Children and adolescents in full-time special education : an epidemiological and magnetic resonance imaging study

The need for special education (SE) is increasing. The majority of those whose problems are due to neurodevelopmental disorders have no specific aetiology. The aim of this study was to evaluate the contribution of prenatal and perinatal factors and factors associated with growth and development to later need for full-time SE and to assess joint structural and volumetric brain alterations among subjects with unexplained, familial need for SE. A random sample of 900 subjects in full-time SE allocated into three levels of neurodevelopmental problems and 301 controls in mainstream education (ME) provided data on socioeconomic factors, pregnancy, delivery, growth, and development. Of those, 119 subjects belonging to a sibling-pair in full-time SE with unexplained aetiology and 43 controls in ME underwent brain magnetic resonance imaging (MRI). Analyses of structural brain alterations and midsagittal area and diameter measurements were made. Voxel-based morphometry (VBM) analysis provided detailed information on regional grey matter, white matter, and cerebrospinal fluid (CSF) volume differences. Father’s age ≥ 40 years, low birth weight, male sex, and lower socio-economic status all increased the probability of SE placement. At age 1 year, one standard deviation score decrease in height raised the probability of SE placement by 40% and in head circumference by 28%. At infancy, the gross motor milestones differentiated the children. From age 18 months, the fine motor milestones and those related to speech and social skills became more important. Brain MRI revealed no specific aetiology for subjects in SE. However, they had more often ≥ 3 abnormal findings in MRIs (thin corpus callosum and enlarged cerebral and cerebellar CSF spaces). In VBM, subjects in full-time SE had smaller global white matter, CSF, and total brain volumes than controls. Compared with controls, subjects with intellectual disabilities had regional volume alterations (greater grey matter volumes in the anterior cingulate cortex bilaterally, smaller grey matter volume in left thalamus and left cerebellar hemisphere, greater white matter volume in the left fronto-parietal region, and smaller white matter volumes bilaterally in the posterior limbs of the internal capsules). In conclusion, the epidemiological studies emphasized several factors that increased the probability of SE placement, useful as a framework for interventional studies. The global and regional brain MRI findings provide an interesting basis for future investigations of learning-related brain structures in young subjects with cognitive impairments or intellectual disabilities of unexplained, familial aetiology.

Innate immune system and adiponectin in diabetic nephropathy in type 1 diabetes

Introduction: The pathogenesis of diabetic nephropathy remains a matter of debate, although strong evidence suggests that it results from the interaction between susceptibility genes and the diabetic milieu. The true pathogenetic mechanism remains unknown, but a common denominator of micro- and macrovascular complications may exist. Some have suggested that low-grade inflammation and activation of the innate immune system might play a synergistic role in the pathogenesis of diabetic nephropathy. Aims of the study: The present studies were undertaken to investigate whether low-grade inflammation, mannan-binding lectin (MBL) and α-defensin play a role, together with adiponectin, in patients with type 1 diabetes and diabetic nephropathy. Subjects and methods: This study is part of the ongoing Finnish Diabetic Nephropathy Study (FinnDiane). The first four cross-sectional substudies of this thesis comprised 194 patients with type 1 diabetes divided into three groups (normo-, micro-, and macroalbuminuria) according to their albumin excretion rate (AER). The fifth substudy aimed to determine whether baseline serum adiponectin plays a role in the development and progression of diabetic nephropathy. This follow-up study included 1330 patients with type 1 diabetes and a mean follow-up period of five years. The patients were divided into three groups depending on their AER at baseline. As a measure of low-grade inflammation, highly sensitive CRP (hsCRP) and α-defensin were measured with radio-immunoassay, and interleukin-6 (IL-6) with high- sensitivity enzyme immuno-assay. Mannan-binding lectin and adiponectin were determined with time-resolved immunofluorometric assays. The progression of albuminuria from one stage to the other served as a measure of the progression of diabetic nephropathy. Results: Low-grade inflammatory markers, MBL, adiponectin, and α-defensin were all associated with diabetic nephropathy, whereas MBL, adiponectin, and α-defensin per se were unassociated with low-grade inflammatory markers. AER was the only clinical variable independently associated with hsCRP. AER, HDL-cholesterol and the duration of diabetes were independently associated with IL-6. HbA1c was the only variable independently associated with MBL. The estimated glomerular filtration rate (eGFR), AER, and waist-to-hip ratio were independently associated with adiponectin. Systolic blood pressure, HDL-cholesterol, total cholesterol, age, and eGFR were all independently associated with α-defensin. In patients with macroalbuminuria, progression to end-stage renal disease (ESRD) was associated with higher baseline adiponectin concentrations. Discussion and conclusions: Low-grade inflammation, MBL, adiponectin, and defensin were all associated with diabetic nephropathy in these cross-sectional studies. In contrast however, MBL, adiponectin, and defensin were not associated with low-grade inflammatory markers per se. Nor was defensin associated with MBL, which may suggest that these different players function in a coordinated fashion during the deleterious process of diabetic nephropathy. The question of what causes low-grade inflammation in patients with type 1 diabetes and diabetic nephropathy, however, remains unanswered. We could observe in our study that glycemic control, an atherosclerotic lipid profile, and waist-to-hip ratio (WHR) were associated with low-grade inflammation in the univariate analysis, although in the multivariate analysis, only AER, HDL-cholesterol, and the duration of diabetes, as a measure of glycemic load, proved to be independently associated with inflammation. Notably, all these factors are modifiable with changes in lifestyle and/or with a targeted medication. In the follow-up study, elevated serum adiponectin levels at baseline predicted the progression from macroalbuminuria to ESRD independently of renal function at baseline. This observation does not preclude adiponectin as a favorable factor during the process of diabetic nephropathy, since the rise in serum adiponectin concentrations may remain a mechanism by which the body compensates for the demands created by the diabetic milieu.

