualidade dos registros, mapearem hipertensos e diabéticos de risco e promoção de saúde), buscando alcançá-los através de metas e ações pré-estabelecidas, nos eixos de monitoramento e avaliação, organização e gestão do serviço, engajamento público e qualificação profissional. Os resultados foram várias mudanças na rotina do serviço com a criação do Programa de Atenção ao Hipertenso e Diabético da Unidade de Saúde (HIPERDIA) tais como: adoção de ficha-espelho, monitoramento das ações, vinculação da odontologia, padronização do atendimento, ampliação de exames complementares, priorização do cuidado de acordo classificação de risco cardiovascular, aprimoramento do acolhimento, busca aos faltosos, facilitações ao acesso, sistematização das orientações quanto à alimentação saudável, prática de atividade física e riscos do tabagismo. A maioria das metas foi alcançada. Houve um aumento de cobertura do programa de atenção dos hipertensos dos 144 estimados 121 foram avaliados para uma cobertura de (84%), dos diabéticos 23 foram acompanhados pelo programa de um total de 24 estimados, resultando em 95,8% de cobertura. Apesar das limitações, a intervenção promoveu uma melhora substancial na qualidade de atendimento ao hipertenso e diabético. A maioria das ações previstas já foi incorporada à rotina da unidade e o equipe de NASF foi inserido nas atividades programadas nutrindo o projeto de intervenção.

Plano de intervenção para o aumento da adesão ao tratamento não farmacológico para os diabéticos tipo II da área adstrita a Estratégia Saúde da Família Alto Santos Dumond, Pará de Minas, Minas Gerais

O diabetes mellitus é considerado um problema de saúde pública devido a sua prevalência onerosa do ponto vista social e econômico e com potencial reconhecido para prevenção. Após observação ativa e entrevistas realizadas com pessoas chaves na comunidade de Alto Santos Dumont, Pará de Minas/Minas Gerais, percebeu-se que, dentre vários problemas, o grande número de pacientes diabéticos tipo II com descontrole glicêmico. Além disso, muitos casos de internação de pacientes da área adscrita da Estratégia de Saúde da Família Alto Santos Dumont eram consequências de complicações crônicas de pacientes diabéticos tipo II. Por esse motivo foi realizada um revisão da literatura sobre o tratamento não medicamentoso do paciente diabetes para subsidiar um plano de intervenção para os diabéticos com fins de estimular a promoção da saúde e incentivar o auto cuidado, visando a melhoria da qualidade de vida dos usuários dessa região.

Estratégias para alcançar o controle dos níveis pressóricos dos pacientes hipertensos atendidos pelo PSF Jardim das Oliveiras, Machado - MG

A hipertensão arterial sistêmica (HAS) representa o mais importante fator de risco isolado para mortalidade e o principal fator de risco modificável para doença cardiovascular. Esse agravo está conceituado como uma condição clínica multifatorial que tem altas prevalências e baixas taxas de controle e é considerado como um dos principais fatores de risco modificáveis e um dos maiores problemas em saúde pública. A adesão ao tratamento, definida como a correta execução da prescrição do médico, incluindo alterações em medicamentos e/ou no estilo de vida, é um fator significativo no sucesso do tratamento. A não adesão ao tratamento é identificada como a causa principal da Pressão Arterial (PA) não controlada, representando assim um risco significativo de eventos cardiovasculares. Sendo assim, a equipe de Estratégia de Saúde da Família do Jardim das Oliveiras, elaborou uma proposta de intervenção que possa contribuir para a adesão dos usuários ao tratamento medicamentoso e não medicamentoso, por meio da readequação do tratamento pelo médico da unidade, controle domiciliar dos medicamentos, grupos de atividade física e de educação em saúde. A colocação do plano de ação em prática poderá trazer benefícios para essa população, como melhora na qualidade de vida e redução da mortalidade por doenças cardiovasculares

Pipkiiα Is Widely Expressed In Hematopoietic-derived Cells And May Play A Role In The Expression Of Alpha- And Gamma-globins In K562 Cells.

