Subclinical thyroid dysfunction and fracture risk: a meta-analysis.

IMPORTANCE Associations between subclinical thyroid dysfunction and fractures are unclear and clinical trials are lacking. OBJECTIVE To assess the association of subclinical thyroid dysfunction with hip, nonspine, spine, or any fractures. DATA SOURCES AND STUDY SELECTION The databases of MEDLINE and EMBASE (inception to March 26, 2015) were searched without language restrictions for prospective cohort studies with thyroid function data and subsequent fractures. DATA EXTRACTION Individual participant data were obtained from 13 prospective cohorts in the United States, Europe, Australia, and Japan. Levels of thyroid function were defined as euthyroidism (thyroid-stimulating hormone [TSH], 0.45-4.49 mIU/L), subclinical hyperthyroidism (TSH <0.45 mIU/L), and subclinical hypothyroidism (TSH ≥4.50-19.99 mIU/L) with normal thyroxine concentrations. MAIN OUTCOME AND MEASURES The primary outcome was hip fracture. Any fractures, nonspine fractures, and clinical spine fractures were secondary outcomes. RESULTS Among 70,298 participants, 4092 (5.8%) had subclinical hypothyroidism and 2219 (3.2%) had subclinical hyperthyroidism. During 762,401 person-years of follow-up, hip fracture occurred in 2975 participants (4.6%; 12 studies), any fracture in 2528 participants (9.0%; 8 studies), nonspine fracture in 2018 participants (8.4%; 8 studies), and spine fracture in 296 participants (1.3%; 6 studies). In age- and sex-adjusted analyses, the hazard ratio (HR) for subclinical hyperthyroidism vs euthyroidism was 1.36 for hip fracture (95% CI, 1.13-1.64; 146 events in 2082 participants vs 2534 in 56,471); for any fracture, HR was 1.28 (95% CI, 1.06-1.53; 121 events in 888 participants vs 2203 in 25,901); for nonspine fracture, HR was 1.16 (95% CI, 0.95-1.41; 107 events in 946 participants vs 1745 in 21,722); and for spine fracture, HR was 1.51 (95% CI, 0.93-2.45; 17 events in 732 participants vs 255 in 20,328). Lower TSH was associated with higher fracture rates: for TSH of less than 0.10 mIU/L, HR was 1.61 for hip fracture (95% CI, 1.21-2.15; 47 events in 510 participants); for any fracture, HR was 1.98 (95% CI, 1.41-2.78; 44 events in 212 participants); for nonspine fracture, HR was 1.61 (95% CI, 0.96-2.71; 32 events in 185 participants); and for spine fracture, HR was 3.57 (95% CI, 1.88-6.78; 8 events in 162 participants). Risks were similar after adjustment for other fracture risk factors. Endogenous subclinical hyperthyroidism (excluding thyroid medication users) was associated with HRs of 1.52 (95% CI, 1.19-1.93) for hip fracture, 1.42 (95% CI, 1.16-1.74) for any fracture, and 1.74 (95% CI, 1.01-2.99) for spine fracture. No association was found between subclinical hypothyroidism and fracture risk. CONCLUSIONS AND RELEVANCE Subclinical hyperthyroidism was associated with an increased risk of hip and other fractures, particularly among those with TSH levels of less than 0.10 mIU/L and those with endogenous subclinical hyperthyroidism. Further study is needed to determine whether treating subclinical hyperthyroidism can prevent fractures.

Ms. Barth. 146 - Aristoteles-Kommentare

Vorbesitzer: Benediktinerabtei Amorbach; Bartholomaeusstift Frankfurt am Main

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 888 - Mitteilung über den Aufenthalt der Eltern in London

u.a. Angaben für Arthur Schopenhauer zur Verbesserung des Schreibens;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 146 - Zusendung eines Manuskriptes mit der Bitte der kritischen Prüfung

u.a.: Dr. Friedrich Ernst Suchsland;

Ms. Praed. 146 - Gesta Romanorum

Vorbesitzer: Dominikanerkloster Frankfurt am Main

Ms.Ff.F.Stoltze 3. 146 - Brief von Gustav Kanngießer an Friedrich Stoltze

Persönliche Nachrichten, Der wahre Jakob

Na 1 Nachlass Max Horkheimer, 508 - Korrespondenzen mit Theodor W. Adorno (p. VI 1E, 146 - 320)

Briefwechsel zwischen Theodor W. Adorno, Gretel Adorno und Max Horkheimer, 1949-1954; Briefwechsel zwischen Alice Maier uind Max Horkheimer; Briefwechsel zwischen dem Hessischen Minister für Erziehung und Volksbildung und Theodor W. Adorno sowie Max Horkheimer; 1 Brief von Alice Maier an Leo Löwenthal; 1 Brief von Alice Maier an die Bank of America in Los Angeles, 29.10.1953; 3 Briefe zwischen Marie Jahoda und Theodor W. Adorno, 1953;

Na 1 Nachlass Max Horkheimer, 541 - Korrespondenzen mit Leo Löwenthal (p. VI 16, 1 - 146)

109 Briefe zwischen Leo Löwenthal und Max Horkheimer, 1943; 4 Briefe von der Office War Information (Washington) an Leo Löwenthal, Januar 1943; 1 Brief von J. H. Randall an Leo Löwenthal, 24.11.1942; 1 Brief von Dan Levin an Leo Löwenthal, 10.01.1943;

