Governor's Inaugural Address, 1929 (43rd General Assembly)

A transcript of the Governor's Inaugural Address by Governor Hammill.

Governor's Inaugural Address, 1931 (44th General Assembly)

A transcript of the Governor's Inaugural Address by Governor Turner.

Governor's Inaugural Address, 1933 (45th General Assembly)

A transcript of the Governor's Inaugural Address by Governor Herring.

Governor's Inaugural Address, 1935 (46th General Assembly)

A transcript of the Governor's Inaugural Address by Governor Herring.

Surface assembly of poly(I:C) on PEGylated microspheres to shield from adverse interactions with fibroblasts.

By expressing an array of pattern recognition receptors (PRRs), fibroblasts play an important role in stimulating and modulating the response of the innate immune system. The TLR3 ligand polyriboinosinic acid-polyribocytidylic acid, poly(I:C), a mimic of viral dsRNA, is a vaccine adjuvant candidate to activate professional antigen presenting cells (APCs). However, owing to its ligation with extracellular TLR3 on fibroblasts, subcutaneously administered poly(I:C) bears danger towards autoimmunity. It is thus in the interest of its clinical safety to deliver poly(I:C) in such a way that its activation of professional APCs is as efficacious as possible, whereas its interference with non-immune cells such as fibroblasts is controlled or even avoided. Complementary to our previous work with monocyte-derived dendritic cells (MoDCs), here we sought to control the delivery of poly(I:C) surface-assembled on microspheres to human foreskin fibroblasts (HFFs). Negatively charged polystyrene (PS) microspheres were equipped with a poly(ethylene glycol) (PEG) corona through electrostatically driven coatings with a series of polycationic poly(L-lysine)-graft-poly(ethylene glycol) copolymers, PLL-g-PEG, of varying grafting ratios g from 2.2 up to 22.7. Stable surface assembly of poly(I:C) was achieved by incubation of polymer-coated microspheres with aqueous poly(I:C) solutions. Notably, recognition of both surface-assembled and free poly(I:C) by extracellular TLR3 on HFFs halted their phagocytic activity. Ligation of surface-assembled poly(I:C) with extracellular TLR3 on HFFs could be controlled by tuning the grafting ratio g and thus the chain density of the PEG corona. When assembled on PLL-5.7-PEG-coated microspheres, poly(I:C) was blocked from triggering class I MHC molecule expression on HFFs. Secretion of interleukin (IL)-6 by HFFs after exposure to surface-assembled poly(I:C) was distinctly lower as compared to free poly(I:C). Overall, surface assembly of poly(I:C) may have potential to contribute to the clinical safety of this vaccine adjuvant candidate.

Educació virtual : Els dispositius mòbils com a eina d'ensenyament-aprenentatge

Aquest treball pretén aprofundir en com es poden aprofitar les noves eines tecnològiques per millorar l'entorn educatiu. Analitzarem de quina manera els dispositius mòbils poden ajudar a incrementar la motivació, la curiositat i la cooperació dels alumnes i, en definitiva, l'aprentatge.

A plan for an electronic library and information services program for Iowa : presented to the Honorable Terry E. Branstad and members of the Iowa General Assembly, 1995

This document summarizes the conclusions and recommendations of the Library Services Advisory Council who were appointed by Governor Terry E. Branstad to develop a coordinated, cost-effective and comprehensive plan for the implementation of an electronic statewide library and information services program.

Postmortem imaging: real or virtual?

Since the earliest years after the discovery of X-rays, radiological images have been used successfully for answering medico-legal and forensic questions. The possibility to evaluate the inside of a body without actually opening it has been appreciated and used in forensic pathology since then. However, the introduction of modern cross-sectional imaging techniques into post-mortem investigations has created controversial discussions among the medico-legal community. Terms like "Virtual Autopsy" and "Necro-Radiology" have led to confusion and controversy concerning the role of radiological techniques in forensic case work. Regardless, the use of those techniques in post-mortem investigations is increasing, especially the one of Muti-Detector Computed Tomography (MDCT). But also other imaging techniques such as Postmortem Angiography and Magnetic Resonance Imaging are increasingly applied. This presentation shall give an overview over the different techniques of postmortem imaging. It will critically explain their advantages and limitations in forensic death investigations compared to conventional autopsy. The role of postmortem imaging shall be discussed in order to distinguish between real state of the art and virtual reality.

