Experimental NMR and MS study of benzoylguanidines. Investigation of E/Z isomerism

Molecules containing the guanidinic nuclei possess several pharmacological applications, and knowing the preferred isomers of a potential drug is important to understand the way it operates pharmacologically. Benzoylguanidines were synthesized in satisfactory to good yields and characterized by NMR, Electrospray Ionization Mass Spectrometry (ESI-MS) and Fourrier Transform InfraRed Spectroscopy techniques (FTIR). E/Z isomerism of the guanidines was studied and confirmed by NMR analysis in solution (1H-13C Heteronuclear Single Quantum Coherence (HSQC) and Heteronuclear Multiple-Bond Correlation (HMBC), 1H-15N HMBC, 1H- 1H Correlation Spectroscopy (COSY) and Nuclear Overhauser Effect Spectroscopy (NOESY) experiments) at low temperatures. Compounds with p-Cl and p-Br aniline moiety exist mainly as Z isomer with a small proportion of E isomer, whereas compounds with p-NO2 moiety showed a decrease in proportion of isomer Z. The results are important for the application of these molecules as enzymatic inhibitors. Copyright © 2013 John Wiley & Sons, Ltd.

Modelo de Marcus, elementos de matriz de tunelamento, efeitos de solvente e controle nuclear em reações de transferência de elétrons

This paper aims to give an initial presentation to physics students of the area of electron transfer, addressing its major aspects. The subject is then presented in an introductory way, highlighting and discussing the key points. Primarily, the problem is approached in a simplified manner through a two-state system, and aspects of calculating the matrix-element are discussed. Then, the electron transfer problem, influenced by nuclear reaction coordinates, is addressed and treated by the Marcus theory. Time scales and the concepts of adiabatic and nonadiabatic phenomena are discussed in the context of electron transfer. The classical, semi-classical and quantum formalisms of for the nuclear reactions coordinates are presented, and aspects of solvents are also discussed. Finally, we conclude by examining some recent examples of problems discussed in the literature.

An experimental verification of newton's second law

We describe an experimental procedure to probe the validity of Newton's second law. The experimental arrangement allows us to accelerate a glider on an air track by means of forces that are both steady and known. We also show how to determine acceleration from average speeds calculated for successive time intervals of the motion measured by using several electronic counters connected to a single-crystal oscillator circuit. Within experimental errors, the experiments clearly show the proportionality between acceleration and force for a fixed mass and between acceleration and inverse of mass for a fixed force. © by the Sociedade Brasileira de Física.

Qualidade física de ovos armazenados em diferentes condições de embalagens sob temperatura ambiente

The objective was to evaluate the internal quality of white-shelled consume eggs, sanitized or not, stored under different packaging conditions at room temperature. It was used 300 eggs, distributed in a completely randomized experimental design in a 3×2×4+1 factorial arrangement, three packaging conditions (PVC film, partial vacuum, partial vacuum with oxygen gas absorber), storage period (7, 14, 21 and 28 days), sanitized or not, and control (fresh eggs), with four repetitions. At the end of each period the analysis were performed. Partial vacuum condition was able to maintained Haugh unit, and promoted the best results for yolk index. The weight maintenance was better when packaged under vacuum, with or without O2 sachets absorbers. Lower values of water activity were obtained in eggs packed in PVC film, and when the sanitation was performed. It can be concluded that the internal egg quality decreases with storage time sharper in the eggs packed in PVC film, because vacuum has preserved some features of them. With sanitation, the storage conditions of eggs in PVC film should be improved because its internal quality decrease was greatest.

Percepção de tempo e outras funções cognitivas, funcionalidade motora e o nível de atividade física de idosos com Doença de Alzheimer no estágio leve

Pós-graduação em Ciências da Motricidade - IBRC

Os significados e as implicações da extensão universitária na formação inicial e na atuação profissional em educação física

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Aspectos morfológicos e histoquímicos do intestino delgado e ultra-estrutura de células caliciformes de ratos diabéticos-induzidos: influência da atividade física

Pós-graduação em Ciências Biológicas (Biologia Celular e Molecular) - IBRC

Efeitos do treinamento aeróbio na hepatocarcinogênese química em ratos Wistar alimentados com dieta basal ou hiperlipídica

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Caracterização física e química do solo e avaliação do desenvolvimento de plantas de eucalipto em função do espaçamento e da adubação, visando a colheita precoce para utilização em bioenergia

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

A influência da prática de atividade física regular na qualidade de vida e na composição corporal de portadores de osteoartrite

Pós-graduação em Alimentos e Nutrição - FCFAR

Determinação física e numérica de corridas de lama resultantes de ruptura de barreira retendo material viscoplástico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Associação de doses baixas de heparina não fracionada e de heparina de baixo peso molecular na prevenção de trombose venosa experimental

Pós-graduação em Bases Gerais da Cirurgia - FMB

Livros didáticos de física para o ensino médio: uma análise de conteúdo das práticas de eletricidade e magnetismo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Educação tecnológica no ensino de física: análise de uma experiência didática utilizando objetos tecnológicos

Pós-graduação em Educação para a Ciência - FC

Um estudo da monitoria de licenciandos em um centro de ciências para a melhoria da formação inicial de professores de física

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)