CARACTERIZAÇÃO E ATIVIDADE CATALÍTICA DE K2CO3/AL2O3 NA TRANSESTERIFICAÇÃO DO ÓLEO DE GIRASSOL COM AQUECIMENTO CONVENCIONAL E MICRO-ONDAS

Commercial and synthetic mesoporous aluminas impregnated with potassium carbonate were characterized by X-ray diffraction (XRD), nitrogen physisorption, infrared spectroscopy and 27Al MAS NMR. The activities in the transesterification reaction of sunflower oil with methanol for biodiesel production were evaluated. 27Al MAS NMR spectra evidenced the presence of AlIV and AlVI in the samples, and also of AlV sites in the mesoporous synthesized alumina, which disappeared after impregnation with potassium salt followed by calcination. All aluminas containing potassium were active for biodiesel production from sunflower seed oil, with high conversions by both conventional heating and microwave irradiation.

DESENVOLVIMENTO DE MATERIAIS HÍBRIDOS MICRO-MESOPOROSOS DO TIPO ZSM-12/MCM-41

Micro-mesoporous hybrid materials of ZSM-12/MCM-41 type with different micro- and mesoporosity contributions were prepared by a procedure that uses the desilication of the zeolite in an alkaline medium, followed by recrystallization onto the mesostructure, where the zeolite is used as the silica source in the formation of mesoporous phase. The materials were characterized by X-ray diffraction, nitrogen adsorption-desorption at 77 K, scanning electron microscopy and thermal analysis. The results showed that the methodology utilized is efficient for obtaining hybrid materials of ZSM-12/MCM-41 type with optimized micro-and mesoporosity.

PRODUÇÃO DE BIODIESEL A PARTIR DE ÁCIDOS GRAXOS PROVENIENTES DO REFINO DE ÓLEOS VEGETAIS VIA CATÁLISE ÁCIDA HETEROGENEA E MICRO-ONDAS

This work presents the biofuel production results of the esterification of fatty acids (C12-C18) and high-acid-content waste vegetable oils from different soap stocks (soybean, palm, and coconut) with methanol, ethanol, and butanol by acid catalysis. We used Amberlyst-35 (A35) sulfonic resin as a heterogeneous acid catalyst and p-toluenesulfonic acid as a homogeneous catalyst for comparison. Both the heterogeneous (A35) and homogeneous (p-toluenesulfonic acid) reactions were performed with 5% w/w of catalyst. The final products were analyzed by proton nuclear magnetic resonance (1H NMR). The homogeneous catalyzed esterification of fatty acids with methanol, ethanol, and butanol produced esters with yields higher than 90%. In the reaction with fatty acids and methanol catalyzed by A35, the best results were achieved with lauric acid and methanol, with a yield of 97%. An increase in the hydrocarbon chain decreased the rate of conversion and yield for stearic acid with methanol, which was 90%. Maximum biodiesel production was achieved from coconut and soybean soap stocks and methanol (96%-98%), which showed conversions very close to those obtained from their respective fatty acids. Microwave irradiation reduced the reaction time from 6 to 1 h in the esterification reaction of fatty acids with butanol.

Test automation scheme for LTE core network element

Modern sophisticated telecommunication devices require even more and more comprehensive testing to ensure quality. The test case amount to ensure well enough coverage of testing has increased rapidly and this increased demand cannot be fulfilled anymore only by using manual testing. Also new agile development models require execution of all test cases with every iteration. This has lead manufactures to use test automation more than ever to achieve adequate testing coverage and quality. This thesis is separated into three parts. Evolution of cellular networks is presented at the beginning of the first part. Also software testing, test automation and the influence of development model for testing are examined in the first part. The second part describes a process which was used to implement test automation scheme for functional testing of LTE core network MME element. In implementation of the test automation scheme agile development models and Robot Framework test automation tool were used. In the third part two alternative models are presented for integrating this test automation scheme as part of a continuous integration process. As a result, the test automation scheme for functional testing was implemented. Almost all new functional level testing test cases can now be automated with this scheme. In addition, two models for integrating this scheme to be part of a wider continuous integration pipe were introduced. Also shift from usage of a traditional waterfall model to a new agile development based model in testing stated to be successful.

