Plan digital : estrategias digitales para negocios

En el presente documento se desarrollará un Plan Digital de Medios con el cuál se pretende impulsar un producto que será lanzado al mercado por la empresa de Nairo Quintana, la cual construye y comercializa bicicleta y accesorios para toda la familia y todo tipo de terreno. El producto innovador que revolucionará la industria, será un casco, cuyo objetivo principal es proporcionar a su portador los más altos niveles de seguridad, diseño y calidad, generando al consumidor experiencias de uso gratificantes, por su confort y tecnología aerodinámica. De igual forma, se busca conquistar nuevos mercados y audiencias, por medio de una cuidadosa segmentación de mercado basada en variables que permitan enfocarse en el nicho de consumidores más atractivos para dicho producto. Así mismo, cabe resaltar que esta estrategia digital aunque se enfoca en la promoción del casco, también pretende enriquecer el reconocimiento y posicionamiento de la marca, al igual que todas las líneas de producto con las que esta cuenta.

PLAN DIRECTOR URBANO DE SAN JOSÉ

Este documento  resume el Plan Director Urbano del Cantòn Central de San José. Este Plan Urbano-Territorial ha sido diseñado como respuesta concreta del Gobierno Local, a la necesidad de regular y planificar el desarrollo general de la ciudad y el proceso de urbanización. Se incluye en un primer apartado una caracterización de la problemática y las tendencias urbanas josefinas; un segundo contenido se definen ls objetivos y líneas estratégicas de la ciudad que queremos. Un tercer apartado sobre la propuesta regional sobre la estructura urbana a nivel regional; y el quinto y último apartado presenta las prpuestas a nivel cantonal de San Josè, que se propone dividirlo por temas y sectores, en cada una de estas propuestas se presenta la problemática, los objetivos y las estratégias.

CAMBIO EN EL USO DEL SUELO EN GENERAL VIEJO DE PEREZ ZELEDON

El presente trabajo es un intento de análisis de las características geográficas de sector de Valle del General. Para delimitar el área se tomó la confluencia del río Buena Vista con el Chirripó; o sea, a partir de donde se origina el río General, hasta confluencia de éste con el río Peñas Blancas, esto es, la margen izquierda del río General, entre las cotas 500 m hacia el sur del área y la de 100m al norte. El área de estudio tiene una superficie de 87.8 km²  3.251 habitantes (mapa nº 1). Se expande por la izquierda del río General y tiene como centro de atracción al antiguo pueblo de General Viejo, entre Rivas y las Juntas de Pacuar; en general, coincide con los limites político-administrativos de del distrito segundo del cantón de Pérez Zeledón. Se pretende, también, aplicar el método de trabajo de la geografía regional. Por eso, el plan de trabajo elaborado contempla el aspecto físico y humano. En el conjunto de la estructura productiva, se toma como base los cambios ocurridos en el uso del suelo entre 1973-1979; en este sentido, se pretende dar una explicación global de los elementos que intervinieron para que operaran dichos cambios y la explicación de ello en función del sistema económico imperante.   SUMMARY This article intent to analyze the geographic characteristics of sector of the General Valley. The junction of Buena Vista and Chirripó rivers was chosen in order to delimit the area; or in other words, starting from the origin of the General river to its junction with the Peñas Blancas river, that corresponds to the left margin of the General river, between the benchmarks 500 meters to the south of the area and 1000 meters to the north. The area being studied has a surface area of 87.7 square kilometers and a total of 3.251 habitants (map nº 1). Expansion occurs on the left side of the General River whose center of attraction is the old town of General Viejo, located between Rivas and the Juntas Pacuar; in general, it coincides with the political-administrative limits of the second district of Perez Zeledon canton. The application of the work method used in regional geography is also contemplated. As such, the elaborated work plan takes into account the human and physical aspects. In the combined total of the production structure, the changes that occurred in the land use between the years 1973-1979, was chosen as a base; in this sense, a global explanation is given of the elements that intervened in order to make possible such changes and of the functions of the current economic system.       RESUME Ce travail concerne seulement un secteur de la Vallée de El General, délimité comme suit : de la confluence du Rio Buena Vista et du Rio Chirripó, dont l’union donne naissance au Rio General, jusqu’i au confluence de ce Dornier avec son affluent le Rio Peñas Blancas. Il correspond à la rive gauche du General, entre les côtes 1.000 au nord, prés de Rivas, et 500 au sud (Juntas de Pacuar) courne 87.8 km² et compte 3.251 hab (carte nº 1). Il s’étend autour de l’ancien petit centre rural, El General Viejo, et coïncide plus ou moins, avec le district Nº 2 du Canton de Pérez Zeledón. On y applique la méthode d’analyse de la géographique régionale, à la fois sur les plans humain et physique, pour définir son organisation de production et son évolution entre 1973-1979, surtout pour ce qui concerne l’utilisation des terres; évolution à laquelle on présente une explication globale en fonction du système ecónomique.    

