Sermon by Jacques Judah Lyons on the death of President William Henry Harrison

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Directional dominance on stature and cognition in diverse human populations

Homozygosity has long been associated with rare, often devastating, Mendelian disorders1, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness2. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power3, 4. Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 × 10−300, 2.1 × 10−6, 2.5 × 10−10 and 1.8 × 10−10, respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months’ less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples5, 6, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection7, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been.

Tumour islet Foxp3+ T-cell infiltration predicts poor outcome in nonsmall cell lung cancer

The impact of host immunity on outcome in nonsmall cell lung cancer (NSCLC) is controversial. We examined the relationship between lymphoid infiltration patterns in NSCLC and prognosis. Tumour- and stroma-infiltrating CD3+, CD8+ and forkhead box P3 (Foxp3)+ T-lymphocytes were identified using immunohistochemistry and a novel image analysis algorithm to assess total, cytotoxic and regulatory T-lymphocyte counts, respectively, in 196 NSCLC cases. The median cell count was selected as a cut-point to define patient subgroups and the ratio of the corresponding tumour islet:stroma (TI/S) counts was determined. There was a positive association between overall survival and increased CD8+ TI/S ratio (hazard ratio (HR) for death 0.44, p<0.001) but an inverse relationship between Foxp3+ TI/S ratio and overall survival (HR 4.86, p<0.001). Patients with high CD8+ islet (HR 0.48, p<0.001) and Foxp3+ stromal (HR 0.23, p<0.001) counts had better survival, whereas high CD3+ and CD8+ stromal counts and high Foxp3+ islet infiltration conferred a worse survival (HR 1.55, 2.19 and 3.14, respectively). By multivariate analysis, a high CD8+ TI/S ratio conferred an improved survival (HR 0.48, p=0.002) but a high Foxp3+ TI/S ratio was associated with worse survival (HR 3.91, p<0.001). Microlocalisation of infiltrating T-lymphocytes is a powerful predictor of outcome in resected NSCLC.

Document page layout analysis using Harris corner points

Extraction of text areas from the document images with complex content and layout is one of the challenging tasks. Few texture based techniques have already been proposed for extraction of such text blocks. Most of such techniques are greedy for computation time and hence are far from being realizable for real time implementation. In this work, we propose a modification to two of the existing texture based techniques to reduce the computation. This is accomplished with Harris corner detectors. The efficiency of these two textures based algorithms, one based on Gabor filters and other on log-polar wavelet signature, are compared. A combination of Gabor feature based texture classification performed on a smaller set of Harris corner detected points is observed to deliver the accuracy and efficiency.

T. E. Harris and branching processes

T. E. Harris was a pioneer par excellence in many fields of probability theory. In this paper, we give a brief survey of the many fundamental contributions of Harris to the theory of branching processes, starting with his doctoral work at Princeton in the late forties and culminating in his fundamental book ``The Theory of Branching Processes,'' published in 1963.

Averting biodiversity collapse in tropical forest protected areas

The rapid disruption of tropical forests probably imperils global biodiversity more than any other contemporary phenomenon(1-3). With deforestation advancing quickly, protected areas are increasingly becoming final refuges for threatened species and natural ecosystem processes. However, many protected areas in the tropics are themselves vulnerable to human encroachment and other environmental stresses(4-9). As pressures mount, it is vital to know whether existing reserves can sustain their biodiversity. A critical constraint in addressing this question has been that data describing a broad array of biodiversity groups have been unavailable for a sufficiently large and representative sample of reserves. Here we present a uniquely comprehensive data set on changes over the past 20 to 30 years in 31 functional groups of species and 21 potential drivers of environmental change, for 60 protected areas stratified across the world's major tropical regions. Our analysis reveals great variation in reserve `health': about half of all reserves have been effective or performed passably, but the rest are experiencing an erosion of biodiversity that is often alarmingly widespread taxonomically and functionally. Habitat disruption, hunting and forest-product exploitation were the strongest predictors of declining reserve health. Crucially, environmental changes immediately outside reserves seemed nearly as important as those inside in determining their ecological fate, with changes inside reserves strongly mirroring those occurring around them. These findings suggest that tropical protected areas are often intimately linked ecologically to their surrounding habitats, and that a failure to stem broad-scale loss and degradation of such habitats could sharply increase the likelihood of serious biodiversity declines.

