Novos complexos de 'PD'(II): síntese, caracterização e efeito dos ligantes na citotoxicidade e interação com DNA

Pós-graduação em Química - IQ

Nanopartículas magnéticas de 'FE''CO'@'AU': preparação, caracterização e funcionalização com complexo de 'RU'(II) luminescente

Pós-graduação em Química - IQ

Modelo estrutural do maciço rochoso do Depósito de Cobre e Ouro da Mina da Chapada, Alto Horizonte, GO

The Cu-Au mine of Chapada is located in the municipality of Alto Horizonte, in the northwestern portion of Goiás state and is inserted in the geological context of the Brasilia Belt, specifically the Mara Rosa Magmatic Arc, which hosts important deposits of Au and Cu-Au. The rocks found in the study area belong mainly to the Volcano-Sedimentary Sequence of Mara Rosa and are composed of basic to acidic metavolcanic rocks, psammiticpellitic metasedimentary rocks, chemical rocks and also hydrothermal products. Late intrusions occur and are represented by pegmatitic dikes and tonalitic bodies. The ore deposit of the Chapada mine is formed predominantly by the chalcopyrite-pyritemagnetite association, where pyrite is the most abundant mineral. Through the structural mapping of the mining fronts, it was able to recognize three deformational phases (Dn, Dn +1, Dn +2). During the Dn phase, isoclinal recumbent folds were formed, in association with amphibolites facies metamorphism. Later, in phase Dn +1, there was formation of drag folds and intrafolial folds in association with retrograde metamorphism in the greenschist facies. The deformational phase Dn +2, in its turn, was responsible for late symmetrical folding of the foliation, with NS and EW axes, resulting in an interference pattern of the dome-and-basin type

Genotipagem de HLA de classe I e II para seleção de células precursoras dendríticas para estudo da imunobiologia do vírus associado ao Sarcoma de Kaposi (KSHV)

The Kaposi-associated Herpesvirus (KSHV) also known as Human Herpesvirus 8 (HHV-8) is associated with the development of Kaposi’s sarcoma (KS) and others limphoprolipheratives diseases such as Primary Effusion Lymphoma (PEL) and Multicentric Castleman Disease (MCD). Even though the virus is considered lymphotropic, it is able to infect others cell types such as macrophages, dendritic cells, endothelial cells, monocytes and fibroblasts. After infection, KSHV be latent expressing essential viral genes to its maintenance in a infected cell. However, in some circumstances may occur the reactivation of lytic cycle producing new viral particles. K1 protein of KSHV interferes in the cellular signaling inducing proliferation and supporting cellular transformation. K1 is encoded by viral ORF-K1, which shows high variability between different genotypes of KSHV. So far, it is not clear whether different isoforms of K1 have specific immunobiological features. The KSHV latency is maintained under strict control by the immune system supported by an adequate antigen presentation involving Human Leucocyte Antigen (HLA) class I and II. Polymorphisms of HLA class I and II genes confer an enormous variability in molecules that recognize a large amount of antigens, but also can increase the susceptibility to autoimmune diseases. Therefore, the present study aims to genotype HLA class I (A and B) and class II (DR and DQ) from volunteers to identify haplotypes that can provide better response to K1 epitopes of different KSHV genotypes. First of all, 20 volunteers were selected to genotype HLA genes. In our results we observed prevalence of certain HLA class I haplotypes as HLAA1, HLA-A2, HLA-A24, HLA-A26, HLA-B8, HLA-B18 e HLA-B44. After the in silico analysis using BIMAS and SYFPEITHI databases, we observed high scores for epitopes from the B genotype of KSHV, indicating...(Complete abstract click electronic access below)

Efeitos da injeção intracerebroventricular de peróxido de hidrogênio ou de ATZ sobre a resposta pressora da angiotensina II centralmente