Characterized for the first time in erythrocytes, phosphatidylinositol phosphate kinases (PIP kinases) belong to a family of enzymes that generate various lipid messengers and participate in several cellular processes, including gene expression regulation. Recently, the PIPKIIα gene was found to be differentially expressed in reticulocytes from two siblings with hemoglobin H disease, suggesting a possible relationship between PIPKIIα and the production of globins. Here, we investigated PIPKIIα gene and protein expression and protein localization in hematopoietic-derived cells during their differentiation, and the effects of PIPKIIα silencing on K562 cells. PIPKIIα silencing resulted in an increase in α and γ globins and a decrease in the proliferation of K562 cells without affecting cell cycle progression and apoptosis. In conclusion, using a cell line model, we showed that PIPKIIα is widely expressed in hematopoietic-derived cells, is localized in their cytoplasm and nucleus, and is upregulated during erythroid differentiation. We also showed that PIPKIIα silencing can induce α and γ globin expression and decrease cell proliferation in K562 cells.

Homozygous Inactivating Mutation In Nanos3 In Two Sisters With Primary Ovarian Insufficiency.

Despite the increasing understanding of female reproduction, the molecular diagnosis of primary ovarian insufficiency (POI) is seldom obtained. The RNA-binding protein NANOS3 poses as an interesting candidate gene for POI since members of the Nanos family have an evolutionarily conserved function in germ cell development and maintenance by repressing apoptosis. We performed mutational analysis of NANOS3 in a cohort of 85 Brazilian women with familial or isolated POI, presenting with primary or secondary amenorrhea, and in ethnically-matched control women. A homozygous p.Glu120Lys mutation in NANOS3 was identified in two sisters with primary amenorrhea. The substituted amino acid is located within the second C2HC motif in the conserved zinc finger domain of NANOS3 and in silico molecular modelling suggests destabilization of protein-RNA interaction. In vitro analyses of apoptosis through flow cytometry and confocal microscopy show that NANOS3 capacity to prevent apoptosis was impaired by this mutation. The identification of an inactivating missense mutation in NANOS3 suggests a mechanism for POI involving increased primordial germ cells (PGCs) apoptosis during embryonic cell migration and highlights the importance of NANOS proteins in human ovarian biology.

Factors Associated With The Onset Of Hypertension In Women Of 50 Years Of Age Or More In A City In Southeastern Brazil.

To evaluate factors associated with hypertension in Brazilian women of 50 years of age or more. A cross-sectional population based study using self-reports. A total of 622 women were included. The association between sociodemographic, clinical and behavioral factors and the woman's age at the onset of hypertension was evaluated. Data were analyzed according to cumulative continuation rates without hypertension, using the life-table method and considering annual intervals. Next, a Cox multiple regression analysis model was adjusted to analyze the occurrence rates of hypertension according to various predictor variables. Significance level was pre-established at 5% (95% confidence level) and the sampling plan (primary sampling unit) was taken into consideration. Median age at onset of hypertension was 64.3 years. Cumulative continuation rate without hypertension at 90 years was 20%. Higher body mass index (BMI) at 20-30 years of age was associated with a higher cumulative occurrence rate of hypertension over time (coefficient=0.078; p<0.001). Being white was associated with a lower cumulative occurrence rate of hypertension over time (coefficient= -0.439; p=0.003), while smoking >15 cigarettes/day was associated with a higher rate over time (coefficient=0.485; p=0.004). The results of the present study highlight the importance of weight control in young adulthood and of avoiding smoking in preventing hypertension in women aged ≥50 years.

Prevalence Of Urinary Incontinence And Its Association With Multimorbidity In Women Aged 50 Years Or Older: A Population-based Study.

