818 resultados para international development


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BACKGROUND A recombinant, replication-competent vesicular stomatitis virus-based vaccine expressing a surface glycoprotein of Zaire Ebolavirus (rVSV-ZEBOV) is a promising Ebola vaccine candidate. We report the results of an interim analysis of a trial of rVSV-ZEBOV in Guinea, west Africa. METHODS For this open-label, cluster-randomised ring vaccination trial, suspected cases of Ebola virus disease in Basse-Guinée (Guinea, west Africa) were independently ascertained by Ebola response teams as part of a national surveillance system. After laboratory confirmation of a new case, clusters of all contacts and contacts of contacts were defined and randomly allocated 1:1 to immediate vaccination or delayed (21 days later) vaccination with rVSV-ZEBOV (one dose of 2 × 10(7) plaque-forming units, administered intramuscularly in the deltoid muscle). Adults (age ≥18 years) who were not pregnant or breastfeeding were eligible for vaccination. Block randomisation was used, with randomly varying blocks, stratified by location (urban vs rural) and size of rings (≤20 vs >20 individuals). The study is open label and masking of participants and field teams to the time of vaccination is not possible, but Ebola response teams and laboratory workers were unaware of allocation to immediate or delayed vaccination. Taking into account the incubation period of the virus of about 10 days, the prespecified primary outcome was laboratory-confirmed Ebola virus disease with onset of symptoms at least 10 days after randomisation. The primary analysis was per protocol and compared the incidence of Ebola virus disease in eligible and vaccinated individuals in immediate vaccination clusters with the incidence in eligible individuals in delayed vaccination clusters. This trial is registered with the Pan African Clinical Trials Registry, number PACTR201503001057193. FINDINGS Between April 1, 2015, and July 20, 2015, 90 clusters, with a total population of 7651 people were included in the planned interim analysis. 48 of these clusters (4123 people) were randomly assigned to immediate vaccination with rVSV-ZEBOV, and 42 clusters (3528 people) were randomly assigned to delayed vaccination with rVSV-ZEBOV. In the immediate vaccination group, there were no cases of Ebola virus disease with symptom onset at least 10 days after randomisation, whereas in the delayed vaccination group there were 16 cases of Ebola virus disease from seven clusters, showing a vaccine efficacy of 100% (95% CI 74·7-100·0; p=0·0036). No new cases of Ebola virus disease were diagnosed in vaccinees from the immediate or delayed groups from 6 days post-vaccination. At the cluster level, with the inclusion of all eligible adults, vaccine effectiveness was 75·1% (95% CI -7·1 to 94·2; p=0·1791), and 76·3% (95% CI -15·5 to 95·1; p=0·3351) with the inclusion of everyone (eligible or not eligible for vaccination). 43 serious adverse events were reported; one serious adverse event was judged to be causally related to vaccination (a febrile episode in a vaccinated participant, which resolved without sequelae). Assessment of serious adverse events is ongoing. INTERPRETATION The results of this interim analysis indicate that rVSV-ZEBOV might be highly efficacious and safe in preventing Ebola virus disease, and is most likely effective at the population level when delivered during an Ebola virus disease outbreak via a ring vaccination strategy. FUNDING WHO, with support from the Wellcome Trust (UK); Médecins Sans Frontières; the Norwegian Ministry of Foreign Affairs through the Research Council of Norway; and the Canadian Government through the Public Health Agency of Canada, Canadian Institutes of Health Research, International Development Research Centre, and Department of Foreign Affairs, Trade and Development.

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Due to their biodiversity, forests generate a range of products and services that are of economic, social or cultural value to human beings. Natural resource management provisions should ensure the creation and maintenance of these goods and services in the long term. However, unsustainable management practices of forests do not only generate short-term benefits but also considerable costs for society. Payment by the beneficiaries of the services would enable us to internalise external costs and promote sustainable management. Two days of conferences on ”Forest and water”, on the multifunctionality of forests, on interactions between forests and water, on sustainable resource management, on payments for environmental services, their institutional and economic perspectives, were the basis of this brochure which presents an in-depth analysis of the information exchanged among conference participants and the public. It is intended for readers who work in international development cooperation and assistance in Switzerland and abroad. It offers additional information for local programmes in the field and at policy level.