Growth in the Asian elephant

Records of captive Asian elephants (Elephas maximus) were used to derive parameters of the von Bertalanffy function for growth in height, body weight and circumference of tusks with age. There was some evidence for a post-pubertal secondary growth spurt in both male and female elephants. Domestic elephants which were born in captivity or captured at a young age also showed a reduced growth in height in both the sexes and in body weight in males compared to wild elephants. Aspects of allometric growth such as height-body weight relationship are examined. The height was twice the circumference of front foot throughout the life span, indicating an isometric relationship.

Roofed polyquinanes: synthesis and electronic structure

Starting from readily available norbornenobenzoquinone 7 and employing a photothermal metathesis reaction as the main strategy, novel "roofed" polyquinane bisenones 3 and 13 have been synthesized. Among these, the former is potentially serviceable for further elaboration to dodecahedrane 1. Catalytic hydrogenation of 3 provided the dione 12, which fully inscribes the circumference of dodecahedrane sphere. The "roofed" C-16-bisenone 3 has been successfully annulated to C19-bisenone 24 and C19-trisenone 26 by employing the Greene methodology and Pauson-Khand reaction, respectively. The molecular structures of 3 and 13 were computed using molecular mechanics and semiempirical MO methods. The nonbonded distances between the double bonds vary strongly with the method employed. The interactions between the pi-MO's were, therefore, probed by means of photoelectron (PE) spectroscopy. Comparison with the PE spectra of a series of model systems with increasing complexity enabled an unambiguous assignment of the observed peaks. The symmetric and antisymmetric combinations of the pi-MO's of the enone moieties of 3 and 13 show large splittings, characteristic of propano-bridged systems in which through-space and through-bond effects act in concert.

Enhancing reproducibility of ultrasonic measurements by new users

Perception of operator influences ultrasound image acquisition and processing. Lower costs are attracting new users to medical ultrasound. Anticipating an increase in this trend, we conducted a study to quantify the variability in ultrasonic measurements made by novice users and identify methods to reduce it. We designed a protocol with four presets and trained four new users to scan and manually measure the head circumference of a fetal phantom with an ultrasound scanner. In the first phase, the users followed this protocol in seven distinct sessions. They then received feedback on the quality of the scans from an expert. In the second phase, two of the users repeated the entire protocol aided by visual cues provided to them during scanning. We performed off-line measurements on all the images using a fully automated algorithm capable of measuring the head circumference from fetal phantom images. The ground truth (198.1 +/- 1.6 mm) was based on sixteen scans and measurements made by an expert. Our analysis shows that: (1) the inter-observer variability of manual measurements was 5.5 mm, whereas the inter-observer variability of automated measurements was only 0.6 mm in the first phase (2) consistency of image appearance improved and mean manual measurements was 4-5 mm closer to the ground truth in the second phase (3) automated measurements were more precise, accurate and less sensitive to different presets compared to manual measurements in both phases. Our results show that visual aids and automation can bring more reproducibility to ultrasonic measurements made by new users.