As espécies reativas de oxigênio podem participar de mecanismos envolvidos em respostas fisiológicas, como os efeitos hipertensores e dipsogênicos da angiotensina II (ANG II) central, que seriam pelo menos em parte devidos a produção de radical superóxido (O2 −). Por isso, uma superexpressão da enzima superóxido dismutase que reduz a disponibilidade de O2 − convertendo-o em peróxido de hidrogênio (H2O2) inibiria o efeito pressor da ANG II administrada centralmente. Porém, alguns resultados de nosso laboratório demonstram que H2O2 injetado intracerebroventricularmente (icv) reduz a ingestão de água induzida pela ANG II em ratos normotensos. Portanto, no presente trabalho propomos estudar os efeitos de injeções de H2O2 ou de ATZ (inibidor da catalase) sozinhos ou combinados no ventrículo lateral (VL) e também os efeitos do ATZ injetado intravenosamente (i.v.) sozinho ou combinado com H2O2 no VL sobre a resposta pressora da ANG II também injetada no VL em ratos normotensos, espontaneamente hipertensos (SHRs) ou em ratos com hipertensão renovascular do tipo 2 rins 1 clipe (2R1C). Foram utilizados ratos Holtzman normotensos, SHRs e ratos com hipertensão renovascular 2R1C com cânulas de aço inoxidável previamente implantadas no VL. A pressão arterial e a freqüência cardíaca foram registradas em sistema computadorizado diretamente da aorta em ratos não anestesiados por uma cânula de polietileno introduzida pela artéria femoral e a injeção i.v. foi realizada por meio de uma cânula de polietileno introduzida na veia femoral. A pressão arterial e freqüência cardíaca foram registradas continuamente desde 30 minutos antes da primeira injeção (veículo, salina, H2O2 ou ATZ) até 30 minutos após a injeção de ANG II. Os resultados demonstraram que a injeção icv de H2O2 (5 μmol/1 μL) reduziu fortemente a reposta pressora produzida pela injeção... (Resumo completo, clicar acesso eletrônico abaixo)

Caracterização petrográfica das zonas de alteração hidrotermais no alvo Arex, do depósito polimetálico de Aripuanã, MT

The Roosevelt-Domain Aripuanã that by Filho et al 2004 is characterized by a metavolcanic sedimentary sequence, containing acidic to interemediary metavolcanic rocks and clastic and chemical sediments, deformed and metamorphosed at low grade, with U-Pb age of 1.743 +- 4 Ma, (by Granito Zé do Torno), and circumscribed bodies of granites late to post-orogenic (Aripuanã)...

Avaliação da prevalência do tipo de crescimento crânio facial nas diferentes más oclusões, de acordo com a classificação de angle

During the orthodontic correction planning in addition to dental-jaw correction, facial aesthetics is the orthodontist's and patient's major concern. To prevent facial aesthetics damage is really important to take into account the type of craniofacial growth: mesofacial (balanced), dolichofacial (vertical) or brachyfacial (horizontal). We evaluated 152 documentation files from the Department of Orthodontics of Dental University of Sao Jose dos Campos- UNESP in order to analyze what kind of growth occurs in most Class I malocclusions, Class II and Class III Angle of treated individuals from 6 to 12 years old. From the randomly collected samples, 15 of them belonged to Class I Angle malocclusions; 123 belonged to Angle Class II and 14 to Class III malocclusion. The results showed that in Class I, 66.67% were classified as dolicocephalic; in Class II, 64.23% were classified as dolicocephalic and in Class III, 50% were brachycephalic. We conclude that the dolichofacial was the type which ocurred the most, both in females and males and both in malocclusion Class I and Class II. The brachyfacial type most occurred in Class III malocclusion and the mesofacial type occurred in smaller numbers in the three malocclusions studied

Dinâmica de rotação de exoplanetas tipo terrestre com perturbação de terceiro corpo