An estimate of the number of tropical tree species

The high species richness of tropical forests has long been recognized, yet there remains substantial uncertainty regarding the actual number of tropical tree species. Using a pantropical tree inventory database from closed canopy forests, consisting of 657,630 trees belonging to 11,371 species, we use a fitted value of Fisher's alpha and an approximate pantropical stem total to estimate the minimum number of tropical forest tree species to fall between similar to 40,000 and similar to 53,000, i.e., at the high end of previous estimates. Contrary to common assumption, the Indo-Pacific region was found to be as species-rich as the Neotropics, with both regions having a minimum of similar to 19,000-25,000 tree species. Continental Africa is relatively depauperate with a minimum of similar to 4,500-6,000 tree species. Very few species are shared among the African, American, and the Indo-Pacific regions. We provide a methodological framework for estimating species richness in trees that may help refine species richness estimates of tree-dependent taxa.

En las raíces ideológicas de Montoneros : John William Cooke lee a Gramsci en Cuba

Desde 1945 la izquierda argentina no pudo resolver el enigma planteado por el hecho de que la clase obrera era peronista. Varios intentos teóricos fracasaron antes de que John William Cooke hiciera el suyo a mediados de los años sesenta. Influenciado por Gramsci, consideró que la clase obrera es una categoría histórica, por lo que el peronismo era la experiencia histórica de la clase obrera argentina y, como tal, revolucionario. Neutralizó el papel político de Perón convirtiéndolo en el símbolo de la identidad peronista. Por esto, la teoría de Cooke fue clave para que guerrilleros de izquierda se declararan peronistas sin que les importaran las opiniones e intenciones políticas de Perón. Las limitaciones de esa teoría quedaron expuestas cuando el general regresó a la Argentina y fue electo presidente por tercera vez.

Proceedings of the 1998 Science Board Symposium on The Impacts of the 1997/98 El Niño Event on the North Pacific Ocean and Its Marginal Seas

