Expression and biological activities of bovine interleukin 4: effects of recombinant bovine interleukin 4 on T cell proliferation and B cell differentiation and proliferation in vitro

Interleukin 4 (IL-4) is a pleotropic cytokine affecting a wide range of cell types in both the mouse and the human. These activities include regulation of the growth and differentiation of both T and B lymphocytes. The activities of IL-4 in nonprimate, nonmurine systems are not well established. Herein, we demonstrate in the bovine system that IL-4 upregulates production of IgM, IgG1, and IgE in the presence of a variety of costimulators including anti-IgM, Staphylococcus aureus cowan strain I, and pokeweed mitogen. IgE responses are potentiated by the addition of IL-2 to IL-4. Culture of bovine B lymphocytes with IL-4 in the absence of additional costimulators resulted in the increased surface expression of CD23 (low-affinity Fc epsilon RII), IgM, IL-2R, and MHC class II in a dose-dependent manner. IL-4 alone increased basal levels of proliferation of bulk peripheral blood mononuclear cells but in the presence of Con A inhibited proliferation. In contrast to the activities of IL-4 in the murine system, proliferation of TH1- and TH2-like clones was inhibited in a dose-dependent manner as assessed by antigen-or IL-2-driven in vitro proliferative responses. These observations are consistent with the role of IL-4 as a key player in regulation of both T and B cell responses.

Ms. Ff. Mus. 1119 - Am XI post Trinit. : Herr! sey mir gnädig, denn mir ist angst pp. ; C. A. T. B., 2 violini, 2 oboe se piace, 1 viola, violoncello et organo

von Telemann. [Textdichter: Gottfried Simonis]

Wahre Abcontrafactur deß Processes, Welcher bey der Crönung deß Durchleuchtigsten, Großmächtigen Fürsten vnd Herrn, Herrn Friderichen deß Ersten, Königs in Böheim, Pfaltzgrafen bey Rhein vnd ... : den 4 Novemb. Neuen Calenders ... des 1619 Jahrs zu Prag gehalten worden

Bibliograph. Nachweis: Paas P-438; Sehr ähnliches von E. Kieser in d. Messrelation zur Fastenmesse 1620 (Nachstich od. Vorlage?)

Ms. Ff. Mus. 1044 - Festo SS. Trinitat. : Gelobet sey Gott u. der Vater unsers Herrn Jesu Christi ; à 2 hautbois, 2 violini, canto, alto, tenore, basso con i ripieni, violoncello, violono, bassono ed organo

par Telemann

Na 1 Nachlass Max Horkheimer, 687 - "Experimental Movie Project", "The Police and Minority Groups" u.a. (p. IX 150.1-17 - IX 152.1-2)

