993 resultados para 108-663B


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Vorbesitzer: Johannes Blasbalg; Bartholomaeusstift Frankfurt am Main

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BACKGROUND: Among patients with steroid-refractory ulcerative colitis (UC) in whom a first rescue therapy has failed, a second line salvage treatment can be considered to avoid colectomy. AIM: To evaluate the efficacy and safety of second or third line rescue therapy over a one-year period. METHODS: Response to single or sequential rescue treatments with infliximab (5mg/kg intravenously (iv) at week 0, 2, 6 and then every 8weeks), ciclosporin (iv 2mg/kg/daily and then oral 5mg/kg/daily) or tacrolimus (0.05mg/kg divided in 2 doses) in steroid-refractory moderate to severe UC patients from 7 Swiss and 1 Serbian tertiary IBD centers was retrospectively studied. The primary endpoint was the one year colectomy rate. RESULTS: 60% of patients responded to the first rescue therapy, 10% went to colectomy and 30% non-responders were switched to a 2(nd) line rescue treatment. 66% of patients responded to the 2(nd) line treatment whereas 34% failed, of which 15% went to colectomy and 19% received a 3(rd) line rescue treatment. Among those, 50% patients went to colectomy. Overall colectomy rate of the whole cohort was 18%. Steroid-free remission rate was 39%. The adverse event rates were 33%, 37.5% and 30% for the first, second and third line treatment respectively. CONCLUSION: Our data show that medical intervention even with 2(nd) and 3(rd) rescue treatments decreased colectomy frequency within one year of follow up. A longer follow-up will be necessary to investigate whether sequential therapy will only postpone colectomy and what percentage of patients will remain in long-term remission.

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Die Foliierung geht nur bis Bl. 422; zusätzlich gibt es das Blatt 98a.

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Boberach: Es muß verhindert werden, daß die Beschlüsse über das Budgetrecht so ausgelegt werden können, daß bei einem neuen Konflikt zwischen Krone und Parlament eine Steuerverweigerung möglich wird

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Vorbesitzer: Abraham Merzbacher;

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u.a.: Anspielung auf Maîtresse von Schopenhauer; Friedrich Eduard Beneke;

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Vorbesitzer: Dominikanerkloster Frankfurt am Main

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Vorbesitzer: Abraham Merzbacher;

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Vorbesitzer: Augustinereremitenkloster Como; F.P.; de Nigris; Osvaldo Calvi; D. Filippo Nodari; Arnulf Kogler

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Bitte um Nachdruck-Erlaubnis für eine Hampelmann-Kolumne im "Stuttgarter Beobachter", Bitte um Auskunft zu einer historischen Anekdote