Ms. Barth. 119 - Theologische Sammelhandschrift

Vorbesitzer: Bartholomaeusstift Frankfurt am Main

Na 1 Nachlass Max Horkheimer, 291 - Korrespondenzen u.a. mit Heinz Joachim Heydorn (p. V 82, 119-246)

3 Briefe zwischen Graf Lazy Henckel von Donnersmarck und Max Horkheimer, 1968; 2 Briefe zwischen Gräfin Nina Henckel von Donnersmarck und Max Horkheimer, 1968; 4 Briefe zwischen der Sängerin Carla Henius und Max Horkheimer, 1970-1971; 1 Brief an K. H. Hennings von Max Horkheimer, 1967; 4 Briefe zwischen Professor Wilhelm Hennis und Max Horkheimer, 1971; 1 Brief an Professor Dieter Henrich von Max Horkheimer, 1964; 2 Briefe zwischen Caroline Hergert und Max Horkheimer, 1970; 1 Brief von Professor Fred Herman an Max Horkheimer, 1959; 2 Briefe zwischen der Fachschülerin Dora Herrmann und Max Horkheimer, 1972; 2 Briefe zwischen Professor Franz Herrmann und Max Horkheimer, 1970; 6 Briefe zwischen Dr. phil. Gert-Julius Herrmann und Max Horkheimer, 1968; 2 Briefe zwischen Dipl. Kfm. Dr. Dr. Otto O. Herz und Max Horkheimer, 1969; 4 Briefe zwischen Professor und Museumsdirektor Erich Herzog und Max Horkheimer, 1970; 2 Briefe zwischen Hans Eberhard Hess und Max Horkheimer, 1970; 16 Briefe zwischen Professor Eugen Hess-Baer und Max Horkheimer, 1966-1971; 3 Briefe zwischen Karl Hess und Max Horkheimer, 1969-1971; 1 Drucksache von Pfarrer Walter Hess, 1971; 6 Briefe zwischen dem Bankier Walter Hesselbach und Max Horkheimer, 1971-1973; Drucksachen vom Hessischen Kreis, 1968; Briefe zwischen dem Hessischen Landesmuseum Darmstadt und Max Horkheimer, 1969; 25 Briefe zwischen Professor Heinz Joachim Heydorn und Max Horkheimer, 1965-1973; 2 Briefe zwischen Dr. Karl Heymann und Max Horkheimer, 1970; 1 Brief an den Hippokrates-Verlag von Max Horkheimer, 1971; 9 Briefe zwischen Walter Hirschmann und Max Horkheimer, 1969-1971;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 119 - Bitte um Weiterleitung einiger Briefe an Madame Herbigny

u.a.: Heinrich August Carl Ganslandt;

Ms. Praed. 119 - Homiliae

Vorbesitzer: Dominikanerkloster Frankfurt am Main

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 743 - Weiterleitung eines Briefes von Hinrich Burghart Abegg

u.a.: Finanzen;

Ms.Ff.F.Stoltze 3. 119 - Brief von Hermann jun. Herf an Friedrich Stoltze

Angebot, eine in Sachsenhausen polizeilich abgebrochene Wahlrede Stoltzes in Mainz fortzusetzen

Ms. lat. oct. 119 - Stundenbuch nach dem Gebrauch von Evreux

Vorbesitzer: Marguareta Moteau; Michel Andrieu;

Na 1 Nachlass Max Horkheimer, 667 - "Research Project on Anti-Semitism", "Notes on the latest phase of Nazi Antisemitism" (p. IX 119-IX 120)

Institute of Social Research: "Project on Antisemitism. Report to the American Jewish Committee on the first year of the Project ending March 15, 1944" (April 1944), a) Typoskript, 153 Blatt, b) Teilstück, Typoskript mit handschriftlichen Korrekturen, 22 Blatt, c) Entwurf der Gliederung, 16.11.1943, Typoskript, 2 Blatt, d) "Annex 1: List of Contributors to the Project on Antisemitism", Typoskript, 3 Blatt; "Notes on the latest phase of Nazi Antisemitism" (12.5.1944), a) Typoskript mit handschriftlichen Korrekturen und Ergänzungen, 4 Blatt, b) Typoskript, 3 Blatt;

RNA polymerase II large subunit degradation induced by ecteinascidin 743: Molecular characterization and subsequent rational investigation of antitumor mechanisms in cancers with clinical response