Montagem de uma disciplina experimental: contribuição para a química geral

The purpose of this paper is to present a classification criterion for general chemistry experiments departing from a survey of 35 years of the experimental general chemistry discipline at the Chemistry Institute - UNICAMP. It is shown that by considering the most remarkable characteristics of an experiment and classifying it under Conceptual, Fundamental, Methodological or Quantitative criterion, teachers could better develop the discipline plan and prevent a subject superposition. Taking into account the system Fe3+/SCN- , the article also exemplify how is possible to modify an experimental approach and to conceive other procedures with different didactic purposes.

Analise comparativa das caracteristicas cinematicas da coluna durante a marcha e a corrida

Universidade Estadual de Campinas . Faculdade de Educação Física

Educação Fisica no ensino medio-periodo noturno : um estudo participante

Universidade Estadual de Campinas. Faculdade de Educação Física

Desvelando os significados da vivencia da ginastica geral para adolescentes de uma instituição salesiana de proteção a criança e ao adolescente

Universidade Estadual de Campinas. Faculdade de Educação Física

Relações entre marcadores digito-palamres e aptidão fisica em atletas de judo de elite

Universidade Estadual de Campinas . Faculdade de Educação Física

O ensino das disciplinas esportivas coletivas nos cursos de Licenciatura em Goias : um estudo descritivo

Universidade Estadual de Campinas . Faculdade de Educação Física

Proposta de avaliação da simetria e transferencia de peso e a relação dessa condição com a atividade funcional do hemiplegico

Universidade Estadual de Campinas . Faculdade de Educação Física

The Southern Brazilian shelf: general characteristics, quaternary evolution and sediment distribution

Extending from latitude 34ºS to 22ºS the Southern Brazilian shelf constitutes the only part of the Brazilian shelf with a subtropical to temperate environment. The studies on the different geological aspects of the area began in the 1960's and have recently been reassessed after studies related to the determination of the Economic Exclusive Zone. In terms of morphology, the Southern Brazilian shelf may be divided into three sectors, the São Paulo Bight, the Florianópolis-Mostardas Sector and the Rio Grande Cone, characterized by conspicuous differences in terms of geological determining factors, bathymetry, declivities and the presence of canyons and channels. Despite the existence of hundreds of radiocarbon datings the sea level changes curve of southern Brazil during the Last Glacial Cycle is still a matter of debate. A recent controversy on the Middle and late Holocene sea level changes curve raised the question of the amplitude of the oscillations which occurred in the period. Also, a few but relatively consistent radiocarbon datings suggest the occurrence of a high sea level during Isotope Stage 3. In terms of sedimentary cover the Southern Brazilian shelf exhibits a very strong hydrodynamic control, both latitudinal and bathymetrical. The sector southward from 25ºS is characterized by the influence of the plume of water carrying sediments originating from the Río de La Plata. Actually its presence is conspicuous up to 28ºS, with the area between this latitude and 25ºS constituting a transitional zone. In terms of bathymetry the outer shelf is marked by the "floor-polisher" effect of the Brazil Current, which is responsible for the maintenance of a relict facies in areas deeper than 100 meters.