Preface [pdf, 0.01 Mb] James J. O'Brien The big picture - The ENSO of 1997-98 [pdf, 0.01 Mb] James E. Overland, Nicholas A. Bond & Jennifer Miletta Adams Atmospheric anomalies in 1997: Links to ENSO? [pdf, 0.54 Mb] Vladimir I. Ponomarev, Olga Trusenkova, Serge Trousenkov, Dmitry Kaplunenko, Elena Ustinova & Antonina Polyakova The ENSO signal in the northwest Pacific [pdf, 0.47 Mb] Robert L. Smith, A. Huyer, P.M. Kosro & J.A. Barth Observations of El Niño off Oregon: July 1997 to present (October 1998) [pdf, 1.31 Mb] Patrica A. Wheeler & Jon Hill Biological effects of the 1997-1998 El Niño event off Oregon: Nutrient and chlorophyll distributions [pdf, 1.13 Mb] William T. Peterson Hydrography and zooplankton off the central Oregon coast during the 1997-1998 El Niño event [pdf, 0.26 Mb] William Crawford, Josef Cherniawsky, Michael Foreman & Peter Chandler El Niño sea level signal along the west coast of Canada [pdf, 1.25 Mb] Howard J. Freeland & Rick Thomson The El Niño signal along the west coast of Canada - temperature, salinity and velocity [pdf, 0.49 Mb] Frank A. Whitney, David L. Mackas, David W. Welch & Marie Robert Impact of the 1990s El Niños on nutrient supply and productivity of Gulf of Alaska waters [pdf, 0.06 Mb] Craig McNeil, David Farmer & Mark Trevorrow Dissolved gas measurements at Stn. P4 during the 97-98 El Niño [pdf, 0.13 Mb] Kristen L.D. Milligan, Colin D. Levings & Robert E. DeWreede Data compilation and preliminary time series analysis of abundance of a dominant intertidal kelp species in relation to the 1997/1998 El Niño event [pdf, 0.05 Mb] S.M. McKinnell, C.C. Wood, M. Lapointe, J.C. Woodey, K.E. Kostow, J. Nelson & K.D. Hyatt Reviewing the evidence that adult sockeye salmon strayed from the Fraser River and spawned in other rivers in 1997 [pdf,0.03 Mb] G.A. McFarlane & R.J. Beamish Sardines return to British Columbia waters [pdf, 0.34 Mb] Ken H. Morgan Impact of the 1997/98 El Niño on seabirds of the northeast Pacific [pdf, 0.06 Mb] Thomas C. Royer & Thomas Weingartner Coastal hydrographic responses in the northern Gulf of Alaska to the 1997-98 ENSO event [pdf, 0.76 Mb] John F. Piatt, Gary Drew, Thomas Van Pelt, Alisa Abookire, April Nielsen, Mike Shultz & Alexander Kitaysky Biological effects of the 1997/98 ENSO in Cook Inlet, Alaska [pdf, 0.22 Mb] H.J. Niebauer The 1997-98 El Niño in the Bering Sea as compared with previous ENSO events and the "regime shift" of the late 1970s [pdf, 0.10 Mb] A.S. Krovnin, G.P. Nanyushin, M.Yu. Kruzhalov, G.V. Khen, M.A. Bogdanov, E.I. Ustinova, V.V. Maslennikov, A.M. Orlov, B.N. Kotenev, V.V. Bulanov & G.P. Muriy The state of the Far East seas during the 1997/98 El Niño event [pdf, 0.15 Mb] Stacy Smith & Susan Henrichs Phytoplankton collected by a time-series sediment trap deployed in the southeast Bering Sea during 1997 [pdf, 0.21 Mb] Cynthia T. Tynan Redistributions of cetaceans in the southeast Bering Sea relative to anomalous oceanographic conditions during the 1997 El Niño [pdf, 0.02 Mb] Akihiko Yatsu, Junta Mori, Hiroyuki Tanaka, Tomowo Watanabe, Kazuya Nagasawa, Yikimasa Ishida, Toshimi Meguro, Yoshihiko Kamei & Yasunori Sakurai Stock abundance and size compositions of the neon flying squid in the central North Pacific Ocean during 1979-1998 [pdf, 0.11 Mb] O.B. Feschenko A new point of view concerning the El Niño mechanism [pdf, 0.01 Mb] Nathan Mantua 97/98 Ocean climate variability in the northeast Pacific: How much blame does El Niño deserve? [pdf, 0.01 Mb] Vadim P. Pavlychev Sharp changes of hydrometeorological conditions in the northwestern Pacific during the 1997/1998 El Niño event [pdf, 0.01 Mb] Jingyi Wang Predictability and forecast verification of El Niño events [pdf, 0.01 Mb] (Document contains 110 pages)

Collecção das Leis do Imperio do Brasil de 1834

Parte 1 - Leis

El cólera en las transformaciones del siglo XIX en Álava. La epidemia de 1834

747 p. (Bibliogr.: 521-546]

Why brush up your Shakespeare and your theory?: an Angela Carter companion to myths

Essa dissertação visa estudar a formação do que veio a ser conhecido como o mito Shakespeariano e sua relação com a produção literária contemporânea, exemplificada pelo romance Wise Children, da romancista inglesa Angela Carter. Tal objetivo pretende ser alcançado por meio uma revisão teórica de elementos relacionados à concepção de mito desenvolvida pelo filósofo francês Roland Barthes, tais quais a concepção tradicional de mito, o Estruturalismo, o Pós-estruturalismo, a crítica ideológica marxista e os Estudos Culturais. Um estudo dos processos históricos que deram origem ao e ajudaram a propagar o mito Shakespeariano também é levado a cabo nessa dissertação: a apropriação da figura e da obra de William Shakespeare feita pelos pré-românticos e pelos românticos em geral; a associação da figura de Shakespeare com a identidade nacional do Império Britânico; o advento da industria Shakespeariana e o papel das adaptações das peças de Shakespeare na propagação do mito Shakespeariano

O período de Garrett na Bélgica (1834-1836) em Memorias Biographicas (de Gomes de Amorim, 1881-1884) e em A Lua de Bruxelas (de Amadeu Lopes Sabino, 2000)

