Si hay moreras hay cristianos nuevos: Los Duques de Pastrana y la industria de la seda en la formación de un espacio de conflicto (Pastrana, c. 1569- c. 1609)

Durante las últimas décadas del siglo XVI los moriscos, amparados por el poder ducal, acapararon la producción y comercio de la seda de la villa de Pastrana, así como adquirieron cada vez mayores cotas de poder municipal. En este artículo se analiza la constitución en la villa ducal de Pastrana de un espacio de odio a causa de la competencia social entre cristianos viejos y moriscos. Este odio se tradujo en una caracterización de los moriscos, sobre todo a partir de 1572, como cristianos nuevos sospechosos. Esta experiencia estigmatizadora sería un precedente de lo que ocurriría en las primeras decadas del siglo XVII con los mercaderes portugueses que sustituyeron en el negocio de la seda a los moriscos tras su expulsión. Entonces se contruiría la imagen del portugués critptojudío.

Relationship between technological properties and slab surface roughness of siliceous dimension stones

Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)[06/52521-0]

Systematic review: Terlipressin in acute oesophageal variceal haemorrhage

Background: Controversy exists surrounding pharmacological therapy in acute variceal bleeding. Methods: To determine the efficacy and safety of terlipressin. Methods: Randomized trials were identified and duplicate, independent, review identified 20 randomized trials involving 1609 patients that compared terlipressin with placebo, balloon tamponade, endoscopic treatment, octreotide, somatostatin or vasopressin for treatment of acute oesophageal variceal haemorrhage. Results: Meta-analysis showed that compared to placebo, terlipressin reduced mortality (relative risk 0.66, 95% CI 0.49-0.88), failure of haemostasis (relative risk 0.63, 95% CI 0.45-0.89) and the number of emergency procedures per patient required for uncontrolled bleeding or rebleeding (relative risk 0.72, 95% CI 0.55-0.93). When used as an adjuvant to endoscopic sclerotherapy, terlipressin reduced failure of haemostasis (relative risk 0.75, 95% CI 0.58-0.96), and had an effect on reducing mortality that approached statistical significance (relative risk 0.74, 95% CI 0.53-1.04). No significant difference was demonstrated between terlipressin and endoscopic sclerotherapy, balloon tamponade, somatostatin or vasopressin. Haemostasis was achieved more frequently with octreotide compared to terlipressin (relative risk 1.62, 95% CI 1.05-2.50), but this result was based on unblinded studies. Adverse events were similar between terlipressin and the other comparison groups except for vasopressin, which caused more withdrawals due to adverse events. Conclusions: Terlipressin is a safe and effective treatment for acute oesophageal variceal bleeding, with or without adjuvant endoscopic sclerotherapy. Terlipressin appears to reduce mortality in acute oesophageal variceal bleeding compared to placebo, and is the only pharmacological agent shown to do so. Future studies will be required to detect potential mortality differences between terlipressin and other therapeutic approaches.

Expression and characterization of HPV-16 L1 capsid protein in Pichia pastoris

Human papillomaviruses (HPVs) are responsible for the most common human sexually transmitted viral infections. Infection with high-risk HPVs, particularly HPV16, is associated with the development of cervical cancer. The papillomavirus L1 major capsid protein, the basis of the currently marketed vaccines, self-assembles into virus-like particles (VLPs). Here, we describe the expression, purification and characterization of recombinant HPV16 L1 produced by a methylotrophic yeast. A codon-optimized HPV16 L1 gene was cloned into a non-integrative expression vector under the regulation of a methanol-inducible promoter and used to transform competent Pichia pastoris cells. Purification of L1 protein from yeast extracts was performed using heparin-sepharose chromatography, followed by a disassembly/reassembly step. VLPs could be assembled from the purified L1 protein, as demonstrated by electron microscopy. The display of conformational epitopes on the VLPs surface was confirmed by hemagglutination and hemagglutination inhibition assays and by immuno-electron microscopy. This study has implications for the development of an alternative platform for the production of a papillomavirus vaccine that could be provided by public health programs, especially in resource-poor areas, where there is a great demand for low-cost vaccines.

