Antioxidant activity of apple extract protects against rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide

Several studies have shown that apple (Malus sp.) has many components able to exert chemopreventive activity. The aim of this study was to evaluate the chemopreventive potential of apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline 1-oxide (4NQO) by means of histopathological analysis and gene expression of antioxidant enzymes, such as CuZnSOD, MnSOD and catalase. A total of 30 male Wistar rats were distributed into five groups, as follows (n = 6 per group): Group 1 - negative control group (non-treated group); Group 2 - received 4NQO during 8 weeks in drinking water and treated with apple extract by gavage between the 1st and 4th weeks daily (initiation phase); Group 3 - received 4NQO for 8 weeks in drinking water and treated with apple extract by gavage between the 5th and 8th weeks daily (promotion phase); Group 4 - received apple extract by gavage for eight consecutive weeks only; and Group 5 - received 4NQO for 8 weeks in drinking water daily. Histopathological analysis revealed that apple extract protect oral lesions induced by 4NQO at initiation or promotion phase. Higher gene expression of CuZnSOD and MnSOD enzymes were noticed in groups treated with apple extract as well. Taken together, our results demonstrate that the apple extract is able to modulate medium-term oral carcinogenesis assay as a result of antioxidant activity.

Educação Popular e Educação do Campo: análise a partir do Programa Nacional de Educação da Reforma Agrária no curso Pedagogia da Terra em São Carlos - SP

Pós-graduação em Educação - FCT

Jules Laforgue e Carlos Drummond de Andrade: a ironia e a construção do gauche

Pós-graduação em Estudos Literários - FCLAR

Religiosidade e mito na obra de José Carlos Mariátegui e a teologia da libertação

Pós-graduação em Ciências Sociais - FCLAR

O papel de enfermeiros na equipe multidisciplinar frente ao sobrepeso/obesidade em ambiente de trabalho

Overweight and obesity are pandemics and have been widely discussed in Public Health and Health at Work. Comorbidities such as metabolic syndrome, hypertension, diabetes mellitus type 2, orthopedic disorders and coronary diseases can induce to absenteeism, reduced work performance, disability and death. The aim of this review is to discuss the role of the nurse in control and prevention of these illnesses in the workplace. We concluded that occupational health nurses work should act proactively with a multidisciplinary team aimed at individual and collective monitoring of actions designed to control and prevent overweight and obesity. Furthermore, this professional should follow up the health of individual workers with a high body mass index in order to warn and prevent comorbidities related to these conditions.

Qualidade de água utilizada para consumo em escolas e creches no município de São Carlos - SP

We know the importance of treating water for human consumption because changes in the physicochemical and / or biological has been associated with various health problems, the quality of water intended for human consumption must meet potability standards established by governmental decree 518/2004. The aim of this study was to evaluate the quality of water supplied schools and daycare in the city of São Carlos - SP. We selected 31 schools and kindergartens, and at intervals of 3 months, two water samples taken at three different points - network, tank and fi lter - totaling 186 samples, with an interval of three months, to verify possible differences in sampling points and at different times. The samples were evaluated for the following parameters: presence of total coliform and fecal coliform / E. coli count of heterotrophic bacteria, determination of pH, fl uoride, free residual chlorine, turbidity and color. The largest number of samples outside the standard for coliform was coming from the fi lters and the network, heterotrophic bacteria in most samples was taken out of standard fi lters. In the physical-chemical analysis of samples as many non-standard pH occurred in the network, network, and fl uoride in the fi lter pair in the fi lter to free chlorine and turbidity in the reservoir. The parameter with a larger sample size was inadequate fl uoride. We need more attention to the conservation, cleaning and maintenance of building reservoirs and fi lters in schools and kindergartens of San Carlos, since the water was considered unfi t for consumption.

La historia de Carlos Chagas como recurso para la formación de profesores de biología: algunas posibilidades

This paper analyzes the history of the doctor and scientist Carlos Chagas in the research that led to the identification of the agent and vector responsible for Chagas disease (American trypanosomiasis), in the early twentieth century, pointing out some possibilities of using this piece of history in shaping Biology teachers, as regards the discussion of science as a process of human construction and therefore historical.

Gestão de portfólio de produtos: práticas adotadas por uma empresa de base tecnológica de médio porte localizada na cidade de São Carlos, SP

In the context of the product development process (PDP), portfolio management plays an important role by determing the set of products that a company uses to compete. Due to its characteristics, performing continuous technological forecasting activities for developing and transferring technologies to their products through the PDP, this tends to make portfolio management a complex activity for products at these companies. This paper’s objective was to identify practices for product portfolio management in a medium-sized technology-based firm located in São Carlos, SP. Qualitative research was used and it was operationalized through a case study. Among the main results, it was noted that decisions on product portfolio depend mainly on the perception of senior management and the financial analyzes constitute the main method used for supporting the decision.

Formación de profesores en Educación Física en Brasil: comprensión de estudiantes noveles de la Universidad Federal de San Carlos

The frequent characterization about the Physical Education Degree is associated to technical-sport and training aspects and this is the reason of this study. The objective is to understand the motives to the basis of this situation. In this sense, a theoretical study was developed regarding the Physical Education Teaching Training in Brazil; at the same time, an empirical investigation was carried out with first-year students of the cited degree. The register tool to collect the students' understandings was an open question expressed as: "Why did you choose the course of Physical Education Degree?" which was answered in written form by the students. So as to make up an understanding of the data collected, the information was organized in two thematic categories; Category A: no identification with schooling; Category B: reasons in relation to the (lack) of professional vocation. Based on the students' answers, it was possible to comprehend that choosing the mentioned degree it is mostly set up by a lack of option, instead of a real professional identity and thoughtful processes of transformation in society.