A prototype of a first-responder indoor localization system

In this paper we present an approach to build a prototype. model of a first-responder localization system intended for disaster relief operations. This system is useful to monitor and track the positions of the first-responders in an indoor environment, where GPS is not available. Each member of the first responder team is equipped with two zero-velocity-update-aided inertial navigation systems, one on each foot, a camera mounted on a helmet, and a processing platform strapped around the waist of the first responder, which fuses the data from the different sensors. The fusion algorithm runs real-time on the processing platform. The video is also processed using the DSP core of the computing machine. The processed data consisting of position, velocity, heading information along with video streams is transmitted to the command and control system via a local infrastructure WiFi network. A centralized cooperative localization algorithm, utilizing the information from Ultra Wideband based inter-agent ranging devices combined with the position estimates and uncertainties of each first responder, has also been implemented.

Non-invasive pressure monitoring by hoop strain using Fiber Bragg Grating sensor

Non-invasive, real-time dynamic monitoring of pressure inside a column with the aid of Fiber Bragg Grating (FBG) sensor is presented in the present work. A bare FBG sensor is adhered on the circumference of a pressure column normal to its axis, which has the ability to acquire the hoop strain induced by the pressure variation inside the column. Pressure induced hoop strain response obtained using FBG sensor is validated against the pressure measurements obtained from conventional pressure gauge. Further, a protrusion setup on the outer surface of the column has been proposed over which a secondary FBG sensor is bonded normal to its axis, in order to increase the gauge length of this FBG sensor. This is carried out in order to validate the variation in sensitivity of the protrusion bonded FBG sensor compared to the bare FBG sensor bonded over the surface. A comparative study is done between the two FBG sensors and a conventional pressure gauge in order to establish the capacity of FBG sensor obtained hoop strain response for pressure monitoring inside the column.

Analysis of instability of a cylindrical soap film of finite dimensions

By means of experiments of instability of a uniform cylindrical soap film, Boys had showed that the bubble molded by the film is unstable when its length is greater than its circumference. Recently that is generally called the Rayleigh Criterion. In this paper, a linear theory in hydrodynamics is applied to analyze the stability of the cylindrical soap film supported by two equal size disks; all conditions of the stationary wave on the end plates of two disks are given. From here we get that the Rayleigh Criterion on the stability of the cylindrical soap film is proved.

Uma aproximação à condição de saúde dos parlamentares da Câmara dos Deputados

Avalia a condição de saúde dos membros da 54ª Legislatura (2011-2014), mediante avaliação de alguns parâmetros de saúde. O texto levanta dados sócio demográficos, antropométricos, clínicos e hábitos individuais de um grupo de parlamentares. Foram pesquisadas variáveis para avaliação de riscos à saúde, abrangendo a síndrome metabólica, o sedentarismo, o estresse, a alimentação desregrada, o tabagismo e as próprias peculiaridades da atividade legislativa na Câmara dos Deputados. Junto às questões referentes a situações de possível potencial patológico, foi aplicado questionário de risco cardíaco elaborado pela Michigan Hearth Association. Foi aplicado questionário, na forma de entrevista semiestruturada, para obter-se a percepção dos deputados acerca do impacto da atividade legislativa na sua saúde. A pesquisa levantou dados que permitem confrontar os desconfortos relatados e os dados antropométricos obtidos. Os números obtidos para o índice de massa corporal e circunferências abdominal, de quadril e de cintura apontam para a existência de doença metabólica entre aqueles de nenhuma ou pouca prática de atividade física regular, além de um risco cardiovascular estimado em médio e alto para 45% da amostra.

Eine zusätzliche Möglichkeit für die Ostseedorsch-Fischerei: Steerte aus 90° gedrehtem Netztuch

In 2004, comparative selectivity investigations were made with the now legal BACOMA codend of 110 mm mesh opening and alternative codends made of netting turned 90° of similar mesh openings on both commercial boats and on research vessels. The results show a certain variability of the BACOMA results – depending on ship type and season (L50 varying between 36,8 and 40,6) – and a general equal efficiency of codends made of netting turned 90° of the same mesh opening. Underwater observations and reduced performance of codends of equal circumference in meshes as the joining round at the end of the tapered part of the trawl indicate the need to reduce the relation of the cir-cumferences of codend and extension to 1 to 0.7 to achieve optimum fit and selectivity.