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This chapter aims to overcome the gap existing between case study research, which typically provides qualitative and process-based insights, and national or global inventories that typically offer spatially explicit and quantitative analysis of broader patterns, and thus to present adequate evidence for policymaking regarding large-scale land acquisitions. Therefore, the chapter links spatial patterns of land acquisitions to underlying implementation processes of land allocation. Methodologically linking the described patterns and processes proved difficult, but we have identified indicators that could be added to inventories and monitoring systems to make linkage possible. Combining complementary approaches in this way may help to determine where policy space exists for more sustainable governance of land acquisitions, both geographically and with regard to processes of agrarian transitions. Our spatial analysis revealed two general patterns: (i) relatively large forestry-related acquisitions that target forested landscapes and often interfere with semi-subsistence farming systems; and (ii) smaller agriculture-related acquisitions that often target existing cropland and also interfere with semi-subsistence systems. Furthermore, our meta-analysis of land acquisition implementation processes shows that authoritarian, top-down processes dominate. Initially, the demands of powerful regional and domestic investors tend to override socio-ecological variables, local actors’ interests, and land governance mechanisms. As available land grows scarce, however, and local actors gain experience dealing with land acquisitions, it appears that land investments begin to fail or give way to more inclusive, bottom-up investment models.

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BACKGROUND As access to antiretroviral therapy (ART) expands, increasing numbers of older patients will start treatment and need specialised long-term care. However, the effect of age in ART programmes in resource-constrained settings is poorly understood. The HIV epidemic is ageing rapidly and South Africa has one of the highest HIV population prevalences worldwide. We explored the effect of age on mortality of patients on ART in South Africa and whether this effect is mediated by baseline immunological status. METHODS In this retrospective cohort analysis, we studied HIV-positive patients aged 16-80 years who started ART for the first time in six large South African cohorts of the International Epidemiologic Databases to Evaluate AIDS-Southern Africa collaboration, in KwaZulu-Natal, Gauteng, and Western Cape (two primary care clinics, three hospitals, and a large rural cohort). The primary outcome was mortality. We ascertained patients' vital status through linkage to the National Population Register. We used inverse probability weighting to correct mortality for loss to follow-up. We estimated mortality using Cox's proportional hazards and competing risks regression. We tested the interaction between baseline CD4 cell count and age. FINDINGS Between Jan 1, 2004, and Dec 31, 2013, 84,078 eligible adults started ART. Of these, we followed up 83,566 patients for 174,640 patient-years. 8% (1817 of 23,258) of patients aged 16-29 years died compared with 19% (93 of 492) of patients aged 65 years or older. The age adjusted mortality hazard ratio was 2·52 (95% CI 2·01-3·17) for people aged 65 years or older compared with those 16-29 years of age. In patients starting ART with a CD4 count of less than 50 cells per μL, the adjusted mortality hazard ratio was 2·52 (2·04-3·11) for people aged 50 years or older compared with those 16-39 years old. Mortality was highest in patients with CD4 counts of less than 50 cells per μL, and 15% (1103 of 7295) of all patients aged 50 years or older starting ART were in this group. The proportion of patients aged 50 years or older enrolling in ART increased with successive years, from 6% (290 of 4999) in 2004 to 10% (961 of 9657) in 2012-13, comprising 9% of total enrolment (7295 of 83 566). At the end of the study, 6304 (14%) of 44,909 patients still alive and in care were aged 50 years or older. INTERPRETATION Health services need reorientation towards HIV diagnosis and starting of ART in older individuals. Policies are needed for long-term care of older people with HIV. FUNDING National Institutes of Health (National Institute of Allergy and Infectious Diseases), US Agency for International Development, and South African Centre for Epidemiological Modelling and Analysis.

