State-of-the-art in product-service systems

A Product-Service System (PSS) is an integrated combination of products and services. This Western concept embraces a service-led competitive strategy, environmental sustainability, and the basis to differentiate from competitors who simply offer lower priced products. This paper aims to report the state-of-the-art of PSS research by presenting a clinical review of literature currently available on this topic. The literature is classified and the major outcomes of each study are addressed and analysed. On this basis, this paper defines the PSS concept, reports on its origin and features, gives examples of applications along with potential benefits and barriers to adoption, summarizes available tools and methodologies, and identifies future research challenges.

Gas-liquid simulation of an airlift bubble column reactor

The simulation of two-phase flow for an experimental airlift reactor (32-l volume) using commercially available software from Fluent Incorporated is presented here (http://www.fluent.co.uk). Data from the simulation is compared with the experimental data obtained by the tracking of a magnetic particle and analysis of the pressure drop to determine the gas hold-up. Comparisons between vertical velocity and gas hold-up were made for a series of experiments where the superficial gas velocity in the riser was adjusted between 0.01 and 0.075 m s-1. © 2003 Elsevier B.V. All rights reserved.

Three-dimensional gas-liquid simulation of an airlift bubble column reactor

Basic hydrodynamic parameters of an airlift reactor with internal loop were estimated experimentally and simulated using commercially available CFD software from Fluent. Circulation velocity in a 32-dm(3)-airlift reactor was measured using the magnetic tracer method, meanwhile the gas hold-up was obtained by analysis of the pressure drop using the method of inverted U-tube manometers. Comparison of simulated (in two and three dimensions) and experimental data was performed at different superficial gas velocities in the riser.

Fire and grazing in a mesic tallgrass prairie: impacts on plant species and functional traits

Fire is a globally distributed disturbance that impacts terrestrial ecosystems and has been proposed to be a global “herbivore.” Fire, like herbivory, is a top-down driver that converts organic materials into inorganic products, alters community structure, and acts as an evolutionary agent. Though grazing and fire may have some comparable effects in grasslands, they do not have similar impacts on species composition and community structure. However, the concept of fire as a global herbivore implies that fire and herbivory may have similar effects on plant functional traits. Using 22 years of data from a mesic, native tallgrass prairie with a long evolutionary history of fire and grazing, we tested if trait composition between grazed and burned grassland communities would converge, and if the degree of convergence depended on fire frequency. Additionally, we tested if eliminating fire from frequently burned grasslands would result in a state similar to unburned grasslands, and if adding fire into a previously unburned grassland would cause composition to become more similar to that of frequently burned grasslands. We found that grazing and burning once every four years showed the most convergence in traits, suggesting that these communities operate under similar deterministic assembly rules and that fire and herbivory are similar disturbances to grasslands at the trait-group level of organization. Three years after reversal of the fire treatment we found that fire reversal had different effects depending on treatment. The formerly unburned community that was then burned annually became more similar to the annually burned community in trait composition suggesting that function may be rapidly restored if fire is reintroduced. Conversely, after fire was removed from the annually burned community trait composition developed along a unique trajectory indicating hysteresis, or a time lag for structure and function to return following a change in this disturbance regime. We conclude that functional traits and species-based metrics should be considered when determining and evaluating goals for fire management in mesic grassland ecosystems.

Reduced Androgen Receptor Expression Accelerates the Onset of ERBB2 Induced Breast Tumors in Female Mice

Androgen receptor (AR) is commonly expressed in both the epithelium of normal mammary glands and in breast cancers. AR expression in breast cancers is independent of estrogen receptor alpha (ERα) status and is frequently associated with overexpression of the ERBB2 oncogene. AR signaling effects on breast cancer progression may depend on ERα and ERBB2 status. Up to 30% of human breast cancers are driven by overactive ERBB2 signaling and it is not clear whether AR expression affects any steps of tumor progression in this cohort of patients. To test this, we generated mammary specific Ar depleted mice (MARKO) by combining the floxed allele of Ar with the MMTV-cre transgene on an MMTV-NeuNT background and compared them to littermate MMTV-NeuNT, Arfl/+ control females. Heterozygous MARKO females displayed reduced levels of AR in mammary glands with mosaic AR expression in ductal epithelium. The loss of AR dramatically accelerated the onset of MMTV-NeuNT tumors in female MARKO mice. In this report we show that accelerated MMTV-NeuNT-dependent tumorigenesis is due specifically to the loss of AR, as hormonal levels, estrogen and progesterone receptors expression, and MMTV-NeuNT expression were similar between MARKO and control groups. MMTV-NeuNT induced tumors in both cohorts displayed distinct loss of AR in addition to ERα, PR, and the pioneer factor FOXA1. Erbb3 mRNA levels were significantly elevated in tumors in comparison to normal mammary glands. Thus the loss of AR in mouse mammary epithelium accelerates malignant transformation rather than the rate of tumorigenesis.