Comportamento fotofísico do antraceno em sistemas micro-heterogêneos argila-surfactantes-íons metálicos

Argilas constituem uma classe de complexos micro-heterogêneos e podem ser utilizados como substrato para adsorção. O seu comportamento de sorção em fase sólida intensificada pela presença de surfactantes, argilas organofílicas, é um importante fenômeno explorado pela tecnologia ambiental para a remoção de compostos orgânicos policíclicos (hidrocarbonetos aromáticos policíclicos, HPA) da água, introduzidos no ambiente por fontes antropogênicas. Este trabalho tem por objetivo estudar o comportamento fotofísico do antraceno, como modelo de HPA, em sistemas micro-heterogêneos argila-surfactantes-íons metálicos (M(II)= Cd(II), Cu(II), Hg(II), Ni(II) e Pb(II); surfactantes: CTACl; SDS; TR-X100). Os estudos foram conduzidos pelo monitoramento na mudança das propriedades de fluorescência estática e na supressão da emissão do antraceno utilizado como sonda fluorescente. Como supressores foram utilizados os cátions metálicos: Cd(II), Cu(II), Hg(II), Ni(II) e Pb(II). O perfil do espectro de fluorescência e os resultados dos ensaios de supressão da fluorescência da sonda permitiram inferir na localização do sítio de solubilização do antraceno nos sistemas micro-heterogêneos estudados e na conseqüente organização dos mesmos.

Kuulla vai kuunnella – käyttäjää osallistavan palveluinnovoinnin lähestymistavan toteuttamisen haasteita julkisella sektorilla