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It is the aim of this paper to examine iron supplementation programs which receive funding from United States Agency for International Development (USAID) but approach combating iron deficiency anemia in two vastly different ways. A brief literature review and background information on iron deficiencies and the differences between supplementation programs and micronutrient fortification were reviewed. Two non-governmental organizations (NGO's) were examined for this paper: the Food and Nutrition Technical Assistance II (FANTA) and the MicroNutrient Initiative. The FANTA program included an educational component to their supplementation program while the MicroNutrient Initiative solely used supplementation of micronutrients to their population. Methods used were cost-benefit analysis and cost-effectiveness analysis to determine the overall effectiveness of each program in reducing iron deficiency anemia in each population, if the added costs of the incentives in the FANTA program changed the cost-effectiveness of the program compared to the MicroNutrient Initiative program and to determine which program imparted the greatest benefit to each population by reducing the disease burden in Disability Adjusted Life Years (DALY). Results showed that the unit cost of the FANTA program per person was higher than the MicroNutrient Initiative program due to the educational component. The FANTA program reduced iron deficiency anemia less overall but cost less for each percentage point of anemia decreased in their respective populations. The MicroNutrient Initiative program had a better benefit cost ratio for the populations it served. The MicroNutrient Initiative's large scale program imparted many advantages by reducing unit cost per person and decreasing iron deficiency anemia. The FANTA program was more effective at decreasing iron deficiency anemia with less money: $5,660 per 1% decrease in iron deficiency anemia versus $18,450 per 1% decrease in iron deficiency anemia for the MicroNutrient Initiative program. ^ In conclusion, economic analysis cannot measure all of the benefits associated with programs that contain an educational component or large scale supplementation. More information needs to be gathered by NGOs and reported to USAID, such as detailed prevalence rates of iron deficiency anemia among the populations served. Further research is needed to determine the effects an educational supplementation program has on compliance rates of participants and motivation to participate in supplementation programs whose aim is to decrease iron deficiency anemia in a targeted population.^

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The “Basic Infrastructure for Development and Sustainability” Cooperation Group of the Universidad Polítecnica de Madrid has developed a project in the city of Beira, Mozambique, financed by the Spanish International Development Cooperation Agency, to mitigate the consequences associated with climate change, which together with the city’s location and the lack of suitable maintenance in the area, have left Beira more exposed to flooding and coastal erosion. In order to provide a solution to these problems, consideration has been given to the renovation of coastal defence infrastructure and the system of stormwater drainage channels.

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Los Objetivos de Desarrollo del Milenio señalan la importancia de promover el conocimiento del estado de salud materno-infantil, en especial en las zonas más desprotegidas. El presente artículo detalla las acciones llevadas a cabo durante los años 2008 y 2011 en algunas comunidades rurales de Nicaragua con el objetivo de brindar un servicio de comunicaciones de bajo coste. Dicho servicio es administrado por el centro de salud de Cusmapa, que lidera el programa y mantiene una estrecha comunicación entre su personal y los brigadistas de salud de 26 comunidades aisladas. Los agentes locales, a través de la red de datos y voz WiMAX/WiFi instalada, pueden utilizar el sistema de comunicaciones para informar acerca de episodios urgentes de salud materno-infantil a fin de que sean evaluados o atendidos por dos médicos y seis enfermeras que se encuentran en el centro de salud. El objetivo de monitorizar el estado de salud y nutrición de la población materno-infantil es prevenir la aparición de enfermedades, evitar la desnutrición e incluso la muerte. Esta investigación asume los principios básicos de la tecnología adecuada buscando soluciones basadas en la comunidad, sostenibles, replicables y escalables a fin de garantizar futuros despliegues de acuerdo con las estrategias de Naciones Unidas.

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Millennium Development Goals point out the necessity of actively promoting maternal-child health care status, especially in underserved areas. This article details the development actions carried out between 2008 and 2011 in some rural communities of Nicaragua with the aim to provide a low-cost tele-health communication service. The service is managed by the health care center of Cusmapa, which leads the program and maintains a communication link between its health staff and the health brigades of 26 distant communities. Local agents can use the system to report urgent maternal-child health care episodes to be assessed through WiMAX-WiFi voice and data communications attended by two physicians and six nurses located at the health care center. The health and nutritional status of the maternal-child population can be monitored to prevent diseases, subnutrition, and deaths. The action approach assumes the fundamentals of appropriate technology and looks for community- based, sustainable, replicable, and scalable solutions to ensure future deployments according to the strategies of the United Nations.