Macrozoobenthos abundance on a tropical oyster culture in an Amazon estuary, Para state, northern Brazil

The present study describes the biofouling composition of the surface of the mangrove oyster Crassostrea rhizophorae (Guilding, 1828), cultivated in an Amazon estuary, located in the state of Pará, northern Brazil. In total, 6.124 macroinvertebrates were sampled in the months of July, August, October and December 2013. Collected epifauna was presented by five taxa (Bivalvia, Gastropoda, Polychaeta, Crustacea and Anthozoa), 20 families and 37 species. Bivalvia was the most abundant class, presenting 5.183 mussels Mytella charruana (d'Orbigny, 1842). Knowledge of biofouling composition associated to the surface cultured bivalves enables the implementation of mitigation measures to the impacts caused by this association.

Morphometry and biomass of the cultured mangrove oyster Crassostrea rhizophorae at the Urindeua river, eastern Amazonia, northern Brazil

The malacocultura, particularly oyster farming, appears on the world stage as one of the most viable alternatives to fishing decline and supply of fresh product. In Brazil, the development of mollusc cultivationis through the genus oyster cultivation Crassostrea, among them Crassostrea rhizophorae (Guilding, 1828), known for oyster-the-swamp, one of the main species of farmed bivalves in the state of Pará. This so it aimed to characterize the biomorphometrics relations, estimate the Shape Stabilization Index (IEF) of the shell and the yield of edible meat C. rhizophorae grown in an Amazonian coast, state of Pará, northern Brazil. When all is sampled 1,028 individuals, in April 2016, measuring the external morphometric measures (length, width and height) and total and visceral biomass. The results obtained are C. rhizophorae with (1) excellent biomorphometrics relationships among both external measures, the measures of the shell and biomass generating equations that satisfy morphometric pet species, (2) yield of edible meat 15% of the total biomass and variation in the shell along its development to adulthood, with a tendency to stabilize the reach 60mm in length.

Multi-modes approach to modelling of vortex-induced vibration

Acknowledgements A.P. would like to acknowledge the support of the National Subsea Research Institute (NSRI) UK. E.P. and M.W. are grateful for partial support provided by the Italian Ministry of Education, University and Research (MIUR) by the PRIN funded program 2010/11 N.2010MBJK5B

Role of Ptf1a in the development of endocrine and exocrine pancreas of Xenopus laevis embryos

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

Nanotechnology in food industry II: risk assessment and legislation

Currently, there is increasing use of nanomaterials in the food industry thanks to the many advantages offered and make the products that contain them more competitive in the market. Their physicochemical properties often differ from those of bulk materials, which require specialized risk assessment. This should cover the risks to the health of workers and consumers as well as possible environmental risks. The risk assessment methods must go updating due to more widespread use of nanomaterials, especially now that are making their way down to consumer products. Today there is no specific legislation for nanomaterials, but there are several european dispositions and regulations that include them. This review gives an overview of the risk assessment and the existing current legislation regarding the use of nanotechnology in the food industry.

Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835

The free fatty acid receptor 1 (FFA1), a G protein-coupled receptor (GPCR) naturally activated by long-chain fatty acids is a novel target for the treatment of metabolic diseases. The basic amine spirocyclic periphery of Eli Lilly's drug candidate LY2881835 for treatment of type 2 diabetes mellitus (which reached phase I clinical trials) inspired a series of novel FFA1 agonists. These were designed to incorporate the 3-[4-(benzyloxy)phenyl]propanoic acid pharmacophore core decorated with a range of spirocyclic motifs. The latter were prepared via the Prins cyclization and subsequent modification of the 4-hydroxytetrahydropyran moiety in the Prins product. Here, we synthesize 19 compounds and test for FFA1 activity. Within this pilot set, a nanomolar potency (EC50=55nM) was reached. Four lead compounds (EC50 range 55-410nM) were characterized for aqueous solubility, metabolic stability, plasma protein binding and Caco-2 permeability. While some instability in the presence of mouse liver microsomes was noted, mouse pharmacokinetic profile of the compound having the best overall ADME properties was evaluated to reveal acceptable bioavailability (F=10.3%) and plasma levels achieved on oral administration.