Julkisen sektorin itsensä synnyttämien innovaatioiden ja innovoinnin näkökulma on verrattain tuore innovaatiotutkimuksen tutkimuskohde. Vielä uudempaa lähestymistapaa edustaa käyttäjälähtöinen ja käyttäjää osallistava palveluinnovaatiotutkimus julkisella sektorilla. Käyttäjälähtöisen ja käyttäjää osallistavan palveluinnovoinnin lähestymistavan toteuttamisesta ollaan kiinnostuneita, mutta tieteelliseen tutkimukseen perustuva tieto lähestymistavasta on vielä kohtuullisen niukkaa. Tämän käyttäjälähtöiseen palvelujen innovointiin keskittyvän väitöskirjatutkimuksen päätavoitteena on mikrotasolla tunnistaa ja ryhmitellä käyttäjää osallistavan palveluinnovoinnin lähestymistavan toteuttamisen haasteita julkisella sektorilla. Väitöskirjatutkimuksen alatavoitteena on tutkimuksesta saatavan tiedon avulla muodostaa kysymyslista tukemaan lähestymistavan käyttöönottamista ja toteuttamista julkisen sektorin palveluorganisaatioissa ja -verkostoissa. Julkisen palvelusektorin ohella väitöskirjan tutkimustuloksia voivat soveltuvin osin hyödyntää myös yksityisen ja kolmannen sektorin palveluorganisaatiot ja -verkostot sekä käyttäjälähtöisen innovaatiopolitiikan suunnitteluun ja sen jalkauttamiseen osallistuvat tahot. Haasteita lähestytään tutkimuksessa käyttäjälähtöisen ja käyttäjää osallistavan palveluinnovoinnin lähestymistavan piirteiden kautta ja haasteita tarkastellaan kehittäjäviranomaisten (ryhmätaso) näkökulmasta. Kuntasektori on valittu tutkimukseen edustamaan julkista sektoria. Lähestymistavan piirteiksi tutkimuksessa määritellään käyttäjänäkökulman ohjaava rooli organisaation innovaatiotoiminnan strategisella tasolla ja palvelujen uudistamisprosessien tasoilla, avoimuus (erityisesti käyttäjärajapinta) ja tulkinnallisuus innovaatioprosessien varhaisessa vaiheessa sekä laaja-alainen käsitys innovaatioiden lähteistä käyttäjänäkökulmaa muodostettaessa. Tutkimuksen kohteena on hyvinvointipalveluinnovaatioprosessien varhainen vaihe, jolloin keskeisessä asemassa on uusien ideoiden sekä uuden tiedon ja ymmärryksen hankinta hyödynnettäväksi innovaatioprosessien seuraavissa vaiheissa. Tutkimuksessa rajaudutaan käyttäjälähtöisen palveluinnovoinnin muotoon, jossa käyttäjät intentionaalisesti ja konkreettisesti osallistetaan kehittäjäviranomaisjohtoisiin palveluinnovaatioprosesseihin. Käyttäjiksi tutkimuksessa ymmärretään palvelun loppukäyttäjät palvelujen ”ulkoisina hyödyntäjinä” ja yli sektorialisten palveluprosessien henkilöstö palvelujen ”sisäisinä hyödyntäjinä”. Hyvinvointipalveluista tutkimuksessa ovat edustettuina sosiaali- ja terveyspalvelut sekä ikäihmisten palvelukeskusten tarjoamat palvelut. Kuntasektorin innovaatiotoiminnan kenttä ymmärretään tutkimuksessa verkostomaisena kokonaisuutena, joka ylittää kuntien hallinnolliset rajat. Artikkeliväitöskirjana toteutetun väitöskirjatutkimuksen metodologia perustuu usean tapauksen tapaustutkimukseen (multiple case-studies) ja kvalitatiiviseen tutkimusotteeseen. Työn empiirinen osuus koostuu viidestä artikkelina julkaistusta osatutkimuksesta. Osatutkimuksissa käytetään tapaustutkimuksen eri variaatioita, ja tutkimusaineistot on kerätty kolmesta eri perustutkimusympäristöstä. Osatutkimuksien tapaukset on valittu palvelun käyttäjien ”äänen jatkumon” (the voice of the customer) eri kohdista. Käyttäjän ääntä käytetään tutkimuksessa metodisena ratkaisuna ja metaforana. Lisäksi käyttäjän ääni ymmärretään tutkimuksessa paremminkin kollektiivisena ja laajemmista palvelujen