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Increased globalization and outsourcing to developing countries is fostering the interest in supply chain sustainability. From the academic point of view, while environmental impacts of supply chains have been largely analysed, the research on social issues has been scattered and fragmented. This paper thereby sets out to close this gap. We have identified an emerging sphere of knowledge at the interface between sustainable supply chain management, business strategy and international development literature, which seeks to propose innovative strategies for poverty alleviation. The incorporation of impoverished farmers into supply chains is presented here as one of those strategies, and illustrated through a case study on the integration of these farmers in the Senegalese horticulture supply chain.

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Haití, es un país claramente prioritario como receptor de cooperación para el desarrollo. Tras el terremoto del 12 de enero de 2010, se ha desarrollado un Proyecto de Cooperación Interuniversitaria entre la Universidad del Estado de Haití y la Universidad Politécnica de Madrid, financiado por la Agencia Española de Cooperación Internacional para el Desarrollo.El proyecto consiste en la formación y capacitación de los técnicos Haitianos para reconstruir su país. Se está trabajando en la creación de una escala macrosísmica Haitiana, partiendo como base de la Escala Macrosísmica Europea 1998. En este sentido, se hace un análisis exhaustivo de toda la documentación técnica y científica existente hasta la fecha sobre tipos de edificios, clases de vulnerabilidad y grados de daños dependiendo del tipo de edificio. Como caso de estudio se aplica en la ciudad de Puerto Príncipe.En primer lugar se ha clasificado el parque inmobiliario de Puerto Príncipe en diferentes tipologías constructivas, tras un trabajo de campo y teniendo en cuenta las guías de auto-construcción y reparación de edificios publicadas por el Ministerio de Obras Públicas, Transporte y Comunicaciones de Haití. (MTPTC).En el estudio de la vulnerabilidad, además del tipo de estructura de los edificios, se tiene en cuenta la habitabilidad básica que debe tener todo asentamiento humano, analizando no sólo el edificio, sino todo el entorno externo de espacios públicos, infraestructuras, dotaciones y servicios que, en conjunto,conforman el núcleo de cada población y permiten el funcionamiento eficiente del sistema de asentamientos del territorio habitado; pues, en última instancia, dicho territorio construido es el que mejor acota los riesgos ante la vulnerabilidad material y más garantiza la vida saludable de las personas. Los parámetros estudiados son: urbanísticos (anchos de vías, dimensiones de manzanas, trazado, infraestructuras,...), geológicos (estudios del efecto local e identificación de las fallas activas respecto a la edificación) y topográficos (implantación del edificio en zonas llanas, en laderas...). En último lugar, con todos estos datos y los daños registrados en el terremoto de enero de 2010, se hace una escala de intensidades macrosísmica y un plano de ordenación de la vulnerabilidad en Puerto Príncipe, que sirva de base a las autoridades haitianas para la planificación urbanística y la reconstrucción, mitigando de esta manera el riesgo símico. SUMMARY Haiti is a clear priority country as a recipient of development cooperation. After the earthquake of January 12, 2010, an Inter-University Cooperation Project has been developed between the State University of Haiti and the Polytechnic University of Madrid, funded by the Spanish Agency for International Development.The project consists of training and qualifying Haitian technicians to rebuild their country. We are currently working on the creation of a Haitian Macroseismic Scale,based on the European Macroseismic Scale 1998.For the accomplishment of this goal, a comprehensive (deep) analysis is being held, going through all the scientific and technical documentation to date, related to building types, kinds of vulnerability and degrees/ levels of damage depending on the type of building. As a case study, this has been applied to the city of Port-au-Prince.First of all, we have classified the housing typology of Port-au-Prince in different construction types, after carrying on field work in this area and keeping in mind the guidelines for self-construction and repairment of buildings published by the Ministry of Work, Transport and Communications of Haiti. (MTPTC).Regarding the study of vulnerability, besides the type of structure of the buildings, we take into account the basic habitability every human settlement should have, analyzing not only the building, but all the external environment of public spaces,infrastructures, amenities and services, which, as a whole, shape the core of each population and allow the efficient functioning of the settlement system on the inhabited territory. It is this territory,ultimately, the one that better narrows the risks when facing material vulnerability and that better ensures a healthy life for people. The studied parameters are: urban (lane width, block dimensions, layout, infrastructure...), geological (studies focusing on local effects and identification of the active faults in relation to the building) and topographical (implementation of the building on flat areas, slopes...)Finally, with all this data (information) and the registered damages related to the earthquake occurred in 2010, we create a Macroseismic Intensity Scale and a Management Plan of the vulnerability in Port-au-Prince. They will serve as a guideline for Haitians authorities in the urban planning and reconstruction, thus reducing seismic risk.