Traktorin sähköistysanalyysi virtuaalisimulaatiomallilla

Tämä diplomityö on tehty Lappeenrannan teknilliselle yliopistolle osana yliopiston sähköisen liikkumisen tutkimusta. Työssä on jatkokehitetty ja dokumentoitu Drive!-projektin hybriditraktorin simulaatiomallia, joka toimii Mevea- ja Simulink-ohjelmistoissa. Mevean simulaatioalustalla on mallinnettu traktorin mekaniikkaa ja ympäristöä, kun taas Simulinkillä on simuloitu hybriditraktorin sähkötekniikkaa, dieselgeneraattoria, energiavarastoa ja apulait-teita. Työssä on tarkasteltu traktorin erilaisia maatalouden työtehtäviä ja tämän jälkeen tarkasteltu simulaatiomallin ja simulaatioiden avulla minkälaisella hybriditraktorilla näitä töitä olisi mahdollista suorittaa. Lopuksi tarkastellaan vielä simulaatiomallilla noin 75 kW:n hybriditraktorin toimintaa maatalon pihapiirin työtehtävissä ja lasketaan hybridisoinnin lisäinvestoinnille takaisinmaksuaika. Virtuaalimallilla tehtyjen simulaatioiden ja laskelmien perusteella saatiin tulokseksi, että tämän hetken komponentti- ja energiahinnoilla maataloustraktorin hybridisointi ei ole taloudellisesti kannattavaa. Kuitenkin on huomionarvoista, että ajettaessa pelkällä akkusähköllä käytetyn energian hinta on noin kolmannes verrattaessa perinteiseen dieseltraktoriin.

Development of a simple and fast “DNA extraction kit” for sea food identification and marine species

Seafood products fraud, the misrepresentation of them, have been discovered all around the world in different forms as false labeling, species substitution, short-weighting or over glazing in order to hide the correct identity, origin or weight of the seafood products. Due to the value of seafood products such as canned tuna, swordfish or grouper, these species are the subject of the commercial fraud is mainly there placement of valuable species with other little or no value species. A similar situation occurs with the shelled shrimp or shellfish that are reduced into pieces for the commercialization. Food fraud by species substitution is an emerging risk given the increasingly global food supply chain and the potential food safety issues. Economic food fraud is committed when food is deliberately placed on the market, for financial gain deceiving consumers (Woolfe, M. & Primrose, S. 2004). As a result of the increased demand and the globalization of the seafood supply, more fish species are encountered in the market. In this scenary, it becomes essential to unequivocally identify the species. The traditional taxonomy, based primarily on identification keys of species, has shown a number of limitations in the use of the distinctive features in many animal taxa, amplified when fish, crustacean or shellfish are commercially transformed. Many fish species show a similar texture, thus the certification of fish products is particularly important when fishes have undergone procedures which affect the overall anatomical structure, such as heading, slicing or filleting (Marko et al., 2004). The absence of morphological traits, a main characteristic usually used to identify animal species, represents a challenge and molecular identification methods are required. Among them, DNA-based methods are more frequently employed for food authentication (Lockley & Bardsley, 2000). In addition to food authentication and traceability, studies of taxonomy, population and conservation genetics as well as analysis of dietary habits and prey selection, also rely on genetic analyses including the DNA barcoding technology (Arroyave & Stiassny, 2014; Galimberti et al., 2013; Mafra, Ferreira, & Oliveira, 2008; Nicolé et al., 2012; Rasmussen & Morrissey, 2008), consisting in PCR amplification and sequencing of a COI mitochondrial gene specific region. The system proposed by P. Hebert et al. (2003) locates inside the mitochondrial COI gene (cytochrome oxidase subunit I) the bioidentification system useful in taxonomic identification of species (Lo Brutto et al., 2007). The COI region, used for genetic identification - DNA barcode - is short enough to allow, with the current technology, to decode sequence (the pairs of nucleotide bases) in a single step. Despite, this region only represents a tiny fraction of the mitochondrial DNA content in each cell, the COI region has sufficient variability to distinguish the majority of species among them (Biondo et al. 2016). This technique has been already employed to address the demand of assessing the actual identity and/or provenance of marketed products, as well as to unmask mislabelling and fraudulent substitutions, difficult to detect especially in manufactured seafood (Barbuto et al., 2010; Galimberti et al., 2013; Filonzi, Chiesa, Vaghi, & Nonnis Marzano, 2010). Nowadays,the research concerns the use of genetic markers to identify not only the species and/or varieties of fish, but also to identify molecular characters able to trace the origin and to provide an effective control tool forproducers and consumers as a supply chain in agreementwith local regulations.