Self-organized generation of transverse waves in diverging cylindrical detonations

Self-organized generation of transverse waves associated with the transverse wave instabilities at a diverging cylindrical detonation front was numerically studied by solving two-dimensional Euler equations implemented with an improved two-step chemical kinetic model. After solution validation, four mechanisms of the transverse wave generation were identified from numerical simulations, and referred to as the concave front focusing, the kinked front evolution, the wrinkled front evolution and the transverse wave merging, respectively. The propagation of the cylindrical detonation is maintained by the growth of the transverse waves that match the rate of increase in surface area of the detonation front to asymptotically approach a constant average number of transverse waves per unit length along the circumference of the detonation front. This cell bifurcation phenomenon of cellular detonations is discussed in detail to gain better understanding on detonation physics.

Some problems in nonlinear elasticity

Two separate problems are discussed: axisymmetric equilibrium configurations of a circular membrane under pressure and subject to thrust along its edge, and the buckling of a circular cylindrical shell.

An ordinary differential equation governing the circular membrane is imbedded in a family of n-dimensional nonlinear equations. Phase plane methods are used to examine the number of solutions corresponding to a parameter which generalizes the thrust, as well as other parameters determining the shape of the nonlinearity and the undeformed shape of the membrane. It is found that in any number of dimensions there exists a value of the generalized thrust for which a countable infinity of solutions exist if some of the remaining parameters are made sufficiently large. Criteria describing the number of solutions in other cases are also given.

Donnell-type equations are used to model a circular cylindrical shell. The static problem of bifurcation of buckled modes from Poisson expansion is analyzed using an iteration scheme and pertubation methods. Analysis shows that although buckling loads are usually simple eigenvalues, they may have arbitrarily large but finite multiplicity when the ratio of the shell's length and circumference is rational. A numerical study of the critical buckling load for simple eigenvalues indicates that the number of waves along the axis of the deformed shell is roughly proportional to the length of the shell, suggesting the possibility of a "characteristic length." Further numerical work indicates that initial post-buckling curves are typically steep, although the load may increase or decrease. It is shown that either a sheet of solutions or two distinct branches bifurcate from a double eigenvalue. Furthermore, a shell may be subject to a uniform torque, even though one is not prescribed at the ends of the shell, through the interaction of two modes with the same number of circumferential waves. Finally, multiple time scale techniques are used to study the dynamic buckling of a rectangular plate as well as a circular cylindrical shell; transition to a new steady state amplitude determined by the nonlinearity is shown. The importance of damping in determining equilibrium configurations independent of initial conditions is illustrated.

Ion cascade acceleration from the interaction of a relativistic femtosecond laser pulse with a narrow thin target

Particle-in-cell simulations are performed to study the acceleration of ions due to the interaction of a relativistic femtosecond laser pulse with a narrow thin target. The numerical results show that ions can be accelerated in a cascade by two electrostatic fields if the width of the target is smaller than the laser beam waist. The first field is formed in front of the target by the central part of the laser beam, which pushes the electron layer inward. The major part of the abaxial laser energy propagates along the edges to the rear side of the target and pulls out some hot electrons from the edges of the target, which form another electrostatic field at the rear side of the target. The ions from the front surface are accelerated stepwise by these two electrostatic fields to high energies at the rear side of the target. The simulations show that the largest ion energy gain for a narrow target is about four times higher than in the case of a wide target. (c) 2006 American Institute of Physics.

紧聚焦的超短超强激光脉冲在真空中加速斜入射的相对论电子

研究了紧聚焦的线偏振飞秒超强高斯激光脉冲俘获并剧烈加速斜入射低能相对论电子的效应，发现被俘获的电子在激光脉冲纵向有质动力的强大加速作用下，可以获得GeV量级的能量，并详细研究了入射电子的初能量、斜入射角、电子与激光脉冲的相对延迟时间和激光脉冲宽度等条件对电子能量增益的影响，发现当激光脉宽超过10λ时，脉宽对电子能量增益影响不大．

Intraobserver error associated with anthropometric measurements made by dietitians

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