In this work we study some topics of Celestial Mechanics, namely the problem of rigid body rotation and “spin-orbit” resonances. Emphasis is placed on the problem formulation and applications to some exoplanets with physical parameters (e.g. mass and radius) compatible with a terrestrial type constitution (e.g. rock) belonging to multiple planetary systems. The approach is both analytical and numerical. The analytical part consists of: i) the deduction of the equation of motion for the rotation problem of a spherical body with no symmetry, disturbed by a central body; ii) modeling the same problem by including a third-body in the planet-star system; iii) formulation of the concept of “spin-orbit” resonance in which the orbital period of the planet is an integer multiple of the rotation’s period. Topics of dynamical systems (e.g. equilibrium points, chaos, surface sections, etc.) will be included at this stage. In the numerical part simulations are performed with numerical models developed in the previous analytical section. As a first step we consider the orbit of the planet not perturbed by a third-body in the star-planet system. In this case the eccentricity and orbital semi-major axis of the planet are constants. Here the technique of surface sections, widely used in dynamical systems are applied. Next, we consider the action of a third body, developing a more realistic model for planetary rotation. The results in both cases are compared. Since the technique of disturbed surface sections is no longer applicable, we quantitatively evaluate the evolution of the characteristic angles of rotation (e.g. physical libration) by studying the evolution of individual orbits in the dynamically important regions of phase space, the latter obtained in the undisturbed case

Aplicação de produtos de efeitos fisiológicos na pro- dução de brócolis tipo ramoso

Pós-graduação em Agronomia (Horticultura) - FCA

Caracterização térmica e físico-química do sistema argila-8-hidroxiquinolina na remoção de íons Fe(III), Ni(II) e Co(II)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo da estabilidade da cirurgia do tipo sagital da mandíbula com vista a correção de deformidades faciais

This research evaluated the surgical stabilily in patients with mandibular prognathism and retrognathism in which was used sagital split technic to correct those detormities. Twelve patients were selected from the clinic of only one experienced surgeon. Six patients presenter a Class III 6 a Class II molar relationship. A comparative cefalometric analysis using linear and angular measurements was performed of pre-surgery, imediate pós-surgery and 1 year follow-up. The following conclusions were obtained. 1 The Dal Pont sagital split technic modified by Epker to correct mandibular prognathisn and retroghnatism is a stable technic and must be indicated to correct those deformities. 2 Small relapses are easily corrected by the post-surgical orthodontic treatment. 3 A small over correction is advised in cases of large mandibular advancements or set bascks. 4 In those cases which a large amount of mandibular retrusion on advancement need to be performed, a combination of maxillary and mandibular surgery should be used. Rigid fixation technic is also indicated in those cases

Utilização dos arcos seccionados para o tratamento da má oclusão de classe II, divisão 2

A má oclusão de Classe II divisão 2 é caracterizada pela verticalização dos incisivos superiores. Nesse tipo de má oclusão, é comum a presença de sobremordida profunda e curva de Spee inferior acentuada. O presente artigo ilustra que o tratamento dessa má oclusão pode ser facilitado com o emprego dos arcos seccionados, como por exemplo, o arco utilidade, segundo a técnica Bioprogressiva de Ricketts.

Oclusão em prótese sobre implante - parte II

In part I of this article, the factors related to the establishment of a favourable occlusion for the implant prosthodontics as well as its real importance in this kind of rehabilitation were showed up. However, it is known that the occlusal characteristics adopted in implant prosthodontics show specific patterns which must be different between each other in accordance to the type of prosthesis installed. The objective of the second part of this work is to present to the reader, by a literature review, those characteristics, justifying the reason because they must be associated to specific kind of prosthesis for favor the treatment established.

Estudo genético de populações de soja com fonte de resistência à Heterodera glycines (raça 3) oriundas de topocruzamentos tipo alimento x tipo grão

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Compostos de Pd(II) contendo ligantes N,S-doadores: síntese, caracterização e estudo da atividade citotóxica

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)