"Experimental Movie Project" (1945-46):; 1. "Below the Surface", Drehbuch des Testfilms, a) als Typoskript vervielfältigt, 46 Blatt, b) als Typoskript vervielfältigt, 26 Blatt, c) als Typoskript vervielfältigt, 26 Blatt, d) als Typoskript vervielfältigt, 26 Blatt "Experimental Movie Project" (1945-46): Memoranden zum Test; 2. 'Notes' 25.4.1946, Typoskript, 1 Blatt; 3. "Memorandum on Experimental Movie Project", 19.4.1946. Typoskript, 3 Blatt; 4. "Memorandum re: 'Below the Surface" (Juli 1945). Typoskript, 2 Blatt; 5. Dore Schary und Allen Rivkin: 'Memorandum, Subject: New Suggested Treatment for 'Below the Surface'", 13.7.1945. Typoskript, 2 Blatt; 6. Hans Richter: "Report about the film script 'Below the surface'", 7. u. 8.7.1945, a) Typoskript, 1 Blatt, b) Typoskript, 1 Blatt; 7. Hans Richter: Bestätigung der Vereinbarung mit dem American Jewish Committee, 3.7.1945. Typoskript, 1 Blatt; 8. "Notes and Suggestions re Experimental Motion Picture", Juni 1945. Typoskript, 2 Blatt; 9. Siegfried Kracauer; "Suggestions for the Dialogue" (4.4.1945). Typoskript, 3 Blatt; 10. "Motion Picture", März 1945. Typoskript, 5 Blatt; 11. "Project on a Test film", a) Typoskript, 4 Blatt, b) Typoskript, 5 Blatt; 12. "Memorandum re: 'Below the Surface'", a) Typoskript, 3 Blatt, b) Typoskript mit eigenhändigen Korrekturen von Theodor W. Adorno, 3 Blatt; "Experimental Movie Project" (1945-46): Korrespondenz zum Test-Film-Projekt:; 13. Friedrich Pollock: 1 Brief an Max Horkheimer, Santa Monica, California, 12.10.1945; 14. Theodor W. Adorno: 2 Briefe an Max Horkheimer, Los Angeles und Santa Monica, California, 1945; 15. Joseph M. Proskauer: 1 Brief von Max Horkheimer, o.O., 29.6.1945, 1 Brief mit Unterschrift an Max Horkheimer, o.O., o.D., 3 Blatt; 16. Alexander Hackenschmied, 1 Brief mit Unterschrift an Max Horkheimer, New York, 19.6.1945, 1 Blatt; 17. Gilbert Gabriel: 1 Brief von John Slawson, o.O., 22.3.1945, 2 Blatt; "The Police and Minority Groups" (1946):; 1. "The Police and Minority Groups". Typoskript, 2 Blatt; 2. Robert W. Kenny: "Police and Minority Groups - an Experiment". Als Typoskript vervielfältigt, 17 Blatt; 3. Davis McEntire, Robert B. Powers: "Police Training Bulletin. A Guide to Race Relations for Police Officers", State of California, 1946, 38 Seiten; Max Horkheimer: "Memorandum on a Study of Race Hatred in Post-War Germany" (1946):; 1. Memorandum, a) Typoskript, 8 Blatt, b) Typoskript mit eigenhändigen und handschriftlichen Korrekturen, 6 Blatt, c) Typoskript, 5 Blatt, d) Teilstück, Typoskript mit eigenhändigen Korrekturen, 1 Blatt e) Typoskript mit eigenhändigen Korrekturen, 5 Blatt, f) Teilstück, Typoskript mit handschriftlichen Korrekturen, 2 Blatt, g) Typoskript mit eigenhändigen Korrekturen, 7 Blatt, h) Teilstück, Typoskript mit eigenhändigen Korrekturen und Ergänzungen, 1 Blatt, i) Typoskript, 2 Blatt; 2. Theodor W. Adorno: "Ad Memorandum Neumann", Manuskript, 3 Blatt;

Ascorbic acid effects on the immune system and type -1 /type -2 cytokine balance in humans

Vitamin C (ascorbic acid--AA) can have a substantial impact on human health by reducing the incidence and/or severity of coryza. Studies also suggest it has immunomodulatory functions in humans. Immune function is controlled by cytokines, such as type-1 cytokines (IFNγ) that promote antiviral immunity and type-2 cytokines (IL-4, IL-10) that promote humoral immunity. Knowing the mechanisms responsible for both antiviral immunity and type-1/type-2 cytokine balance, we sought to identify AA-induced alterations of human peripheral blood mononuclear cells (PBMC) in vivo and in vitro . We hypothesized that AA modulates the immune system, altering both number and function of PBMC. We first described the effect of 14 days of oral (1 gram) AA in healthy subjects. AA increased circulating natural killer (NK) cells, CD25+ and HLA-DR+ T cells, and PMA/ionomycin-stimulated intracellular IFNγ. We subsequently developed models for in vitro use. We determined that AA was toxic in vitro to T cells when used at doses found intracellularly but doses found in plasma from individuals taking 1gm/day AA were nontoxic. The model that most fully reproduced our in vivo intracellular cytokine findings used dehydroascorbic acid and buffers to deliver AA intracellularly. This model generated the largest increase in IFNγ at physiologic plasma concentrations. Previous studies demonstrate that chronic psychological stress is associated with a type-2 cytokine response. We hypothesized that vitamin C could prevent the type-2 cytokine shift associated with stress. In a study of medical students taking 1 g AA or placebo, a significant increase in IFNγ was seen intracellularly in CD4+ and CD8+ cells and in tetanus-stimulated cultures in the AA group only. We also observed increases in IFNγ/IL-4 and IFNγ/IL-10 ratios with AA supplementation, indicating a type-1 shift. Furthermore, we noted increased numbers of NK cells and activated T cells in the peripheral blood in the AA treated group only. Lastly, we investigated the role of the CD40L/CD40 and CD28/B7 costimulatory pathway in these cytokine alterations. AA did not have any effect on either pathway studied. Thus costimulatory pathways are not contributing to AA induced modulation of the type-1/type-2 immune balance. ^