Electrocardiographic study on geriatric dogs undergoing general anesthesia with isoflurane

The purpose of this study was to clarify the degree of influence of anesthetic agents commonly used during anesthesia on the heart conduction systems of geriatric dogs, with or without the presence of electrocardiographic changes in the pre-anesthetic electrocardiogram and also to determine the possible causes of ST-segment and T-wave changes during anesthesia, by monitoring ventilation and oxygenation. 36 geriatric dogs were evaluated. In addition to electrocardiographic evaluation, the pre-anesthetic study included serum levels of urea, creatinine, total protein, albumin and electrolytes. The pre-anesthetic medication consisted of acepromazine (0.05mg kg-1) in association with meperidine (3.0mg kg-1) by IM injection. Anesthesia was induced with propofol (3.0 to 5.0mg kg-1) by IV injection and maintained with isoflurane in 100% oxygen. During the anesthesia, the animals were monitored by continued computerized electrocardiogram. Systemic blood pressure, heart rate, respiratory rate, end-tidal carbon dioxide, partial pressure of carbon dioxide in arterial blood, arterial oxygen saturation, partial pressure of arterial oxygen and oxygen saturation of hemoglobin were closely monitored. During maintenance anesthesia, normal sinus rhythm was more common (78%). ST-segment and T-wave changes during the anesthetic procedure were quite common and were related to hypoventilation. The use of isoflurane did not result in arrhythmia, being therefore a good choice for this type of animal; Electrocardiographic findings of ST-segment and T-wave changes during the maintenance anesthesia were evident in animals with hypercapnia, a disorder that should be promptly corrected with assisted or controlled ventilation to prevent complicated arrhythmias.

TCF7L2 variant genotypes and type 2 diabetes risk in Brazil: significant association, but not a significant tool for risk stratification in the general population

Background: Genetic polymorphisms of the TCF7L2 gene are strongly associated with large increments in type 2 diabetes risk in different populations worldwide. In this study, we aimed to confirm the effect of the TCF7L2 polymorphism rs7903146 on diabetes risk in a Brazilian population and to assess the use of this genetic marker in improving diabetes risk prediction in the general population. Methods: We genotyped the single nucleotide polymorphisms (SNP) rs7903146 of the TCF7L2 gene in 560 patients with known coronary disease enrolled in the MASS II (Medicine, Angioplasty, or Surgery Study) Trial and in 1,449 residents of Vitoria, in Southeast Brazil. The associations of this gene variant to diabetes risk and metabolic characteristics in these two different populations were analyzed. To access the potential benefit of using this marker for diabetes risk prediction in the general population we analyzed the impact of this genetic variant on a validated diabetes risk prediction tool based on clinical characteristics developed for the Brazilian general population. Results: SNP rs7903146 of the TCF7L2 gene was significantly associated with type 2 diabetes in the MASS-II population (OR = 1.57 per T allele, p = 0.0032), confirming, in the Brazilian population, previous reports of the literature. Addition of this polymorphism to an established clinical risk prediction score did not increased model accuracy (both area under ROC curve equal to 0.776). Conclusion: TCF7L2 rs7903146 T allele is associated with a 1.57 increased risk for type 2 diabetes in a Brazilian cohort of patients with known coronary heart disease. However, the inclusion of this polymorphism in a risk prediction tool developed for the general population resulted in no improvement of performance. This is the first study, to our knowledge, that has confirmed this recent association in a South American population and adds to the great consistency of this finding in studies around the world. Finally, confirming the biological association of a genetic marker does not guarantee improvement on already established screening tools based solely on demographic variables.

