[ 12 grañthne 103 (101?) ginān

Pīr Imām Shāh, Pīr Sohodev, Pīr Shams, ... [et al.]].

[ Four ginān books

Pīr Imām Shāh ... [et al.]].

[ Three ginān books

Pīr Imām Shāh ... [et al.]].

Investigating the Role of cAMP-Signaling in the Regulation of Vascular Endothelial Cell Adaptive Responses to Fluid Shear Stress

The circulating blood exerts a force on the vascular endothelium, termed fluid shear stress (FSS), which directly impacts numerous vascular endothelial cell (VEC) functions. For example, high rates of linear and undisturbed (i.e. laminar) blood flow maintains a protective and quiescent VEC phenotype. Meanwhile, deviations in blood flow, which can occur at vascular branchpoints and large curvatures, create areas of low, and/or oscillatory FSS, and promote a pro-inflammatory, pro-thrombotic and hyperpermeable phenotype. Indeed, it is known that these areas are prone to the development of atherosclerotic lesions. Herein, we show that cyclic nucleotide phosphodiesterase (PDE) 4D (PDE4D) activity is increased by FSS in human arterial endothelial cells (HAECs) and that this activation regulates the activity of cAMP-effector protein, Exchange Protein-activated by cAMP-1 (EPAC1), in these cells. Importantly, we also show that these events directly and critically impact HAEC responses to FSS, especially when FSS levels are low. Both morphological events induced by FSS, as measured by changes in cell alignment and elongation in the direction of FSS, and the expression of critical FSS-regulated genes, including Krüppel-like factor 2 (KLF2), endothelial nitric oxide synthase (eNOS) and thrombomodlin (TM), are mediated by EPAC1/PDE4D signaling. At a mechanistic level, we show that EPAC1/PDE4D acts through the vascular endothelial-cadherin (VECAD)/ platelet-cell adhesion molecule-1 (PECAM1)/vascular endothelial growth factor receptor 2 (VEGFR2) mechanosensor to activate downstream signaling though Akt. Given the critical role of PDE4D in mediating these effects, we also investigated the impact of various patterns of FSS on the expression of individual PDE genes in HAECs. Notably, PDE2A was significantly upregulated in response to high, laminar FSS, while PDE3A was upregulated under low, oscillatory FSS conditions only. These data may provide novel therapeutic targets to limit FSS-dependent endothelial cell dysfunction (ECD) and atherosclerotic development.

Indian Camp

on verso: No. 84. Indian Camp. Birch bark canoes on bank of Kaministiquia River, Canada.

Camp, court and siege; a narrative of personal adventure and observation during two wars: 1861-1865; 1870-1871.

The writer served successively on the staffs of Generals T. Williams, T.W. Sherman, and W.B. Franklin, 1862-1864 and E.R.S. Canby, 1865 in Louisiana and the lower Mississippi Valley; and was assistant secretary and secretary of the U.S. legation at Paris, 1866-1871.

Reminiscences of an emigrant Milesian. The Irish abroad and at home; at the court and in the camp; with souvenirs of "The Brigade."

Mode of access: Internet.

The court and camp of Buonaparte.

Mode of access: Internet.

Camp Creek radioactive mineral placer area, Blaine and Camas Counties, Idaho /

"June 1955."

Camp site development.

Mode of access: Internet.

Minnesota and its resources : to which are appended Camp-fire sketches, or, Notes of a trip from St. Paul to Pembina and Selkirk settlement on the Red River of the north /

Advertisements on front end-paper and fly-leaf.

In Ruhleben, letters from a prisoner to his mother, with an account of the "university" life, classes, sports, good, accommodation, etc., of the internment camp of British prisoners,

Mode of access: Internet.