Influencia da elevacao sustentada da pressao arterial sobre a dP/dt do ventriculo esquerdo mantendo-se constante a pressao diastolica do ventriculo esquerdo

Purpose - To evaluate the influence of sustained elevations of arterial pressure on dP/dt values, which the left ventricular end diastolic pressure was kept constant. Methods - Thirteen anesthetized dogs, mechanically ventilated and submitted to thoracotomy and pharmacological autonomic block (atropine - 0.5 mg/kg IV + oxprenolol - 3 mg/kg IV) were studied. The arterial pressure elevation was obtained by mechanical constriction of the descending thoracic aorta. Analyses were made in control (C) situation and after two successives increments of arterial pressure, sustained for 10min, called hypertension 1 (H1) and hypertension 2 (H2), respectively. The end diastolic left ventricular pressure was kept constant by utilization of a perfusion system connected to the left atria. Results - Heart rate did not change (C: 125 ± 13.9bpm; H1: 125 ± 13.5bpm; H2: 123 ± 14.1bpm; p > 0.05); the LVSP increased (C: 119 ± 8.1mmHg; H1: 142 ± 7.9mmHg; H2: 166 ± 7.7mmHg; p < 0.01); the AoDP increased (C: 89 ± 11.6mmHg; H1: 99 ± 9.5mmHg; H2: 120 ± 11.8mmHg; p < 0.01); the LVEDP (C: 6.2 ± 2.48mmHg; H1: 6.3 ± 2.43mmHg; H2: 6.1 ± 2.51mmHg; p > 0.05) and the dP/dt (C: 3068 ± 1057.1mmHg/s; 3112 ± 995.7mmHg/s; H2: 3086 ± 979.5mmHg/s; p > 0.05) did not change. Conclusion - dP/dt values are not influenced by a sustained elevation of arterial pressure, when the end diastolic left ventricular pressure is kept constant.

The Probe, Issue 164 – April 1996

Opportunities and Challenges Within Wildlife Damage Management, by Robert H. Schmidt, Department of Fisheries and Wildlife, Utah State University, Logan Utah 84322-5210 IVFDM Not IVPDM by Robert H. Giles, Jr., Department of Fisheries and Wildlife Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0321 Letter to Editor RE: Pet Sterilization and Animal Rights Correspondence Course Announcement-- Utah State University Virus "Cure" for Rabbit Problem Eludes Human Controls Call for Nominations for Berryman Institute Awards Video Review: Review of "Professional Coyote Trapping" Produced by Fur-Fish-Game, 2878, E. Main St., Columbus, OH 43209. 80 minutes. Wildlife Control Seminar Makes Points With Michigan Man

Do Paediatric and Adult Surgeons Follow Different Approaches to Physeal Fractures?

INTRODUCTION: The treatment of paediatric fractures is the concern of several different surgical specialties. There has been no scientific investigation on the different concepts of paediatric (PS) and adult surgeons (AS). METHODS: 62 paediatric traumatologists were asked concerning their experience with physeal fractures of the leg, including ten cases. RESULTS: Growth disturbances was estimated to be more rare by PS. On evaluation of the examples there were no significant differences in the judgement of degree and direction of the displacement. For displaced fractures, PS rather preferred closed reduction and immobilisation, whereas AS favoured osteosynthesis. DISCUSSION: There were no basic differences between PS and AS in the treatment of lower limb fractures. AS tend to act more invasively. At the same time they are more concerned about growth disturbances.

Preventive effects of octreotide (SMS 201-995) on diabetic ketogenesis during insulin withdrawal

1. Exogenous somatostatin inhibits glucagon secretion and prevents ketoacidosis in diabetic patients, but has the therapeutic disadvantage of requiring continuous intravenous infusion to exhibit these effects. 2. Consequently, we examined the effect of subcutaneous administration of the long-acting somatostatin analogue octreotide (SMS 201-995) on early ketogenesis in diabetic ketoacidosis. On two separate occasions insulin was withdrawn over a period of 9 h from seven type I diabetic patients. On the second occasion the patients were given 50 micrograms octreotide s.c. before the insulin withdrawal and every 3 h during insulin withdrawal. 3. Differences in integrated free fatty acid responses (4706 +/- 1227 mumol l-1 h vs 3026 +/- 835 mumol l-1 h, AUC, P = NS) were not significant, but the peak increments of acetoacetate (1413 +/- 354 mumol l-1 vs 612 +/- 176 mumol l-1, P less than 0.05), beta-hydroxybutyrate (2180 +/- 475 mumol l-1 vs 922 +/- 246 mumol l-1, P less than 0.01) and the decrements in plasma bicarbonate (-8 +/- 1 mumol l-1 vs -4 +/- 1 mumol l-1, P less than 0.05) and pH (-0.07 +/- 0.01 vs -0.03 +/- 0.01, P less than 0.05) were significantly less with octreotide. 4. At the same time peak increments of glucagon were lower with octreotide treatment (329 +/- 206 pg ml-1 vs 39 +/- 30 pg ml-1, P less than 0.05). 5. We conclude that, despite accelerated lipolysis and provision of substrate for ketogenesis during insulin withdrawal, this somatostatin analogue significantly reduces ketogenesis resulting from insulin deprivation, probably secondary to decreasing glucagon secretion. This drug may be useful in short term prophylactic treatment of diabetic patients during periods of increased risk for ketoacidosis.

Ms. Barth. 164 - De spiritu et anima

Vorbesitzer: Brune-Kütze-Legat; Bartholomaeusstift Frankfurt am Main

Ms. hebr. oct. 164 Film - Derashot

Vorbesitzer: Israel Aron; Coppel Monsieur; Lehman Hertz;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 164 - Nachfrage des Stellmachermeisters zur Büchervermittlung

u.a.: Angaben zu den Veröffentlichungen Schopenhauers; Friedrich Schiller; Jean Paul; Immanuel Kant; George Gordon Byron;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 995 - Auskunft von Heimsoeth zu den Kontakten mit Arthur Schopenhauer im Zusammenhang der geplanten Biographie

u.a. Sibylle Mertens-Schaaffhausen; Herr Lampert; Übergabe einer Briefsammlung an die Universitätsbibliothek Bonn; Kopie des Goethe-Albums der Stadt Frankfurt; Johanna und Adele Schopenhauer;

Ms. Praed. 164 - Auctoritates Aristotelis et aliorum philosophorum

Vorbesitzer: Dominikanerkloster Frankfurt am Main

Ms. hebr. oct. 164 - Derashot

Vorbesitzer: Israel Aron; Coppel Monsieur; Lehman Hertz;

Ms.Ff.F.Stoltze 3. 164 - Brief von Theobald Kerner an Friedrich Stoltze

Dank für ein Gedicht, Einladung nach Weinsberg, Ankündigung eines Fäßchens Wein

Na 1 Nachlass Max Horkheimer, 447 - Korrespondenzen mit der UNESCO (p. V 169, 1-164)

UNESCO: Drucksachen und Schriftwechsel, 1957-1965; 4 Briefe mit Beilagen zwischen Prof. Georg Eckert und Max Horkheimer, 1967; 9 Briefe mit Beilagen zwischen R. William Jones (UNESCO) und Max Horkheimer, 1964-1965;