Effects of Bisphenol A on ion channels: Experimental evidence and molecular mechanisms

Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) produced in huge quantities in the manufacture of polycarbonate plastics and epoxy resins. It is present in most humans in developed countries, acting as a xenoestrogen and it is considered an environmental risk factor associated to several diseases. Among the whole array of identified mechanisms by which BPA can interfere with physiological processes in living organisms, changes on ion channel activity is one of the most poorly understood. There is still little evidence about BPA regulation of ion channel expression and function. However, this information is key to understand how BPA disrupts excitable and non-excitable cells, including neurons, endocrine cells and muscle cells. This report is the result of a comprehensive literature review on the effects of BPA on ion channels. We conclude that there is evidence to say that these important molecules may be key end-points for EDCs acting as xenoestrogens. However, more research on channel-mediated BPA effects is needed. Particularly, mechanistic studies to unravel the pathophysiological actions of BPA on ion channels at environmentally relevant doses.

Diary and account book, 1780-1786

Shapleigh explains on the first page that this account book contains "an accurate account of the several articles I've received from my Guardian since the first day of May Anno 1780, continuing from year to year." The book lists material goods and money given to Shapleigh by Samuel Leighton, as well as many goods and services which Shapleigh appears to have purchased independently. Among the items he received were "a pair [of] Silver Knee Buckles," "an outside coat, alias, a Rapper," "two pair worsted stockings," and multiple ferry crossings during travel. Entries detail expenses incurred while traveling, including those "at Mystick for a glass of anisseed" and "at Newell's for 3 glasses of wine;" the costs of attending both Dummer Academy and Harvard; and myriad other goods and services. The volume contains some brief diary entries, lists of "items wanted," and records of books borrowed from and loaned to fellow students.

Ceramic formulation and processing design for plutonium disposition

The focus of this research programme is to develop a single phase ceramic wasteform for waste PuO2 that is unsuitable for fuel manufacture. A suite of synthetic mineral systems have been considered including titanate, zirconate, phosphate and silicate based matrices. Although a wealth of information on plutonium disposition in some of the systems exists in the literature, the data is not always directly comparable which hinders comparison between different ceramic hosts. The crux of this research has been to compile a database of information on the proposed hosts to allow impartial comparison of the relative merits of each system. © 2009 Materials Research Society.

An evaluation of cotton dust control systems in the picking and garnetting areas of the Atlanta Federal Penitentiary /

Mode of access: Internet.

Treatment and utilization of landfill gas : Mountain View project feasibility study ... /

Mode of access: Internet.

1992 census of manufactures. industries 3211, 3221, 3229, and 3231.

Mode of access: Internet.

The solidarity of the industries, as illustrated by the relations of the woollen manufacture : an address, delivered at the Fair of the American Institute, New-York City, October 13, 1870 /

Mode of access: Internet.

The manufacture of leather /

Disbound Original Held in Oak Street Library Facility.

Substitute foaming agent for the manufacture of Part 572 dummy flesh components. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

On the healthy manufacture of bread; a memoir on the system of Dr. Dauglish.

Mode of access: Internet.

Technology and labor in oil and gas, extraction and commercial banking.

Mode of access: Internet.

A descriptive account of the several processes which are usually pursued in the manufacture of the article known in commerce by the name of tin-plate /

Printed by the executors of S. Russell, Manchester.

Silica for glass manufacture in South Carolina,

Mode of access: Internet.

The manufacture of iron, in all its various branches. Also, a description of forge hammers, rolling mills, blast machines, hot blast, etc., etc. To which is added an essay on the manufacture of steel.

Mode of access: Internet.