kehittämisnäkökulmista kertovana tekijänä kuin yksittäisten palvelun käyttäjien tarpeista ja toiveista kertovana metaforana. Käyttäjää osallistavan palveluinnovoinnin lähestymistavan toteuttamisen haasteiksi julkisella sektorilla tutkimuksessa tunnistetaan viisi haastetta. Tiivistetysti haasteena on 1. palvelujen käyttäjien subjektiuteen perustuva käyttäjälähtöisyys palvelujen uudistamisessa 2. tunnistaa palvelun käyttäjät innovaatiotoiminnan voimavarana ja rohkaistua heidän osallistamiseensa 3. sitoutuminen yhteistoiminnallisuuteen käyttäjä- ja muita rajapintoja ylittävissä palvelujen uudistamisprosesseissa ja innovaatiohakuisuus työskentelyssä 4. oivaltaa palvelutoivelistoja ja asiakaspalautteita laajempia kehittämisnäkökulmia 5. synnyttää luottamukseen perustuva hyvä kierre palvelun käyttäjien ja kehittäjien välille. Tutkimustuloksena syntyneet haasteet paikannetaan tutkimuksessa käyttäjän äänen jatkumolle erilaisin painotuksin. Lisäksi tutkimustulosten pohjalta tehdään kolme keskeistä johtopäätöstä. Ensinnäkin palvelun kehittäjätahon sekä palvelun loppukäyttäjien ja palvelujen sisäisten hyödyntäjien väliltä on tunnistettavissa innovaatiopotentiaalia sisältäviä rakenteellisia aukkoja. Toiseksi kehittäjäviranomaistahon valmius ja halu laajentaa tiedonmuodostustaan palvelujen uudistamisessa palvelun käyttäjien kanssa yhteisöllisen tiedonmuodostuksen suuntaan on puutteellinen. Kolmanneksi palvelujen kehittäjätaho ei ole sisäistänyt riittävässä määrin käyttäjää osallistavan palveluinnovoinnin lähestymistavan metodologisia perusajatuksia. Tutkimuksessa tunnistetut viisi haastetta osoittavat, että käyttäjää osallistavan palveluinnovoinnin lähestymistavan käyttöönotto hyvinvointipalveluorganisaation tai -verkoston palvelujen innovoinnin lähestymistavaksi ei ole mekaaninen toimenpide. Lähestymistavan käyttöönottoa tukeva kysymyslista perustuu tutkimuksessa tunnistettuihin haasteisiin. Kysymyslista on laadittu siten, että kysymykset liittyvät laajasti julkisten palveluorganisaatioiden ja -verkostojen innovaatiokulttuuriin. Kaksiosaisen kysymyslistan ensimmäisen osan kysymykset käsittelevät innovointia ohjaavia mentaalisia malleja. Ensimmäisessä osassa esitetään esimerkiksi seuraava kysymys: ”Millaista käsitystäpalvelun käyttäjistä (kuntalaisista) sekä käyttäjien ja kehittäjien (viranomaisten) välisestä suhteesta ilmennämme palvelujen innovoinnissa; onko palvelujen käyttäjä (kuntalainen) kohde, jolle kehitetään palveluja, vai onko hän jopa välttämätön kehittämiskumppani?”. Kysymyslistan toisen osan kysymykset liittyvät innovaatiokäytänteisiin ja valmiuksiin. Esimerkkinä voidaan mainita seuraava kaksiosainen kysymys: ”Tukevatko innovaatiokäytänteemme käyttäjärajapinnan ylittäviä innovaatioprosesseja ja sitoudummeko avoimin mielin työskentelyyn palvelun käyttäjien, potentiaalisten käyttäjien tai ei-käyttäjien kanssa? Mitä hyötyjä koemme yhteistoiminnallisuudesta koituvan meille ja käyttäjille sekä innovaation laatuominaisuuksiin?”. Mitä tulee tutkimuksen otsikon alkuosaan ”kuulla vai kuunnella”, vastaus on, että pääpaino on sanalla ”kuulla”. Pohdintaluvussa tuodaan myös esille tarve – tai ainakin kriittisen tarkastelun tarve – käyttäjälähtöisen ja käyttäjää osallistavan palveluinnovoinnin käsitteen ja sen luonteen sekä tavoitteiden määrittelemiselle julkisen sektorin ominaispiirteistä käsin vastapainona alkuperältään yksityisen sektorin liiketoimintakontekstista lähtöisin oleville määrittelyille.

