European Ancestry Predominates in Neuromyelitis Optica and Multiple Sclerosis Patients from Brazil

Background: Neuromyelitis optica (NMO) is considered relatively more common in non-Whites, whereas multiple sclerosis (MS) presents a high prevalence rate, particularly in Whites from Western countries populations. However, no study has used ancestry informative markers (AIMs) to estimate the genetic ancestry contribution to NMO patients. Methods: Twelve AIMs were selected based on the large allele frequency differences among European, African, and Amerindian populations, in order to investigate the genetic contribution of each ancestral group in 236 patients with MS and NMO, diagnosed using the McDonald and Wingerchuck criteria, respectively. All 128 MS patients were recruited at the Faculty of Medicine of Ribeirão Preto (MS-RP), Southeastern Brazil, as well as 108 healthy bone marrow donors considered as healthy controls. A total of 108 NMO patients were recruited from five Neurology centers from different Brazilian regions, including Ribeirão Preto (NMO-RP). Principal Findings: European ancestry contribution was higher in MS-RP than in NMO-RP (78.5% vs. 68.7%) patients. In contrast, African ancestry estimates were higher in NMO-RP than in MS-RP (20.5% vs. 12.5%) patients. Moreover, principal component analyses showed that groups of NMO patients from different Brazilian regions were clustered close to the European ancestral population. Conclusions: Our findings demonstrate that European genetic contribution predominates in NMO and MS patients from Brazil. © 2013 Brum et al.

O realismo mágico na comunhão estética entre Memorial do convento e Cem anos de solidão

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

A modernidade no ensaísmo político de Octávio Paz

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Espaço e focalização em The ambassadors, de Henry James

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Romance e experimentação com a linguagem em Boquitas pintadas, de Manuel Puig, e Onde andará Dulce Veiga?, de Caio Fernando de Abreu

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

As estratégias de representação ficcional das contingências humanas em contos de Raymond Carver

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Leituras e imagens do 11 de setembro: reavaliações da história em Falling Man (2007), de Don DeLillo e em Fahrenheit 9/11 (2004), de Michael Moore

Pós-graduação em Letras - IBILCE

O cut-up em Naked Lunch de Willian Burroughs: a narrativa em estilhaços

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O realismo mágico e seus desdobramentos em romances de José Saramago

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O intelectual exilado em Augusto Roa Bastos

Pós-graduação em Letras - FCLAS

O romance, leituras da história: a saga de Cristóvão Colombo em terras americanas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Ensino de história e cultura afro-brasileira: uma análise do caderno do professor de história do ensino médio público paulista

Pós-graduação em Educação - FFC

Conflitos e conciliações: a relação da personagem Blanche DuBois, de Streetcar Named Desire, com a sociedade americana moderna

This paper presents a reflection on the relationship of the character Blanche DuBois, the protagonist of Tennessee Williams’s play A Streetcar Named Desire, with the society in which she is inserted. There is also a brief analysis of the construction of this character. To do this, the historical context of both the play and the author were studied, as well as his biography, which has great relevance in his work, and also a concise analysis of the elements presented in the literary work itself. In order to have an overview of Blanche, a few lines of this character were collected, as well as the lines of other characters that refer to her and some opposing viewpoints. The aim of this paper is to confront the character’s psychological and social conflicts, setting them in the context of modern American society

Mil años de ciencia ficción hermética latinoamericana [1492-2500]: En tres episodios: Borges, la conspiración; Sor Juana y Antônio Vieira, íntimos herejes; Bizarros profetas ciberculturales

Pós-graduação em Letras - IBILCE

O evento 11 de setembro: (re)criação da história no romance Extremely Loud & Incredibly Close (2005), de Jonathan Safran Foer

Pós-graduação em Letras - IBILCE