De la Condition politique et civile des juifs dans le Royaume de Pologne : examen critique d'un rapport adressé en l'année 1858 à l'Empereur Alexandre II, par le départememt de l'intérieur et des cultes du Royaume de Pologne ; texte précédé et suivi d'observations historiques, politiques et législatives

par Louis Lubliner

L' Empereur Nicolas II. et les Juifs : essais sur la révolution russe dans ses rapports avec l'activité universelle du Judaisme contemporain

par A. Netchvolodow. Trad. du Russe par I. M. Narischkina

Textes classiques de la littérature religieuse des Israélites : précédés d'un précis de grammaire Hébrai͏̈que ...

par Léon Nordmann, aum ônier Israélite du Lycée Louis-le-Grand ...

Invitation à la topologie algébrique. Tome II. Cohomologie, variétés

Ce Tome II introduit la cohomologie, qui est une théorie duale de l'homologie, et examine les liens avec cette dernière ainsi que les divers produits construits sur les modules d'homologie et de cohomologie. Nous étudions en détail les variétés topologiques avec ou sans bord, définissons sur celles-ci au moyen de l'homologie une notion d'orientation et la comparons avec les définitions classiques d'orientation pour les variétés différentiables ou triangulables. Nous exposons les théorèmes de dualité de Poincaré, Alexander et Lefschetz et en déduisons les propriétés des formes d'intersection et de la signature des variétés. Le dernier chapitre du livre présente les résultats fondamentaux concernant la différentiabilité et la triangulabilité des variétés, obtenus depuis les années soixante du siècle dernier, tant en grandes dimensions qu'en dimension quatre. Nous discutons également la conjecture de Poincaré classique et ses généralisations. Bien que des démonstrations complètes de ces résultats soient hors de portée d'un ouvrage tel que le nôtre, nous nous sommes attachés à rendre leurs énoncés compréhensibles. Cette vue d'ensemble, et les références à la littérature qui l'accompagnent, fournissent une introduction aux développements récents dans ce riche domaine de la topologie.

Bevacizumab, Pemetrexed, and Cisplatin, or Bevacizumab and Erlotinib for Patients With Advanced Non-Small-Cell Lung Cancer Stratified by Epidermal Growth Factor Receptor Mutation: Phase II Trial SAKK19/09

Treatment allocation by epidermal growth factor receptor mutation status is a new standard in patients with metastatic nonesmall-cell lung cancer. Yet, relatively few modern chemotherapy trials were conducted in patients characterized by epidermal growth factor receptor wild type. We describe the results of a multicenter phase II trial, testing in parallel 2 novel combination therapies, predefined molecular markers, and tumor rebiopsy at progression. Objective: The goal was to demonstrate that tailored therapy, according to tumor histology and epidermal growth factor receptor (EGFR) mutation status, and the introduction of novel drug combinations in the treatment of advanced nonesmall-cell lung cancer are promising for further investigation. Methods: We conducted a multicenter phase II trial with mandatory EGFR testing and 2 strata. Patients with EGFR wild type received 4 cycles of bevacizumab, pemetrexed, and cisplatin, followed by maintenance with bevacizumab and pemetrexed until progression. Patients with EGFR mutations received bevacizumab and erlotinib until progression. Patients had computed tomography scans every 6 weeks and repeat biopsy at progression. The primary end point was progression-free survival (PFS) ≥ 35% at 6 months in stratum EGFR wild type; 77 patients were required to reach a power of 90% with an alpha of 5%. Secondary end points were median PFS, overall survival, best overall response rate (ORR), and tolerability. Further biomarkers and biopsy at progression were also evaluated. Results: A total of 77 evaluable patients with EGFR wild type received an average of 9 cycles (range, 1-25). PFS at 6 months was 45.5%, median PFS was 6.9 months, overall survival was 12.1 months, and ORR was 62%. Kirsten rat sarcoma oncogene mutations and circulating vascular endothelial growth factor negatively correlated with survival, but thymidylate synthase expression did not. A total of 20 patients with EGFR mutations received an average of 16.

Local Heat Application for the Treatment of Buruli Ulcer: Results of a Phase II Open Label Single Center Non Comparative Clinical Trial.

