Design, synthesis and biological evaluation of new aryl thiosemicarbazone as antichagasic candidates

The present work reports on the synthesis, biological assaying and docking studies of a series of 12 aryl thiosemicarbazones, which were planned to act over two main enzymes, cruzain and trypanothione reductase. These enzymes are used as targets of trypanocidal activity in Chagas disease control with a minimal mutagenic profile. Three p-nitroaromatic thiosemicarbazones showed high activity against Trypanosoma cruzi in in vitro assays (IC50 < 57 μM), and no mutagenic profile was observed in micronucleous tests. Although the in vitro inhibition test showed that 10-μM doses of eight compounds inhibited cruzain activity, no correlation was found between cruzain inhibition and trypanocidal activity. © 2013 Elsevier Masson SAS. All rights reserved.

Management and water resources in Latin America and the Caribbean

Includes bibliography

Characteristics, design, construction and operation of rural electric systems in the United States

Includes bibliography

Some economic considerations in the design, commissioning and operation of power stations containing large generating units

Includes bibliography

Environmental conservation, water management, and privatization: identifying win-win situations

Includes bibliography

Poverty measurement as an instrument to design, monitor and evaluate health policy in Chile

Includes bibliography

Informe del Seminario Regional sobre Gestión Ambiental y Grandes Obras Hidráulicas = Report of the Regional Seminar on Environmental Management and Large Water Resource Project

Conclusiones y recomendaciones del Seminario cuyo objetivo fue examinar una de las formas mas importantes de intervencion humana en el medio ambiente, para derivar de ellas las politicas de desarrollo globales y sobre todo regionales, y lograr el maximo aprovechamiento sostenible de los recursos creados por la obra, junto con minimizar los efectos sociales y ambientales negativos de ella. Incluye lista de participantes y documentos presentados.

Contribuição da comunicação visual para o design de superfície

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Transactions at the Conference on Environmental Management and Economic Growth in the Smaller Caribbean Islands = Proceedings of the Conference on Environmental Management and Economic Growth in the Smaller Caribbean Islands

Includes bibliography

Roads: a new approach for road network management and conservation

Includes bibliography

Gestión ambiental y los grandes proyectos de aprovechamiento de recursos hídricos = Environmental management and large water resource development projects

Incluye Bibliografía

Comprehensive national child protection systems: legal basis and current practice in Latin America and the Caribbean

Includes bibliography.