997 resultados para menores


Relevância:

20.00% 20.00%

Publicador:

Resumo:

Mode of access: Internet.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Mode of access: Internet.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

In 2 parts; pt. 1, v. 1-2 (paged separately); pt. 2: (Inedita) impressa por ordem do Instituto historico e geografico brasileiro; v. 1-3 (paged continuously)

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Salivary gland neoplasms exhibit a wide variety of biological behavior and a high morphological diversity raises the interest in researching these lesions. The stem cells are the main source for the generation and maintenance of cell diversity, disorders in the regulation of these cells can lead to the production of altered stem cells, termed cancer stem cells capable of generate the tumor. Researches on cancer stem cells and associated proteins have been developed in some oral cancers; however, their role in salivary gland neoplasms is not well established. Thus, the aim of this study was to identify the tumor parenchyma cells exhibiting stem cell characteristics, by evaluating the immunoreactivity of OCT4 and CD44, in a number of cases of salivary gland neoplasms. The sample consisted of 20 pleomorphic adenomas, 20 mucoepidermoid carcinomas and 20 adenoid cystic carcinoma located in minor and major salivary glands. The expression of OCT4 and CD44 was evaluated by the percentage of positive cells (PP) and the intensity of expression (IE), it is realized the sum of the scores, resulting in the total score immunostaining (PIT) ranging 0-7. All studied cases showed positive expression of OCT4 and CD44 and higher values than the control groups. It was observed that for OCT4 luminal cells and non-luminal were immunostained in the case of pleomorphic adenomas and adenoid cystic carcinoma. Already the immunoreactivity of CD44 was particularly evident in the non-luminal cells of these lesions. In mucoepidermoid carcinomas for both markers, there was immunoreactivity in squamous and intermediate cells and absence of staining mucous cells. For both markers, a statistically significant higher immunostaining was verified in neoplasms located in the major salivary glands compared with lesions in the minor salivary (p<0.001). At the total sample and in the group of minor salivary glands, malignant neoplasms exhibited higher immunoreactivity for OCT4 than pleomorphic adenoma. However, there was no statistically significant difference between the lesions and between their classifications histomorphologic. Analyzing the correlation between OCT4 and CD44 immunoexpressions, a statistically significant moderate positive correlation (r = 0.444) was observed. The high expression of OCT4 and CD44 may indicate that these proteins play an important role in identifying cancer stem cells, allowing a prediction of biological behavior of salivary gland neoplasms.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Cuando hacemos referencia a la conducta antisocial nos referimos a una serie de comportamientos que infringen las normas o leyes establecidos; en el momento actual con una repercusión a nivel individual, clínico, familiar y a nivel social esto nos lleva a tener que poner mucho más empeño en poder poner de manifiesto la necesidad de estudiar aquellos factores de riesgo que está influyendo en dicha conducta. Numerosos son los estudios que se han llevado a cabo sobre este asunto por distintos autores y conocedores de la materia, y en este recorrido ya se han podido vislumbran muchos factores no solo de riesgo sino de protección, que pueden llevarnos a comprender y entender de un modo más claro y conciso la naturaleza del fenómeno que estamos abordando. A pesar de todo lo anterior no existe, hasta el momento suficiente consenso sobre la conceptualización de la conducta antisocial, dado por ser un constructor complejo y su uso en la investigación es frecuentemente ambiguo ya que, en no pocas ocasiones, se emplea haciendo alusión a diferentes conductas sin una clara delimitación terminológica (Rutter, Giller y Hagell, 2000). En general, la conducta antisocial hace referencia a una diversidad de actos que generan daño en los demás, frecuentemente en forma de agresión, o que violan las normas sociales y los derechos de los demás (Burt y Donnellan, 2009; Peña y Graña, 2006). Sin embargo, el que una conducta se conceptualice como antisocial también está en función del juicio o valoración social acerca de la gravedad de los actos cometidos y de su alejamiento de las pautas normativas en una sociedad en concreto (Kazdin y Buela-Casal, 2002). En esta valoración intervienen multitud de factores tales como la edad del menor, su sexo, la clase social y otras circunstancias socio-contextuales (Pahlavan y Andreu, 2009; Romero, Sobral y Luengo, 1999; Vázquez, 2003)...