To evaluate the prevalence and associated risk factors for urinary incontinence, as well as its association with multimorbidity among Brazilian women aged 50 or over. This was a secondary analysis of a cross-sectional population-based study including 622 women 50 years or older, conducted in the city of Campinas-SP-Brazil. The dependent variable was Urinary Incontinence (UI), defined as any complaint of urine loss. The independent variables were sociodemographic data, health-related habits, self-perception of health and functional capacity evaluation. Statistical analysis was carried out using the Chi-square test and Poisson regression. The mean age of the women was 64. UI was prevalent in 52.3% of these women: Mixed UI (26.6%), Urge UI (13.2%) and Stress UI (12.4%). Factors associated with a higher prevalence of UI were hypertension (OR 1.21, CI 1:01-1:47, P = 0.004), osteoarthritis (OR 1.24, CI 1:03-1:50, P = 0.022), physical activity ≥3 days/week (OR 1.21, CI 1:01-1:44, P = 0.039), BMI ≥ 25 at the time of the interview (OR 1.25, CI 1:04-1:49, P = 0.018), negative self-perception of health (OR 1.23, CI 1:06-1:44 P = 0.007) and limitations in daily living activities (PR 1:56 CI 1:16-2:10, P = 0.004). The prevalence of UI was high. Mixed incontinence was the most frequent type of UI. Many associated factors can be prevented or improved. Thus, health policies targeted at these combined factors could reduce their prevalence rate and possibly decrease the prevalence of UI. Neurourol. Urodynam. © 2014 Wiley Periodicals, Inc.

Waist-to-height Ratio Percentiles And Cutoffs For Obesity: A Cross-sectional Study In Brazilian Adolescents.

This study aimed to describe the distribution of waist-to-height ratio (WHtR) percentiles and cutoffs for obesity in Brazilian adolescents. A cross-sectional study including adolescents aged 10 to 15 years was conducted in the city of São Paulo, Brazil; anthropometric measurements (weight, height, and waist-circumference) were taken, and WHtRs were calculated and then divided into percentiles derived by using Least Median of Squares (LMS) regression. The receiver operating characteristic (ROC) curve was used in determining cutoffs for obesity (BMI ≥ 97th percentile) and Mann-Whitney and Kruskal-Wallis tests were used for comparing variables. The study included 8,019 adolescents from 43 schools, of whom 54.5% were female, and 74.8% attended public schools. Boys had higher mean WHtR than girls (0.45 ± 0.06 vs 0.44 ± 0.05; p=0.002) and higher WHtR at the 95th percentile (0.56 vs 0.54; p<0.05). The WHtR cutoffs according to the WHO criteria ranged from 0.467 to 0.506 and 0.463 to 0.496 among girls and boys respectively, with high sensitivity (82.8-95%) and specificity (84-95.5%). The WHtR was significantly associated with body adiposity measured by BMI. Its age-specific percentiles and cutoffs may be used as additional surrogate markers of central obesity and its co-morbidities.

Characterization Of Anfo Explosive By High Accuracy Esi(±)-ftms With Forensic Identification On Real Samples By Easi(-)-ms.

Ammonium nitrate fuel oil (ANFO) is an explosive used in many civil applications. In Brazil, ANFO has unfortunately also been used in criminal attacks, mainly in automated teller machine (ATM) explosions. In this paper, we describe a detailed characterization of the ANFO composition and its two main constituents (diesel and a nitrate explosive) using high resolution and accuracy mass spectrometry performed on an FT-ICR-mass spectrometer with electrospray ionization (ESI(±)-FTMS) in both the positive and negative ion modes. Via ESI(-)-MS, an ion marker for ANFO was characterized. Using a direct and simple ambient desorption/ionization technique, i.e., easy ambient sonic-spray ionization mass spectrometry (EASI-MS), in a simpler, lower accuracy but robust single quadrupole mass spectrometer, the ANFO ion marker was directly detected from the surface of banknotes collected from ATM explosion theft.

Weight Variation In Users Of Depot-medroxyprogesterone Acetate, The Levonorgestrel-releasing Intrauterine System And A Copper Intrauterine Device For Up To Ten Years Of Use.

