El Congreso por la Libertad de la Cultura y su apoyo a la disidencia intelectual durante el franquismo

El artículo reconstruye los principales aspectos de la labor del Congreso por la Libertad de la Cultura entre la oposición antifranquista del interior. Se describen las circunstancias políticas que motivaron la fundación del Comité Español (1959-1977), así como las principales características de esa célula intelectual antifranquista. El artículo indaga en los objetivos ideológicos y políticos de la actividad del Congreso por la Libertad de la Cultura entre las elites intelectuales y culturales disidentes durante el tardofranquismo. Nos concentramos especialmente en el capítulo que atañe a la ayuda directa dispensada por el Congreso por la Libertad de la Cultura a los intelectuales y artistas españoles mediante la concesión de becas de libros y bolsas de viaje a través del Comité d’Ecrivains et d’Editeurs pour une Entraide Européenne. Reconstruimos asimismo los nombres de los principales beneficiarios españoles de esas ayudas, así como la principal problemática vinculada al desarrollo del programa. El análisis histórico se apoya en documentos procedentes de diversos archivos nacionales e internacionales.

Autonomia e Satisfação com a Vida em Jovens Institucionalizados: Lares de Infância e Juventude vs Apartamentos de Autonomização

O principal objectivo deste estudo centra-se na compreensão das relações entre autonomia, satisfação com a vida e a satisfação com a instituição em jovens institucionalizados. Analisaram-se estes três conceitos nas suas relações com a idade, sexo e tipo de resposta social, incidindo a atenção nas diferenças existentes num acolhimento em lar de infância e juventude [LIJ] e apartamento de autonomização [AA]. Participaram neste estudo 181 jovens, de ambos os sexos, com idades compreendidas entre os 13 e os 21 anos. Em LIJ estavam acolhidos 155 jovens e 26 em AA. Para avaliar a autonomia utilizou-se o Questionário de Autonomia dos Adolescentes e para a satisfação com a vida a Escala de Satisfação com a Vida. Foi elaborado um questionário com o intuito de avaliar a satisfação com a instituição. De uma forma geral, os resultados indicam-nos que a satisfação com a vida está relacionada positivamente com a autonomia, na sua forma geral, com a dimensão autonomia funcional e com a satisfação com a instituição. A autonomia funcional encontra-se igualmente relacionada positivamente com a satisfação com a instituição. Os rapazes manifestam-se mais satisfeitos com a vida e com a instituição, assim como se sentem mais autónomos do que as raparigas. Os jovens mais velhos mostram-se mais autónomos que os mais novos, e a nível da resposta social é nos AA que se verifica maior autonomia, satisfação com a vida e com a instituição. Podemos salientar que os jovens institucionalizados apresentam níveis de satisfação com a vida baixos, sejam eles jovens mais novos ou mais velhos. Verificámos também que a satisfação com a vida destes jovens é influenciada positivamente pela percepção de competência face à escolha de uma estratégia e sua concretização para atingir um objectivo. Finalmente, podemos perceber que os jovens acolhidos em AA se mostram menos insatisfeitos com a vida e com a instituição, assim como manifestam uma percepção de autonomia superior, aos acolhidos em LIJ. / The main objective of this study focuses on understanding the relationship between autonomy, life satisfaction and institution satisfaction for institutionalized youngters. The analysis was based in these three concepts related to their age relations, sex and type of social care, focuses the attention on the differences between residential care and apartment care. In this study participated 181 youngsters, of both sexes, aged between 13 and 21 years old. Of the 181 youngsters, 155 were placed in residential care and 26 in the apartments care (apartments focused in autonomy development). In order to evaluate autonomy was used the Adolescent Autonomy Questionnaire, for evaluate life satisfaction was used the Students’ Life Satisfaction Scale. To access satisfaction with the institution, was developed a questionnaire, Satisfaction with the Institution Scale. In a general way, the results indicate that life satisfaction is positively related to autonomy, in its general form, with functional autonomy dimension and satisfaction with the institution. Functional autonomy is also positively related to satisfaction with the institution. The boys manifest, themselves, more satisfied with life and the institution as well as feel more autonomous than girls. The older youngsters appear to be more autonomous than younger ones. Analyzing the type of care, is in the apartment care that appear to be greater autonomy, satisfaction with life and with the institution. We point out that institutionalized youngsters have low life satisfaction, low levels whether they be younger or older youngsters. We also observed that life satisfaction of these youngsters is positively influenced by the perception of competence given the choice of a strategy and its implementation to achieve a goal. Finally, we can observe that youngsters in apartment care are less dissatisfied with life and the institution as well as express a greater sense of autonomy to those living in residential care.

