Despesas com tratamento de doenças causadas ou agravadas pelo álcool : análise de propostas para seu financiamento

Consultoria Legislativa - Área IX - Política e Planejamento Econômicos, Desenvolvimento Econômico, Economia Internacional.

高超声速飞行器-进气道一体化热流数值计算

采用CFD(计算流体动力学)技术,开展了飞行器前体/发动机一体化气动热环境分析.对层流区、转捩区和湍流区分别采用计算模型,在湍流区利用压缩性修正的SSGZ-J k-ε湍流模型,在转捩区引入代数型转捩因子模型描述边界层由层流逐渐过渡为完全湍流的流动过程.计算了前体和内通道的表面热流,并与实验结果进行了对比.结果表明所采用的计算方法可以较好地预测前体及发动机内通道热流率,流动状态、几何结构及激波入射对热流值影响较大.

Sand Transport Studies in Monterey Bay, California: Annual Report, Part 5, 1973

(PDF contains 71 pages)

Contributions to unsupervised and supervised learning with applications in digital image processing

311 p. : il.

miRNA polymorphisms are associated with risk of developing chronic lymphocytic leukemia

Chronic Lymphocytic Leukemia (CLL) is the most frequent leukemia of adults in Western countries and shows a ~8.5-fold increased relative risk in first-degree relatives. Up to date several studies have identified low-penetrance susceptibility alleles in CLL. Nevertheless, these studies scarcely study regions that do not encode proteins such as microRNAs (miRNAs). Abnormalities in miRNAs, as altered expression patterns and mutations, have been described in CLL, suggesting their implication in the development of the disease. Polymorphisms in these miRNAs may deregulate miRNAs expression levels and affect to the miRNA function. However, despite accumulating evidence that inherited genetic variation in miRNA genes can contribute to the predisposition for CLL, the role of these in the risk of CLL has not been extensively studied. Therefore, the aim of this study was to find new genetic markers of risk to CLL. To that end, we made a systematic search for SNPs in miRNAs and miRNAs deregulated in CLL and genotyped 213 polymorphisms in 401 samples of Spanish individuals. The literature search resulted in more than 100 miRNAs deregulated in CLL and 43 polymorphisms studied in the disease. Out of 213 genotyped SNPs, 13 showed to be significantly associated with CLL risk. rs2682818 in pre-mature miR618 was the most significant result, with 0.49 fold decreased risk to CLL. Interestingly, a previous study associated this SNP with an increased risk of developing follicular lymphoma. Secondly, rs10173558 SNP in mir- 1302-4 showed the highest risk association, with a 5.24 fold increased risk, but there were no previous works studying it. Finally, rs61992671 in miR412, previously associated with CLL risk, showed also association in our sample. In conclusion, we find 13 alleles which could contribute to the risk of CLL. However, new large-scale studies including functional analyses will be needed to validate our findings.

SCID2hu 小鼠: HIV研究的小型动物模型

长期以来缺乏病毒体内感染的小动物模型是制约HIV21 研究取得突破性进展的一大障碍。研究者将 胎儿的胸腺和胎肝组织移植到重症联合免疫缺陷(SCID) 小鼠体内, 构建了SCID2hu (Thy/Liv) 人鼠嵌合模型。 该模型具备正常功能性的人造血器官“Thy/Liv”, 较真实地模拟了HIV21 感染人胸腺后的状况, 是研究HIV21 体内感染较成功且很有潜力的嵌合鼠模型。SCID2hu (Thy/Liv) 模型的构建使得在小型动物体内研究HIV 的某 些致病机制、临床前评价各种先导药物的体内抗HIV 活性、评价新的治疗方案及寻求合适的基因治疗等成为可 能, 为在体内研究人造血系统和免疫系统的病理生理机能及人干细胞基因治疗提供了有力的工具, 有广泛的应 用前景。

香溪河库湾春季水华期间硝酸盐、磷酸盐的时空分布

在三峡水库香溪河库湾春季水华连续暴发期间(2005年2月26日—4月28日)对香溪河与长江汇合处(河口)至香溪河库湾上游库尾处总计14个采样点进行连续监测,结果表明硝酸盐和磷酸盐在库湾中存在明显的时空分布规律。在空间上,河口的硝酸盐浓度高,库尾浓度低,其变化趋势是随着与河口距离的增加而降低;磷酸盐的分布规律是库尾的浓度高,河口的浓度低,其变化趋势与硝酸盐恰好相反。各采样点硝酸盐和磷酸盐浓度在时间上也呈现出明显的规律。河口硝酸盐的浓度在不同时间变化幅度较小,库尾采样点的硝酸盐浓度的变化幅度较大,随着与河口距