La gestión de los libros electrónicos en la Biblioteca Virtual de la UOC

El texto que se presenta muestra cómo se lleva a cabo la gestión de los libros electrónicos en la Biblioteca Virtual (en adelante BV) de la Universitat Oberta de Catalunya (en adelante UOC). La BV pone especial énfasis en la adquisición de libros digitales para mejorar el acceso de los usuarios a los recursos y a lascolecciones de una universidad caracterizada por su virtualidad. El documento presenta, en primer lugar, el entorno en el que se adquieren y se utilizan los libros electrónicos: se describen los distintos escenarios de adquisición en los que se puede encontrar la BV y se definen los circuitos internos que permiten su gestión, así como los procesos técnicos de los documentos. A continuación, se muestran las distintas opciones de acceso y consulta de libros electrónicos que actualmente se ofrecen desde la BV y se exponenlos análisis de uso de dichos documentos. Por último, se presentan las conclusiones a las que llega la BV sobre el nuevo contexto de libros electrónicos.

Programari de consulta offline al campus virtual de la UOC

L'objectiu del projecte és el desenvolupament d'una aplicació d'escriptori que permeti a l'estudiant la consulta offline de les darreres novetats disponibles a les aules del campus UOC. Es tracta d'automatitzar el procés de consulta i descàrrega local de dades per tal de poder consultar-les posteriorment fora de línia.

Projecte de botiga virtual de XsysPC

El projecte es basa en el desenvolupament d'una aplicació web per a la companyia fictícia XsysPC que ha decidit oferir la venta per Internet dels productes que tenen en les seves botigues, tals com ordinadors, components informàtics, perifèrics i altres.

Typing less common ovarian tumors: A training tool based on a pattern-based algorithm applied to a set of 20 virtual slides.

Context: Ovarian tumors (OT) typing is a competency expected from pathologists, with significant clinical implications. OT however come in numerous different types, some rather rare, with the consequence of few opportunities for practice in some departments. Aim: Our aim was to design a tool for pathologists to train in less common OT typing. Method and Results: Representative slides of 20 less common OT were scanned (Nano Zoomer Digital Hamamatsu®) and the diagnostic algorithm proposed by Young and Scully applied to each case (Young RH and Scully RE, Seminars in Diagnostic Pathology 2001, 18: 161-235) to include: recognition of morphological pattern(s); shortlisting of differential diagnosis; proposition of relevant immunohistochemical markers. The next steps of this project will be: evaluation of the tool in several post-graduate training centers in Europe and Québec; improvement of its design based on evaluation results; diffusion to a larger public. Discussion: In clinical medicine, solving many cases is recognized as of utmost importance for a novice to become an expert. This project relies on the virtual slides technology to provide pathologists with a learning tool aimed at increasing their skills in OT typing. After due evaluation, this model might be extended to other uncommon tumors.

Tenda Virtual

Aquest projecte està principalment destinat a aconseguir un bon maneig d'algunes de les eines involucrades en aquest tema, com són JSP, TOMCAT i Struts 2 per a les necessitats web i MySQL per al registre de materials i transaccions.

Projecte de botiga virtual de XsysPC

El projecte es basa en el desenvolupament d'una aplicació web per a la companyia fictícia XsysPC que ha decidit oferir la venta per Internet dels productes que tenen en les seves botigues, tals com ordinadors, components informàtics, perifèrics i altres.

Iowa Child Advocacy Board Recommendations to the Iowa General Assembly, February 15, 2008

The Iowa Child Advocacy Board (ICAB) is an independent board composed of nine members appointed by the Governor of Iowa and confirmed by the Iowa Senate. This report is about recommendations to the Iowa General Assembly.