White Adipose Tissue Re-growth after Partial Lipectomy in High Fat Diet Induced Obese Wistar Rats

The effects of partial removal of epididymal (EPI) and retroperitoneal (RET) adipose tissues (partial lipectomy) on the triacylglycerol deposition of high fat diet induced obese rats were analyzed, aiming to challenge the hypothesized body fat regulatory system. Male 28-day-old wistar rats received a diet enriched with peanuts, milk chocolate and sweet biscuits during the experimental period. At the 90th day of life, rats were submitted to either lipectomy (L) or sham surgery. After 7 or 30 days, RET, EPI, liver, brown adipose tissue (BAT), blood and carcass were obtained and analyzed. Seven days following surgery, liver lipogenesis rate and EPI relative weight were increased in L. After 30 days, L, RET and EPI presented increased lipogenesis, lipolysis and percentage of small area adipocytes. L rats also presented increased liver malic enzyme activity, BAT lipogenesis, and triacylglycerol and corticosterone serum levels. The partial removal of visceral fat pads affected the metabolism of high fat diet obese rats, which leads to excised tissue re-growth and possibly compensatory growth of non-excised depots at a later time.

A Palatable Hyperlipidic Diet Causes Obesity and Affects Brain Glucose Metabolism in Rats

Background We have previously shown that either the continuous intake of a palatable hyperlipidic diet (H) or the alternation of chow (C) and an H diet (CH regimen) induced obesity in rats. Here, we investigated whether the time of the start and duration of these feeding regimens are relevant and whether they affect brain glucose metabolism. Methods Male Wistar rats received C, H, or CH diets during various periods of their life spans: days 30-60, days 30-90, or days 60-90. Experiments were performed the 60th or the 90th day of life. Rats were killed by decapitation. The glucose, insulin, leptin plasma concentration, and lipid content of the carcasses were determined. The brain was sliced and incubated with or without insulin for the analysis of glucose uptake, oxidation, and the conversion of [1-14C]-glucose to lipids. Results The relative carcass lipid content increased in all of the H and CH groups, and the H30-60 and H30-90 groups had the highest levels. Groups H30-60, H30-90, CH30-60, and CH30-90 exhibited a higher serum glucose level. Serum leptin increased in all H groups and in the CH60-90 and CH30-90 groups. Serum insulin was elevated in the H30-60, H60-90, CH60-90, CH30-90 groups. Basal brain glucose consumption and hypothalamic insulin receptor density were lower only in the CH30-60 group. The rate of brain lipogenesis was increased in the H30-90 and CH30-90 groups. Conclusion These findings indicate that both H and CH diet regimens increased body adiposity independent treatment and the age at which treatment was started, whereas these diets caused hyperglycemia and affected brain metabolism when started at an early age.

Optimization and Applications of Large-Scale Biomedical Event Networks

The overwhelming amount and unprecedented speed of publication in the biomedical domain make it difficult for life science researchers to acquire and maintain a broad view of the field and gather all information that would be relevant for their research. As a response to this problem, the BioNLP (Biomedical Natural Language Processing) community of researches has emerged and strives to assist life science researchers by developing modern natural language processing (NLP), information extraction (IE) and information retrieval (IR) methods that can be applied at large-scale, to scan the whole publicly available biomedical literature and extract and aggregate the information found within, while automatically normalizing the variability of natural language statements. Among different tasks, biomedical event extraction has received much attention within BioNLP community recently. Biomedical event extraction constitutes the identification of biological processes and interactions described in biomedical literature, and their representation as a set of recursive event structures. The 2009–2013 series of BioNLP Shared Tasks on Event Extraction have given raise to a number of event extraction systems, several of which have been applied at a large scale (the full set of PubMed abstracts and PubMed Central Open Access full text articles), leading to creation of massive biomedical event databases, each of which containing millions of events. Sinece top-ranking event extraction systems are based on machine-learning approach and are trained on the narrow-domain, carefully selected Shared Task training data, their performance drops when being faced with the topically highly varied PubMed and PubMed Central documents. Specifically, false-positive predictions by these systems lead to generation of incorrect biomolecular events which are spotted by the end-users. This thesis proposes a novel post-processing approach, utilizing a combination of supervised and unsupervised learning techniques, that can automatically identify and filter out a considerable proportion of incorrect events from large-scale event databases, thus increasing the general credibility of those databases. The second part of this thesis is dedicated to a system we developed for hypothesis generation from large-scale event databases, which is able to discover novel biomolecular interactions among genes/gene-products. We cast the hypothesis generation problem as a supervised network topology prediction, i.e predicting new edges in the network, as well as types and directions for these edges, utilizing a set of features that can be extracted from large biomedical event networks. Routine machine learning evaluation results, as well as manual evaluation results suggest that the problem is indeed learnable. This work won the Best Paper Award in The 5th International Symposium on Languages in Biology and Medicine (LBM 2013).

