Estudo de causas de falhas em selos mecânicos de bombas centrífugas para circulação de óleo térmico

This study is about a heating line that uses thermal oil. It is located in a facility that produces interlayers used in cars windshields. A plastic resin is melted and is sent to a matrix called DIE where the interlayers are produced. The DIE needs to receive heat from the circulation of thermal oil in four different regions of its interior, to ensure the correct thickness of the interlayer. The thermal energy is provided by electric heaters and the flow of thermal oil is impelled by four mechanically sealed centrifugal pumps (one per region). The key point of this study is the fact that these four pumps of the system have reported successive failures in the mechanical seals. Apparently, a poorly designed project has burdened the system intermittently. The pumps operation condition is located in a region of low efficiency, according to the characteristic curves. This fact is the source of the noticeable reduced time between failures. Changes in the configuration of the facility and in the number of pumps will be proposed, aiming to achieve higher operational efficiency. The proposals will be mathematically analyzed according to the Hydraulic Institute criteria. At the same time, we will also keep focus on an in-depth study of a heating system structure, starting with a detailed approach for each component and discussion about its real need and economic viability. At the end of this paper it is shown that the gain in efficiency achieved with the new proposed configuration reflects not only in the reduction of maintenance costs, but also a potential improvement in energy efficiency. It is shown that these two aspects are closely related and together form the basis for the design of a reliable and efficient pumping system

Isoeritrólise neonatal eqüina

Equine neonatal isoerythrolysis is a neonatal foals’ illness. Results from the incompatibility of blood type between the foal and the mare and mediated by maternal antibody absorbed by the colostrum against foal’s red blood cells. Characterized by a type ll hypersensitivity reaction, where the exhibition of the organism to a strange antigen, that it takes the sensitization of the lymphocytes B that after the removal of the antigens by the reticule-endothelial system the production of immunoglobulin is decreased, with the formation of cellular immunological will cause the occurrence of the illness in foal of sensitized mares. The most important clinical signs are severe anemia and jaundice, and this illness should be differentiated of other as: hemolysis induced by bacterial toxins, diseases of the hepatobiliary system, disseminated intravascular coagulation and incompatibility in blood transfusions. Like the sensitization happens during the previous incompatible foal’s birth, most cases occur in foals of multiparous mares. However during the first pregnancy the mare can generate a foal with neonatal 7 isoerythrolysis if she have developed placental anomaly in the beginning of the pregnancy which blood cells in her circulation

IL-10 e TNF-α no sangue materno e nas placentas de gestações complicadas por diabete ou hiperglicemia gestacional leve - correlação com controle glicêmico e resultados perinatais

Objective - At evaluating the IL-10 production in maternal blood and placenta and correlate them with perinatal outcomes in pregnancies complicated by hyperglycemia, or with risk to developing it, differentiated by the glycemic mean (GM < or ≥ 100mg/dL). Method- 186 pregnant women were distributed into groups GM < 100 mg/dL and GM ≥ 100 mg/dL. We evaluated the GM, HbA1c levels, maternal and placental IL-10 and TNF-α and the correlation between placental cytokines and perinatal outcomes. Results - In maternal blood, the lower concentrations of IL-10 (1.01 ± 0.87 vs. 3.08 ± 5.57 pg / mL, p = 0.0019) were observed in GM ≥ 100 mg / dL group. Placental IL-10 was directly correlated with hemoglobin levels (r = 0.63, p = 0.02) and insulin (r = 0.78, p = 0.01) from umbilical cord and with Apgar scores 1 (r = 0.53, p = 0.0095) and Apgar 5 (r = 0.69, p = 0.0003). Conclusion - GM ≥ 100mg/dL was associated with decreased of maternal IL-10. Placental IL-10 was similar in both groups and correlated directly with hemoglobin and insulin and with Apgar scores of 1st. and 5th. minutes

Educação ambiental e práticas pedagógicas em escolas do ensino básico: o que dizem as teses e dissertações produzidas no estado de São Paulo?

Não disponível

Estudo da viscosidade do sangue: quantidade de amostra necessária à obtenção de medida

Os valores encontrados para a viscosidade sanguínea tendem a aparecer com diferenças significativas, de acordo com o sexo, avançar da idade e uso de substâncias. Pelo fato de o sangue ser um fluido não newtoniano, não podemos expressar sua viscosidade em termos absolutos sem que sejam levadas em conta as condições em que a mensuração é feita. Estudos anteriores destacaram a importância esta medida, considerando o efeito da idade, o uso de substâncias, bem como sua relação com Fluxo Sanguíneo Regional Cerebral, o que pode indicar correlação com declínios cognitivos. Entretanto, a prática médica carece ainda de um método simples e clinicamente prático para a verificação desta medida, além de valores de referência. Como passo inicial no sentido de padronizar os procedimentos e condições do processo de medição, avaliamos a quantidade mínima de amostra necessária para a medição da viscosidade sanguínea, utilizando este equipamento. Um total de 20 amostras de sangue foram coletadas de indivíduos saudáveis, entre 18 e 60 anos, em tubos com EDTA, e cada amostra dividida em 9 sub-amostras (de 600μl, 550μl, 500μl, 450μl, 400μl, 350μl, 300μl, 250μl e 200μl), totalizando, portanto, um total de aproximadamente 180 medições. A quantidade de 200 μl apresentou diferenças significativas com relação à primeira medida obtida, quando comparada com todas as demais quantidades (p<0,001), o que indica que com o uso desta quantidade, não é possível obter resultados confiáveis, pois existe alteração nos valores de VS obtidos relacionada à quantidade de material utilizado. Considerando a menor quantidade, bem como, que estivesse dentro da faixa de variação aceitável de 0,2 mPa.s, e a qual não apresentasse diferença significativa quando comparadas às demais (p>0,05), foi verificada a quantidade de 250 μl como a mais eficiente... (Resumo completo, clicar acesso eletrônico abaixo)