Relative reduction in annual soil loss in micro watersheds due to the relief and forest cover

With the intense debate, in Brazil, between landowners and public agencies about the amount of area with forest cover needed in different regions, there is an increase of the need for provision of technical data used as a basis for decision making. One of the criteria to evaluate the effect of forest cover in protecting water resources is the soil loss, which leads to several consequences on the environment, including the silting of the rivers. Therefore, this study aimed to evaluate the reduction in the soil loss in micro watersheds with different reliefs, size and location of forest cover, in the Corumbataí River watershed, in the state of São Paulo, using the Revised Universal Soil Loss Equation (RUSLE) in a GIS environment. For this study, 18 watersheds in three degrees of slope were selected, and 20 scenarios for land-use were established, by analyzing the influence of the PPA size, and the size and the location of the Legal Reserve. The results showed that: a) the effect of forest cover in reducing annual soil loss varies depending on the average slope of the watershed; b) the PPA width must be determined taking into account the slope of the watershed; c) the Legal Reserve must be located along the PPA. These provide better results in reducing annual soil loss.

Element speciation and behaviour in metal-rich Boreal river and estuarine systems using ultrafiltration and chemical modelling

The bioavailability of metals and their potential for environmental pollution depends not simply on total concentrations, but is to a great extent determined by their chemical form. Consequently, knowledge of aqueous metal species is essential in investigating potential metal toxicity and mobility. The overall aim of this thesis is, thus, to determine the species of major and trace elements and the size distribution among the different forms (e.g. ions, molecules and mineral particles) in selected metal-enriched Boreal river and estuarine systems by utilising filtration techniques and geochemical modelling. On the basis of the spatial physicochemical patterns found, the fractionation and complexation processes of elements (mainly related to input of humic matter and pH-change) were examined. Dissolved (<1 kDa), colloidal (1 kDa-0.45 μm) and particulate (>0.45 μm) size fractions of sulfate, organic carbon (OC) and 44 metals/metalloids were investigated in the extremely acidic Vörå River system and its estuary in W Finland, and in four river systems in SW Finland (Sirppujoki, Laajoki, Mynäjoki and Paimionjoki), largely affected by soil erosion and acid sulfate (AS) soils. In addition, geochemical modelling was used to predict the formation of free ions and complexes in these investigated waters. One of the most important findings of this study is that the very large amounts of metals known to be released from AS soils (including Al, Ca, Cd, Co, Cu, Mg, Mn, Na, Ni, Si, U and the lanthanoids) occur and can prevail mainly in toxic forms throughout acidic river systems; as free ions and/or sulfate-complexes. This has serious effects on the biota and especially dissolved Al is expected to have acute effects on fish and other organisms, but also other potentially toxic dissolved elements (e.g. Cd, Cu, Mn and Ni) can have fatal effects on the biota in these environments. In upstream areas that are generally relatively forested (higher pH and contents of OC) fewer bioavailable elements (including Al, Cu, Ni and U) may be found due to complexation with the more abundantly occurring colloidal OC. In the rivers in SW Finland total metal concentrations were relatively high, but most of the elements occurred largely in a colloidal or particulate form and even elements expected to be very soluble (Ca, K, Mg, Na and Sr) occurred to a large extent in colloidal form. According to geochemical modelling, these patterns may only to a limited extent be explained by in-stream metal complexation/adsorption. Instead there were strong indications that the high metal concentrations and dominant solid fractions were largely caused by erosion of metal bearing phyllosilicates. A strong influence of AS soils, known to exist in the catchment, could be clearly distinguished in the Sirppujoki River as it had very high concentrations of a metal sequence typical of AS soils in a dissolved form (Ba, Br, Ca, Cd, Co, K, Mg, Mn, Na, Ni, Rb and Sr). In the Paimionjoki River, metal concentrations (including Ba, Cs, Fe, Hf, Pb, Rb, Si, Th, Ti, Tl and V; not typical of AS soils in the area) were high, but it was found that the main cause of this was erosion of metal bearing phyllosilicates and thus these metals occurred dominantly in less toxic colloidal and particulate fractions. In the two nearby rivers (Laajoki and Mynäjoki) there was influence of AS soils, but it was largely masked by eroded phyllosilicates. Consequently, rivers draining clay plains sensitive to erosion, like those in SW Finland, have generally high background metal concentrations due to erosion. Thus, relying on only semi-dissolved (<0.45 μm) concentrations obtained in routine monitoring, or geochemical modelling based on such data, can lead to a great overestimation of the water toxicity in this environment. The potentially toxic elements that are of concern in AS soil areas will ultimately be precipitated in the recipient estuary or sea, where the acidic metalrich river water will gradually be diluted/neutralised with brackish seawater. Along such a rising pH gradient Al, Cu and U will precipitate first together with organic matter closest to the river mouth. Manganese is relatively persistent in solution and, thus, precipitates further down the estuary as Mn oxides together with elements such as Ba, Cd, Co, Cu and Ni. Iron oxides, on the contrary, are not important scavengers of metals in the estuary, they are predicted to be associated only with As and PO4.