La memoria literaria de la provincia de Misiones (2ª parte). 16H301

ASISTENCIA A CONGRESOS: 17 TRABAJOS PRESENTADOS. 1- I JORNADAS TEMÁTICAS DE LITERATURA ARGENTINA CONTEMPORÁNEA: EL HUMOR EN LA LITERATURA ARGENTINA. Mendoza, del 25 al 27 de agosto de 2011 Ponencias presentadas: A) El humor de María Elena: infancia, memoria y crítica, María de las Mercedes García Saraví- María Alejandra Viana. B) Una mirada humorística en Dormir al sol, Karina Lemes y Natalia Aldana. C) De los Cambios en tu hijo adolescente a la alienación del ser. Karina Lemes. D) Isidoro Blaisten; el Humor como coartada, elaborado por Marisa Renaut; 2 - II CONGRESO INTERNACIONAL DE LITERATURA Y CULTURA ESPAÑOLAS CONTEMPORÁNEAS. Diálogos transatlánticos 3, 4 y 5 de octubre de 2011. Presentadas las siguientes ponencias: A) Laberintos y zonas de densidad: Barcelona y La Plata en dos novelas policiales de Manuel Vázquez Montalbán y Néstor Ponce. Carolina Repetto Mercedes García Saraví. B) El asedio: eco del mundo novelesco de Arturo Pérez Reverte, Haydée Borowski – Mercedes García Saraví. C) De la metaficción y otros procedimientos en La loca de la casa, Karina Beatriz Lemes. 3– XVI CONGRESO NACIONAL DE LITERATURA ARGENTINA. Resistencia, 6, 7 y 8 de octubre de 2011. Presentadas las siguientes ponencias. A) “Ceviche: una nueva cocina del policial”, María Aurelia Escalada- Mercedes García Saraví. B) Entre Santa María y Ruvichá: mundos ficcionales de Latinoamérica. Jorge Hernando Otero. C) El titirimundi de Juan Enrique Acuña: resignificaciones de un arte menor. Ana Eugenia Kushidonchi - Carina Mabel Pereira. D) Gauna: el hallazgo de un manuscrito, Mara Rabbe. E) Filiaciones en el borde. Lorca y Acuña. Karina Lemes y Natalia Aldana. F) Un Amable trasgresor de los géneros, Gabriela Román. 4- IV JORNADAS NACIONALES DE MINIFICCIÓN: HORIZONTES DE LA BREVEDAD EN EL MUNDO IBEROAMERICANO. HOMENAJE A DAVID LAGMANOVICH (1927-2010) Mendoza. 2, 3 y 4 de noviembre de 2011. Presentadas las siguientes ponencias: A) Falsificaciones, de Marco Denevi: la traducción y el apócrifo, aportes al género microrrelato Gabriela Román y Mercedes García Saraví. B) Formas breves en la narrativa de Hugo Wenceslao Amable, por Gabriela Román. Aceptado para actas. 5- IV CONGRESO CELEHIS, Mar del Plata, 7, 8 y 9 de noviembre 2011. Presentadas las siguientes ponencias. A) De la crítica y otros procedimientos en la Loca de la casa, Karina B. Lemes; b) Trayectorias y fronteras en Cádiz: El asedio (2009) de Arturo Pérez Reverte. Haydée Borowski – Mercedes García Saraví. C) Algunos mundos ficcionales de América Latina. Por Jorge Hernando Otero.// Defensa de Tesinas: Jorge Hernando Otero. Relatos ruvichenses: un espacio misionero/latinoamericano. Directora: Mercedes García Saraví. Codirectora: Karina B. Lemes. Defendida 02/11/2011, Nota: 10 (diez).

Geochemical parameters of sediments and water of the Black Sea, data of Cruise 8 of R/V Vityaz-2

The book presents results of comprehensive geological investigations carried out during Cruise 8 of R/V "Vityaz-2" to the western part of the Black Sea in 1984. Systematic studies in the Black Sea during about hundred years have not weakened interest in the sea. Lithological and geochemical studies of sediments in estuarine areas of the Danube and the Kyzyl-Irmak rivers, as well as in adjacent parts of the deep sea and some other areas were the main aims of the cruise. Data on morphological structures of river fans, lithologic and chemical compositions of sediments in the fans and their areal distribution, forms of occurrence of chemical elements, role of organic matter and gases in sedimentation and diagenesis are given and discussed in the book.