BACKGROUND Buruli ulcer (BU) is a necrotizing skin disease most prevalent among West African children. The causative organism, Mycobacterium ulcerans, is sensitive to temperatures above 37°C. We investigated the safety and efficacy of a local heat application device based on phase change material. METHODS In a phase II open label single center noncomparative clinical trial (ISRCTN 72102977) under GCP standards in Cameroon, laboratory confirmed BU patients received up to 8 weeks of heat treatment. We assessed efficacy based on the endpoints 'absence of clinical BU specific features' or 'wound closure' within 6 months ("primary cure"), and 'absence of clinical recurrence within 24 month' ("definite cure"). RESULTS Of 53 patients 51 (96%) had ulcerative disease. 62% were classified as World Health Organization category II, 19% each as category I and III. The average lesion size was 45 cm(2). Within 6 months after completion of heat treatment 92.4% (49 of 53, 95% confidence interval [CI], 81.8% to 98.0%) achieved cure of their primary lesion. At 24 months follow-up 83.7% (41 of 49, 95% CI, 70.3% to 92.7%) of patients with primary cure remained free of recurrence. Heat treatment was well tolerated; adverse effects were occasional mild local skin reactions. CONCLUSIONS Local thermotherapy is a highly effective, simple, cheap and safe treatment for M. ulcerans disease. It has in particular potential as home-based remedy for BU suspicious lesions at community level where laboratory confirmation is not available. CLINICAL TRIALS REGISTRATION ISRCT 72102977.

Gedenkblatt für S. M. König Ludwig II. Schutzpatron des Wort- und Tondichters Meister Richard Wagner. Für Bayern starbst Du viel zu früh - die Wagnerstadt vergisst Dich nie. : Erinnerung an die I. Parsifal Aufführung, Bayreuth, 1882

Signatur des Originals: S 36/F07044

Gedenkblatt für S. M. König Ludwig II. Schutzpatron des Wort- und Tondichters Meister Richard Wagner. Für Bayern starbst Du viel zu früh - die Wagnerstadt vergisst Dich nie. : Erinnerung an die I. Parsifal Aufführung, Bayreuth, 1882

Signatur des Originals: S 36/F07045

Gedenkblatt für S. M. König Ludwig II. Schutzpatron des Wort- und Tondichters Meister Richard Wagner. Für Bayern starbst Du viel zu früh - die Wagnerstadt vergisst Dich nie. : Erinnerung an die I. Parsifal Aufführung, Bayreuth, 1882

Signatur des Originals: S 36/F07568

Die Glaubenskrone : Jubelpredigt über Offenb. Joh. 3. B. II. "Halt was du hast, dass niemand deine Krone nehme!" gehalten am Schlusse der dritten Jubelfeyer der Reformation den 2. November 1817 und seinen geliebten Pfarrgemeinden Gries, Weitbruch und Kurtzenhaußen im Unter Elsaße zum Andenken gewidmet

von ihrem treuen Freunde und Lehrer Johann Jakob Hüter

Wrestling With Tradition: Japanese Activities at Amache, a World War II Incarceration Facility

I employ archaeological analyses, archival research, and oral histories to investigate traditional Japanese practices that were performed at Amache, a World War II Japanese American incarceration facility. I argue that these inter-generational practices helped to bridge a cultural gap that existed between several generations of Japanese Americans. For many incarcerated Japanese Americans, their first exposure to many traditional activities occurred during incarceration. The resulting social environment incorporated aspects of Japanese, Japanese American, and mainstream American influences, all of which were adapted to conditions during incarceration. Similarly, archaeological analyses allow for the investigation of traditional practice features. These provide evidence regarding the significance of the adapted landscape at Amache. Evidence of these practices suggests Amache internees had both a strong desire to maintain and celebrate these aspects of their Japanese heritage but they also incorporated non-traditional elements that reflected the unique living conditions during incarceration. Incarceration, I argue, created an environment in which a unique internee consciousness was formed in which the use of traditional practices was a focal point. The physical remains of traditional practices allow archaeologists to determine aspects of this newly formed consciousness that are not readily apparent in historical documentation.