CYP2C19 and ABCB1 gene polymorphisms are differently distributed according to ethnicity in the Brazilian general population

Background: Recent studies have reported the clinical importance of CYP2C19 and ABCB1 polymorphisms in an individualized approach to clopidogrel treatment. The aims of this study were to evaluate the frequencies of CYP2C19 and ABCB1 polymorphisms and to identify the clopidogrel-predicted metabolic phenotypes according to ethnic groups in a sample of individuals representative of a highly admixtured population. Methods: One hundred and eighty-three Amerindians and 1,029 subjects of the general population of 4 regions of the country were included. Genotypes for the ABCB1c.C3435T (rs1045642), CYP2C19*2 (rs4244285), CYP2C19*3 (rs4986893), CYP2C19*4 (rs28399504), CYP2C19*5 (rs56337013), and CYP2C19*17 (rs12248560) polymorphisms were detected by polymerase chain reaction followed by high resolution melting analysis. The CYP2C19*3, CYP2C19*4 and CYP2C19*5 variants were genotyped in a subsample of subjects (300 samples randomly selected). Results: The CYP2C19*3 and CYP2C19*5 variant alleles were not detected and the CYP2C19*4 variant allele presented a frequency of 0.3%. The allelic frequencies for the ABCB1c.C3435T, CYP2C19*2 and CYP2C19*17 polymorphisms were differently distributed according to ethnicity: Amerindian (51.4%, 10.4%, 15.8%); Caucasian descent (43.2%, 16.9%, 18.0%); Mulatto (35.9%, 16.5%, 21.3%); and African descent (32.8%, 20.2%, 26.3%) individuals, respectively. As a result, self-referred ethnicity was able to predict significantly different clopidogrel-predicted metabolic phenotypes prevalence even for a highly admixtured population. Conclusion: Our findings indicate the existence of inter-ethnic differences in the ABCB1 and CYP2C19 variant allele frequencies in the Brazilian general population plus Amerindians. This information could help in stratifying individuals from this population regarding clopidogrel-predicted metabolic phenotypes and design more cost-effective programs towards individualization of clopidogrel therapy.

PARALLAXES OF SOUTHERN EXTREMELY COOL OBJECTS. I. TARGETS, PROPER MOTIONS, AND FIRST RESULTS

We present results from the PARallaxes of Southern Extremely Cool objects ( PARSEC) program, an observational program begun in 2007 April to determine parallaxes for 122 L and 28 T southern hemisphere dwarfs using the Wide Field Imager on the ESO 2.2 m telescope. The results presented here include parallaxes of 10 targets from observations over 18 months and a first version proper motion catalog. The proper motions were obtained by combining PARSEC observations astrometrically reduced with respect to the Second US Naval Observatory CCD Astrograph Catalog, and the Two Micron All Sky Survey Point Source Catalog. The resulting median proper motion precision is 5 mas yr(-1) for 195,700 sources. The 140 0.3 deg(2) fields sample the southern hemisphere in an unbiased fashion with the exception of the galactic plane due to the small number of targets in that region. The proper motion distributions are shown to be statistically well behaved. External comparisons are also fully consistent. We will continue to update this catalog until the end of the program, and we plan to improve it including also observations from the GSC2.3 database. We present preliminary parallaxes with a 4.2 mas median precision for 10 brown dwarfs, two of which are within 10 pc. These increase the present number of L dwarfs by 20% with published parallaxes. Of the 10 targets, seven have been previously discussed in the literature: two were thought to be binary, but the PARSEC observations show them to be single; one has been confirmed as a binary companion and another has been found to be part of a binary system, both of which will make good benchmark systems. These results confirm that the foreseen precision of PARSEC can be achieved and that the large field of view will allow us to identify wide binary systems. Observations for the PARSEC program will end in early 2011 providing three to four years of coverage for all targets. The main expected outputs are: more than a 100% increase in the number of L dwarfs with parallaxes, increment in the number of objects per spectral subclass up to L9-in conjunction with published results-to at least 10, and to put sensible limits on the general binary fraction of brown dwarfs. We aim to contribute significantly to the understanding of the faint end of the H-R diagram and of the L/T transition region.