Evidence for a recommended dietary allowance for vitamin C from pharmacokinetics: A comment and analysis

The current recommended dietary allowance (RDA) for vitamin C, as proposed by the Food and Nutrition Board/National Research Council in 1980 and reconfirmed in 1989, is 60 mg daily for nonsmoking adult males. Levine et al. [Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R. W., Washko, P. W., et al. (1996) Proc. Natl. Acad. Sci. USA 93, 3704–3709], based on a study of vitamin C pharmacokinetics in seven healthy men, have now proposed that the RDA should be increased to 200 mg daily. I have examined, in brief, the experimental and conceptual bases for this new recommendation and its implications for public health and nutrition policy and programs. Using, for illustrative purposes only, data extracted from each of two recent dietary surveys of noninstitutionalized adult males living in households in the Netherlands and the United States, it is predicted that the prevalence of intakes inadequate to meet the individual’s own requirement would be about 96% or 84%, respectively, if the criteria of adequacy used for derivation of the 200 mg RDA are accepted. Depending upon the particular average requirement value for ascorbic acid that might be derived from their data, the proposal by Levine et al. would mean a desirable increase in mean intakes in these two populations by as much about 2- to 3-fold. Hence, before an action of this kind is to be recommended, an answer must be sought to the question whether current experimental data including the criteria selected (saturation kinetics) are adequate to establish a new set of requirements for vitamin C, which then carry such profound policy implications. This will require critical assessment of all of the available evidence emerging from laboratory, clinical, and epidemiological studies to determine whether it provides a sufficient rationale for accepting criteria of vitamin C adequacy such as those proposed by Levine et al. and the requirement estimates so derived.

The Evaluation of Forensic DNA Evidence*

The following is an excerpt from the Executive Summary of the National Research Council Report.

The Atomic Bomb Casualty Commission in retrospect

For 50 years, the Atomic Bomb Casualty Commission (ABCC) and its successor, the Radiation Effects Research Foundation (RERF), have conducted epidemiological and genetic studies of the survivors of the atomic bombs and of their children. This research program has provided the primary basis for radiation health standards. Both ABCC (1947–1975) and RERF (1975 to date) have been a joint enterprise of the United States (through the National Academy of Sciences) and of Japan. ABCC began in devastated, occupied Japan. Its mission had to be defined and refined. Early research revealed the urgent need for long term study. In 1946, a Directive of President Truman enjoined the National Research Council of the National Academy of Sciences to develop the program. By 1950, ABCC staff exceeded 1,000, and clinical and genetic studies were underway. Budgetary difficulties and other problems almost forced closure in 1953. In 1955, the Francis Report led to a unified epidemiological study. Much progress was made in the next decade, but changing times required founding of a binational nonprofit organization (RERF) with equal participation by Japan and the United States. New programs have been developed and existing ones have been extended in what is the longest continuing health survey ever undertaken.

La divulgación de la Ciencia española en la Web 2.0: el caso del Consejo Superior de Investigaciones Científicas en Andalucía y Cataluña

El sistema ciencia, tecnología y sociedad no está consolidado en España por el desequilibrio que existe entre el desarrollo de la investigación y su divulgación. Además, la cultura científica de la sociedad está por debajo de la media europea y en la última década han descendido las vocaciones científicas entre los más jóvenes. En este contexto, se ha analizado si las instituciones de investigación utilizan las herramientas de la Web 2.0, principal canal de comunicación de los jóvenes entre 15 y 24 años, para mostrar a la sociedad los resultados de sus trabajos. Para ello, se han seleccionado como objeto de estudio los centros de investigación del Consejo Superior de Investigaciones Científicas en Andalucía y Cataluña. Entre los principales resultados obtenidos, a través del diseño de una checklist ad hoc, destaca el escaso uso que hacen de este canal de comunicación, ya que solo un 4,5% de los centros analizados utilizan todas las herramientas estudiadas. La efectividad de la comunicación ha sido otro de los valores observados, en este caso, en función de la conectividad (seguidores en sus perfiles sociales) e intensidad (número de publicaciones). Ambos ítems presentan también valores muy bajos. Por otro lado se observa un escaso nivel de popularidad de sus sitios web (número de enlaces que reciben) y una casi inexistente relación entre los mismos a través de hipervínculos que los conecten. Este último aspecto, se ha determinado con las herramientas webmétricas Webometric Analyst y ScoSciBot.

Youth Sport Programs: An Avenue to Foster Positive Youth Development

Concern about the growth in adolescent problem behaviours (e.g. delinquency, drug use) has led to increased interest in positive youth development, and a surge in funding for ‘after school programs.’ We evaluate the potential of youth sport programs to foster positive development, while decreasing the risk of problem behaviours. Literature on the positive and negative outcomes of youth sport is presented. We propose that youth sport programs actively work to assure positive outcomes through developmentally appropriate designs and supportive child–adult (parent/coach) relationships. We also highlight the importance of sport programs built on developmental assets (Benson, 1997 ) and appropriate setting features (National Research Council and Institute of Medicine, 2002 ) in bringing about the five ‘C’s of positive development (competence, confidence, character, connections, and compassion/caring: Lerner et al., 2000 ). An applied sport-programming model, which highlights the important roles of policy-makers, sport organizations, coaches and parents in fostering positive youth development is presented as a starting point for further applied and theoretical research.

Causes and measurements of walkway slipperiness, present status and future needs.

Mode of access: Internet.

Underground insulated piping systems : excluding walk-in tunnels.

"Prepared under Contract No. CST 263 between the National Academy of Sciences and the National Bureau of Standards."

Culture conflict and crime,

Mode of access: Internet.