Samlade vitterhesarbeten af svenska författare från Stjernhjelm till Dalin /

v.1--G. Stjernhjelm, G. Rosenhane, och J. Columbus. v.2--Thomas, Urban, Carl Urban, Johan och Erland Fredrik Hjärne. v.4--P. Lagerlöf, E. Lindschöld, Edmund, Nils och Carl Gripenhjelm, J. G. Werwing och J. T. Geisler. v.5--Wollimhaus-Gyllenborg. v.6--G. Eurelius, C. Leyoncrona I. Holmstrm̈, J. Paulinus och O. Wexionius. v.7--Magnus Gabriel de la Gardie, Jacob Arrhenius, Israel Kolmodin, Gustaf Ollon, Jacob Boëthius och Peter Brask. v.8--Märta Berendes, Ebba Marie och Joh. Eleonora de la Gardie, Amalia Wilh. och Maria Aurora von Königsmark, Thorsten Rudeen samt Carl och Ulrik Rudenschöld. v.9--Sven Dalius. Lars Wivallius och Johan Gabriel von Beyer. v.10--Lasse Johanson (Lucidor den Olycklige) och Nils Keder. v.11--En svensk fånge i Simbirsk, And. Rydelius, Harald Oxe, Germund, Carl Gustaf och Carl Wilhelm Cederhjelm. v.12--Olaf Rudbeck, (Far och sön) Erik Wennaesius, Carl Arosell, och Henrik Georg von Brobergen. v.13--Andreas Wallenius, Johan Vultejus, Christ. Tiburtius, Ernst Gestrinius, Michael Renner, Jonas Hjortzberg, och Peter Warnmark. v.15--J. Svedberg, H. Ausius, A. Amnelius, N. Tiällman, J. Schmedeman, P. Törnevall, och C. Eldh. v.16--Samuel Westhius, Gabr. Tuderus, W. von Rosenfeldt, Lars Stjerneld, Didr. Granatenflycht, Daniel Achrelius, Johan Risell, Lars Salvius, och Olof Carelius. v.17--Sophia Elisabeth Brenner. v.19--Johan Göstaf Hallman, Gustaf Palmfelt, och Carl Johan Lohman. v.22--Samuel Petri Brask, Magnus Stenbock, Jacob Fabricius.

Helicons blomster, plåckade ok vid åtskilliga tillfällen utdelte af Lucidor den Olyklige.

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A phase I biological and pharmacologic study of the heparanase inhibitor PI-88 in patients with advanced solid tumors

Purpose: PI-88 is a mixture of highly sulfated oligosaccharides that inhibits heparanase, an extracellular matrix endoglycosidase, and the binding of angiogenic growth factors to heparan sulfate. This agent showed potent inhibition of placental blood vessel angiogenesis as well as growth inhibition in multiple xenograft models, thus forming the basis for this study. Experimental Design: This study evaluated the toxicity and pharmacokinetics of PI-88 (80-315 mg) when administered s.c. daily for 4 consecutive days bimonthly (part 1) or weekly (part 2). Results: Forty-two patients [median age, 53 years (range, 19-78 years); median performance status, 1] with a range of advanced solid tumors received a total of 232 courses. The maximum tolerated dose was 250 mg/d. Dose-limiting toxicity consisted of thrombocytopenia and pulmonary embolism. Other toxicity was generally mild and included prolongation of the activated partial thromboplastin time and injection site echymosis. The pharmacokinetics were linear with dose. Intrapatient variability was low and interpatient variability was moderate. Both AUC and C-max correlated with the percent increase in activated partial thromboplastin time, showing that this pharmacodynamic end point can be used as a surrogate for drug exposure, No association between PI-88 administration and vascular endothelial growth factor or basic fibroblast growth factor levels was observed. One patient with melanoma had a partial response, which was maintained for >50 months, and 9 patients had stable disease for >= 6 months. Conclusion: The recommended dose of PI-88 administered for 4 consecutive days bimonthly or weekly is 250 mg/d. PI-88 was generally well tolerated. Evidence of efficacy in melanoma supports further evaluation of PI-88 in phase II trials.

Intermediate pyrolysis of biomass

A comparison of fast and intermediate processes is given. New developments in technology are described for intermediate pyrolysis and an advanced integrative combination of biomass based processes is proposed. © 2013 Woodhead Publishing Limited All rights reserved.

Fast pyrolysis of biomass for the production of liquids

This chapter examines the fast pyrolysis of biomass to produce liquids for use as fuels and chemicals. The technology for fast pyrolysis is described and the characteristics of the main product bio-oil. This primary liquid is characterised by the many properties that affect its use. These properties have caused increasingly extensive research to be undertaken to address properties that need modification and this area is reviewed in terms of physical, catalytic and chemical upgrading. Of particular note is the increasing diversity of upgrading methods. © 2013 Woodhead Publishing Limited All rights reserved.

Helicopter-borne sea ice thickness measurements during cruises ARK-XX/2 and ARK-XXII/2 (SPACE) in the Arctic Ocean

Helicopter-borne electromagnetic sea ice thickness measurements were performed over the Transpolar Drift in late summers of 2001, 2004, and 2007, continuing ground-based measurements since 1991. These show an ongoing reduction of modal and mean ice thicknesses in the region of the North Pole of up to 53 and 44%, respectively, since 2001. A buoy derived ice age model showed that the thinning was mainly due to a regime shift from predominantly multi- and second-year ice in earlier years to first-year ice in 2007, which had modal and mean summer thicknesses of 0.9 and 1.27 m. Measurements of second-year ice which still persisted at the North Pole in April 2007 indicate a reduction of late-summer second-year modal and mean ice thicknesses since 2001 of 20 and 25% to 1.65 and 1.81 m, respectively. The regime shift to younger and thinner ice could soon result in an ice free North Pole during summer.