Die Emancipation der Juden in Rumänien oder 888 von 300000 : Marsescu, Istoczy, Harr, Stöcker, Treitschke

von M. Herzfeld

Na 1 Nachlass Max Horkheimer, 678 - "Antisemitism among American Labor" Band I (p. IX 146.1 Bd. I)

"Antisemitism among American Labor. Report on a Research Projekt conducted by the Institute of Social Research in 1944-1945". Typoskript, in 4 Bänden gebunden, 1450 Blatt;

Na 1 Nachlass Max Horkheimer, 679 - "Antisemitism among American Labor" Band II (p. IX 146.1 Bd. II)

"Antisemitism among American LAbor. Report on a Research Project conducted by the Institut of Social Research in 1944-1945". Typoskript, in 4 Bänden gebunden, 1450 Blatt;

Na 1 Nachlass Max Horkheimer, 680 - "Antisemitism among American Labor" Band III (p. IX 146.1 Bd III)

"Antisemitism among American Labor. Report on a Research Project conducted by the Institute of Social Research in 1944-1945". Typoskript, in 4 Bänden gebunden, 1450 Blatt;

Na 1 Nachlass Max Horkheimer, 681 - "Antisemitism anong American Labor" Band IV (p. IX 146.1 Bd. IV)

"Antisemitism among Amercan Labor. Report on a Research Project conducted by the Institute of Soial Research in 1944-1945". Typoskript, in 4 Bänden gebunden, 1450 Blatt;

Na 1 Nachlass Max Horkheimer, 682 - "Antisemitism among American Labor" (p. IX 146.2-4 - IX 146.5-23)

"Antisemitism and American Labor. A Research Project of the Institut of Social Research", Januar 1944 (revised June 1944); a) als Typoskript vervielfältigt, 14 Blatt; b) Typoskript, 14 Blatt; Institut of Social Research: "Project an Antisemitism and American Labor", Januar 1944; a) Typoskript, 18 Blatt; b) Typoskript, mit handschriftlichen Korrekturen, 17 Blatt, c) Teilstück, Typoskript mit handschriftlichen Korrekturen, 1 Blatt; d) Teilstück, Typoskript mit handschriftlichen Korrekturen, 1 Blatt; e) Teilstück, Typoskript mit handschriftlichen Korrekturen, 5 Blatt; f) Teilstück, Typoskript mit handschriftlichen Korrekturen, 4 Blatt; "Project on Antisemitism an American Labor", Dezember 1943; a) Typoskript mit handschriftlichen Korrekturen, 18 Blatt; b) Typoskript mit handschriftlichen Korrekturen von Theodor W. Adorno, 17 Blatt; c) Typoskript mit handschriftlichen Korrekturen, 12 Blatt; Memoranden 1941-1949; Adorno, Theodor W. to Löwenthal, Leo: "Supplement to the Memorandum of 7/28/49 by Pollock, Friedrich re Labor Study", 18.09.1949. Typoskript, 6 Blatt; Adorno, Theodor W.: "Memorandum re: Antisemitism among American Labor, as edited by the Bureau of Applied Social Research", 19.07.1949. Typoskript, 8 Blatt; "Expenses for Project: Antisemitism among Labor, june 1, 1944- May 31,1945". Typoskript, 1 Blatt; Institut of Social Research: "Interim Memorandum on Progress of Project on Antisemitism within Labor", 04.09.1944. Typoskript, 11 Blatt; Institut of Social Research: "Re: Project on Labor and Antisemitism. Difficulties to be expected", 21.03.1944. Typoskript, 3 Blatt; "Re: Project on Labor and Antisemitism. Plants to be Contacted", 21.03.1944. Typoskript, 2 Blatt; "Some Remarks to Dr. Gelle's Report 'Der deutsche Progrom, a, 10. November 1938'", 11.03.1944. Typoskript, 12 Blatt; Adorno, Theodor W. ?: "Adress to ameeting of the Jewish Labor Committee, January 20th, 1944, los Angeles". Typoskript mit eigenhändigen Ergänzungen, 2 Blatt; Pollock, Friedrich: "Re: Sherman", 31.12.1943, 1 Blatt; "Memorandum re: Jewish Labor Committee", 23.12.1943. Typoskript mit handschriftlichen Korrekturen, 2 Blatt; "Tentative Budget for a Trial Survey on Antisemitism among American Labor", 23.12.1943. Typoskript, 1 Blatt; "Council for Democracy. Survey on Antisemitism. Hartford, Conn., late 1941". Typoskript, 4 Blatt; "Council for Democracy. Survey on Antisemitism. Terre Haute, Ind.". Typoskript, 2 Blatt; Horkheimer, Max: Eigenhändige Notizen zum Projekt, 3 Blatt; "Some heading lind", handschriftlichen Notizen, 1 Blatt; Institut of Social research: "Instructuins", Fragebogen, als Typoskript vervielfältigt, 3 Blatt; "Instructions for Interviews on Attitudes of Workers and White Collar Workers towards Jews". Als Typoskript vervielfältigt, 1 Blatt; Horkheimer, Max: 1 Briefentwurf an Friedrich Pollock, ohne Ort, ohne Datum, 1 Blatt; Pollock, Friedrich: 3 Briefe an Max Horkheimer, ohne Ort, 1943, 3 Blatt; Sherman, Charles B.: 1 Brief mit Unterschrift an Friedrich Pollock, New York, 23.12.1943; 3 Briefe von Friedrich Pollock, New York, 1943-1944, 5 Blatt;