Ecteinascidin 743 (Et-743), which is a novel DNA minor groove alkylator with a unique spectrum of antitumor activity, is currently being evaluated in phase II/III clinical trials. Although the precise molecular mechanisms responsible for the observed antitumor activity are poorly understood, recent data suggests that post-translational modifications of RNA polymerase II Large Subunit (RNAPII LS) may play a central role in the cellular response to this promising anticancer agent. The stalling of an actively transcribing RNAPII LS at Et-743-DNA adducts is the initial cellular signal for transcription-coupled nucleotide excision repair (TC-NER). In this manner, Et-743 poisons TC-NER and produces DNA single strand breaks. Et-743 also inhibits the transcription and RNAPII LS-mediated expression of selected genes. Because the poisoning of TC-NER and transcription inhibition are critical components of the molecular response to Et-743 treatment, we have investigated if changes in RNAPII LS contribute to the disruption of these two cellular pathways. In addition, we have studied changes in RNAPII LS in two tumors for which clinical responses were reported in phase I/II clinical trials: renal cell carcinoma and Ewing's sarcoma. Our results demonstrate that Et-743 induces degradation of the RNAPII LS that is dependent on active transcription, a functional 26S proteasome, and requires functional TC-NER, but not global genome repair. Additionally, we have provided the first experimental data indicating that degradation of RNAPII LS might lead to the inhibition of activated gene transcription. A set of studies performed in isogenic renal carcinoma cells deficient in von Hippel-Lindau protein, which is a ubiquitin-E3-ligase for RNAPII LS, confirmed the central role of RNAPII LS degradation in the sensitivity to Et-743. Finally, we have shown that RNAPII LS is also degraded in Ewing's sarcoma tumors following Et-743 treatment and provide data to suggest that this event plays a role in decreased expression of the Ewing's sarcoma oncoprotein, EWS-Fli1. Altogether, these data implicate degradation of RNAPII LS as a critical event following Et-743 exposure and suggest that the clinical activity observed in renal carcinoma and Ewing's sarcoma may be mediated by disruption of molecular pathways requiring a fully functional RNAPII LS. ^

Solar radiation over and under sea ice and photographic quantification of Ice algal aggregates during the POLARSTERN cruise ARK-XXVII/3 (IceArc) in summer 2012

The ice cover of the Arctic Ocean has been changing dramatically in the last decades and the consequences for the sea-ice associated ecosystem remain difficult to assess. Algal aggregates underneath sea ice have been described sporadically but the frequency and distribution of their occurrence is not well quantified. We used upward looking images obtained by a remotely operated vehicle (ROV) to derive estimates of ice algal aggregate biomass and to investigate their spatial distribution. During the IceArc expedition (ARK-XXVII/3) of RV Polarstern in late summer 2012, different types of algal aggregates were observed floating underneath various ice types in the Central Arctic basins. Our results show that the floe scale distribution of algal aggregates in late summer is very patchy and determined by the topography of the ice underside, with aggregates collecting in dome shaped structures and at the edges of pressure ridges. The buoyancy of the aggregates was also evident from analysis of the aggregate size distribution. Different approaches used to estimate aggregate biomass yield a wide range of results. This highlights that special care must be taken when upscaling observations and comparing results from surveys conducted using different methods or on different spatial scales.

Carbon and oxygen isotopic compositions of Cibicidoides spp. and fine fraction separates (<10 µm) from ODP Holes 113-689B, 119-738B, and 120-748B

A prominent middle Eocene warming event is identified in Southern Ocean deep-sea cores, indicating that long-term cooling through the middle and late Eocene was not monotonic. At sites on Maud Rise and the Kerguelen Plateau, a distinct negative shift in d18O values (~1.0 per mil) is observed ca. 41.5 Ma. This excursion is interpreted as primarily a temperature signal, with a transient warming of 4°C over 600 k.y. affecting both surface and middle-bathyal deep waters in the Indian-Atlantic region of the Southern Ocean. This isotopic event is designated as the middle Eocene climatic optimum, and is interpreted to represent a significant climatic reversal in the midst of middle to late Eocene deep-sea cooling. The lack of a significant negative carbon isotope excursion, as observed during the Paleocene-Eocene thermal maximum, and the gradual rate of high-latitude warming suggest that this event was not triggered by methane hydrate dissociation. Rather, a transient rise in pCO2 levels is suspected, possibly as a result of metamorphic decarbonation in the Himalayan orogen or increased ridge/arc volcanism during the late middle Eocene.