[Illustrations de Decem Tragediae] / [Non identifié] ; Sénèque, aut. du texte

Comprend : [Frontispice : scènes bibliques, saints et martyres. Christ, saint Jean-Baptiste, saint Sébastien, Adam et Eve, saint Christophe etc.] [Cote : Res m Yc 1008/Microfilm R 122295] ; [pl. en reg. p.13 : illustration de la tragédie I de Seneque "La colère d'Hercule" (Hercules furens).] [Cote : Res m Yc 1008/Microfilm R 122295] ; [Fig. p.57 : illustration de la tragédie II de Seneque "Thyestes".] [Cote : Res m Yc 1008/Microfilm R 122295] ; [Fig. en reg. p.93 : illustration de la tragédie III de Seneque "Thebais".] [Cote : Res m Yc 1008/Microfilm R 122295] ; [Fig. à la tragédie IV : illustration de la tragédie IIII de Seneque "Hypolite" (Hypolytus).] [Cote : Res m Yc 1008/Microfilm R 122295] ; [Fig. à la tragédie V : illustration de la tragédie V de Seneque "Oedipe" (Oedypus).] [Cote : Res m Yc 1008/Microfilm R 122295] ; [Fig. à la tragédie VI : illustration de la tragédie VI de Seneque "Les Troyennes" (Troas).] [Cote : Res m Yc 1008/Microfilm R 122295] ; [Fig. à la tragédie VII : illustration de la tragédie V de Seneque "Médée" (Medea).] [Cote : Res m Yc 1008/Microfilm R 122295] ; [Fig. à la tragédie VIII : illustration de la tragédie VIII de Seneque "Agamemnon" .] [Cote : Res m Yc 1008/Microfilm R 122295] ; [Fig. à la tragédie IX : illustration de la tragédie IX de Seneque "Octavie" (Octavia) . ] [Cote : Res m Yc 1008/Microfilm R 122295] ; [Fig. à la tragédie X : illustration de la tragédie X de Seneque "Hercules oetheus" .] [Cote : Res m Yc 1008/Microfilm R 122295]

Underdiagnosed and undertreated: obesity in the portuguese population.

Comment on: Post RE, Mainous AG 3rd, Gregorie SH, Knoll ME, Diaz VA, Saxena SK. The influence of physician acknowledgment of patients' weight status on patient perceptions of overweight and obesity in the United States. Arch Intern Med. 2011 Feb 28;171(4):316-21. PMID: 21357807.

Polyphenol-rich foods in the Mediterranean diet are associated with better cognitive function in elderly subjects at high cardiovascular risk

Brain oxidative processes play a major role in age-related cognitive decline, thus consumption of antioxidant-rich foods might help preserve cognition. Our aim was to assess whether consumption of antioxidant-rich foods in the Mediterranean diet relates to cognitive function in the elderly. In asymptomatic subjects at high cardiovascular risk (n = 447; 52% women; age 5580 y) enrolled in the PREDIMED study, a primary prevention dietary-intervention trial, we assessed food intake and cardiovascular risk profile, determined apolipoprotein E genotype, and used neuropsychological tests to evaluate cognitive function.We also measured urinary polyphenols as an objective biomarker of intake. Associations between energy-adjusted food consumption, urinary polyphenols, and cognitive scores were assessed by multiple linear regression models adjusted for potential confounders. Consumption of some foods was independently related to better cognitive function. The specific associations [regression coefficients (95% confidence intervals)] were: total olive oil with immediate verbal memory [0.755 (0.1511.358)]; virgin olive oil and coffee with delayed verbal memory [0.163 (0.0100.316) and 0.294 (0.0550.534), respectively];walnuts with working memory [1.191 (0.0612.322)]; and wine with Mini-Mental State Examination scores [0.252 (0.0060.496)]. Urinary polyphenols were associated with better scores in immediate verbal memory [1.208 (0.2362.180)]. Increased consumption of antioxidant-rich foods in general and of polyphenols in particular is associated with better cognitive performance in elderly subjects at high cardiovascular risk. The results reinforce the notion that Mediterranean diet components might counteract age-related cognitive decline.

IL-12-mediated STAT4 signaling and TCR signal strength cooperate in the induction of CD40L in human and mouse CD8(+) T cells.

CD40L is one of the key molecules bridging the activation of specific T cells and the maturation of professional and nonprofessional antigen-presenting cells including B cells. CD4(+) T cells have been regarded as the major T-cell subset that expresses CD40L upon cognate activation; however, we demonstrate here that a putative CD8(+) helper T-cell subset expressing CD40L is induced in human and murine CD8(+) T cells in vitro and in mice immunized with antigen-pulsed dendritic cells. IL-12 and STAT4-mediated signaling was the major instructive cytokine signal boosting the ability of CD8(+) T cells to express CD40L both in vitro and in vivo. Additionally, TCR signaling strength modulated CD40L expression in CD8(+) T cells after primary differentiation in vitro as well as in vivo. The induction of CD40L in CD8(+) T cells regulated by IL-12 and TCR signaling may enable CD8(+) T cells to respond autonomously of CD4(+) T cells. Thus, we propose that under proinflammatory conditions, a self-sustaining positive feedback loop could facilitate the efficient priming of T cells stimulated by high affinity peptide displaying APCs.

Asphyxie positionnelle: une cause de décès induffisamment connue

L'asphyxie positionnelle (AP) est une entité fatale consistant en une entrave mécanique des mouvements respiratoires, due à la position du corps. Les conséquences en sont une hypoventilation alvéolaire importante et, le cas échéant, une hyperexcitabilité cardiaque. Cette dernière se produit en raison d'une acidose respiratoire associée à une libération massive de catécholamines lorsqu'un individu est entravé et soumis à une contrainte physique. Ainsi, ce syndrome, qui peut se produire lors de diverses circonstances, est surtout observé lors de contraintes physiques et en association avec un Excited delirium (ED). Le diagnostic de l'AP se base essentiellement sur trois critères : une position corporelle entravant l'échange normal de gaz, l'impossibilité de se libérer de cette position et l'exclusion d'autres causes possibles de décès.

Retroviral infection of neonatal Peyer's patch lymphocytes: the mouse mammary tumor virus model.

Mouse mammary tumor virus is known to infect newborn mice via mother's milk. A proposed key step for viral spread to the mammary gland is by the infection of lymphocytes. We show here that although in suckling mice retroviral proteins are found in all epithelial cells of the gut, viral DNA is exclusively detectable in the Peyer's patches. As early as 5 d after birth the infection leads to a superantigen response in the Peyer's patches but not in other lymphoid organs draining the intestine. Viral DNA can be detected before the superantigen response and becomes first evident in the Peyer's patches followed by mesenteric lymph nodes and finally all lymphoid organs.

A female melanin ornament signals offspring fluctuating asymmetry in the barn owl.

Sexual selection theory predicts that males advertise quality by displaying extravagant ornaments. By contrast, whether phenotypic variation in females has a signalling function remains an open question. Here, to our knowledge, we provide the first evidence that a female plumage trait can signal fluctuating asymmetry in the offspring. We experimentally demonstrate in wild barn owls (Tyto alba) that the extent to which females display black spots on their plumage does not only signal offspring parasite resistance as shown in a previous study but also developmental homeostasis in the offspring. A greater number of spotted females produced offspring that had more symmetrical feathers during the period of growth. Males, that pair non-randomly with respect to female plumage spottiness therefore appear to gain substantial benefits by mating with heavily spotted females. Genetic variation in plumage spottiness is nevertheless maintained as the covariation between offspring body mass and mother plumage spottiness varies annually depending on environmental conditions.