Experimental and discrete element simulation studies of bell-less charging of blast furnace

This thesis presents an experimental study and numerical study, based on the discrete element method (DEM), of bell-less charging in the blast furnace. The numerical models are based on the microscopic interaction between the particles in the blast furnace charging process. The emphasis is put on model validation, investigating several phenomena in the charging process, and on finding factors that influence the results. The study considers and simulates size segregation in the hopper discharging process, particle flow and behavior on the chute, which is the key equipment in the charging system, using mono-size spherical particles, multi-size spheres and nonspherical particles. The behavior of the particles at the burden surface and pellet percolation into a coke layer is also studied. Small-scale experiments are used to validate the DEM models.

Technology park as an element of innovative infrastructure- its role in internationalization support.

The Thesis concentrates on two central terms – Technology park and the resource-based view of the organization. General attention is devoted to competencies and capabilities of organizations that operate in foreign environment. It is difficult to go abroad without any experience and support from local government, especially for small or medium company. Technology and Science parks are the main sources of competitive advantage for this kind of organizations. They provide a huge range of services as well as business consultations and financial support on different stages of companies’ development. The Thesis was made with the assistance of Technopolis Oy in Lappeenranta. During the research companies in Finland and Russia were interviewed. Based on empirical findings important capabilities for entering foreign market were identified and some recommendations for the Technology park were given.

Variação da força de resistência à micro-tração de fragmentos de ossos corticais preservados em diversos meios e a fresco: estudo experimental em coelhos

Devido ao crescente uso dos aloenxertos nas cirurgias ortopédicas, há a necessidade do conhecimento de suas características biomecânicas ao longo do tempo de preservação. O presente trabalho consistiu na análise da força de resistência à micro-tração de amostras de ossos corticais de coelho preservadas em diversos meios por até 180 dias e a fresco. Os resultados revelaram que a resistência e o tempo de preservação apresentaram uma relação inversamente proporcional, significando que, quanto maior o tempo de preservação, menor a resistência física avaliada no ensaio biomecânico de resistência à micro-tração. Dos meios utilizados, a glicerina apresentou menores valores quanto ao teste de resistência, demonstrando, após 30 dias de preservação, apenas 24,58% da força presente no osso a fresco e, aos 180 dias, 1,76%. As amostras submetidas à autoclavagem também demonstraram baixos valores ao final do experimento, quando permaneceram com apenas 12,31% da força presente no osso a fresco. Os ossos preservados em plasma homólogo, líquido de dakin e aqueles criopreservados apresentaram os melhores índices de resistência ao final do experimento, permanecendo, respectivamente, com 82,47; 70,34 e 66,72% da força máxima quando comparados com a resistência dos ossos frescos. Concluiu-se que a escolha do método e o tempo de preservação interferiu diretamente na biomecânica dos ossos corticais, promovendo a diminuição da capacidade de resistência à tração ao longo do período de preservação.

Tunable lumped-element bandpass filters for Cognitive Radio application

In this thesis the design of bandpass filters tunable at 400 MHz – 800 MHz was under research. Microwave filters are vital components which provide frequency selectivity in wide variety of electronic systems operating at high frequencies. Due to the occurrence of multi-frequency bands communication and diverse applications of wireless devices, requirement of tunable filters exists. The one of potential implementation of frequency-agile filters is frontends and spectrum sensors in Cognitive Radio (CR). The principle of CR is to detect and operate at a particular available spectrum without interfering with the primary user’s signals. This new method allows improving the efficiency of utilizing allocated spectrum such as TV band (400 MHz – 800 MHz). The focus of this work is development of sufficiently compact, low cost tunable filters with quite narrow bandwidth using currently available lumped-element components and PCB board technology. Filter design, different topologies and methods of tuning of bandpass filters are considered in this work. As a result, three types of topologies of bandpass filter were simulated and realised. They use digitally tunable capacitors (DTCs) for adjusting central frequency at TV "white space" spectrum. Measurements revealed that schematics presented in this work have proper output response and filters are successfully tuned by DTCs.