O propósito desta dissertação é analisar o período no qual Almeida Garrett esteve em Bruxelas (1834-1836) como Encarregado de Negócios Estrangeiros e Cônsul Geral de Portugal. Para isso, serão tomadas como base as obras Garrett Memorias Biographicas (1881-1884) de Francisco Gomes de Amorim e A Lua de Bruxelas (2000) de Amadeu Lopes Sabino. Estas obras apresentam as dificuldades financeiras de Garrett, devido ao desprezo do governo português. A biografia é marcada pelo discurso moldado de Amorim, por causa da forte relação de amizade que teve com Garrett, sendo este seu pai literário. Já Sabino apresenta um romance centrado nessa temporada, misturando narrativa histórica, dados biográficos e ficção. Dessa forma, neste trabalho, os discursos serão comparados, explicitando o tom específico de cada um: ambos apresentam as relações do intelectual com o país e com a sociedade, em uma época de grandes mudanças; porém, Amorim guarda um certo verniz e silencia sobre alguns acontecimentos, principalmente relacionados ao casamento de Garrett. Sabino tem, nesse relacionamento com a esposa (Luísa Midosi), o teor do seu romance documentado, se pautando exatamente a partir do que Amorim deixa como enigma

Pensamento científico, integridade de caráter e coletividade: uma leitura sobre a ética da crença de William Kingdon Clifford

Nesta tese abordamos alguns aspectos das inter-relações entre conhecimento, ética e valores dentro da atividade científica segundo as ideias do matemático-filósofo vitoriano William Clifford. O nosso tema geral coloca em jogo o envolvimento da produção, da avaliação e da transmissão de conhecimento científico com os comportamentos, as responsabilidades e os traços de caráter do investigador. Nosso objetivo é oferecer uma introdução ao pensamento e a algumas produções intelectuais de Clifford, um autor pouco familiar ao público filosófico brasileiro, bem como uma descrição comentada de seu escrito mais famoso, intitulado A Ética da Crença. Mediante esse objetivo, extraímos suas concepções a respeito das características e consequências éticas do empreendimento científico. As questões que orientam a tese são as seguintes: de que maneira a produção de conhecimento estaria condicionada à personalidade e ao comportamento ético de quem se lança àquela prática? Em que medida essa prática promove o cultivo de características pessoais socialmente desejáveis e favoráveis? Quais as conseqüências para a sociedade dessa inter-relação entre o caráter do investigador e os valores epistêmicos que estes colocam em ação e, sem os quais parece não ser possível a obtenção de conhecimento confiável?

Os caminhos da instrução pública elementar em Maricá de 1834 a 1854

Este trabalho de pesquisa buscou compreender como ocorriam e quais eram as ações no campo das políticas públicas para a instrução primária no século XIX no município de Maricá. Escolhemos como recorte temporal o período do século compreendido entre os anos de 1834 e 1854. A escolha das duas datas se prendeu ao fato de que este período contempla algumas mudanças importantes no campo das políticas públicas para a educação e instrução. Em 1834 temos o Ato Adicional à Constituição de 1824 que delega para as províncias competências para legislar e gerir a instrução primária e secundária. Em 1849 ocorre a implantação do Regulamento Couto Ferraz na província do Rio de Janeiro e, em 1854, o então Ministro do Império encaminha a reforma do ensino na Corte. A proximidade do município com a capital da província e com a Corte pode ser considerado como um dos fatores que instigou a nossa curiosidade em verificar até que ponto esta aproximação contribuiu para o crescimento de Maricá. No decorrer da pesquisa, começamos a perceber que os ritmos de crescimento e desenvolvimento foram diferentes, a cidade continuou como rota de passagem por muitos anos, mesmo com a sua importância econômica (produção agrícola e o pescado), mercado de abastecimento regional. A proximidade com a capital da Província do Rio de Janeiro (Niterói) e a Corte não garantiu à cidade de Maricá crescimento do número de escolas públicas primárias, foio que se verificou ao longo do período analisado. Além da pesquisa bibliográfica sobre o tema utilizamos também como fonte as publicações dos memorialistas locais, os relatórios dos presidentes da província do Rio de Janeiro, assim como documentos disponíveis no Arquivo Público do Estado do Rio de Janeiro.