Determinação de fatores angiogênicos e anti-angiogênicos em plasma de gestantes portadoras de pré-eclâmpsia precoce e tardia

Changes in circulating angiogenic factors have been implicated in the pathogenesis of preeclampsia. Thus, evaluation of angiogenesis agonist and antagonist factors is of greater importance to understand the mechanisms responsible for this disorder. The objective of the present study was to evaluate whether circulating angiogenic and anti-angiogenic factors may differentiate early-onset from late-onset preeclampsia. The study was conducted in 86 women with preeclampsia diagnosed in the third trimester of pregnancy. Preeclampsia was classified according to the onset of clinical manifestation in early-onset (before 34 weeks of gestation; n=31) or in late-onset (from 34 weeks of gestation on; n=55) preeclampsia. Serum was obtained from the patients in the moment of the diagnosis and assayed for placental growth factor (PlGF), vascular endothelial growth factor (VEGF), soluble Endoglin (sEng) and soluble form of vascular endothelial growth factor receptor (sVEGFR-1) determination by enzyme-linked immunosorbent assay. The results showed that early-onset preeclampsia was characterized by significant lower levels of PlGF (median 38.3 vs 123.5 pg/mL) and VEGF (median 23.1 vs 35.3 pg/mL) in serum as well as by higher serum levels of sEng (median 54.7 vs 42.1 pg/mL) and sVEGFR-1 (median 5211.0 vs 4657.6 pg/mL) compared with late-onset preeclampsia. In this study serum levels of angiogenic and anti-angiogenic factors prove useful in differentiating early-onset from late-onset preeclampsia in the third trimester of pregnancy. Therefore, these findings suggest that angiogenic factors determination may indicate that early- and late-onset preeclampsia have different pathophysiology

Efeito das baixas concentrações de agentes antineoplásicos sobre linfócitos humanos de sangue periférico

Our previous studies have shown that low concentrations (noncytotoxics) of antineoplastic agents modulate positively the dendritic cells, favoring their in vitro maturation and improving their antigen presenting function. The effects on colorectal cancer cells (HCT-116) were also investigated and we have observed an increased immunogenicity and susceptibility to cytotoxic T cells. Thereby, this study aimed to investigate the effect of 5-fluorouracil (5-FU) an azacitidine (AZA), in minimum effective and noncytotoxic concentrations on lymphocytes of healthy donors. In this study we have analyzed the cytotoxic effect of drugs at these concentrations as well as the proliferative ability of lymphocytes. In vitro production of IL-10 and IFN-γ has been also evaluated. We have observed that low concentrations of those chemotherapeutic agents are not cytotoxic for lymphocytes. However, the minimum effective concentrations (5-FU: 0,410±0,088 e AZA: 0,757±0,233; p<0, 05) have reduced the cell number. Proliferative activity of allogeneic lymphocytes in a mixed reaction (MLR) was not affected by the treatment. The cytokine production was not affected by the treatments, either. In conclusion, low concentrations of 5-FU and AZA has no deleterious effects on human peripheral blood lymphocytes and seems to be safe for combinatory administration with DC vaccines

Análise multivariada de leucograma e da resposta de fase aguda em equinos acometidos por síndrome cólica de origem natural ou experimental

Pós-graduação em Medicina Veterinária - FCAV

Células T reguladoras em sangue periférico de cães portadores de mastocitoma cutâneo

Pós-graduação em Medicina Veterinária - FCAV

O debate modernidade / pós-modernidade e a crise socioambiental: um estudo sobre teses e dissertações brasileiras em educação ambiental

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Da Campanha de Educação de Adolescentes e Adultos aos Grupos Escolares noturnos: São Carlos, SP (1930 a 1950)

Pós-graduação em Educação Escolar - FCLAR

O imaginário sertanejo no Romance d‘A Pedra do Reino e o príncipe do sangue do vai-e-volta: memória e invenção em uma imagística quadernesca

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

O valor mágico do sangue no capítulo 35 do livro I do 'Opus Agriculturae' , de Paládio

Blood is one of the most important and powerful elements in magical and religious symbology. As it is an essential substance for animal survival, it does not sound strange that through the ages blood has been given many significant symbolic values (both positive and negative). It can provide life, protection and prosperity in the same proportion that it can cause calamities, destruction and even death. In Opus agriculturae, a farming treatise written by Palladius (V AD), more specifically in Book I, Chapter 35, the author presents prescriptions to protect farms against scourges and climatic phenomena. He mentions some procedures in which blood is a fundamental component in the success of the prescriptions. The aim of the present article is to identify any magic power associated with these practices, their specific symbolic value, especially when related to menstrual blood and to other feminine elements with some magical or religious value. An evaluation is also made of the extent of these symbologies in the context of other practices and situations linked not only to agricultural magic, but to religion and to the ritual practices of other communities, whether in ancient times or not.

Avaliação da circulação na pesquisa do linfonodo sentinela pós tratamento cirúrgico para o câncer de mama

Pós-graduação em Ginecologia, Obstetrícia e Mastologia - FMB

Isolamento, cultivo, caracterização e criopreservação de células tronco mesenquimais derivadas de membrana amniótica, geléia de Wharton e sangue do cordão umbilical de fetos bovinos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)