Data on record regarding weight variation in depot-medroxyprogesterone acetate (DMPA) and levonorgestrel-releasing intrauterine system (LNG-IUS) users are controversial. To date, no studies have yet evaluated weight variation in DMPA and LNG-IUS users in up to ten years of use compared to non-hormonal contraceptive users. A retrospective study analysed weight variations in 2138 women using uninterruptedly DMPA (150 mg intramuscularly, three-monthly; n = 714), the LNG-IUS (n = 701) or a copper-intrauterine device (Cu-IUD; n = 723). At the end of the first year of use, there was a mean weight increase of 1.3 kg, 0.7 kg and 0.2 kg among the DMPA-, LNG-IUS- and Cu-IUD users, respectively, compared to weight at baseline (p < 0.0001). After ten years of use, the mean weight had risen by 6.6 kg, 4.0 and 4.9 kg among the DMPA-, LNG-IUS- and Cu-IUD users, respectively. DMPA-users had gained more weight than LNG-IUS- (p = 0.0197) and than Cu-IUD users (p = 0.0294), with the latter two groups not differing significantly from each other in this respect (p = 0.5532). Users of hormonal and non-hormonal contraceptive methods gained a significant amount of weight over the years. DMPA users gained more weight over the treatment period of up to ten years than women fitted with either a LNG-IUS or a Cu-IUD.

Whey And Soy Protein Supplements Changes Body Composition In Patients With Crohn's Disease Undergoing Azathioprine And Anti-tnf-alpha Therapy.

Crohn´s disease (CD) is a chronic transmural inflammation of the gastrointestinal tract of unknown cause. Malnutrition associated with active CD has been reduced although obesity has increased. Dietary strategies such as those with high-protein have been proposed to reduce body fat. This study compares the effects of two supplements on the nutritional status of CD patients. 68 CD patients were randomized in two groups: whey protein group (WP) and soy protein group (SP). Using bioimpedance analysis, anthropometry and albumin and pre-albumin dosages the nutritional status was measured before starting the intervention and after 8 and 16 weeks. The disease activity was determined by Crohn's Disease Activity Index and serum C-reactive protein dosage and dietary intake by 24h dietary recalls. Forty-one patients concluded the study and both supplements changed body composition similarly. Triceps skin fold thickness (p< 0.001) and body fat percentage (p=0.001) decreased, whereas mid-arm muscle circumference (p=0.004), corrected arm muscle area (p=0.005) and body lean percentage (p=0.001) increased. For Crohn's disease patients undergoing anti TNF-alpha and azatioprine therapies, supplementation with whey and soy proteins changes body composition through reduction of body fat and thus contributes to control inflammation.

Cerebral Cortex Involvement In Machado-joseph Disease.

Machado-Joseph disease (MJD/SCA3) is the most frequent spinocerebellar ataxia, characterized by brainstem, basal ganglia and cerebellar damage. Few magnetic resonance imaging based studies have investigated damage in the cerebral cortex. The objective was to determine whether patients with MJD/SCA3 have cerebral cortex atrophy, to identify regions more susceptible to damage and to look for the clinical and neuropsychological correlates of such lesions. Forty-nine patients with MJD/SCA3 (mean age 47.7 ± 13.0 years, 27 men) and 49 matched healthy controls were enrolled. All subjects underwent magnetic resonance imaging scans in a 3 T device, and three-dimensional T1 images were used for volumetric analyses. Measurement of cortical thickness and volume was performed using the FreeSurfer software. Groups were compared using ancova with age, gender and estimated intracranial volume as covariates, and a general linear model was used to assess correlations between atrophy and clinical variables. Mean CAG expansion, Scale for Assessment and Rating of Ataxia (SARA) score and age at onset were 72.1 ± 4.2, 14.7 ± 7.3 and 37.5 ± 12.5 years, respectively. The main findings were (i) bilateral paracentral cortex atrophy, as well as the caudal middle frontal gyrus, superior and transverse temporal gyri, and lateral occipital cortex in the left hemisphere and supramarginal gyrus in the right hemisphere; (ii) volumetric reduction of basal ganglia and hippocampi; (iii) a significant correlation between SARA and brainstem and precentral gyrus atrophy. Furthermore, some of the affected cortical regions showed significant correlations with neuropsychological data. Patients with MJD/SCA3 have widespread cortical and subcortical atrophy. These structural findings correlate with clinical manifestations of the disease, which support the concept that cognitive/motor impairment and cerebral damage are related in disease.