992 resultados para DURKHEIM, EMIL


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von Germanicus

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E. Flanter

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Was das Heilige ist und wie man darüber sprechen kann, ist eine offene Frage in der religionswissenschaftlichen und theologischen Forschung. Jenseits der klassischen Entwürfe von Durkheim, Otto oder Eliade kann Heiliges heute nur in multiperspektivischer Betrachtung angemessen untersucht werden. Die Beiträge zu diesem Band analysieren Diskurse über Heiliges in spätantiken Religionskulturen: griechisch-römische Religion, Judentum und Christentum. Terminologien, Handlungen und Reflexionen in Bezug auf Heiliges werden in ihrem jeweiligen religiösen Bezugssystem thematisiert, aber darüber hinaus auch miteinander ins Gespräch gebracht. Hierfür dienen Kategorien wie Zeit, Ort, Individuum und Gruppe der Zuordnung der Befunde. Besonderes Augenmerk liegt zudem auf quellensprachlichen und forschungsinternen Begrifflichkeiten von Heiligem sowie auf der geschichtlichen Dynamik von Heiligkeitsvorstellungen. Dieses interdisziplinäre Vorgehen macht Diskontinuitäten und Kontinuitäten des Diskurses über „das Heilige“ in der Vielfalt seiner Erscheinungsformen präziser als bisher identifizierbar.

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Coumarins are extensively studied anticoagulants that exert additional effects such as anticancerogenic and even anti-inflammatory. In order to find new drugs with anticancer activities, we report here the synthesis and the structural analysis of new coumarin derivatives which combine the coumarin core and five member heterocycles in hydrazinylidene-chroman-2,4-diones. The derivatives were prepared by derivatization of the appropriate heterocyclic amines which were used as electrophiles to attack the coumarin ring. The structures were characterized by spectroscopic techniques including IR, NMR, 2D-NMR and MS. These derivatives were further characterized especially in terms of a potential cytotoxic and apoptogenic effect in several cancer cell lines including the breast and prostate cancer cell lines MCF-7, MDA-MB-231, PC-3, LNCaP, and the monocytic leukemia cell line U937. Cell viability was determined after 48 h and 72 h of treatment with the novel compounds by MTT assay and the 50% inhibitory concentrations (EC50 values) were determined. Out of the 8 novel compounds screened for reduced cell viability, 4c, 4d and 4e were found to be the most promising and effective ones having EC50 values that were several fold reduced when compared to the reference substance 4-hydroxycoumarin. However, the effects were cancer cell line dependent. The breast cancer MDA-MB-231 cells, the prostate cancer LNCaP cells, and U937 cells were most sensitive, MCF-7 cells were less sensitive, and PC-3 cells were more resistant. Reduced cell viability was accompanied by increased apoptosis as shown by PARP-1 cleavage and reduced activity of the survival protein kinase Akt. In summary, this study has identified three novel coumarin derivatives that in comparison to 4-hydroxycoumarin have a higher efficiency to reduce cancer cell viability and trigger apoptosis and therefore may represent interesting novel drug candidates

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von Emil Berger

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von Emil v. Boxberger

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von E. Flanter

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von Emil Simonson

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nach den Inschriften dargest. von Emil Schürer

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von Emil Lehmann. Hrsg. im Verein mit seinen Kindern [Johannes Lehmann, Betty Hepner, Siegfried Hepner] von einem Kreis seiner Freunde

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von Emil Bernhard Cohn

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componirt von Emil Brod