Algunos aspectos del financiamiento industrial en América Latina

Incluye Bibliografía

Design de superfície: por uma visão projetual geométrica e tridimensional

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estimativa da vulnerabilidade natural do aquífero livre no município de Rio Claro/SP

Pós-graduação em Geociências e Meio Ambiente - IGCE

Absorção de água, germinação e dormência de sementes de mucuna preta

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Revista CEPAL no.105

La dinámica del consumo energético industrial en América Latina y sus implicancias para un desarrollo sostenible / Hugo Altomonte, Nelson Correa, Diego Rivas y Giovanni Stumpo .-- La desigualdad del ingreso y los mercados de crédito / Adolfo Figueroa .-- Trinidad y Tabago: Desigualdades salariales intersectoriales / Allister Mounsey y Tracy Polius .-- México: Alza de precios de los alimentos y restricciones al crecimiento / Moritz Cruz, Armando Sánchez y Edmund Amann .-- Una mirada al auge exportador chileno / Raphael Bergoeing, Alejandro Micco y Andrea Repetto .-- Chile: Pensión anticipada, impaciencia y aversión al riesgo / Jaime Ruiz-Tagle y Pablo Tapia .-- Márgenes de ganancia, financiamiento e inversión del sector empresarial peruano (1998-2008) / Germán Alarco T. .-- ¿Se debe el mayor rendimiento de las escuelas de gestión privada en la Argentina al tipo de administración? / María Marta Formichella .-- Tecnología, comercio y calificación en el Brasil: Evidencias de datos microeconómicos / Bruno César Araújo, Francesco Bogliacino y Marco Vivarelli .-- Brasil: Cambio estructural y crecimiento con restricción de balanza de pagos / João Prates Romero, Fabrício Silveira y Frederico G. Jayme Jr. .-- Jueces de la Revista CEPAL año 2010 y enero-agosto 2011 .-- Orientaciones para los colaboradores de la Revista cepal.

Valores, crenças e comportamentos nas ações e atitudes dos indivíduos de caráter ambiental no município de Lavras -MG

The concept of environment involves social, political and economic aspects, in addition to natural elements. The acknowledgement that the environmental issue is complex highlights the importance of understanding the dynamics of relations that guide the individuals in their interactions with the environment. In this sense, studies have shown the relation between values, beliefs and behaviors. The theory on values developed by Schwartz (1992) identifies the complexity of the relations between values and behavior, organizing the field of human motivation into ten motivational types. Studies conducted by Pato (2004) on environmental beliefs are capable of indicating how the individuals relate to the environment, and its predisposition in acting or not in an ecological manner, allowing an understanding of ecological behavior and its forms of manifestation. Therefore, the objective of this study consisted of analyzing the value perception over environmental beliefs and ecological behavior of the individuals inserted into the environmental theme of the municipality of Lavras, Minas Gerais, Brazil. The research was conducted using a sample of 82 participants, comprised in its majority of male (62.2%), married (54.9%) individuals, and those with age from 31 to 40 years (35.4%). A survey of four segments was conducted: Ecological Behavior Scale (EBS), Environmental Beliefs Scale (EBeS), Schwatz Value Profile (SVP-40) and sociodemographic variables. The participants assumed, first, a value orientation directed to the universalism motivational type, which involves an important set of values for understanding the behaviors in relation to the environment. Furthermore, the results showed that the behaviors related to urban cleaning and economy of water and energy are more easily assimilated, while behaviors oriented to activism/consumerism and recycling were not yet incorporated in a satisfactory manner. On the other hand, the fact of belonging to an institution of which mission is to care for the environment seems to induce the participants to show a greater predisposition to pro-environmental behaviors. The environmental issue, urgent and moved by not always confluent debates, points to the need for reorganizing daily life, which necessarily involves change in values and behaviors. Thus, this study is relevant given that the interaction between the constructs can contribute with the research and the proposition of strategies that promote a reduction of behaviors damaging to the environment, as well as the strengthening of those that contribute for its preservation, sensitizing the actors involved to reorder their roles for benefiting the environment.