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Esta investigación nace de la necesidad de aunar el máximo conocimiento sobre el sector Desarrollo Rural, Seguridad Alimentaria y Nutrición en la Cooperación Española, tanto desde un punto de vista teórico como práctico, que facilite, por un lado, precisar los límites que abarca el sector, conceptuales y de aplicación, mejorando la eficiencia y eficacia de las intervenciones en él, y por otro, conformar una prospectiva del mismo. La tesis propone una metodología de investigación-acción, puesto que por la propia posición de trabajo de la investigadora en la AECID y en el sector, esta es, a la vez, objeto y actora de la realidad vivida y del cambio a futuro. Para el trabajo de campo se ha contado con un importante grupo de expertos en la materia, que han participado en talleres de reflexión y en la encuesta Delphi, así como con una serie de entrevistas en profundidad. El requisito de contar con un marco teórico en el que se sustente el sector es esencial y el capítulo IV contempla este, partiendo de los antecedentes y marco normativo de la política de cooperación española, substancialmente la Ley de Cooperación Internacional para el Desarrollo, pasando por los principales instrumentos de planificación de esta política: Planes Directores, Estrategias sectoriales y Plan de Actuación Sectorial de Desarrollo Rural y Lucha contra el Hambre. Se puntualiza la cooperación reembolsable en el sector, y se repasan las principales actuaciones que han tenido lugar en el contexto internacional con especial hincapié en la crisis provocada por la subida del precio de los alimentos y las medidas más significativas que se tomaron para combatirla, pasando a continuación al proceso post-2015, los Objetivos de Desarrollo Sostenible y la posición española en él. En el marco conceptual se revisan términos tales como Derecho Humano a la Alimentación, Seguridad Alimentaria y Nutrición, Seguridad alimentaria, Seguridad alimentaria nutricional, Soberanía alimentaria, Seguridad alimentaria como Bien Público Mundial, Desarrollo Rural, Desarrollo Rural Territorial, Enfoque Territorial y Resiliencia, concluyendo este apartado con la búsqueda de las interrelaciones entre Seguridad alimentaria, Derecho Humano a la Alimentación y Desarrollo Rural Territorial. El capítulo termina con un breve repaso de lo que hacen en esta materia las principales agencias de Cooperación Internacional de los donantes más importantes del CAD. En el Marco de Aplicación se acomete una comparación de la evolución de la AOD en el marco temporal de la investigación, del 2000 al 2013, concedida al sector por la Cooperación Española en función de los distintos subsectores y también una comparativa de la ayuda otorgada por los principales donantes del CAD para este mismo periodo. Posteriormente se examinan las intervenciones centrales de la Cooperación Española en Derecho Humano a la Alimentación con la sociedad civil, con la FAO y con el relator especial de NNUU para el Derecho a la Alimentación, Seguridad Alimentaria Nutricional, destacando el Fondo España-ODM y el Programa Especial de Seguridad Alimentaria (PESA)y Desarrollo Rural Territorial , sobre el proyecto EXPIDER I y II (Experiencias de desarrollo local rural en América Latina) , y el proyecto PIDERAL ( Proyecto de políticas innovadoras de desarrollo de los territorios rurales en América Latina ) y tres intervenciones con enfoque regional como son :La Iniciativa América Latina y Caribe sin Hambre (IALCSH), la Estrategia Centroamericana de Desarrollo Rural Territorial (ECADERT) y la intervención de la Cooperación Española apoyando la Política Agraria de la CEDEAO. La investigación empírica esencialmente con un enfoque cualitativo, se examina y detalla en el capítulo VI, reflejándose las principales conclusiones de la misma en el capítulo del mismo nombre, tras haber contrastado las hipótesis formuladas y posteriormente cotejar las aplicaciones prácticas de la tesis y proponer posibles nuevas líneas de investigación. ABSTRACT This research stems from the need to combine the best knowledge about the Rural Development, Food Security and Nutrition sectors in Spanish Cooperation, both from a theoretical and practical point of view, that enables, on the one hand, to specify the limits that the sector covers, both conceptual and of implementation, improving the efficiency and effectiveness of interventions in it, and on the other, shape the future thereof. The thesis proposes a methodology of research-action, which is the AECID researcher´s own position in the sector, being at the same time, both researcher and participant of the reality experienced and future change. The field work benefitted from the support of a major group of experts in the field, who participated in reflection workshops, the Delphi survey and a series of in-depth interviews. The requirement for a theoretical framework that sustains the sector is essential and Chapter IV provides for this, starting with the background and legal framework of the policy of Spanish cooperation, essentially the International Development Cooperation Law, through the main instruments of policy planning: Master Plans; sectorial strategies; the Sectorial Action Plan for Rural Development; Fight against hunger. Refundable cooperation in the sector is specified, and the key actions that have taken place in the international context with special emphasis on the crisis caused by rising food prices and the most significant measures taken to combat it are reviewed. Then continuing with the post-2015 process, the Sustainable Development Objectives and the Spanish position in them. Conceptional framework terms such as Human Right to Food, Food Security and Nutrition, Food Security, Nutritional Food Security, Food Sovereignty, Food Security as a global public good, Rural Development, Rural Regional Development, Regional Approach and Resilience are reviewed, ending this section with the search for the interrelationship between Food Security, Human Right to Food and Rural Regional Development. The chapter ends with a brief overview of what the main agencies for International Cooperation of the major DAC donors do in this area. In the implementation framework, a comparison is provided of the evolution of the ODA within the time frame of the investigation, from 2000 to 2013, granted to the sector by the Spanish Cooperation in terms of the various subsectors and also a comparison is made of the support provided by the DAC's major donors for the same period. Subsequently the core interventions of Spanish Cooperation in the Human Right to Food with civil society, with FAO and the UN Special Rapporteur on the Right to Food, Food Security Nutrition are examined, highlighting the Spain MDG Fund and the Special Programme for Food Security (PESA) and Regional Rural Development on the EXPIDER I and II project (Rural local development experiences in Latin America), and the PIDERAL project (Innovative policy development project of rural areas in Latin America) and three regionally focused interventions such as: the Latin America and Caribbean without Hunger (HFLACI) Initiative, the Central American Strategy for Rural Development (ECADERT) and the intervention of the Spanish Cooperation to support the ECOWAS Agricultural Policy. Empirical research, essentially with a qualitative approach, is examined and detailed in Chapter VI, reflecting the main conclusions of the investigation in the chapter of the same name, after having contrasted the ideas put forward, and then later compares the practical applications of the thesis and proposes possible new lines of research.