Proteomics in the assessment of the therapeutic response of antineoplastic drugs: strategies and practical applications

Uncovering mechanisms of unknown pathological mechanisms and body response to applied medication are the drive forces toward personalized medicine. In this post-genomic era, all eyes are tuned to proteomic field, searching for the answers and explanations by investigating the final physiological functional units – proteins and their proteoforms. Development of cutting-edge mass spectrometric technologies and powerful bioinformatics tools, allowed life-science community mining of disease-specific proteins as biomarkers, which are often hidden by high complexity of the samples and/or small abundance. Nowadays, there are several proteomics-based approaches to study the proteome. This chapter focuses on gold standard proteomics strategies and related issues towards candidate biomarker discovery, which may have diagnostic/prognostic as well as mechanistic utility.

The everyday life of the revolution: gender, violence and memory

The ‘heroic life’ or the life of the revolutionary is one that resists or even seeks to transcend the everyday and the ordinary. The ‘banal’ vulnerabilities of everyday life, however, continue to constitute the unseen, often unspoken background of such a heroic life. This article turns to women’s memories of everyday life spent ‘underground’ in the context of the late 1960s radical left Naxalbari movement of Bengal. Drawing upon recent published memoirs and my own field interviews with middle class female (and male) activists, I outline the ways in which revolutionary femininity was imagined and lived in the everyday life of this political movement. I focus, in particular, on the gendered and classed nature of political labour, the gendering of revolutionary space, and finally, the extent to which everyday life in the ‘underground’ was a site of vulnerability and powerlessness, especially for women. I also signal how these memories of interpersonal conflict and everyday violence tend to remain buried under a collective mythicisation of the ‘heroic life’.

Nadzór nad funkcjonowaniem ferm zwierząt futerkowych w Polsce

W artykule porównano dwa raporty Najwyższej Izby Kontroli, która przeprowadziła kontrole organów państwowych zobligowane do wykonywania nadzoru nad funkcjonowaniem ferm zwierząt. Wnioski przedstawione przez Najwyższą Izbę Kontroli wykazały, że nadzór nad funkcjonowaniem owych ferm nie jest wystarczająco skuteczny i pozostawia wiele wątpliwości co do działalności organów państwowych. W przytaczanych raportach została opisana niestabilna sytuacja polskich organów kontroli, która stawia pod znakiem zapytania nie tylko działalność wymienionych organów, ale także kondycję całej struktury administracyjnej i kontrolnej. Ponadto wnioski zawarte w raportach wykazały, że podmioty uzyskujące zgodę na prowadzenie danych instalacji środowiskowych nie zawsze spełniają wymogi związane z ochroną środowiska, bowiem dokonują niekorzystnego podziału instalacji. Rozwój nowoczesnego rolnictwa i jego intensyfikacja może powodować szereg zagrożeń środowiskowych, głównie dla mieszkańców znajdujących się w bezpośrednim sąsiedztwie ferm utrzymujących zwierzęta. Przemysłowa hodowla zwierząt nie jest obojętna dla jakości i warunków życia ludzi mieszkających w bliskim sąsiedztwie ferm za sprawą uciążliwych odorów oraz zanieczyszczeń wód, w tym w wyniku przenawożenia gleb, prowadzących do zagrożeń chemicznych i mikrobiologicznych. Skutkiem występujących uciążliwości są protesty lokalnych społeczeństw. Brak odpowiedniego nadzoru zagraża również rodzimym gatunkom zwierząt, wyniszczając zwłaszcza ptaki i niektóre ssaki.

Anteproyecto arquitectónico diseño de un conjunto de residencias universitarias

El presente trabajo de grado previo a la obtención del título de Arquitecto, presenta una propuesta de diseño de un conjunto de residencias universitarias, un servicio y equipamiento que la ciudad evidencia que ya lo necesita. El anteproyecto no sólo está dirigido a la edificación de vivienda para estudiantes sino como un espacio apto para actividades académicas, espacios destina¬dos a dar un lugar para descansar y a su vez para estudiar y prepararse para la próxima vida profesional que le tocará vivir. La edificación está resuelta en base a módulos habitacionales para uno, dos, tres o cuatro usuarios, y otro destinado a un usuario con capacidades diferentes. Los espacios son multifuncionales y versátiles, ayudando así a las diversas tareas que podrían desarrollar los usuarios en las distintas carreras profesionales. Además el proyecto prevé la ubicación de espacios y servicios complementa¬rios indispensables para facilidad de los usuarios: cajeros, salas de estudio, cafetería, gimnasio, etc. Finalmente el proyecto se localizó de tal manera que quedará a distancias equitativas de las princi¬pales universidades de Cuenca.

Coping religioso, resiliência e qualidade de vida de pessoas com HIV/AIDS

Tese (doutorado)—Universidade de Brasília, Instituto de Psicologia, Programa de Pós-Graduação em Processos de Desenvolvimento Humano e Saúde, 2016.