Portaria n?? 81, de 11 de maio de 2011

A pol??tica de acesso ?? internet a ser observada pelos servidores, colaboradores, alunos e visitantes e usu??rios do servi??o de acesso ?? internet disponibilizado pela ENAP foi aprovada pela Portaria n?? 81, de 11 de maio de 2011.

A divulgação voluntária de informação

Nos últimos anos tem vindo a ser discutida a divulgação das informações financeiras necessárias à consecução do objectivo da Contabilidade, ou seja a possibilidade de fornecer informação acrescida de natureza económica, financeira e social aos utilizadores internos e externos da empresa. Há empresas que não consideram necessário relatar as suas acções junto dos diferentes públicos, ou seja separam a empresa do seu meio envolvente, fazendo uma delimitação entre as esferas interna e externa da empresa. Esta perspectiva auto centrada, que elimina a envolvente externa do discurso empresarial a qual considera que alguns resultados são dignos de divulgação contabilística, enquanto outros são irrelevantes e devem ser ignorados tem vindo a ser questionada. Neste sentido existem empresas que passaram a considerar necessário relatar acções junto dos diferentes utilizadores interessados, no entanto quando o fazem, é sem uniformidade. O meio envolvente tem vindo a tornar-se num factor que implica custos, como consequência de requisitos impostos pela regulação governamental sobre o controlo da poluição e devido a uma maior consciencialização do público, que pode afectar a rentabilidade dos negócios enquanto consumidor, empregado ou investidor. O emergir destas exigência baseia-se no pressuposto de que as empresas têm responsabilidades acrescidas, que vão além da obtenção do rendimento financeiro para os accionistas. Verificando-se nos últimos anos um aumento do número de empresas que acedem aos mercados de capitais, gerou-se uma necessidade crescente de uma maior divulgação de informação por parte das empresas, com reflexos no relato financeiro empresarial, motivo pelo qual vários autores e organismos também têm dado atenção à problemática da divulgação voluntária da informação por parte das empresas. Neste contexto, O FASB, elaborou um relatório que identifica quais os benefícios e desvantagens da divulgação voluntária de informação e apresenta algumas recomendações e conclusões para as empresas, enfatizando os efeitos da divulgação voluntária de informação no custo de capital, nas relações com os investidores, e no mercado de capitais. Outros autores e organismos também têm dado atenção à problemática da divulgação voluntária da informação por parte das empresas: Para Boeso (2002) era importante que os organismos de harmonização contabilística emitissem recomendações adicionais no sentido de uma maior harmonização, sem se centrarem apenas nos investidores mas também nos outros utilizadores da informação; Globerman e Singleton (2000) elaboraram um estudo com a finalidade de fornecer a evidência de que as empresas Japonesas se tornariam mais similares ao logo do tempo, na divulgação do relato voluntário da informação contabilística, concluindo que a informação procurada pelos utilizadores é muito diversificada sendo difícil a existência de um padrão comum de divulgação; Colares e Ponte (2003) demonstraram que as empresas ainda têm muito que evoluir no sentido da transparência e qualidade da divulgação voluntária de informação.

Mutilação Genital Feminina: o que Sabem os Profissionais de Saúde?

Portugal is considered by the World Health Organization (WHO) a risk country for the practice of Female Genital Mutilation (FGM). Objectives: To evaluate the knowledge that health professionals from Maternity Dr. Alfredo da Costa (MAC) have regarding FGM. Population and Methods: Analysis of surveys delivered to health professionals from MAC (a hospital dedicated to reproductive health), between April and June 2008, addressing issues related to the knowledge about FGM. Results: Authors collected 112 valid surveys involving 38 doctors, 48 nurses and 26 medical auxiliaries/administrative personnel. From the respondents, 106 (95%) had heard about FMG practice before, the media being the most reported source of information; 59 (53%) replied they could be able to recognize FGM cases in their clinical practice; however, only 31 (28%) claimed to know the FGM type classiication and 32 (29%) admitted to be prepared to recognize and manage these situations in their own clinical practice; 9 had been consulted explicitly by a FGM practice complication and 1 doctor had admitted having been asked to perform/execute FGM; 13 (12%) recognized that the Portuguese legislation its this practice. Regarding the practice of FGM, 100 (89%) of respondentes stated that it should not be maintained and 97 (87%) stated that it should not be tolerated. However, 42 (38%) considered that if these practices were a reality, then they should be medical assisted. Discussion: Health professionals can play an important role in eliminating the practice of FGM, not only by the proper clinical management of this situation, but also by preventing those communities at risk to resort to FGM. Most health professionals are not prepared to deal with FGM in their clinical practice. It is important to promote a better knowledge on the subject and to create protocols for proper clinical management.

