3.2 Lorenzo Greene, Lincoln University History Professor, 1933-72

In late August, Lloyd Gaines filled out an application after conferring with Dr. Lorenzo Greene and one of his civics instructors at Vashon High School, Zaid D. Lenoir.

Integrin-mediated Adhesion of Endothelial Cells Induces JAK2 and STAT5A Activation: Role in the Control of c-fos Gene Expression

Integrin-mediated adhesion induces several signaling pathways leading to regulation of gene transcription, control of cell cycle entry and survival from apoptosis. Here we investigate the involvement of the Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway in integrin-mediated signaling. Plating primary human endothelial cells from umbilical cord and the human endothelial cell line ECV304 on matrix proteins or on antibody to β1- or αv-integrin subunits induces transient tyrosine phosphorylation of JAK2 and STAT5A. Consistent with a role for the JAK/STAT pathway in regulation of gene transcription, adhesion to matrix proteins leads to the formation of STAT5A-containing complexes with the serum-inducible element of c-fos promoter. Stable expression of a dominant negative form of STAT5A in NIH3T3 cells reduces fibronectin-induced c-fos mRNA expression, indicating the involvement of STAT5A in integrin-mediated c-fos transcription. Thus these data present a new integrin-dependent signaling mechanism involving the JAK/STAT pathway in response to cell–matrix interaction.

Fortification and Frontier: The Project Drawn up by Juan Martín Zermeño for Puebla de Sanabria in 1766

Following the death of engineer General Jorge Próspero de Verboom in 1744 and after a few years of transition in the management of Spanish fortifications, Juan Martín Zermeño took on the role, initially with a temporary mandate, but then definitively during a second period that ran from 1766 until his death in 1772. He began this second period with a certain amount of concern because of what had taken place during the last period of conflict. The Seven Years War (1756–1763) which had brought Spain into conflict with Portugal and England in the Caribbean had also lead to conflict episodes along the Spanish–Portuguese border. Zermeño’s efforts as a planner and general engineer gave priority to the northern part of the Spanish–Portuguese border. After studying the territory and the existing fortifications on both sides of the border, Zermeño drew up three important projects in 1766. The outposts that needed to be reinforced were located, from north to south, at Puebla de Sanabria, Zamora and Ciudad Rodrigo, which is where he is believed to have come from. This latter township already had a modern installation built immediately after the war of the Spanish Succession and reinforced with the Fort of La Concepción. However, Zamora and Puebla de Sanabria had some obsolete fortifications that needed modernising. Since the middle of the 15th century Puebla de Sanabria had had a modern castle with rounded turrets, that of the counts of benavente. During the 16th and 17th centuries it had also been equipped with a walled enclosure with small bastions. During the war of the Spanish Succession the Portuguese had enlarged the enclosure and had erected a tentative offshoot to the west. In order to draw up the ambitious Puebla de Sanabria project Zermeño had the aid of some previous reports and projects, such as those by the count of robelin in 1722, the one by Antonio de Gaver in 1752, and Pedro Moreau’s report dated June 1755. This study includes a technical analysis of Zermeño’s project and its strategic position within the system of fortifications along the Spanish–Portuguese border.

Daily pocket journal of John and Hannah Winthrop, 1766-1779

Small printed daily pocket journal repurposed by both John and Hannah between 1766 and 1779 to record household accounts including livestock pasturing, income received, and payments to servants, merchants, and tradesmen for food, livestock, clothing, linen, etc. Many of the pages are unused. The January-April pages contain account records from 1766-1779, one page in June has a few accounting notes from September 1779, the rest of June-November is empty, and three books are listed on a November page. The last three calendar pages contain lists of books in Hannah's handwriting dated 1773 and August 1768.

Payment order for Sylvanus Ames, 1766 July 1

Handwritten order to John Sale to pay scholarship funds to Sylvanus Ames (Harvard AB 1767), signed by Thomas Foxcroft, Charles Chauncey, Thomas Waite, and Daniel Marsh.

List of books received, October 1, 1766

Notation indicates that books were transported by a Captain Marshall.

Annotated almanac, 1766

Almanac containing three laid-in pages with handwritten notes and a few sporadic corrections to the rising and setting times of the moon on the calendar pages. The three laid-in pages consist of a small scrap of paper with the weights of the family, and two folded pages with notes about a lunar eclipse on August 20, 1766.

Annotated almanac, 1766

Almanac containing one interleaved page and sporadic annotations on the calendar pages including some notes about the weather. The interleaved page contains entries about the weather and the repeal of the Stamp Act (March 18).

Annotated almanac, 1766

Almanac containing one folded laid-in leaf and sporadic and minimal annotations on the calendar pages of corrections to the astronomical measurements. The laid-in leaf contains short notes about vegetable and fruit planting in April, May, and June of 1766 and 1767.

Annotated almanac, 1766

Almanac containing sporadic and minimal annotations correcting the printed astronomical measurements. There is one note on the January page about the sun's declension.

Annotated almanac, 1766

Almanac with one interleaved folded leaf and annotations made by John and Hannah Winthrop. The calendar pages are typically annotated with one or two notes at the bottom of page documenting household activities such as the hanging of bacon or bringing the horse from the pasture. The interleaved leaf contains entries by Hannah Winthrop about the weather, an earthquake (January 23), and a note "The Glorious News arrivd of the repeal of the Horrid Stamp Act" (May 16). There are entries of deaths in the community and a bill of mortality for 1766 in John Winthrop's hand.