Preparação e caracterização inicial de complexo de inclusão entre nitrofurazona e 2-hidroxipropil-β-ciclodextrina

Nitrofurazone (NF), 5-nitro-2-furaldehyde semicarbazone, a broad-spectrum antibiotic, has reported toxic effects and low solubility in water. It would be of great interest to form inclusion complexes between NF and a cyclodextrin, to develop more effective and safer antibiotic formulations. This paper focuses on the preparation of inclusion complexes of NF with 2-hydroxypropyl-β- cyclodextrin (HP-β-CD) and their initial characterization by evaluating rates of complex formation, photostability, solubility isotherms, release rate profiles, stoichiometry of the complexes and their morphology, as revealed by scanning electron microscopy. The kinetic tests of complex formation revealed that 17,3 h is enough for stabilization of the NF-cyclodextrin complex. The solubility isotherm studies showed that the isotherm changes from type A to type B, as a function of temperature. The photostability experiments showed that the insertion of the NF in the HP-β-CD cavity protects the drug from photodecomposition. The release kinetic tests showed that the profile of NF release from the complex is altered by the presence of HP-β-CD in the medium. A Job's plot indicated that the stoichiometry of the complex was 1:1 NF:HP-β-CD. The scanning electron micrographs showed changes in the crystal structure of NF in the complex. This study focused on the physicochemical properties of drug-delivery formulations that could potentially be developed into a novel type of therapy with NF.

Estímulo de la demanda, las inversiones y la aceleración del ritmo de crecimiento

Documento en inglés (88754) y también en: Gurrieri, Adolfo, comp.: La obra de Prebisch en la CEPAL. México, DF, Fondo de Cultura Económica, 1982, Tomo I, p. 394-423, Lecturas, No 46, (11934), ingresados en Biblioteca

Análise de processos alternativos na preparação de esqueletos para uso didático

Zoology laboratories at institutions of research and education have shown great demand for anatomical parts for practical lessons. However, although the bibliography is not necessarily scarce, analyses of the cost/benefit relations of such processes are rare, considering aspects such as preparation time, quality of the anatomical parts, and material and human resources. In addition to the common techniques already used, new low-cost products, not cited in literature and easily found in the market, were also tested. The main objective of this work was to elaborate and organize information on techniques of bone parts maceration for study collections, making comparative analyses on the cost/benefit relations of each technique. Twelve products were tested, evaluating experimental conditions such as: concentration and combination of reagents, temperature, pH and time of exposure of the parts to the reagents. The results indicated that the products recommended for the use in the maceration processes were: water, hydrogen peroxide and papaya juice (Carica papaya).

Oferta, demanda e intermediación laboral: aportes para la integración de jóvenes al mercado de trabajo salvadoreño

Incluye Bibliografía

Planeamiento de la expansión de sistemas de transmisión considerando contingencias y demanda incierta

This paper presents a methodology and a mathematical model to solve the expansion planning problem that takes into account the effect of contingencies in the planning stage, and considers the demand as a stochastic variable within a specified range. In this way, it is possible to find a solution that minimizes the investment costs guarantying reliability and minimizing future load shedding. The mathematical model of the expansion planning can be represented by a mixed integer nonlinear programming problem. To solve this problem a specialized Genetic Algorithm combined with Linear Programming was implemented.

El incremento mundial en la demanda de etanol y la pobreza en Brasil

Incluye Bibliografía

El incremento mundial en la demanda de etanol y la pobreza en Brasil

Incluye Bibliografía

Escenarios futuros de políticas de vejez en República Dominicana: la persistente demanda por derechos básicos

Incluye Bibliografía

La dinámica de oferta y demanda de competencias en un sector basado en el conocimiento en Argentina

Incluye Bibliografía

Demanda de exportaciones e importaciones de bienes y servicios para Argentina y Chile

Incluye Bibliografía

Acceso a la vivienda y subsidios directos a la demanda: experiencias latinoamericanas

Incluye Bibliografía

Políticas de viviendas de interés social orientadas al mercado: experiencias recientes con subsidios a la demanda en Chile, Costa Rica y Colombia

Incluye Bibliografía

Reestructuración sectorial y cambios en las pautas de la demanda laboral

Incluye Bibliografía

Demanda por grupos, psicologia e controle

Este artigo traz uma reflexão sobre uma capacitação para o trabalho grupal, destinado às equipes das UBSs (Unidades Básica de Saúde) do SUS (Sistema Único de Saúde) e agentes comunitários de saúde de um município do interior do Estado de São Paulo. Trata-se de analisar o pedido explicitado pela equipe, de mostrar a reflexão a respeito desse pedido, as circunstâncias dos problemas colocados, a experiência dos vários trabalhadores da equipe e a escuta do que se passa do lado da população. Parar para ouvir os parceiros do trabalho e refletir sobre a intervenção fez a equipe trabalhar sua sensibilidade diante das questões da população, do que vem a ser saúde e poder assumir outra postura que não seja a de servir ao controle da população e trabalhar para a construção da sociedade de controle.