992 resultados para cip-fil
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Esta invenção descreve o uso de compostos obtidos a partir do extrato de raízes, caules, cascas e folhas de espécies vegetais do gênero arrabidaea, em especial a arrabidaea brachypoda, também conhecida como cipó-uma ou cervejinha do campo, para tratar doenças ulcerogênicas.
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Esta invenção descreve o uso de compostos obtidos a partir do extrato de raí-zes, caules, cascas e folhas de espécies vegetais do gênero arrabidaea, em especial a arrabidaea brachypoda, também conhecida como cipó-una ou cervejinha do campo, no tratamento de doenças parasitárias como a malária, doença de chagas e leishmaniose.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Eriocaulaceae species are popularly known as sempre-vivas. This family comprising approximately 1.200 species divided into 10 genera, with high endemic levels. Paepalanthus genus has high incidence in the Espinhaço Range region and the report of biological activities. Despite the large number of previous studies with Eriocaulaceae species, Paepalanthus geniculatus has no studies about their scapes, which demonstrates the need for new research to identify their chemical and biological composition. The aim of this work was to study the chemical composition of P. geniculatus ethanolic extract seeking the isolation and identification of metabolites and evaluate the radical scavenging activity of the extract and isolated substances. P. geniculatus were collected in Serra do Cipó-MG in 2013 (Voucher: SANO 3193) and the scapes were dried, crushed and the powder was percolated with ethanol. With the etanolic extract it is carried out a fractionation by gel permeation chromatography, yielding fractions analyzed by TLC assay. The fraction J89 (45,6 mg) was purified by semipreparative HPLC-PDA, resulting in the isolation of substance S1. The fractionation was also performed by medium pressure liquid chromatography, yielding fractions analyzed by TLC assay. The fraction number 4 (92,6 mg) were purified by semipreparative HPLC-PDA resulting in the isolation of substances S2 and S3. The substances S1 and S3 were analyzed by mono and twodimensional NMR, resulting in the identification of 3,4-dihydroxybenzoic acid (protocatechuic acid) and the flavonoid 6-hydroxyquercetin-7-O-β-Dglucopyranoside. The substance S2 were identified by comparison with standards, were it was possible to determine the presence of the flavonoid 6-hydroxy-7- methoxyquercetin-3-O-β-D-glucopyranoside. The evaluation of radical scavenging activity for the extract and the isolated substances using DPPH, showed consistent activity to S1...
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Eriocaulaceae species are popularly known as sempre-vivas. This family comprising approximately 1.200 species divided into 10 genera, with high endemic levels. Paepalanthus genus has high incidence in the Espinhaço Range region and the report of biological activities. Despite the large number of previous studies with Eriocaulaceae species, Paepalanthus geniculatus has no studies about their scapes, which demonstrates the need for new research to identify their chemical and biological composition. The aim of this work was to study the chemical composition of P. geniculatus ethanolic extract seeking the isolation and identification of metabolites and evaluate the radical scavenging activity of the extract and isolated substances. P. geniculatus were collected in Serra do Cipó-MG in 2013 (Voucher: SANO 3193) and the scapes were dried, crushed and the powder was percolated with ethanol. With the etanolic extract it is carried out a fractionation by gel permeation chromatography, yielding fractions analyzed by TLC assay. The fraction J89 (45,6 mg) was purified by semipreparative HPLC-PDA, resulting in the isolation of substance S1. The fractionation was also performed by medium pressure liquid chromatography, yielding fractions analyzed by TLC assay. The fraction number 4 (92,6 mg) were purified by semipreparative HPLC-PDA resulting in the isolation of substances S2 and S3. The substances S1 and S3 were analyzed by mono and twodimensional NMR, resulting in the identification of 3,4-dihydroxybenzoic acid (protocatechuic acid) and the flavonoid 6-hydroxyquercetin-7-O-β-Dglucopyranoside. The substance S2 were identified by comparison with standards, were it was possible to determine the presence of the flavonoid 6-hydroxy-7- methoxyquercetin-3-O-β-D-glucopyranoside. The evaluation of radical scavenging activity for the extract and the isolated substances using DPPH, showed consistent activity to S1...
Las drogas en los centros de iniciacion profesional: aportaciones de algunos estudios del País Vasco
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[ES] Entre las diferentes medidas para prevenir el abandono escolar destacan hoy los Programa de Cualificación Profesional Inicial. Sin embargo, la complejidad de la adolescencia y de la problemática de sus conductas de riesgo invita a reflexionar sobre su sentido y alcance de estas, entre las que resalta el consumo problemático de diferentes drogas. Este artículo aporta datos de algunos estudios realizados con la población atendida en los Centros de Iniciación Profesional (CIP) en el País Vasco, con la mirada puesta en la atención educadora.
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[FR] Grande figure de la géographie française —et européenne— du premier quart du XIXe siècle, Conrad Malte-Brun laisse une oeuvre scientifique écrite considérable, dont une vaste Géographie universelle qui marqua alors son époque, rééditée à de multiples reprises durant plus de 50 ans. Contrairement à Élisée Reclus, autre grande figure de la seconde moitié du XIXe siècle, les écrits de Malte-Brun demeurent mal connus, sinon mésestimés. Or, à travers le fil conducteur que représente le chapitre de sa Géographie universelle consacré à l’Espagne, nous avons pour objectif de montrer que son auteur a su dépasser la simple dimension descriptive caractérisant nombre de textes géographiques de son époque pour introduire une réelle dimension explicative. Rien que pour cela, il mérite très largement, à notre sens, d’être redécouvert…