An intergenic non-coding RNA targets and regulates the ribosome in H. volcanii.

As translation is the final step in gene expression it is particularly important to understand the processes involved in translation regulation. It was shown in the last years that a class of RNA, the nonprotein-coding RNAs (ncRNAs), is involved in regulation of gene expression via various mechanisms (e.g. gene silencing by microRNAs). Almost all of these ncRNA discovered so far target the mRNA in order to modulate protein biosynthesis, this is rather unexpected considering the crucial role of the ribosome during gene expression. However, recent data from our laboratory showed that there is a new class of ncRNAs, which target the ribosome itself [Gebetsberger et al., 2012/ Pircher et al, 2014]. These so called ribosome-associated ncRNAs (rancRNAs) have an impact on translation regulation, mainly by interfering / modulating the rate of protein biosynthesis. The main goal of this project is to identify and describe novel potential regulatory rancRNAs in H. volcanii with the focus on intergenic candidates. Northern blot analyses already revealed interactions with the ribosome and showed differential expression of rancRNAs during different growth phases or under specific stress conditions. To investigate the biological relevance of these rancRNAs, knock-outs were generated in H. volcanii which were used for phenotypic characterization studies. The rancRNA s194 showed association with the 50S ribosomal subunit in vitro and in vivo and was capable of inhibiting peptide bond formation. These preliminary data for the rancRNA s194 make it an interesting candidate for further functional studies to identify the molecular mechanisms by which rancRNAs can modulate protein biosynthesis. Characterization of further rancRNA candidates are also underway.

Osservazioni critiche sopra le antichità cristiane di Cingoli.

Errata, p. [946].

One hundredth anniversary of the consecration of the Rt. Rev. Edward Bass, D. D., as the first Bishop of Massachusetts, May 7, 1797-May 7, 1897.

Cover title: Centennial celebration of the consecration of the Rt. Rev. Edward Bass, D. D., as the first Bishop of Massachussetts, 1897-1897.

Lincoln episcopal records in the time of Thomas Cooper ... bishop of Lincoln, A.D. 1571 to A.D. 1584,

Published also, 1912, as v. 2 of the Publications of the Lincoln record society.

A collection of Lancashire and Cheshire wills not now to be found in any probate registry. 1301-1752.

Errata slip inserted.

Beschreibung des Strassburger künstlichen Münsters und dessen Thurms : worin küzlich das Merkwürdigste davon deutlich erklärt wird : mit beygefügten Kupfern.

Illustrations: engraved plates; woodcut illustrations in the text.

De argilla specimen /

Head- and tail-pieces; decorative initials.

Physoderma maculare; Physodermataceae

Physoderma maculare Wallr.

A survey of the cathedral-church of Worcester; with an account of the bishops thereof, from the foundation of the see, to the year 1660 [i.e. 1610] Also an appendix of many original papers and records, never before printed.

"Chartae originales ex registris sedis episcopalis Wygorn, et decani & capituli ejusdem. Nunc primum editae": 8, 183 p. (Third and fourth groups)

Teachers' notes on the life of Jesus Christ Our Lord : junior course /

Mode of access: Internet.

Le Texas, ou Notice historique sur le Champ-d'Asile, comprenant tout ce qui s'est passé depuis la formation jusqu'à la dissolution de cette colonie, les causes qui l'ont amenée, et la liste de tous les colons français, avec renseignemens utiles à leurs familles

Streeter

The Elector's guide. Addressed to the freeholders of the county of York.

No. I. The "Catholic question".--No. II. The general state of the country banks and paper money; Death of Alexander, emperor of Russia; State of parties in the kingdom; A letter to Fountayne Wilson, esq.; Duncombe and the treadmill; Poetry and miscellanies.--No. III. A letter to the Duke of York; Auri sacra fames; or, Sturdy beggars: a county job; Church Methodism; A Protestant confessor; His Majesty's speech to Parliament; Miscellanies, and poetry.--No. IV. A letter to Daniel Sykes, esq. on West Indian slavery; Catholic and Protestant; The last man; Confidence in banks; Hints to electors; The proceedings in Parliament, &c., &c., &c.--No. V. An address to the suffering people of England; Slavery; A letter to Sir John Bayley, knt,; Banks; The Protestant champion; Poetry, &c., &c.--No. VI. A charge of His Grace the Archbishop of York to the clergy of the diocese; A secret; A good action.--No. VII. Observations upon county representation; A full account of the county meeting, &c., &c.

Journal of the Cork Historical and Archaeological Society.

With 1896-1898 is issued: Cork and Ross (Ireland : Diocese). Index to the marriage license bonds of the diocese of Cork and Ross, Ireland, for the years 1623 to 1750, published 1896-1897.

Histoire de la révolution française.

Half-title; author's name on individual title-pages.

Ordenliche Beschreibung, welcher Gestalt die nachbarliche Bündnuss vnd Verain der dreyen löblichen freien Stätt Zürich, Bern vnd Strassburg, dieses gegenwertigen 1588. Jars im Monat Maio ist ernewert, bestättigt vnd vollzogen worden : sampt etlichen poetischen Glückwünschungen vnd sonsten nötige Erinnerung vnd Vorred : auch Figuren, vnd der gemelten drey Stätt Contrafacturen.

Signatures: )(⁴ A-H⁴.