Neoformação óssea e osteointegração de biomateriais micro e nanoestruturados em ovinos

A substituição de parte do tecido ósseo se faz necessária muitas vezes na rotina cirúrgica, seja em função de fraturas, neoplasias ósseas ou enfermidades ortopédicas que acarretem em perda óssea. Neste sentido, têm se buscado biomateriais capazes de promover esta substituição, evitando o uso de enxertos ou transplantes ósseos. O objetivo deste trabalho foi avaliar a capacidade osteoregenerativa de biomateriais em diferentes composições, em tíbias de ovinos. Foram utilizadas oito ovelhas mestiças texel, com 12 meses de idade e peso médio de 28,5±7,4kg. Após adequada preparação anestésica e cirúrgica, foram produzidos três defeitos ósseos na diáfise das tíbias em sua face medial, totalizando seis defeitos de 6mm cada, sendo que quatro foram preenchidos por biomateriais, e dois por fragmentos ósseos retirados do próprio animal (autocontrole). Os materiais implantados foram: hidroxiapatita (HA), tricálcio fosfato-β (TCP-β), hidroxiapatita/tricálcio fosfato-b 60/40 (HA/TCP-b 60/40) e o nanocompósito hidroxiapatita/alumina a 5% (HA/Al2O3 a 5%). Os animais foram alocados em dois grupos: Grupo 60 (n=04), em que os animais foram eutanasiados após 60 dias da colocação dos implantes e Grupo 90 (n=04), em que a eutanásia ocorreu 90 dias após a colocação dos implantes. Foram realizadas radiografias nos períodos pré-operatório, imediatamente após o procedimento e aos 30, 60 e 90 dias de pós-operatório, a fim de excluir qualquer alteração prévia ou complicação pós-operatória, capaz de comprometer o estudo. Após a eutanásia, foram coletadas as tíbias para avaliação macro e microscópica, por meio de microscopia eletrônica de varredura (MEV) e microscopia óptica. Os resultados encontrados mostraram uma boa capacidade de neoformação óssea e uma lenta absorção da HA. O TCP-β foi rapidamente absorvido e apresentou boa capacidade osteoindutiva e osteocondutiva, sendo observada neoformação óssea no interior dos grânulos deste biomaterial. O composto bifásico HA/TCP-β (60/40) apresentou o melhor resultado a longo prazo, devido ao melhor controle na solubilização e liberação dos íons cálcio e fosfatos para o meio biológico durante o processo de neoformação óssea. O biomaterial nanocompósito HA/Al2O3 a 5% não apresentou resultados promissores neste estudo, e sugerem-se novas pesquisas a fim de investigar melhor o potencial e aplicabilidade deste novo biomaterial. Conclui-se que a hidroxiapatita, o tricálcio fosfato-β e a associação HA/TCP-β (60/40) apresentam excelente capacidade de reparação óssea, podendo ser utilizados como substitutos ósseos; a associação HA/TCP-β (60/40) é o melhor dentre os biomateriais estudados, pois apresenta velocidade de absorção intermediária em relação à HA e ao TCP-β isolados, fornecendo ainda uma sustentação adequada ao tecido neoformado; o biomaterial HA/Al2O3 5% se mostrou incompatível, provocando reação de rejeição por parte do hospedeiro e com insignificante formação de tecido ósseo, sugerindo novas pesquisas acerca deste material.