IOWATER, Vol. 3, no.1, Winter 2002

Water fact sheet for Iowa Department of Natural Resources and the Geological Bureau.

Innovative Outstanding Weatherization Assistance News, January 2005, Vol.3, no.1

This is a quarterly newsletter for the Iowa Weatherization Program. The purpose of the newsletter is to share with you information on all aspects of the program as well as spotlight a couple of agencies in each issue. We will provide information on upcoming events, training schedules, monitoring schedules and general news about the program. There will be a section of questions we have received from you and the answers provided.

Executive Order No. 3, March 1, 1961

Informing several departments that approval for the change in data processing equipment should be approved in writing from the State Comptroller prior to submission to the Executive Council.

Targeted Small Business Link, March 2010, Vol. 3, no. 1

Targeted Small Business News from the Business Development Division of the Iowa Department of Economic Development

Animal Industry News, April 2002, Vol. 3, no. 1

Newsletter produced by Department of Agriculture and Land Stewardship about the animal industry in Iowa.

Healthy Aging Update, December 3, 2007, Vol. 3, no. 1

This bimonthly electronic newsletter will provide information and resources on nutrition and health promotion and disease prevention. The Healthy Aging Update is produced for informal and educational purposes only. The newsletter will be distributed electronically and posted on the Department’s website at www.state.ia.us/elderaffairs.

The White Cane Magazine, Winter 2012, Vol. 3, no. 1

Quarterly newsletter produced by the Iowa Department of Blind, about the information and activities that are on going in the department.

Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition.

Indoleamine 2,3-dioxygenase 1 (IDO1) is an important therapeutic target for the treatment of diseases such as cancer that involve pathological immune escape. Starting from the scaffold of our previously discovered IDO1 inhibitor 4-phenyl-1,2,3-triazole, we used computational structure-based methods to design more potent ligands. This approach yielded highly efficient low molecular weight inhibitors, the most active being of nanomolar potency both in an enzymatic and in a cellular assay, while showing no cellular toxicity and a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO). A quantitative structure-activity relationship based on the electrostatic ligand-protein interactions in the docked binding modes and on the quantum chemically derived charges of the triazole ring demonstrated a good explanatory power for the observed activities.

IRENE newsletter. Volume 3, number 1 (Spring/Summer 2009)

IRENE’s mission is to improve the health and well-being of Iowans through collaboration in practice-based research on questions important to primary care physicians and their patients. IRENE’s purpose is to create and foster a network of research collaboration between the academic medical center and primary care physicians through out the state of Iowa with a particular focus on improving rural health.

Acreage Answers, February-March 2002, Vol. 3, no.1

Newsletter for those who reside on acreages in Iowa. Produced by the Iowa State University Extension Office.

Iowa Manure Matters: Odor and Nutrient Management, Spring 2000, Vol. 3, no. 1

Iowa Manure Matters: Odor and Nutrient Management is published by Iowa State University Extension, with funding support from the USDA Natural Resource Conservation Service.

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.

Indoleamine 2,3-dioxygenase 1 (IDO1) is a key regulator of immune responses and therefore an important therapeutic target for the treatment of diseases that involve pathological immune escape, such as cancer. Here, we describe a robust and sensitive high-throughput screen (HTS) for IDO1 inhibitors using the Prestwick Chemical Library of 1200 FDA-approved drugs and the Maybridge HitFinder Collection of 14,000 small molecules. Of the 60 hits selected for follow-up studies, 14 displayed IC50 values below 20 μM under the secondary assay conditions, and 4 showed an activity in cellular tests. In view of the high attrition rate we used both experimental and computational techniques to identify and to characterize compounds inhibiting IDO1 through unspecific inhibition mechanisms such as chemical reactivity, redox cycling, or aggregation. One specific IDO1 inhibitor scaffold, the imidazole antifungal agents, was chosen for rational structure-based lead optimization, which led to more soluble and smaller compounds with micromolar activity.