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Funding A Health Systems Research Initiative Development Grant from the UK Department for International Development (DFID), Economic and Social Research Council (ESRC), Medical Research Council (MRC (and the Wellcome Trust (MR/N005597/1) funds the research presented in this paper. Support for the Agincourt HDSS including verbal autopsies was provided by The Wellcome Trust, UK (grants 058893/Z/99/A; 069683/Z/02/Z; 085477/Z/08/Z; 085477/B/08/Z), and the University of the Witwatersrand and Medical Research Council, South Africa.

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The primary goal of this research is to document local perspectives by presenting a set of commentaries and meanings, in the form of narratives, related to environmental health conceptions on an Oji-Cree reserve in Northeastern Ontario, Canada. Through an ethnographic case study, this research explores how the modern-day production of a sociocentric and ecocentric self, as ethnic marker and moral category, is contributing to environmental/community health and well-being on Native reserves. Cultural representations of personhood and community based on the Medicine Wheel model, as a cognitive model, create an ontological paradigm that promotes a holistic foundation for human behaviour and interaction, as well as healthy, sustainable communities.

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China will launch a new development bank for Asia later this year, called the AIIB. 58 countries worldwide have already applied to become founding members, including numerous Western nations. This policy brief argues that the AIIB constitutes an important international development, as it reflects a new geopolitical reality and marks a new turn in China’s practice of multilateralism. It also looks critically at the European uncoordinated response to the AIIB, and what it tells about Europe’s shrinking role in the world.