Resultado parcial do xenodiagnóstico realizado em um grupo de pacientes serològicamente positivos para a doença de Chagas e internados no hospital São Pedro (de alienados), em Pôrto Alegre, Rio Grande do Sul, Brasil

Exames sorológicos de Imunofluorescència, Fixação do Complemento e Hemoaglutinação para a Doença de Chagas foram rezalidos em 1609 pacientes. Em 154 casos, as provas foram positivas, com um índice percentual de 9,57%. Posteriormente, 50 casos sorològicamente positivos foram submetidos ao xenodiagnústico. Os xeno-positivos revelaram um índice de 5,35% sobre o total de casos examinados e de 56% sôbre os sorològicamente positivos. Chama-se a atenção para a alta incidência de chagásicos no Hospital São Pedro, ao lado de outras considerações.

RoboCup Soccer Leagues

RoboCup was created in 1996 by a group of Japanese, American, and European Artificial Intelligence and Robotics researchers with a formidable, visionary long-term challenge: “By 2050 a team of robot soccer players will beat the human World Cup champion team.” At that time, in the mid 90s, when there were very few effective mobile robots and the Honda P2 humanoid robot was presented to a stunning public for the first time also in 1996, the RoboCup challenge, set as an adversarial game between teams of autonomous robots, was fascinating and exciting. RoboCup enthusiastically and concretely introduced three robot soccer leagues, namely “Simulation,” “Small-Size,” and “Middle-Size,” as we explain below, and organized its first competitions at IJCAI’97 in Nagoya with a surprising number of 100 participants [RC97]. It was the beginning of what became a continously growing research community. RoboCup established itself as a structured organization (the RoboCup Federation www.RoboCup.org). RoboCup fosters annual competition events, where the scientific challenges faced by the researchers are addressed in a setting that is attractive also to the general public. and the RoboCup events are the ones most popular and attended in the research fields of AI and Robotics.RoboCup further includes a technical symposium with contributions relevant to the RoboCup competitions and beyond to the general AI and robotics.

A new empirical system for rock slope stability analysis in exploitation stage

An empirical system was developed to obtain a quality index for rock slopes in road infrastructures, named Slope Quality Index (SQI), and it was applied to a set of real slopes.The SQI is supported in nine factors affecting slope stability that contemplate the evaluation of different parameters. Consequently, each factor is classified by the degree of importance and influence by assigned weights. These weights were established through a statistical analysis of replies to a survey that was distributed to several experienced professionals in the field. The proposed SQI varies between1 and 5, corresponding to slopes in very good and very bad condition state, respectively. Besides the advantage linked to a quantitative and qualitative evaluation of slopes, theSQI also allows identifying the most critical factors on the slope stability, which is a fundamental issue for an efficient management of the slope network in the road infrastructure, namely in the planning of conservation and maintenance operations.

Extending the reservoir of bla IMP-5: the emerging pathogen Acinetobacter bereziniae

Acinetobacter bereziniae clinical relevance is starting to be recognized; however, very few descriptions of its carbapenem resistance currently exist. Here we characterize two carbapenem-resistant A. bereziniae isolates. Materials & methods: Isolates were obtained from environmental and clinical samples. Carbapenemases were searched by phenotypic, biochemical and PCR assays. Clonality was studied by ApaI-PFGE and genetic location for carbapenemase genes were assessed by I-CeuI and S1 hybridizations. Results: Isolates were not clonally related but both produced the exclusively Portuguese IMP-5, with the clinical isolate also producing an OXA-58. The carbapenemase genes were plasmid located. Conclusion: Our results emphasize the role of non-baumannii Acinetobacter species as important reservoirs of clinically relevant resistance genes that could also contribute to their emergence as nosocomial pathogens

Describing orbitopes by linear inequalities and projection based tools

Magdeburg, Univ., Fak. für Mathematik, Diss., 2011