Synthesis and total 1H- and 13C-NMR assignment of cephem derivatives for use in ADEPT approaches

We report the synthesis and total NMR characterization of 5-thia-1-azabicyclo-[4.2.0]oct-2-ene-2-carboxylic acid-3-[[[(4″- nitrophenoxy)carbonyl]oxy]-methyl]-8-oxo-7-[(2-thienyloxoacetyl)amino] -diphenylmethyl ester-5-dioxide (5), a new cephalosporin derivative. This compound can be used as the carrier of a wide range of drugs containing an amino group. The preparation of the intermediate product, 5-thia-1-azabicyclo[4.2.0] oct-2-ene-2-carboxylic acid-3-[methyl 4-(6-methoxyquinolin-8-ylamino) pentylcarbamate]-8-oxo-7-[(2-thienyloxoacetyl)amino]-diphenylmethyl ester-5-dioxide (6), as well as the synthesis of the antimalarial primaquine prodrug 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid-3-[methyl 4-(6-methoxyquinolin-8-ylamino)pentylcarbamate]-8-oxo-7-[(2-thienyloxoacetyl) amino]- 5-dioxide (7) are also described, together with their total 1H- and 13C-NMR assignments. © 2008 by MDPI.

How Do Software Architects Specify and Validate Quality Requirements?

Software architecture is the result of a design effort aimed at ensuring a certain set of quality attributes. As we show, quality requirements are commonly specified in practice but are rarely validated using automated techniques. In this paper we analyze and classify commonly specified quality requirements after interviewing professionals and running a survey. We report on tools used to validate those requirements and comment on the obstacles encountered by practitioners when performing such activity (e.g., insufficient tool-support; poor understanding of users needs). Finally we discuss opportunities for increasing the adoption of automated tools based on the information we collected during our study (e.g., using a business-readable notation for expressing quality requirements; increasing awareness by monitoring non-functional aspects of a system).

Professional applications in English for architects: the interview guide

Este estudio hace hincapie en la importancia del estudio previo de las necesidades del mercado a la hora de preparar y llevar a cabo una entrevista profesional. Todos estos aspectos se aplican a la entrevista profesional para arquitectos

Boyd Cody Architects. Dublin

"Serene" would be the most appropriate adjective to describe the architecture of Dermot Boyd and Peter Cody. BOYD CODY ARCHITECTS ls part of a close-knit group of young architects - all of them aggressive and belligerent proponents of modern forms - that make up the vibrant core of contemporary Irish architecture .

Stéphane Beel architects. Ghent

I have always been impressed by the clear and precise work of STEPHANE BEEL ARCHITECTS, which is tremendous in quality , if not abundant in quantity. Beel creates what I would call silent architecture - silent ln the way of a Mies buildlng, all clarity and logic.

Tony Fretton architects. London

Some people call Tony Fretton an artist, but I prefer to see him as a unique visionary whose reserved character suits the architecture he makes.

Looking at the Sky : Spanish Architects for the Third Millenium = Mirando al cielo

Looking at the Sky

Offices of the Official College of Architects, Sevilla (1976)

Proyecto de la sede del Colegio de Arquitectos de Sevilla

Performance of historic stone building materials and systems : observations by architects, engineers and building conservators : excerpts from workshop discussions held on August 10, 1987, funded by the U.S. Environmental Protection Agency and the U.S. Department of the Interior, National Park Service, Cultural Resources Acid Rain Research Program.

"June 1988."

Three revolutionary architects : Boullée, Ledoux, and Lequeu.

Includes bibliographical references.