Variants in the Mannose-binding Lectin Gene MBL2 do not Associate With Sepsis Susceptibility or Survival in a Large European Cohort.

BACKGROUND  Sepsis is an increasingly common condition, which continues to be associated with unacceptably high mortality. A large number of association studies have investigated susceptibility to, or mortality from, sepsis for variants in the functionally important immune-related gene MBL2. These studies have largely been underpowered and contradictory. METHODS  We genotyped and analyzed 4 important MBL2 single nucleotide polymorphisms (SNPs; rs5030737, rs1800450, rs1800451, and rs7096206) in 1839 European community-acquired pneumonia (CAP) and peritonitis sepsis cases, and 477 controls from the United Kingdom. We analyzed the following predefined subgroups and outcomes: 28-day and 6 month mortality from sepsis due to CAP or peritonitis combined, 28-day mortality from CAP sepsis, peritonitis sepsis, pneumococcal sepsis or sepsis in younger patients, and susceptibility to CAP sepsis or pneumococcal sepsis in the United Kingdom. RESULTS  There were no significant associations (all P-values were greater than .05 after correction for multiple testing) between MBL2 genotypes and any of our predefined analyses. CONCLUSIONS  In this large, well-defined cohort of immune competent adult patients, no associations between MBL2 genotype and sepsis susceptibility or outcome were identified.

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 640 - Aufmunterungsschreiben wegen der schwierigen Eingewöhnungszeit an der Sprachschule in Wimbledon

u.a.: Erlaubnis des Vaters zur Reise nach London; Aufenthalt in Edinburgh; Reiseberichte der Mutter;

Cuentos medievales : "La dama del castillo del gavilán" y el "Ejemplo de las flechas" Juan de Mandevilla, Libro de las maravillas del mundo

A partir de los últimos estudios acerca de la cuentística medieval, tendientes a ampliar el corpus de relatos insertos no sólo en colecciones de cuentos sino en textos muy variados, se rastrean y clasifican los incluidos en el Libro de las maravillas del mundo de Juan de Mandevilla. Asimismo, se realiza el análisis puntual de dos cuentos: "La dama del castillo del gavilán" y el "Ejemplo de las flechas".

Cuentos medievales : "La dama del castillo del gavilán" y el "Ejemplo de las flechas" Juan de Mandevilla, Libro de las maravillas del mundo

A partir de los últimos estudios acerca de la cuentística medieval, tendientes a ampliar el corpus de relatos insertos no sólo en colecciones de cuentos sino en textos muy variados, se rastrean y clasifican los incluidos en el Libro de las maravillas del mundo de Juan de Mandevilla. Asimismo, se realiza el análisis puntual de dos cuentos: "La dama del castillo del gavilán" y el "Ejemplo de las flechas".

Cuentos medievales : "La dama del castillo del gavilán" y el "Ejemplo de las flechas" Juan de Mandevilla, Libro de las maravillas del mundo

A partir de los últimos estudios acerca de la cuentística medieval, tendientes a ampliar el corpus de relatos insertos no sólo en colecciones de cuentos sino en textos muy variados, se rastrean y clasifican los incluidos en el Libro de las maravillas del mundo de Juan de Mandevilla. Asimismo, se realiza el análisis puntual de dos cuentos: "La dama del castillo del gavilán" y el "Ejemplo de las flechas".

Geochemical data from pore water and solids from cores GS08-153-91GC12 and GS08-153-53-GC6, Arctic Mid-Ocean Ridge

Microbial communities and their associated metabolic activity in marine sediments have a profound impact on global biogeochemical cycles. Their composition and structure are attributed to geochemical and physical factors, but finding direct correlations has remained a challenge. Here we show a significant statistical relationship between variation in geochemical composition and prokaryotic community structure within deep-sea sediments. We obtained comprehensive geochemical data from two gravity cores near the hydrothermal vent field Loki's Castle at the Arctic Mid-Ocean Ridge, in the Norwegian-Greenland Sea. Geochemical properties in the rift valley sediments exhibited strong centimeter-scale stratigraphic variability. Microbial populations were profiled by pyrosequencing from 15 sediment horizons (59,364 16S rRNA gene tags), quantitatively assessed by qPCR, and phylogenetically analyzed. Although the same taxa were generally present in all samples, their relative abundances varied substantially among horizons and fluctuated between Bacteria- and Archaea-dominated communities. By independently summarizing covariance structures of the relative abundance data and geochemical data, using principal components analysis, we found a significant correlation between changes in geochemical composition and changes in community structure. Differences in organic carbon and mineralogy shaped the relative abundance of microbial taxa. We used correlations to build hypotheses about energy metabolisms, particularly of the Deep Sea Archaeal Group, specific Deltaproteobacteria, and sediment lineages of potentially anaerobic Marine Group I Archaea. We demonstrate that total prokaryotic community structure can be directly correlated to geochemistry within these sediments, thus enhancing our understanding of biogeochemical cycling and our ability to predict metabolisms of uncultured microbes in deep-sea sediments.