Structure, microstructure, and selected mechanical properties of Ti-Zr-Mo alloys for biomedical applications

New titanium alloys for biomedical applications have been developed primarily with the addition of Nb, Ta, Mo, and Zr, because those elements stabilize the β phase and they don’t cause cytotoxicity in the organism. The objective of this paper is to analyze the effect of molybdenum on the structure, microstructure, and selected mechanical properties of Ti-15Zr-xMo (x = 5, 10, 15, and 20 wt%) alloys. The samples were produced in an arc-melting furnace with inert argon atmosphere, and they were hot-rolled and homogenized. The samples were characterized using chemical, structural, and microstructural analysis. The mechanical analysis was made using Vickers microhardness and Young’s modulus measurements. The compositions of the alloys were sensitive to the molybdenum concentration, indicating the presence of α’+α”+β phases in the Ti-15Zr-5Mo alloy, α”+β in the Ti-15Zr-10Mo alloy, and β phase in the Ti-15Zr-15Mo and Ti-15Zr-20Mo alloys. The mechanical properties showed favorable values for biomedical application in the alloys presenting high hardness and low Young’s modulus compared with CP-Ti.

Effect of the substitutional elements on the microstructure of the Ti-15Mo-Zr and Ti-15Zr-Mo systems alloys

Titanium alloys have excellent biocompatibility, and combined with their low elastic modulus, become more efficient when applied in orthopedic prostheses. Samples of Ti-15Mo-Zr and Ti-15Zr-Mo system alloys were prepared using an arc-melting furnace with argon atmosphere. The chemical quantitative analysis was performed using an optical emission spectrometer with inductively coupled plasma and thermal conductivity difference. The X-ray diffractograms, allied with optical microscopy, revealed the structure and microstructure of the samples. The mechanical analysis was evaluated by Vickers microhardness measurements. The structure and microstructure of alloys were sensitive to molybdenum and zirconium concentration, presenting α′, α″ and β phases. Molybdenum proved to have greater β-stabilizer action than zirconium. Microhardness was changed with addition of molybdenum and zirconium, having Ti-15Zr-10Mo (436 ± 2 HV) and Ti-15Mo-10Zr (378 ± 4 HV) the highest values in each system.

Revitalização do casarão da avenida Dr. Teixeira de Barros, São Carlos/SP

O antigo Casarão da Avenida Doutor Teixeira de Barros, destoa no bairro da Vila Prado por seu estado degradado, além de ser o único casarão da região. Apesar de abandonado, o Casarão tem um grande valor histórico para o bairro e a cidade e também valor arquitetônico devido seus ornamentos característicos das arquiteturas São-Carlenses do final do século XIX e início do século XX. Este trabalho visa a revitalização do Casarão abandonado, restaurando e preservando suas características e propondo um novo uso para o mesmo, beneficiando a população da cidade tanto com o novo uso proposto como também com a preservação desta parte da história de São Carlos

Encefalopatia hepática: relatório da 1º reunião monotemática da Sociedade Brasileira de Hepatologia

Hepatic encephalopathy (HE) is a functional disorder of the central nervous system (CNS) associated with liver failure, either end-stage chronic liver disease or fulminant hepatic failure. Its pathogenesis remains complex and poorly understood. In view of recent advances in the management of HE, the Brazilian Society of Hepatology endorsed a monothematic meeting regarding HE in order to gather experts in the field to discuss related data and to draw evidence-based recommendations concerning: management of HE and intracranial hypertension in FHF, treatment of episodic HE in cirrhosis, controversies in the management of EH including difficult to treat cases and diagnostic and treatment challenges for minimal HE. The purpose of this review is to summarize the lectures and recommendations made by the panel of experts of the Brazilian Society of Hepatology.

Estudo epidemiológico sobre as perdas reprodutivas em bovinos leiteiros: ocorrência de neospora caninum, brucella abortus, herpesvírus bovino tipo-1 e leptospira spp. em uma propriedade do município de São Carlos-SP

The aim of this work was draw an endemic level of reproductive losses and determine positivity for four infectious agents related to reproductive problems in dairy cattle on a property in São Carlos city. Blood serum samples were collected of 142 breeding animals more than two years old, from which 21.1% showed history of abortions or stillbirths in at least one pregnancy. Immunofluorescent antibody technique, tamponated acidified antigen test, serum neutralization technique and microscopic agglutination test, were used for detection of antibody anti-Neospora caninum, anti- Brucella abortus, anti-Bovine Herpesvirus Type-1 (BoHV-1) and anti-Leptospira spp , respectively. The serological tests carried out showed that 28.9% of the animals had titers greater than or equal to 100 of anti-Neospora caninum. Viral neutralization tests demonstrated that 26.8% of the animals had titers greater or equal to 256 for antibody anti-BoHV-1.Only 7.7% of the animals studied had titers equal to or greater than 100 in the microscopic agglutination test for Leptospira spp. There weren’t observed positive reactions to the tamponated acidified antigen test for diagnosis of bovine brucellosis. The study suggests the presence of BoHV-1, N. caninum and Leptospira spp in contact with dairy cattle property and could be involved in the occurrence of abortions and stillbirths in cattle. Reproductive losses are endemic and implies a possible behavior of chronic infections caused by these microorganisms.