Interleukin-17 is a critical mediator of vaccine-induced reduction of Helicobacter infection in the mouse model.

BACKGROUND & AIMS: Despite the proven ability of immunization to reduce Helicobacter infection in mouse models, the precise mechanism of protection has remained elusive. This study explores the possibility that interleukin (IL)-17 plays a role in the reduction of Helicobacter infection following vaccination of wild-type animals or in spontaneous reduction of bacterial infection in IL-10-deficient mice. METHODS: In mice, reducing Helicobacter infection, the levels and source of IL-17 were determined and the role of IL-17 in reduction of Helicobacter infection was probed by neutralizing antibodies. RESULTS: Gastric IL-17 levels were strongly increased in mice mucosally immunized with urease plus cholera toxin and challenged with Helicobacter felis as compared with controls (654 +/- 455 and 34 +/- 84 relative units for IL-17 messenger RNA expression [P < .01] and 6.9 +/- 8.4 and 0.02 +/- 0.04 pg for IL-17 protein concentration [P < .01], respectively). Flow cytometry analysis showed that a peak of CD4(+)IL-17(+) T cells infiltrating the gastric mucosa occurred in immunized mice in contrast to control mice (4.7% +/- 0.3% and 1.4% +/- 0.3% [P < .01], respectively). Gastric mucosa-infiltrating CD4(+)IL-17(+) T cells were also observed in IL-10-deficient mice that spontaneously reduced H felis infection (4.3% +/- 2.3% and 2% +/- 0.6% [P < .01], for infected and noninfected IL-10-deficient mice, respectively). In wild-type immunized mice, intraperitoneal injection of anti-IL-17 antibodies significantly inhibited inflammation and the reduction of Helicobacter infection in comparison with control antibodies (1 of 12 mice vs 9 of 12 mice reduced Helicobacter infection [P < .01], respectively). CONCLUSIONS: IL-17 plays a critical role in the immunization-induced reduction of Helicobacter infection from the gastric mucosa.

Iowa Department of Transportation Major Items - Preliminary Quantity Report, December 17, 2013; With Addendums

Weekly letting report.

Catalogue des 17 tableaux originaux... composant la collection de feu M. le marquis de Saint-Marc... / [expert] Ch. Rouillard

[Vente. Art. 1859-02-23. Paris]

Arrêt du Conseil d'Etat du Roi qui dispense les religieux de l'ancienne observance de l'ordre de Cluny de l'exécution des édits du mois de mars 1768 et du mois de février 1773... Du 17 octobre 1787...

[Acte. 1787-10-17]

Floods of May 17-20, 1999, in the Volga and Wapsipinicon River Basins, Northeast Iowa, HR-140

Record flooding occurred May 17-20, 1999, in the Volga and Wapsipinicon River Basins following thunderstorm activity over northeast Iowa. On Sunday, May 16, between 6 and 8 inches of rain fell during a 24- hour period over portions of Bremer, Butler, and Fayette Counties. Highest rainfall during this 24-hour period was 8.3 inches recorded north of Oelwein in southwest Fayette County. A peak discharge of 29,800 cubic feet per second in the Volga River at Mederville, 53,900 cubic feet per second in the Turkey River at Garber, and 31, 100 cubic feet per second in the Wapsipinicon River at Independence set new peak discharge records. The peak discharge at Garber was greater than a theoretical 500-year flood, and the peak discharge at Independence was the equivalent of a 90- year flood. Information about the basins, rain storms, flooding, and a profile of high water marks are presented for selected intervals along the Volga River, Wapsipinicon River, Crane Creek, Little Wapsipinicon River, and Otter Creek.

Flood of June 15-17, 1998, Nishnabotna and East Nishnabotna Rivers, Southwest Iowa, HR-140

Record flooding occurred June 15-17, 1998, in the Nishnabotna and East Nishnabotna River basins following severe thunderstorm activity over southwest Iowa. More than 8 inches of rain fell over a large part of Cass County. The rain gage at Atlantic, Iowa recorded a 24-hour total rainfall of 13.18 inches, which established a new official State record for the greatest amount of rainfall in a 24-hour period. The peak discharge was 41,400 cubic feet per second in the East Nishnabotna River near Atlantic, 60,500 cubic feet per second in the East Nishnabotna River at Red Oak, and 65,100 cubic feet per second in the Nishnabotna River above Hamburg. The peak discharge at Atlantic was greater than the theoretical 200-year flood and the peak discharges at Red Oak and Hamburg were greater than the respective theoretical 500-year floods. Information about the basin, the rain storms, the flooding, and a profile of high water marks at selected intervals along the Nishnabotna and East Nishnabotna Rivers are presented in this report.

Oeuvres complètes de J. Michelet. T. 17, 1

Comprend : Oeuvres choisies de Vico

Iowa Department of Transportation Major Items - Preliminary Quantity Report, February 17, 2015; With Addendums

Weekly letting report.

List of Bid Proposal Holders, February 17, 2015

List of Bid Proposal Holders

Point de sanction, ou Deux mots sur le serment imposé aux ecclésiastiques, par le décret du 17 et du 29 novembre 1791 ([Reprod.])

Collection : Les archives de la Révolution française ; 8.667