Quick Reads, August 18, 2010

IDPH Quick Reads is an electronic newsletter produced by the Director’s Office at the Iowa Department of Public Health. IDPH Quick Reads are published every three to four weeks.

Quick Reads, January 18, 2011

IDPH Quick Reads is an electronic newsletter produced by the Director’s Office at the Iowa Department of Public Health. IDPH Quick Reads are published every three to four weeks.

Friday Facts, September 18, 2009, Vol. 37

Bureau of Nutrition and Health Promotion part of the Iowa Department of Public Health produces of weekly newsletter about the Iowa WIC Program for the State of Iowa citizen.

Friday Facts, December 18, 2009, Vol. 44

Bureau of Nutrition and Health Promotion part of the Iowa Department of Public Health produces of weekly newsletter about the Iowa WIC Program for the State of Iowa citizen.

Friday Facts, February 18, 2011, Vol. 89

Bureau of Nutrition and Health Promotion part of the Iowa Department of Public Health produces of weekly newsletter about the Iowa WIC Program for the State of Iowa citizen.

Agri-News, September 13, 2006, Vol. 6, no. 18

Crop and livestock summaries for the state of Iowa, produced by the Iowa Department of Agriculture.

Agri-News, October 15, 2010, Vol. 10, no. 18

Crop and livestock summaries for the state of Iowa, produced by the Iowa Department of Agriculture.

Human alveolar macrophages infected by virulent bacteria expressing SipB are a major source of active interleukin-18.

Recent publications have demonstrated that the protease caspase-1 is responsible for the processing of pro-interleukin 18 (IL-18) into the active form. Studies on cell lines and murine macrophages have shown that the bacterial invasion factor SipB activates caspase-1, triggering cell death. Thus, we investigated the role of SipB in the activation and release of IL-18 in human alveolar macrophages (AM), which are the first line of defense against inhaled pathogens. Under steady-state conditions, AM are a more important source of IL-18 than are dendritic cells (DC) and monocytes. Cytokine production by AM and DC was compared after both types of cells had been infected with a virulent strain of Salmonella enterica serovar Typhimurium and an isogenic sipB mutant, which were used as an infection model. Infection with virulent Salmonella led to marked cell death with features of apoptosis while both intracellular activation and release of IL-18 were demonstrated. In contrast, the sipB mutant did not induce such cell death or the release of active IL-18. The specific caspase-1 inhibitor Ac-YVAD-CMK blocked the early IL-18 release in AM infected with the virulent strain. However, the type of Salmonella infection did not differentially regulate IL-18 gene expression. We concluded that the bacterial virulence factor SipB plays an essential posttranslational role in the intracellular activation of IL-18 and the release of the cytokine in human AM.

Agri-News, March 18, 2009, Vol. 9, no. 4

Crop and livestock summaries for the state of Iowa, produced by the Iowa Department of Agriculture.

Agri-News, August 18, 2009, Vol. 9, no. 13

Crop and livestock summaries for the state of Iowa, produced by the Iowa Department of Agriculture.

Agri-News, November 6, 2009, Vol. 9, no. 18

Crop and livestock summaries for the state of Iowa, produced by the Iowa Department of Agriculture.

Agri-News, November 13, 2009, Vol. 9, no. 18

Crop and livestock summaries for the state of Iowa, produced by the Iowa Department of Agriculture.