Inbreeding, Average Relatedness Coefficient and Effective Population Size In Jaffarabadi Buffaloes Raised In Brazil

The major aim of this study was to evaluate the inbreeding (F), average relatedness coefficient (AR) and effective population size (Ne) in the Jaffarabadi buffalo breed from Brazil. Pedigree information of 1,272 animals born from 1966 was used. The effective population size was calculated in two ways: first, computed via individual increase in inbreeding and second estimated by individual increase in coancestry. The known generation numbers were 1.24, 1.76 and 2.64 for complete, equivalent and maximum generation, respectively. The effective size computed via individual increase in coancestry was small with a value of 10.82 +/- 1.29. The effective size computed by individual increase in inbreeding (10.40 +/- 3.69) was very similar but a little smaller than the previous reported value. The average values of F and AR for the population reference (1,059) were 4.22 and 12.5 percent. The mean of F for inbred animals (319) was 14.0%. The F and AR means were 5.7 and 13.3% for animals with at least 1.5 known equivalent generation and 9.3 and 15.97% for individuals having at least 2.5 equivalent generations known. It was found 78 matings between half sibs (6.14%) and 67 matings (5.27%) between parent-offspring. The estimated inbreeding increase per generation by considering maximum generation, complete generation and equivalent generation were 1.21%, 5.18% and 3.57%, respectively. Considering the uncompleted pedigree, the estimated inbreeding for the reference population could be underestimated.

Jornal da UNESP, 2016, ano XXXI, n. 319

Jornal elaborado pela Assessoria de Comunicação e Imprensa da Reitoria da UNESP

The quassinoid derivative NBT-272 targets both the AKT and ERK signaling pathways in embryonal tumors

The quassinoid analogue NBT-272 has been reported to inhibit MYC, thus warranting a further effort 7to better understand its preclinical properties in models of embryonal tumors (ET), a family of childhood malignancies sharing relevant biological and genetic features such as deregulated expression of MYC oncogenes. In our study, NBT-272 displayed a strong antiproliferative activity in vitro that resulted from the combination of diverse biological effects, ranging from G(1)/S arrest of the cell cycle to apoptosis and autophagy. The compound prevented the full activation of both eukaryotic translation initiation factor 4E (eIF4E) and its binding protein 4EBP-1, regulating cap-dependent protein translation. Interestingly, all responses induced by NBT-272 in ET could be attributed to interference with 2 main proproliferative signaling pathways, that is, the AKT and the MEK/extracellular signal-regulated kinase pathways. These findings also suggested that the depleting effect of NBT-272 on MYC protein expression occurred via indirect mechanisms, rather than selective inhibition. Finally, the ability of NBT-272 to arrest tumor growth in a xenograft model of neuroblastoma plays a role in the strong antitumor activity of this compound, both in vitro and in vivo, with its potential to target cell-survival pathways that are relevant for the development and progression of ET.

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 319 - Anmerkungen für Professor Hugo von Meltzl zur Erhaltung der Schopenhauer-Bibliothek

u.a.: Bedeutung der Volkslieder; Poesie in Amerika; Auflistung der Schopenhauer-Bibliothek; schlechte Verkaufszahlen auf der Auktion; Platzprobleme; Restbibliothek bei Karl Georg Bähr; Randglossen Schopenhauer am Ring der Nibelungen von Richard Wagner; Veröffentlichung der Korrespondenz von Johann August Becker und Schopenhauer; Wilhelm Gwinner; Arthur Schopenhauer;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 272 - Postkarte und Dankesschreiben an den Professor Hugo von Meltzl wegen der Hilfestellung bei der Veröffentlichung eines Artikels

u.a.: David Asher; Arthur Schopenhauer;

Ms.Ff.F.Stoltze 3. 272 - Brief von Ernst Schalck an Friedrich Stoltze

Umzug, Frankfurter Latern

Ms.Ff.F.Stoltze 3. 319 - Brief von Anna Maria Stoltze an Adolf Stoltze und Louise Stoltze

Familiennachrichten

Ms. lat. oct. 272 - Venezianische Magistrate

Vorbesitzer: Johann Hieronymus Zum Jungen