Moodle plataforma, teknologia berria eredu zaharrekin. Esperientzia bat “Hiznet” on-line graduondokoan

Lan honen egilea Eusko Ikaskuntzaren Asmoz Fundazioaren eta UPV/EHUko Sociología II Sailaren artean antolatzen duten eta Moodle plataforma erabiltzen duen HIZNET on-line graduondokoaren modulu baten irakaslea da. Esperientzia hori abiapuntu, komunikazio honetan hausnarketaren beharra planteatu nahi dugu bereziki bi punturen inguruan: Batetik, unibertsitate alorreko formazioan komunikazio sistema gisa Moodle plataforma bezalako IKT teknologiak erabiltzeak berez hezkuntza praktikaren berrikuntza edota eraldaketa suposatzen ote duen hausnarketa. Bestetik, IKT teknologietan oinarritutako formazio proiektuen eraikuntza sustengatzen dituzten eredu edota paradigmei buruzko hausnarketa.

Los proyectos interdisciplinares de módulo: una experiencia innovadora en el Grado de Educación Social de la UPV/EHU

[ES]En este artículo se presenta una experiencia de innovación que se ha articulado, en el seno de un diseño curricular a través de módulos, al objeto de mejorar los procesos de enseñanza-aprendizaje que se están desarrollando en la Facultad de Fª y Ciencias de la Educación de la UPV/EHU. El marco de innovación aprovecha la oportunidad surgida con la configuración de los nuevos planes de estudio para su convergencia en el Espacio Europeo de Educación Superior. El contexto más amplio en el que se enmarca esta experiencia, es el de los cambios organizativos, curriculares y culturales, que está suponiendo la realización de un diseño modular de las nuevas titulaciones de grado (Pedagogía y Educación Social), trabajando en equipos docentes coordinados y contando con el apoyo institucional de la UPV/EHU. La innovación concreta que se presenta, describe minuciosamente uno de los siete módulos que componen la nueva titulación del Grado en Educación Social, y subraya la labor desplegada por el equipo docente que imparte las cinco materias que conforman el módulo en las dos lenguas oficiales: euskara y castellano, al planificar, desarrollar y evaluar la actividad interdisciplinar que les compete de manera coordinada. En este trabajo se reflexiona respecto a las posibilidades que la estructura modular ofrece para acometer un cambio real en la cultura de la práctica docente, y a cómo gestionar factores clave que garanticen el tránsito a un modelo docente activo, participativo y colaborativo. // This paper presents an innovative approach to improving teacher quality that is being developed at the Faculty of Philosophy and Educational Sciences of the UPV / EHU, taking the opportunity arose with the configuration of the new curricula for their convergence in the European Higher Education Area. It is framed in the broader context of organizational change, curriculum and cultural, that is assuming the implementation of a modular design of the new degree (Education and Social Education), working in teams coordinated and with the institutional support of the UPV. The concrete innovation is presented, describes one of the seven modules of the new degree of Social Education, and underlines the work done by the faculty team who teach the five subjects that make up the module in the two official languages: Basque and Spanish, because they must plan, develop and evaluate the interdisciplinary activity in a coordinated manner. We reflect in this paper on the potential that the modular structure offers to undertake real change in the culture of teaching practice, and how to manage key factors to ensure the transition to a teaching model active, participatory and collaborative.