Assocation Between Variation in the Actin-Binding Gene Caldesmon and Diabetic Nephropathy in Type 1 Diabetes

Dysfunction of the actin cytoskeleton is a key event in the pathogenesis of diabetic nephropathy. We previously reported that certain cytoskeletal genes are upregulated in mesangial cells exposed to a high extracellular glucose concentration. One such gene, caldesmon, lies on chromosome 7q35, a region linked to nephropathy in family studies, making it a candidate susceptibility gene for diabetic nephropathy. We screened all exons, untranslated regions, and a 5-kb region upstream of the gene for variation using denaturing high-performance liquid chromatography technology. An A>G single nucleotide polymorphism (SNP) at position -579 in the promoter region was associated with nephropathy in a case-control study using 393 type 1 diabetic patients from Northern Ireland (odds ratio [OR] 1.38, 95% CI 1.02–1.86, P = 0.03). A similar trend was found in an independent sample from a second center. When the sample groups were combined (n = 606), the association between the -579G allele and nephropathy remained significant (OR 1.35, 1.07–1.70, P = 0.01). The haplotype structure in the surrounding 7-kb region was determined. No single haplotype was more strongly associated with nephropathy than the -579A>G SNP. These results suggest a role for the caldesmon gene in susceptibility to diabetic nephropathy in type 1 diabetes.

A SiGe Power Amplifier with Integrated BALUNs for 81-86 GHz E-Band Backhaul Applications

The design of a two-stage differential cascode power amplifier (PA) for 81-86 GHz E-band applications is presented. The PA was realised in SiGe technology with fT/fmax 170/250 GHz. A broadband transformer with efficiency higher than 79.4% from 71 GHz to 96 GHz is used as a BALUN. The PA delivers a 4.5 dBm saturated output power and exhibits a 13.4 dB gain at 83.6 GHz. The input and output return losses agree well with the design specifications.

Integrated Low-Loss Passive SiGe Power Splitter and Combiner Operating Across 78-86 GHz Band

This paper describes the design, implementation, and characterization of a new type of passive power splitting and combining structure for use in a differential four-way power-combining amplifier operating at E-band. In order to achieve lowest insertion loss, input and output coils inductances are resonated with shunt capacitances. Simple C-L-C and L-C networks are proposed in order to compensate inductive loading due to routing line that would otherwise introduce mismatch and increase loss. Across 78-86 GHz band, measured insertion loss is about 7 dB. Measured return losses are >10 dB from 73 GHz to 94 GHz at the input port and >9 dB from 60 GHz to 94 GHz at the output port. When integrated with driver and power amplifier cells, the simulated complete circuit exhibits 18.2 dB gain and 20.3 dBm saturated output power.

DL 86/2003 - uma perspectiva jurídico-política sobre o regime das parcerias público-privadas

Neste artigo é feita uma análise jurídico-política das narinas gerais aplicáveis às Parcerias Público-Privadas (PPP), criadas com a aprovação e publicação do Decreto-Lei n.º 86/2003, de 26 de Abril, e respectiva legislação complementar. Defendo a posição segundo a qual não foram tanto factores de ordem jurídica, entenda-se de necessidade de regulação jurídica da matéria em causa, que levaram à sua elaboração, mas sim motivos de ordem política, de exercício da acção governativa, ditados pela necessidade de o Ministério das Finanças de disciplinar e controlar o processo de criação de despesa pública no âmbito das PPP. Este facto vai influenciar e "marcar" todo o regime jurídico, designadamente, a existência de um regime procedimental muito rigoroso e fortemente dependente do Ministério das Finanças.

Quatre vingt un « arrestz du conseil privé du roy ». 8 décembre 1552-12 juillet 1566. (Fol. 1-67, 74 v°-79, 86 v°-92).

Contient : 1° « Sciendum des notaires et secretaires du roy » ; 2° Règlement pour la tenue du conseil d'Etat, fait par le roi Charles IX. Paris 23 octobre 1563 ; 3° « Règlement faict par le roy [Charles IX] pour la court de parlement et envoyé en icelle par mons. le mareschal de Montmorency ». Paris, 13 octobre 1563 ; Lettre d'envoi du susd. règlement. Paris, 13 octobre 1563 ; 4° « S'ensuivent les noms de messieurs les maistres des requêtes en l'année MVe LXIII » ; 5° « Quartiers de messieurs les maistres des requestes ordinaires de l'hostel du roy » ; « Service de chancellerie, court de parlement, et requestes de l'hostel... Les presens quartiers ont esté faictz... le XVIe jour de mars 1561 »

Resolución N° 86 ¿Cuáles son los criterios que tiene la Cámara de comercio para evaluar las reuniones por derecho propio? ¿Qué tipo de mayorías se exigen en esta clase de reuniones para la adopción de decisiones?

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Resolución N° 86 del 10 de mayo de 2007 ¿Cuáles son los criterios que tiene la Cámara de Comercio para evaluar las reuniones por derecho propio? ¿Qué tipo de mayorías se exigen en esta clase de reuniones para la adopción de decisiones?

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