Propriedades físico-químicas de um latossolo vermelho sob recuperação há 16 anos e a ocorrência espontânea de espécies arbóreas nativas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Uma ironia fantástica: a dicotomia da narrativa em Murilo Rubião

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

As contribuições de Chaim Samuel Hönig para o desenvolvimento da matemática brasileira

Pós-graduação em Educação Matemática - IGCE

Enzyme replacement therapy for Mucopolysaccharidosis Type I among patients followed within the MPS Brazil Network

Mucopolysaccharidosis type I (MPS I) is a rare lysosomal disorder caused by deficiency of alpha-L-iduronidase. Few clinical trials have assessed the effect of enzyme replacement therapy (ERT) for this condition. We conducted an exploratory, open-label, non-randomized, multicenter cohort study of patients with MPS I. Data were collected from questionnaires completed by attending physicians at the time of diagnosis (T1; n = 34) and at a median time of 2.5 years later (T2; n = 24/34). The 24 patients for whom data were available at T2 were allocated into groups: A, no ERT (9 patients; median age at T1 = 36 months; 6 with severe phenotype); B, on ERT (15 patients; median age at T1 = 33 months; 4 with severe phenotype). For all variables in which there was no between-group difference at baseline, a delta of ≥ ± 20% was considered clinically relevant. The following clinically relevant differences were identified in group B in T2: lower rates of mortality and reported hospitalization for respiratory infection; lower frequency of hepatosplenomegaly; increased reported rates of obstructive sleep apnea syndrome and hearing loss; and stabilization of gibbus deformity. These changes could be due to the effect of ERT or of other therapies which have also been found more frequently in group B. Our findings suggest MPS I patients on ERT also receive a better overall care. ERT may have a positive effect on respiratory morbidity and overall mortality in patients with MPS I. Additional studies focusing on these outcomes and on other therapies should be performed.

Mucopolysaccharidoses in northern Brazil: targeted mutation screening and urinary glycosaminoglycan excretion in patients undergoing enzyme replacement therapy

Mucopolysaccharidoses (MPS) are rare lysosomal disorders caused by the deficiency of specific lysosomal enzymes responsible for glycosaminoglycan (GAG) degradation. Enzyme Replacement Therapy (ERT) has been shown to reduce accumulation and urinary excretion of GAG, and to improve some of the patients' clinical signs. We studied biochemical and molecular characteristics of nine MPS patients (two MPS I, four MPS II and three MPS VI) undergoing ERT in northern Brazil. The responsiveness of ERT was evaluated through urinary GAG excretion measurements. Patients were screened for eight common MPS mutations, using PCR, restriction enzyme tests and direct sequencing. Two MPS I patients had the previously reported mutation p.P533R. In the MPS II patients, mutation analysis identified the mutation p.R468W, and in the MPS VI patients, polymorphisms p.V358M and p.V376M were also found. After 48 weeks of ERT, biochemical analysis showed a significantly decreased total urinary GAG excretion in patients with MPS I (p < 0.01) and MPS VI (p < 0.01). Our findings demonstrate the effect of ERT on urinary GAG excretion and suggest the adoption of a screening strategy for genotyping MPS patients living far from the main reference centers.

Responsividade à tetrahidrobiopterina em pacientes com deficiência de fenilalanina hidroxilase

OBJETIVO: Identificar indivíduos responsivos à tetrahibrobiopterina (BH₄) em uma amostra de pacientes brasileiros com hiperfenilalaninemia por deficiência de fenilalanina-hidroxilase (HPA-PAH). MÉTODOS: Estudo intervencional, amostragem por conveniência. Para serem incluídos no estudo, os pacientes deveriam: possuir diagnóstico bioquímico de HPA-PAH; ter idade ≥ 7 anos; estar em tratamento dietético; e apresentar níveis de fenilalanina (Phe) ≥ 6 mg/dL em todas as medidas realizadas no ano anterior à inclusão no estudo. Os níveis de Phe foram determinados por meio de espectrometria de massas in tandem no dia anterior (dia 1) e nos pontos de hora 0, 4 e 8 h (dia 2) e 24 h (dia 3) após ingestão de BH₄. Os critérios utilizados para definir responsividade ao BH₄ foram: critério 1-redução ≥ 30% de Phe após 8 h da administração de BH₄; e critério 2-redução ≥ 30% de Phe após 24 h da administração. RESULTADOS: Dezoito pacientes foram incluídos no estudo (mediana de idade = 14 anos, sexo masculino = 12). Cinco pacientes foram responsivos ao BH₄, sendo três (forma clássica: um; forma leve: dois) de acordo com ambos os critérios, e dois (forma clássica: um; forma não definida: um) de acordo com o critério 2. Os níveis de Phe plasmáticos do dia 1 não demonstraram variação nos pontos de hora (p = 0,523). Entretanto, quando comparamos os níveis de Phe nos pontos de hora dos dias 1 e 2, encontramos uma variação significativa (p = 0,006). A análise da associação genótipo-fenótipo confirmou o caráter multifatorial da responsividade ao BH₄. CONCLUSÃO: Os nossos achados estão de acordo com a literatura e indicam que um número relevante de pacientes brasileiros com HPA-PAH é responsivo à BH₄.

Restauração ecológica de um solo decapitado sob intervenção antrópica há 17 anos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)