A Slaveholders' Republic in the Tumult of War

Review essay of recent work on wartime disaffection in the southern Confederacy: Stephanie McCurry's award-winning _Confederate Reckoning_ and Victorian Bynum's _Long Shadow of the Civil War_. Includes a broader assessment of recent historiography, state of the field.

Potentiation of triclabendazole action in vivo against a triclabendazole-resistant isolate of Fasciola hepatica following its co-administration with the metabolic inhibitor, ketoconazole

An in vivo study in the laboratory rat model has been carried out to monitor morphological changes in adult Fasciola hepatica over a 4-day period resulting from co-treatment with triclabendazole (TCBZ) and ketoconazole (KTZ), a cytochrome P450 inhibitor. Rats were infected with the triclabendazole-resistant Oberon isolate of F. hepatica, dosed orally with triclabendazole at a dosage of 10mg/kg live weight and ketoconazole at a dosage of 10mg/kg live weight. Flukes were recovered at 24, 48, 72 and 96 h post-treatment (p.t.) and changes to fluke ultrastructure were assessed using transmission electron microscopy (TEM). Results showed an increase in the severity of changes to the fluke ultrastructure with time p.t. Swelling of the basal infolds and the associated mucopolysaccharide masses became more severe with time. Golgi complexes, if present, were greatly reduced in size and number by 96 h p.t., and sub-tegumental flooding was seen from the 72 h time-period onwards. Some sloughing of the tegumental covering over the spines was observed at 96 h p.t. The results demonstrated that the Oberon isolate is more sensitive to TCBZ action in the presence of KTZ than to TCBZ alone, reinforcing the idea that altered drug metabolism is involved in the resistance mechanism. Moreover, they support the concept that TCBZ+inhibitor combinations (aimed at altering drug pharmacokinetics and potentiating the action of TCBZ) could be used in the treatment of TCBZ-R populations of F. hepatica.

The Cold War and British Debates over the Boycott of the 1980 Moscow Olympics

This article examines the debate precipitated by the Thatcher government's (unsuccessful) attempt to secure a British boycott of the 1980 Moscow Olympics in response to the Soviet invasion of Afghanistan. Aware that it faced a struggle to win over the autonomous British Olympic Association, but with Thatcher in particular keen to support the United States, the government's case that the invasion required a specific response in the form of a boycott was steadily overshadowed as the public debate increasingly focused on arguments over human rights and détente and the use of state power.