Indenture of Land Sold by Solomon Quick to Henry Woodruff

Indenture regarding land sold by Solomon Quick of Niagara Township to Henry Woodruff from London District consisting of 1/4 acre and 4 perches in the Village of St. Davids. This was registered on February 2, 1826 - instrument no. 6761, February 3, 1821.

Indenture between Henry Mittleberger and Cadwallader Griffith Pelton

Indenture between Henry Mittleberger of St. Catharines and Cadwallader Griffith Pelton of St. Catharines for the sale of part of Lot no. 18 in the 6th Concession in the Township of Grantham - Instrument no. 11.013. May 6, 1836.

Indenture between Johnson T. Butler, Ann Jane Butler and Henry Rogers

Indenture of bargain and sale between Johnson T. Butler and his wife Ann Jane Butler, both of the Township of Niagara to Henry Rogers of the Township of Niagara regarding part of Lot no. 113 in the Township of Niagara - instrument no. 14467 [it is listed as 14467 and 14466 on different parts of the document], April 13, 1864.

Indenture between Henry and Mary Ellen Rogers and John Young

Indenture of bargain and sale between Henry and Mary Ellen Rogers of the Township of Niagara and John Young of the Township of Niagara regarding part of Lot no. 113 in the Township of Niagara - instrument no. 15071. Registered in the County of Lincoln on January 16, 1865 in Book C, folio 344, January 13, !865.

Indenture between Anne Steele, Anne Pickard and Margaret Ellen Rogers

Indenture of deed of land situate between Anne Steele of West Nissouri, wife of Archibald Steele of the first part, Anne Pickard of Niagara Township of the second part and Margaret Ellen Rogers, wife of Henry Rogers of Niagara Township of the third part. This is in regard to part of Lot no. 113 in Niagara Township. This was registered in the Township of Niagara on July 5, 1882 – instrument no. 1744, June 13, 1882.

Invitation to the Funeral of Infant Henry Howard Woodruff

Invitation to the funeral of infant Henry Howard Woodruff on March 17, 1868. He was the son of Henry and Emma Woodruff. This is accompanied by an envelope. March 16, 1868.

Letter - Henry O'Laughlin to H.K. Woodruff

Letter from Henry O’Laughlin, secretary of the Central Fire Station of St. Catharines, Ont. to H.K. Woodruff informing him that he was elected as an active member of the Citizens’ Hose Co. No. 1, March 14, 1883.

Indenture Abraham Fuller Atkinson, Henry Riggs Goodman and William Hamilton Merritt to Thomas Lees Helliwell

Indenture between Abraham Fuller Atkinson of St. Catharines, rector of St. George’s Church, Henry Riggs Goodman and William Hamilton Merritt, wardens of St. George’s Church, to Thomas Lees Helliwell for pew no. 15 in St. George’s Church, Mar. 21, 1857.

Postcard Addressed to Mr. Henry Woodruff

Postcard addressed to Mr. Henry Woodruff of St. Davids regarding 33 bags placed to Mr. Woodruff’s credit. The postcard is signed by John May, Aug. 6, 1883.

Crick, Henry A., includes Application for Loan, and Mortgage Loan Envelope

Crick, Henry A., includes Application for Loan, Jan. 8, 1885 and Mortgage Loan Envelope no. 637 for Jan. 1, 1885 – Jan. 1, 1890.

Letter to S.D. Woodruff regarding a resolution passed that the engineer be requested to examine the fence built by the contractors alongside of the Henry Vandenburgh Farm

Letter to S.D. Woodruff regarding a resolution passed that the engineer be requested to examine the fence built by the contractors alongside of the Henry Vandenburgh Farm and report to the secretary as to whether this is a lawful fence, completed according to Williams’ contract. This is signed by Duncan McFarland, president. There is a reply written by S.D. Woodruff at the bottom of the letter stating that the fence is not built in accordance with the contract, Dec. 18, 1856.

Annual meeting of the Long Point Company attached to a copy of the May 31, 1882 balance sheet

Annual meeting of the Long Point Company (1 page, printed) attached to a copy of the May 31, 1882 balance sheet (1 page, printed). The meeting has the name J.I. Mackenzie, assistant secretary-treasurer on the bottom and the balance sheet has the names J.I. Mackenzie, secretary treasurer and Geo. H. Gillespie, auditor on the bottom of the page, June 6, 1882.

Rough copy of the balance sheet to May 31, 1882

Rough copy of the balance sheet (3 pages, handwritten) to May 31, 1882.

Balance sheet including copy of the cash book and auditor’s report for 12 months ending May 31, 1882

Balance sheet including copy of the cash book and auditor’s report (1 page, printed) for 12 months ending May 31, 1882.

Mirroring Enzymes: The Role of H-Bonding In HQuin-BAM Catalyzed Asymmetric Aza-Henry Reactions: A DFT Study into the Reactivity, Mechanism, and Origins of Selectivity

The exact mechanistic understanding of various organocatalytic systems in asymmetric reactions such as Henry and aza-Henry transformations is important for developing and designing new synthetic organocatalysts. The focus of this dissertation will be on the use of density functional theory (DFT) for studying the asymmetric aza-Henry reaction. The first part of the thesis is a detailed mechanistic investigation of a poorly understood chiral bis(amidine) (BAM) Brønsted acid catalyzed aza-Henry reaction between nitromethane and N-Boc phenylaldimine. The catalyst, in addition to acting as a Brønsted base, serves to simultaneously activate both the electrophile and the nucleophile through dual H-bonding during C-C bond formation and is thus essential for both reaction rate and selectivity. Analysis of the H-bonding interactions revealed that there was a strong preference for the formation of a homonuclear positive charge-assisted H-bond, which in turn governed the relative orientation of substrate binding. Attracted by this well-defined mechanistic investigation, the other important aspect of my PhD research addressed a detailed theoretical analysis accounting for the observed selectivity in diastereoselective versions of this reaction. A detailed inspection of the stereodetermining C-C bond forming transition states for monoalkylated nitronate addition to a range of electronically different aldimines, revealed that the origins of stereoselectivity were controlled by a delicate balance of different factors such as steric, orbital interactions, and the extent of distortion in the catalyst and substrates. The structural analysis of different substituted transition states established an interesting dependency on matching the shape and size of the catalyst (host molecule) and substrates (guest molecules) upon binding, both being key factors governing selectivity, in essence, offering an analogy to positive cooperative binding effect of catalytic enzymes and substrates in Nature. In addition, both intra-molecular (intra-host) and inter-molecular (host-guest, guest-guest) stabilizing interactions play a key role to the high π-facial selectivity. The application of dispersion-corrected functionals (i.e., ωB97X-D and B3LYP-D3) was essential for accurately modeling these stabilizing interactions, indicating the importance of dispersion effects in enantioselectivity. As a brief prelude to more extensive future studies, the influence of a triflate counterion on both reactivity and selectivity in this reaction was also addressed.