881 resultados para Trans Identities
Resumo:
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Resumo:
Pós-graduação em Ciências Odontológicas - FOAR
Resumo:
Pós-graduação em Reabilitação Oral - FOAR
Resumo:
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Resumo:
Pós-graduação em Ciências Fisiológicas - FOA
Resumo:
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Resumo:
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Resumo:
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Resumo:
As áreas de fronteiras internacionais constituem espaços altamente complexos, marcados pela grande diversidade de agentes étnicos e de identidade plurinacionais. Na Amazônia Sul Ocidental, tem-se uma área geopolítica estratégica de fronteira trinacional composta pelo Acre (Brasil), Madre de Dios (Peru) e Pando (Bolívia). A preocupação com a segurança nacional, da qual emana a criação de um território especial ao longo do limite internacional continental do país, embora legítima, não tem sido acompanhada de uma política pública sistemática que atenda às especificidades regionais, nem do ponto de vista econômico, nem da cidadania fronteiriça. A integração física do Brasil, como questão central do interesse nacional e do combate às atividades ilícitas, atribui às fronteiras novo papel estratégico. Reativam-se, assim, o interesse pelas fronteiras a partir desse duplo processo, tornando as relações transfronteiriças um tema prioritário das relações internacionais. Com efeito, a busca de um novo significado para as interações do Brasil com seus países limítrofes vem impondo o redirecionamento da ação do Estado brasileiro, com reflexos na geopolítica internacional dessa região da América do Sul. O objetivo central deste estudo é analisar as políticas e ações de integração regional, no processo de desenvolvimento, em uma área de fronteira sob a jurisdição trinacional do Brasil, Peru e Bolívia.
Resumo:
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Resumo:
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Resumo:
Pós-graduação em Biotecnologia - IQ
Resumo:
Based on the reflections of Habermas and his conception of modernity, understood as an unfinished project, Giddens stresses that in all societies the maintenance of personal identity and its connection to broader social identities is a primordial requirement for ontological security. To achieve ontological security, modernity had to (re) invent traditions and get away from genuine traditions, that is, those values radically linked to the pre-modern past. This is a character of the discontinuity of modernity, the separation between what is presented as the new and that which persists as the legacy of the old. This article discusses the relationship between tradition and modernity and the dialogue between Giddens and Habermas. The goal is to identify the points of contact and the differences in the theses defended by both authors, in order to assess their contributions to discussions of the rationalization of contemporary societies. Late or reflexive modernity is an uninterrupted process of changes that affect the foundations of Western society. Faced with a reality of constant change, it is necessary to choose between the certainty of the past and a new reality of continuous change. In this sense, and according to the Habermasian perspective, the reflexive character of modernity is found in this process of choosing between the certainties inherited from the past and new social forms, a process that that leads to the reflection on - or even the recasting of - social practices, causing the rationalization and (re) invention of various aspects of life in society.
Resumo:
Background levels of exocyclic DNA adducts have been detected in rodent and human tissues. Several studies have focused on bifunctional electrophiles generated from lipid peroxidation as one of the endogenous sources of these lesions. We have previously shown that the reaction of 2'-deoxyguanosine (dGuo) with trans,trans-2,4-decadienal (DDE), a highly cytotoxic aldehyde generated as a product of lipid peroxidation in cell membranes, results in the formation of a number of different base derivatives. Three of these derivatives have been fully characterized as 1,N-2-etheno-2'-deoxyguanosine adducts. In the present work, four additional adducts, designated A3-A6, were isolated from in vitro reactions by reversed-phase HPLC and fully characterized on the basis of spectroscopic measurements. Adducts A3-A6 are four diastereoisomeric 1,N-2-hydroxyethano-2'-deoxyguanosine derivatives possessing a carbon side chain with a double bond and a hydroxyl group. The systematic name of these adducts is 6-hydroxy3-(2'-deoxy-beta-D-erythro-pentafuranosyl)-7-((E)-1-hydroxy-oct-2-enyl)-3,5,6,7-tetrahydro-imidazo- [1,2-a]purin-9-one. The proposed reaction mechanism yielding adducts A3-A6 involves DDE epoxidation at C2, followed by nucleophilic addition of the exocyclic amino group of dGuo to the C1 of the aldehyde and cyclization, via nucleophilic attack, on the C2 epoxy group by N-1. The formation of adducts A1-A6 has been investigated in acidic, neutral, and basic pH in the presence of H2O2 or tent-butyl hydroperoxide. Neutral conditions, in the presence of H2O2, have favored the formation of adducts A1 and A2, with minor amounts of A3-A6, which were prevalent under basic conditions. These data indicate that DDE can modify DNA bases through different oxidative pathways involving its two double bonds. It is important to structurally characterize DNA base derivatives induced by alpha,beta-unsaturated aldehydes so that the genotoxic risks associated with the lipid peroxidation process can be assessed.