996 resultados para family crisis


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Monthly Public Assistance Statistical Report Family Investment Program

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Monthly Public Assistance Statistical Report Family Investment Program

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Monthly Public Assistance Statistical Report Family Investment Program

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Monthly Public Assistance Statistical Report Family Investment Program

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Monthly Public Assistance Statistical Report Family Investment Program

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Booklet produced by the Iowa Civil Rights Commission for individuals who own, design, build, or develop multi-family housing.

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Monthly Public Assistance Statistical Report Family Investment Program

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Monthly Public Assistance Statistical Report Family Investment Program

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En esta nota se introducen algunos ajustes a los datos presupuestarios disponibles sobre los ingresos y los gastos de las comunidades autónomas con el fin de corregir las distorsiones generadas por la forma en la que se han contabilizado algunas partidas. Las series ajustadas se utilizan para analizar la evolución de las finanzas regionales durante la crisis actual y la parte final de la expansión precedente. El ejercicio ayuda a poner en perspectiva la actual controversia sobre las finanzas autonómicas. En ella se suele poner el acento en la dureza de los recortes de los últimos ejercicios, olvidando la temeraria explosión del gasto durante los años anteriores al comienzo de la crisis. Cuando se toma el período en su conjunto, el proceso de consolidación presupuestaria que comienza en 2010 aparece como una corrección parcial y tardía de los excesos de años anteriores. De cara al futuro, convendría tomar medidas que ayuden a hacer menos procíclico el patrón de gasto autonómico. Aunque esto ya se hace en parte en la nueva Ley de Estabilidad Presupuestaria, se argumenta que sería conveniente crear un Fondo de Estabilización Presupuestaria para facilitar el alisamiento del gasto regional.

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We consider stock market contagion as a significant increase in cross-market linkages after a shock to one country or group of countries. Under this definition we study if contagion occurred from the U.S. Financial Crisis to the rest of the major stock markets in the world by using the adjusted (unconditional) correlation coefficient approach (Forbes and Rigobon, 2002) which consists of testing if average crossmarket correlations increase significantly during the relevant period of turmoil. We would not reject the null hypothesis of interdependence in favour of contagion if the increase in correlation only suggests a continuation of high linkages in all state of the world. Moreover, if contagion occurs, this would justify the intervention of the IMF and the suddenly portfolio restructuring during the period under study.

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We investigate the effects of the financial crisis on the stationarity of real interest rates in the Euro Area. We use a new unit root test developed by Peseran et al. (2013) that allows for multiple unobserved factors in a panel set up. Our results suggest that while short-term and long-term real interest rates were stationary before the financial crisis, they became nonstationary during the crisis period likely due to persistent risk that characterized financial markets during that time. JEL codes: E43, C23. Keywords: Real interest rates, Euro Area, financial crisis, panel unit root tests, cross-sectional dependence.

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Monthly Public Assistance Statistical Report Family Investment Program

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Rho GTPases are conformational switches that control a wide variety of signaling pathways critical for eukaryotic cell development and proliferation. They represent attractive targets for drug design as their aberrant function and deregulated activity is associated with many human diseases including cancer. Extensive high-resolution structures (.100) and recent mutagenesis studies have laid the foundation for the design of new structure-based chemotherapeutic strategies. Although the inhibition of Rho signaling with drug-like compounds is an active area of current research, very little attention has been devoted to directly inhibiting Rho by targeting potential allosteric non-nucleotide binding sites. By avoiding the nucleotide binding site, compounds may minimize the potential for undesirable off-target interactions with other ubiquitous GTP and ATP binding proteins. Here we describe the application of molecular dynamics simulations, principal component analysis, sequence conservation analysis, and ensemble small-molecule fragment mapping to provide an extensive mapping of potential small-molecule binding pockets on Rho family members. Characterized sites include novel pockets in the vicinity of the conformationaly responsive switch regions as well as distal sites that appear to be related to the conformations of the nucleotide binding region. Furthermore the use of accelerated molecular dynamics simulation, an advanced sampling method that extends the accessible time-scale of conventional simulations, is found to enhance the characterization of novel binding sites when conformational changes are important for the protein mechanism.

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Monthly Public Assistance Statistical Report Family Investment Program