Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response.

Activation of dendritic cells (DC) by microbial products via Toll-like receptors (TLR) is instrumental in the induction of immunity. In particular, TLR signaling plays a major role in the instruction of Th1 responses. The development of Th2 responses has been proposed to be independent of the adapter molecule myeloid differentiation factor 88 (MyD88) involved in signal transduction by TLRs. In this study we show that flagellin, the bacterial stimulus for TLR5, drives MyD88-dependent Th2-type immunity in mice. Flagellin promotes the secretion of IL-4 and IL-13 by Ag-specific CD4(+) T cells as well as IgG1 responses. The Th2-biased responses are associated with the maturation of DCs, which are shown to express TLR5. Flagellin-mediated DC activation requires MyD88 and induces NF-kappaB-dependent transcription and the production of low levels of proinflammatory cytokines. In addition, the flagellin-specific response is characterized by the lack of secretion of the Th1-promoting cytokine IL-12 p70. In conclusion, this study suggests that flagellin and, more generally, TLR ligands can control Th2 responses in a MyD88-dependent manner.

Traité pratique des maladies des enfants du premier âge : avec 88 figures dans le texte / par le docteur G. Variot, médecin de l'hospice des Enfants-Assistés et de l'hôpital Notre-Dame-du-Perpétuel-Secours, chef des services de l'Institut de puériculture, président-fondateur du dispensaire Goutte de lait de Belleville ; avec la collaboration de MM. le docteur Pironneau, ancien interne des hôpitaux ; Émile Grandjean, interne à l'hospice des Enfants-Assistés

Comprend : Formulaire de thérapeutique infantile / par M. Pierre Lavialle, docteur ès sciences, professeur à la Faculté de pharmacie de Strasbourg

Barnes Wines, Limited By-Law No. 88

By-Law no. 88 reads: "Being a By-Law relating to the qualifications of Directors of the Company. Be it and it is hereby enacted as a By-Law of the Company as follows: By-Law No. 88 Section 4 of By-Law No. 75, as amended by By-Law No. 84, is hereby repealed." It was enacted January 7th, 1974 and confirmed in the shareholders meeting on April 18th, 1974.

Segundo informe anual del período sept. 85 - sept. 88 que rinde la Rectoría

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Tercer informe anual del período sept. 85 - sept. 88 que rinde la Rectoría

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Primer informe anual del período sept. 88 - sept. 91 que rinde la Rectoría

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3er. (i.e. tercer) informe anual : del período septiembre 88-septiembre91

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Exam 88

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